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| EDITORIALS |
| 912 | Adding some NOVELTY to treatable traits
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| 914 | Long-term trends of COPD mortality: Gaps and opportunities
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| 916 | A clinical short-cut to identifying short telomeres in idiopathic pulmonary fibrosis?
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| 918 | A paediatric bronchoscopist's ‘Field of Dreams’: Will the flexible cryoprobe hit a home run?
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| COMMENTARIES |
| 920 | Targeting vasculature to reduce fetal growth restriction associated bronchopulmonary dysplasia
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| 923 | Bronchiectasis: A pulmonary disease with systemic consequences
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| 926 | Choosing and switching biological agents in severe asthma
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 929 | Treatable traits in the NOVELTY study
Alvar Agustí, Eleni Rapsomaniki, Richard Beasley, Rod Hughes, Hana Müllerová, Alberto Papi, Ian D Pavord, Maarten van den Berge, Rosa Faner, for the NOVELTY Study Investigators
10.1111/resp.14325
This study shows which treatable traits are present and/or absent in patients diagnosed with ‘asthma’, ‘COPD’ (chronic obstructive pulmonary disease) and ‘asthma + COPD’ in a global, observational study of more than 11,000 patients (NOVELTY), and how their prevalence changes with disease severity.
See related editorial |
| COPD |
| 941 |
Chronic obstructive pulmonary disease (COPD) mortality trends worldwide: An update to 2019
Federico Mei, Michela Dalmartello, Martina Bonifazi, Paola Bertuccio, Fabio Levi, Paolo Boffetta, Eva Negri, Carlo La Vecchia, Matteo Malvezzi
10.1111/resp.14328
Global age-standardized mortality due to chronic obstructive pulmonary disease (COPD), updated to 2019, reported a decrease in most countries for men, whilst a plateauing or a slight increase for women, although heterogeneity by world region was observed. COPD still remains a leading cause of death and disability, in particular in countries with lower socio-demographic index (SDI).
See related editorial |
| Environmental and Occupational Lung Disease |
| 951 | PM2.5 exposure and risk of lung adenocarcinoma in women of Taiwan: A case–control study with density sampling
Szu-Chun Yang, Fang-Yu Lin, Tzu-I Wu, Chih-Da Wu, Jung-Der Wang
10.1111/resp.14316
While the prevalence of smoking among Taiwanese women is <5%, lung cancer incidence remains high. We used long-term data considering residential changes since 2000, and allowed 5–10 years of latency. PM2.5 (fine particulate matter with an aerodynamic diameter of ≤2.5 μm) exposure over 30 μg/m3 was associated with an increased risk of lung adenocarcinoma in 15,943 women. |
| Interstitial Lung Disease |
| 959 | Extrapulmonary manifestations of a telomere syndrome in patients with idiopathic pulmonary fibrosis are associated with decreased survival
Thijs W Hoffman, Joanne J van der Vis, Douwe H Biesma, Jan C Grutters, Coline H M van Moorsel
10.1111/resp.14264
Clinical features suggestive of a telomere syndrome are present in a quarter of patients with idiopathic pulmonary fibrosis. These features include a history or family history of haematological or liver disease, or haematological laboratory abnormalities. They are associated with lower leukocyte telomere length and are independently associated with decreased survival.
See related editorial |
| Interventional Pulmonology |
| 966 | Cryotherapy in the paediatric airway: Indications, success and safety
Dirk Schramm, Nadine Freitag, Karsten Kötz, Ignacio Iglesias-Serrano, Mario Culebras-Amigo, Vladimir Koblizek, Santiago Pérez-Tarazona, Enrique Cases Viedma, JT Srikanta, Peter Durdik, Kaid Darwiche, Sune Rubak, Patrick Stafler
10.1111/resp.14353
This largest case collection of cryotherapy procedures in the paediatric airway to date demonstrates that cryotherapy can be safely and successfully applied for cryobiopsy, restoration of airway patency and foreign body removal. Paediatric interventional bronchoscopists are encouraged to add cryotherapy to their armamentarium of airway interventions in the paediatric airway.
See related editorial |
| Sleep and Ventilation |
| 975 | Atomoxetine and fesoterodine combination improves obstructive sleep apnoea severity in patients with milder upper airway collapsibility
Ludovico Messineo, Luigi Taranto-Montemurro, Nicole Calianese, Laura K Gell, Ali Azarbarzin, Gonzalo Labarca, Dan Vena, Hyung Chae Yang, Tsai-Yu Wang, Andrew Wellman, Scott A Sands
10.1111/resp.14326
We studied the combination of atomoxetine and fesoterodine (Ato-Feso), an extended-release anti-muscarinic, on obstructive sleep apnoea (OSA) severity and endotypes. Despite the absence of an effect on OSA severity, Ato-Feso led to improvements in OSA profile, reducing apnoea index and overnight hypoxaemia, especially in patients characterized by low-to-moderate pharyngeal collapsibility. |
| FORUM AND DEBATE |
| Scientific Letters |
| 983 | Dual bronchodilator treatment for prevention of COPD in at-risk smokers
Cindy Thamrin, Allison Martin, Tanya Badal, Edward Jeagal, Belinda Cochrane, Claude S Farah, Gregory G King, Mohan Nagarajah, Qiang Li, Xiaoqiu Liu, Norbert Berend, Christine R Jenkins
10.1111/resp.14357 |
| 987 | Predictors and outcomes of respiratory bacterial coinfections in patients with COVID-19 admitted to hospital: An observational prospective study
Giusy Tiseo, Lorenzo Roberto Suardi, Lisa Giusti, Arianna Forniti, Claudio Caroselli, Valentina Galfo, Sara Occhineri, Alessandro Leonildi, Giovanna Moscato, Francesco Menichetti, Marco Falcone
10.1111/resp.14372 |
| LETTERS FROM ASIA-PACIFIC AND BEYOND |
| 991 |
Leading women in respiratory medicine and research: Opportunities for international societies to support women with examples from the American Thoracic Society
Meghan E Rebuli PhD, Ilona Jaspers PhD
Special Series: Leading Women in Respiratory Medicine
Series Editors: Natasha Smallwood and Fanny Wai San Ko
10.1111/resp.14374
See related editorial |
| 994 | Letter from New Zealand
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