| Page | |
| EDITORIAL |
| 821 | Risk of childhood asthma in those born small
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| COMMENTARIES |
| 824 | The potential impact of GLP-1 agonists on obstructive sleep apnoea
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| 826 | Connections and collaboration: Thoracic surgeons and thoracic physicians
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| INVITED REVIEW SERIES |
| The Future of Asthma |
| 828 | Treatable traits, combination inhaler therapy and the future of asthma management
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 841 |
Fetal growth rather than prematurity determines lung function in children with asthma
Hwan Soo Kim, Seung Won Lee, Jin Tack Kim, Jung Hoon Kim, Dae Hyun Lim, Woo Kyung Kim, Dae Jin Song, Young Yoo, Dong In Suh, Hey Sung Baek, Meeyong Shin, Ji Won Kwon, Gwang Cheon Jang, Hyeon-Jong Yang, Eun Lee, Ju Hee Seo, Sung Il Woo, Hyung Young Kim, Youn Ho Shin, Ju Suk Lee, Sungsu Jung, Nang Kyeong Lee, Jinho Yu
10.1111/resp.14528
Preterm birth or fetal growth has been associated with reduced lung function and asthma. We found that lung function decreased according to fetal growth, but did not differ according to history of prematurity in children with stable asthma. Fetal growth rather than prematurity has a lasting effect on lung function.
See related editorial |
| COPD |
| 851 | Predictors of longitudinal changes in body weight, muscle and fat in patients with and ever-smokers at risk of COPD
Akio Yamazaki, Daisuke Kinose, Satoru Kawashima, Yoko Tsunoda, Yumiko Matsuo, Yasuki Uchida, Hiroaki Nakagawa, Masafumi Yamaguchi, Emiko Ogawa, Yasutaka Nakano
10.1111/resp.14537
The relationship between airway and emphysematous lesions and longitudinal changes in body weight and regional body composition in patients with COPD and ever-smokers at risk of COPD was examined from both functional and morphological perspectives for the first time. Severe airflow limitation predicted future muscle wasting. |
| 860 | Elevated blood lactate in COPD exacerbations associates with adverse clinical outcomes and signals excessive treatment with β2-agonists
Martin I MacDonald, Kevan R Polkinghorne, Chris J MacDonald, Paul Leong, Kais Hamza, Gayan Kathriachchige, Christian Robert Osadnik, Paul T King, Philip G Bardin
10.1111/resp.14534
β2-Agonists can cause lactic acidosis but this has not been studied in AECOPD. Lactate was elevated in ~50% of people hospitalized with AECOPD and associated with metabolic abnormalities, higher rates of NIV and cumulative β2-agonist dosages. Injudicious salbutamol may be driving apparent clinical deterioration via lactic acidosis. |
| Lung Cancer |
| 869 | Overexpression of SMAD7 improves the function of EGFR-targeted human CAR-T cells against non-small-cell lung cancer
Guoping Li, Guoliang Liao, Jinbao Xie, Bo Liu, Xu Li, Minglian Qiu
10.1111/resp.14541
The efficacy of TGF-β signalling-resistant CAR-T based on SMAD7 overexpression is restricted to CAR-T cells themselves and potentially reduces systemic effects on TGF-β signalling. SMAD7-CAR-T demonstrates complete elimination of cancer in vivo, high levels of SMAD7-CAR-T proliferation, and activation that are not significantly different from the DNR-CAR-T design. |
| FORUM AND DEBATE |
| Scientific Letter |
| 881 | Observation of peripheral airways using ultra-thin fiberscope
Tomonari Kinoshita, Hideki Terai, Shinnosuke Ikemura, Nao Takada, Takahiro Fukui, Hidehiro Irie, Raita Miyazawa, Yohei Funatsu, Teppei Okamura, Hidefumi Koh, Tatsuya Yamamoto, Risa Shigematsu, Keiko Ohgino, Kiyoshi Oka
10.1111/resp.14547 |
| Personal Reflections |
| 885 | Take a deep breath, speak your truth and Advocate for change—A Patient Advocate's perspective
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| 887 | Healthcare equity—Lung cancer in the Asian-Pacific regions
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| 888 | Hansen's disease and the first patient disease Registry
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| Letters from Asia-Pacific and Beyond |
| 890 | Letter from Malaysia
Andrea Yu-Lin Ban MB, BCh, BAO, MMed, Boon Hau Ng MBBS, MMed, Nik Nuratiqah Nik Abeed MD, MMed
10.1111/resp.14554 |
| 892 | Letter from the United States: An update on the New York experience with COVID-19
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| Correspondence |
| 895 | A snorkel mask with a 3D-printed adaptor to HEPA filter was used in a COVID-19 emergency ward to provide safe respiratory support
Camila Vitelli Molinari MSc, Vivian Bertoni Xavier PhD, Ronaldo Fernandes Rosa MSc, Maria Augusta Junqueira Alves MSc, Luiz Antônio Rivetti PhD, Vera Lúcia dos Santos Alves PhD
10.1111/resp.14 |
