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| EDITORIALS |
| 1091 | Which biologic? New findings from a real-world study
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| 1093 | Extracellular traps as an emerging inflammatory pathway with promising therapeutic potential
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| 1095 | NLR in CBC: A holy grail for biomarker research in COPD?
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| COMMENTARY |
| 1098 | Interventional pneumology—Where we have come from and where we are going
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| INVITED REVIEW SERIES |
| Treatable traits - Personalised Medicine for Life in Airway Disease |
| 1101 | The treatable traits approach to adults with obstructive airways disease in primary and secondary care
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 1117 |
Benralizumab and mepolizumab treatment outcomes in two severe asthma clinics
David Langton, John Politis, Taya Collyer, Su-Wei Khung, Philip Bardin
10.1111/resp.14578
Asthma outcomes after 12 months treatment with either mepolizumab (n = 106) or benralizumab (n = 78) were compared. Both treatments were effective, but superior improvements in exacerbation frequency and FEV1 were observed with benralizumab.
See related editorial |
| Bronchiectasis |
| 1126 | Extracellular traps are evident in Romanowsky-stained smears of bronchoalveolar lavage from children with non-cystic fibrosis bronchiectasis
Amy S Bleakley, Steven Kho, Michael J Binks, Susan Pizzutto, Anne B Chang, Jemima Beissbarth, Gabriela Minigo, Robyn L Marsh
10.1111/resp.14587
The burden of paediatric bronchiectasis is an ongoing global challenge. Extracellular traps (ETs) are a potentially important marker for defining paediatric bronchiectasis endotypes. We demonstrate Romanowsky-stained BAL can be used as a simple and cost-effective ETs detection method. Using this approach, we determined that ETs were present in BAL slides from 79% of 89 children with non-cystic fibrosis bronchiectasis. Multiple ET types were observed, with ETs derived from macrophages (METs) and neutrophils (NETs) the most commonly detected types.
See related editorial |
| COPD |
| 1136 | Predictive role of neutrophil-percentage-to-albumin, neutrophil-to-lymphocyte and eosinophil-to-lymphocyte ratios for mortality in patients with COPD: Evidence from NHANES 2011–2018
Chou-Chin Lan, Wen-Lin Su, Mei-Chen Yang, Sin-Yi Chen, Yao-Kuang Wu
10.1111/resp.14589
Easy-to-use accurate predictors of chronic obstructive pulmonary disease (COPD) prognosis are important. Data from community-dwelling adults with COPD in the United States were analysed to investigate associations and predictive values of several biomarkers derived from routine blood samples. Neutrophil-percentage-to-albumin (NPAR) ratio appeared to be the best indicator of mortality in these patients.
See related editorial |
| Interstitial Lung Disease |
| 1147 | Decline in forced vital capacity as a surrogate for mortality in patients with pulmonary fibrosis
Toby M Maher, Susanne Stowasser, Florian Voss, Elisabeth Bendstrup, Michael Kreuter, Fernando J Martinez, Patricia J Sime, Christian Stock
10.1111/resp.14579
We used data from clinical trials of nintedanib in subjects with pulmonary fibrosis of diverse aetiology to demonstrate a strong association between decline in FVC per cent predicted and mortality over 52 weeks, supporting the use of FVC decline as a surrogate for mortality in clinical trials. |
| Lung Function |
| 1154 | The impact of antenatal and postnatal indoor air pollution or tobacco smoke exposure on lung function at 3 years in an African birth cohort
S Chaya, A Vanker, K Brittain, R MacGinty, C Jacobs, Z Hantos, H J Zar, D M Gray
10.1111/resp.14576
Indoor air pollution (IAP) contributes to the high burden of childhood respiratory illness. We performed comprehensive lung function testing, showing both antenatal and postnatal IAP and environmental tobacco smoke exposure to be associated with impairment in lung function at 3-years of age. This highlights the need for public health awareness and initiatives. |
| FORUM AND DEBATE |
| Scientific Letter |
| 1166 | Lung function and exacerbations in patients with COPD escalated to triple therapy: The RETRIEVE real-world study
Stavros Tryfon, Efthymia Papadopoulou, Maria Bertoli, Konstantinos Exarchos, Alexandros Ginis, Konstantinos Kostikas
10.1111/resp.14612 |
| Personal Reflections |
| 1170 | Zero-sum game
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| 1171 | In case you missed it
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| Letter from Asia-Pacific and Beyond |
| 1173 | Letter from Peru: Why was Peru the country with the world's highest infection and death rates for SARS-CoV-2?
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| Correspondence |
| 1175 | Drive-through delivery of home overnight oximetry
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