| OBITUARY |
| 1123 | J PATRICK BARRON
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| EDITORIALS |
| 1125 | What has been done will be done again
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| 1127 | All that wheezes at night is not asthma
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| 1129 | COPD exacerbations and MACE: More than a chance encounter?
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| 1131 | Long-term non-invasive ventilation in cystic fibrosis: A bridge too far?
John Wilson AM, BSc(Hons), MBBS, PhD, FRACP, Alan Young MBBS, PhD, FRACP
10.1111/resp.13712 |
| 1132 | Auto-titration of EPAP during NIV: A better night's sleep?
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| 1134 | Not just the common cold: Rhinovirus infection in lung allograft recipients
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| COMMENTARIES |
| 1136 | Application of artificial intelligence in respiratory medicine: Has the time arrived?
Christopher A Lovejoy MA (Cantab), MB BChir, Edward Phillips MA (Cantab), MBBS, Mahiben Maruthappu MA (Cantab), BM BCh
10.1111/resp.13676 |
| 1138 | Air pollution: The time has arrived for the medical profession to take ownership of the problem and act
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| INVITED REVIEW SERIES |
| Non-invasive ventilation |
| 1140 | Non-invasive ventilation: A glimpse into the future
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| 1143 | Technological advances in home non-invasive ventilation monitoring: Reliability of data and effect on patient outcomes
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| 1152 | Challenges to and opportunities for the implementation of non-invasive positive pressure ventilation in the Asia-Pacific region
Lili Guan, Luqian Zhou, Liqiang Song, Lingwei Wang, Dandan Chen, Rongchang Chen
10.1111/resp.13586 |
| 1156 | Non-invasive ventilation: Essential requirements and clinical skills for successful practice
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| INVITED REVIEW |
| 1165 | Silica-associated lung disease: An old-world exposure in modern industries
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 1176 | Nocturnal symptoms perceived as asthma are associated with obstructive sleep apnoea risk, but not bronchial hyper-reactivity
Chamara V Senaratna, E Haydn Walters, Garun Hamilton, Adrian J Lowe, Caroline Lodge, John Burgess, Bircan Erbas, Graham G Giles, Paul Thomas, Michael J Abramson, Bruce Thompson, Jennifer L Perret, Shyamali C Dharmage
10.1111/resp.13576
We assessed the roles of nocturnal asthma-like symptoms (NAS) and bronchial hyper-reactivity (BHR) in obstructive sleep apnoea (OSA)–asthma association. OSA is associated with NAS with or without the presence of asthma, but BHR is not associated with NAS when asthma is absent. Some NAS perceived as nocturnal asthma could be symptoms of OSA. |
| COPD |
| 1183 |
Increased risk of major adverse cardiac events following the onset of acute exacerbations of COPD
Mette Reilev, Anton Pottegård, Jesper Lykkegaard, Jens Søndergaard, Truls S Ingebrigtsen, Jesper Hallas
10.1111/resp.13620
We aimed to determine whether acute chronic obstructive pulmonary disease (COPD) exacerbations may trigger major adverse cardiac events and found an almost fourfold increased risk of myocardial infarction, stroke and cardiovascular death in the period following the exacerbation onset. The risk was particularly high for exacerbations requiring hospitalization and among the oldest individuals. |
| Cystic Fibrosis |
| 1191 |
Non-invasive ventilation versus oxygen therapy in cystic fibrosis: A 12-month randomized trial
Maree A Milross, Amanda J Piper, Tiffany J Dwyer, Keith Wong, Scott C Bell, Peter T P Bye, for the Non-Invasive Ventilation in Cystic Fibrosis (NIVCF) Study Group
10.1111/resp.13604
A prospective, randomized, parallel group study in adult patients with cystic fibrosis (CF) and sleep desaturation to compare 12 months of non-invasive ventilation (NIV) ±O2 to low-flow oxygen therapy (LFO2) during sleep was conducted. NIV ±O2 increases event-free survival over 12 months in adults with CF. No differences were seen in arterial blood gases (ABG), lung function, health-related quality of life (HRQoL) or hospitalizations. |
| Interventional Pulmonology |
| 1198 | PD-L1 detection in histology specimens and matched pleural fluid cell blocks of patients with NSCLC
Horiana B Grosu, Aileen Arriola, John Stewart, Junsheng Ma, Roland Bassett, Mike Hernandez, David Ost, Sinchita Roy-Chowdhuri
10.1111/resp.13614
Programmed death ligand-1 (PD-L1) expression in pleural fluid is reliable with fairly good correlation and concordance with PD-L1 expression in surgical biopsy/resection specimens and should be considered in patients who are unable to undergo histological biopsies. |
| Sleep and Ventilation |
| 1204 | Automatic EPAP intelligent volume-assured pressure support is effective in patients with chronic respiratory failure: A randomized trial
Jeremy E Orr, John Coleman, Gerard J Criner, Krishna M Sundar, Sheila C Tsai, Adam V Benjafield, Maureen E Crocker, Leslee Willes, Atul Malhotra, Robert L Owens, Lisa F Wolfe
10.1111/resp.13546
Automated expiratory positive airway pressure (EPAP) titration may be helpful in treating patients with respiratory failure and upper airway obstruction. This study demonstrates that, for a single night's titration, an automated EPAP algorithm is as effective as manually set EPAP for treating desaturation, without compromising ventilation and potentially improving sleep quality. |
| Thoracic Surgery/Transplantation |
| 1212 | Azithromycin reduces airway inflammation induced by human rhinovirus in lung allograft recipients
Kak-Ming Ling, Jessica Hillas, Melanie A Lavender, Jeremy P Wrobel, Michael Musk, Stephen M Stick, Anthony Kicic
10.1111/resp.13550
We highlight the ability of human rhinovirus (RV) to infect both large and small airway epithelial cells of lung allograft recipients resulting in cell death and inflammation. Importantly, we show that prophylactic treatment with azithromycin predominantly mitigates viral replication and the resulting inflammatory effects of viral infection. |
| FORUM AND DEBATE |
| Scientific Letter |
| 1220 | Stonemasons with silicosis: Preliminary findings and a warning message from Australia
Katrina Newbigin, Rex Parsons, David Deller, Robert Edwards, Rhiannon McBean
10.1111/resp.13672 |
| CORRESPONDENCE |
| 1222 | Non-invasive ventilation versus oxygen therapy in cystic fibrosis: Long-term effects
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| 1222 | Non-invasive ventilation versus oxygen therapy in cystic fibrosis: Long-term effects – Reply
Maree A Milross BAppSc (Phty), PhD Amanda J Piper BAppSc (Phty), MEd, PhD Tiffany J Dwyer BAppSc (Phty) Hons 1, PhD Peter T P Bye MBBS, FRACP, PhD
10.1111/resp.13708 |
| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 1224 | Letter from Mexico
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