| EDITORIALS |
| 924 | Inhaler device use: Should we just forgo the detail and go for the 'big picture' approach?
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| 926 | Pseudomonas aeruginosa cross-infection: Is this important in bronchiectasis and COPD?
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| 928 | The patients are the ones missing out: A desperate need to standardize lung function reference equations
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| 930 | Nocturnal hypoxaemia in interstitial lung disease: An easy target to treat?
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| 933 | Sonic biopsy: A new tool for the assessment of peripheral pulmonary lesions
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| 935 | Targeting endosomal NOX2 as a potential therapy to limit influenza A virus infection
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| 937 | Heart and lungs in a single breath
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| COMMENTARIES |
| 939 | Overdiagnosis in respiratory medicine
Claudia C Dobler MBBS, MD, PhD, FRACP, Paul P Glasziou MBBS, PhD, FRACGP
10.1111/resp.13623 |
| 942 | Treatable traits and their application in high-, middle- and low-income countries
Vanessa M McDonald B Nurse, PhD, FThorSoc, Peter G Gibson MBBS, FRACP, FThorSoc, FAPSR, DMed
10.1111/resp.13626 |
| INVITED REVIEW SERIES |
| Non-Invasive Ventilation |
| 944 | Volume-targeted pressure support and automatic EPAP for chronic hypoventilation syndromes: An advance in-home ventilation or just more noise?
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| 952 | Non-invasive ventilation for obese patients with chronic respiratory failure: Are two pressures always better than one?
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| INVITED REVIEW |
| 962 | Tuberculous pleural effusion
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 972 | Real-life effectiveness of inhaler device switch from dry powder inhalers to pressurized metred-dose inhalers in patients with asthma treated with ICS/LABA
Hae-Sim Park, Dukyong Yoon, Hyun Young Lee, Ga-Young Ban, Simon Wan Yau Ming, Joanna Ling Zhi Jie, Victoria Carter, Antony Hardjojo, Job F M Van Boven, David B Price
10.1111/resp.13559
Switching from a dry powder inhaler (DPI) to a pressurized metred-dose inhaler (pMDI) for fixed-dose combination inhaled corticosteroids/long-acting β2-agonist (FDC ICS/LABA) asthma treatment led to decreased asthma exacerbations and was associated with better asthma control. The majority of patients persisted with the change. |
| Bronchiectasis |
| 980 | Transmission of bacteria in bronchiectasis and chronic obstructive pulmonary disease: Low burden of cough aerosols
Rebecca E Stockwell, Melanie Chin, Graham R Johnson, Michelle E Wood, Laura J Sherrard, Emma Ballard, Peter O'Rourke, Kay A Ramsay, Timothy J Kidd, Nassib Jabbour, Rachel M Thomson, Luke D Knibbs, Lidia Morawska, Scott C Bell
10.1111/resp.13544
Our study shows that patients with bronchiectasis and chronic obstructive pulmonary disease (COPD) can release potentially infectious aerosols during coughing; however, no shared stains of Pseudomonas aeruginosa were identified in our study. The results suggest that aerosol transmission is an unlikely mode of cross-infection in patients with bronchiectasis and COPD. |
| Interstitial Lung Disease |
| 988 |
Eligibility for anti-fibrotic treatment in idiopathic pulmonary fibrosis depends on the predictive equation used for pulmonary function testing
Andrew Burgess, Ken Goon, John D Brannan, John Attia, Kerrin Palazzi, Christopher Oldmeadow, Tamera J Corte, Ian Glaspole, Nicole Goh, Gregory Keir, Heather Allan, Sally Chapman, Wendy Cooper, Samantha Ellis, Peter Hopkins, Yuben Moodley, Paul Reynolds, Chris Zappala, Sacha Macansh, Christopher Grainge
10.1111/resp.13540
There is a significant discrepancy in the calculated %FVC (forced vital capacity) and %TLco (transfer factor of the lung for carbon monoxide) depending on which reference equation is used, which differ between interstitial lung disease centres. This variability may impact a patient's access to subsidized treatment creating inequality of access. |
| 996 |
Nocturnal hypoxaemia is associated with adverse outcomes in interstitial lung disease
Lauren K Troy, Iven H Young, Edmund M T Lau, Keith K H Wong, Brendon J Yee, Paul J Torzillo, Tamera J Corte
10.1111/resp.13549
The prevalence of nocturnal oxygen desaturation (NOD) and obstructive sleep apnoea (OSA) was studied in interstitial lung disease (ILD) patients. NOD occurred frequently both with and without associated OSA, and was predictive of survival. The threshold of ≥10% total sleep time with saturation <90% predicted new or worsening pulmonary hypertension at 12 months. |
| Interventional Pulmonology |
| 1005 | Transbronchial evaluation of peripheral pulmonary lesions using ultrasonic spectrum analysis in lung cancer patients
Tsukasa Ishiwata, Jiro Terada, Takahiro Nakajima, Kenji Tsushima, Koichiro Tatsumi
10.1111/resp.13534
Quantitative imaging analysis is warranted for guided bronchoscopy using radial-probe endobronchial ultrasound (RP-EBUS) targeting peripheral pulmonary lesions (PPL). This study demonstrated that radiofrequency spectrum analysis of RP-EBUS can allow non-invasive aetiological evaluation of PPL. |
| Respiratory Infections |
| 1011 | Novel endosomal NOX2 oxidase inhibitor ameliorates pandemic influenza A virus-induced lung inflammation in mice
Eunice E To, Raymond Luong, Jiayin Diao, John J O'Leary, Doug A Brooks, Ross Vlahos, Stavros Selemidis
10.1111/resp.13524
Lung inflammation to influenza A virus (IAV) infection can be fatal when the virus spreads to the alveolar space. We demonstrated that pathogenic inflammation to IAV is promoted by endosomally located NOX2 oxidase and that targeted inhibition of the reactive oxygen species (ROS) generated by this enzyme suppressed this inflammation and improved viral clearance. |
| POSITION STATEMENT |
| 1018 | Management of COPD in Asia: A position statement of the Asian Pacific Society of Respirology
Chin Kook Rhee, Ngo Quy Chau, Faisal Yunus, Kazuto Matsunaga, Diahn-Warng Perng, on behalf the COPD Assembly of the APSR
10.1111/resp.13633 |
| FORUM AND DEBATE |
| Scientific Letter |
| 1026 | Single-breath comprehensive cardiopulmonary assessment utilizing computerized tomography
Paul Leong, Martin I MacDonald, Brian S Ko, Kenneth K Lau, John M Troupis, Philip G Bardin
10.1111/resp.13577 |
| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 1030 | Letter from Brazil
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