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| EDITORIALS |
| 90 | Ultrathin bronchoscopy and cryobiopsy in diagnosing peripheral pulmonary lesions: Another tool in the toolbox
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| 93 | Small babies at birth, small lungs for life?
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| 95 | The global burden of respiratory infectious diseases before and beyond COVID
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| 97 | Holding our breath: Exploring the causes of hypercapnic respiratory failure resulting in mortality
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| 99 | Small for gestational age at term and adult lung function
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| COMMENTARIES |
| 101 | Checkpoint inhibitors are a basic science-based, transformative new treatment for lung cancer
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| 107 | Management of moderate severity outpatients with COVID-19 disease: Proposed criteria and algorithm for initiation of antiviral treatment
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| POSITION PAPER |
| 110 | Australasian Sleep Association position statement on consensus and evidence based treatment for primary snoring
Leba M Sarkis, Andrew C Jones, Andrew Ng, Christopher Pantin, Sarah L Appleton, Stuart G MacKay
10.1111/resp.14443 |
| INVITED REVIEW |
| 120 | Thoracic manifestations of IgG4-related disease
Romain Muller, Mikael Ebbo, Paul Habert, Laurent Daniel, Antoine Briantais, Pascal Chanez, Jean Yves Gaubert, Nicolas Schleinitz
10.1111/resp.14422 |
| ORIGINAL ARTICLES |
| COPD |
| 132 | Smoking induces shifts in cellular composition and transcriptome within the bronchial mucus barrier Senani N H Rathnayake, Benedikt Ditz, Jos van Nijnatten, Tayyaba Sadaf, Philip M Hansbro, Corry A Brandsma, Wim Timens, Annemarie van Schadewijk, Peter S Hiemstra, Nick H T ten Hacken, Brian Oliver, Huib A M Kerstjens, Maarten van den Berge, Alen Faiz
10.1111/resp.14401
We assessed the cellular composition and gene expression shifts of the bronchial-mucus-barrier with single-cell-RNA-sequencing-based cellular deconvolution to predict cell-type composition in RNA-seq data. Smoking increased goblet cell abundance in the bronchial-mucus-barrier, which is partly reversible after 1-year smoking cessation. Cellular deconvolution can predict goblet-cell ratios from RNA-seq data. |
| Interventional Pulmonology |
| 143 | Ultrathin bronchoscopic cryobiopsy of peripheral pulmonary lesions
Masahide Oki, Hideo Saka, Yoshihito Kogure, Hideyuki Niwa, Arisa Yamada, Atsushi Torii, Chiyoe Kitagawa
10.1111/resp.14360
To date, no prospective study has evaluated the use of a 1.1-mm ultrathin cryoprobe in combination with ultrathin bronchoscopy. Ultrathin bronchoscopic cryobiopsy was successfully performed in most of our patients without any significant complications, which enhanced the overall diagnostic yield when combined with forceps biopsy.
See related Editorial |
| 152 | Value of adding ultrathin bronchoscopy to thin bronchoscopy for peripheral pulmonary lesions: A multicentre prospective study
Masahide Oki, Hideo Saka, Daisuke Himeji, Tatsuya Imabayashi, Yoichi Nishii, Masahiko Ando
10.1111/resp.14397
Although the effectiveness of ultrathin bronchoscopy as an initial diagnostic procedure has been established, it has not been prospectively investigated as an adjunct to larger bronchoscopes. Ultrathin bronchoscopy provided higher diagnostic yield than thin bronchoscopy for lesions 'invisible' or 'adjacent to' the endobronchial ultrasound image with thin bronchoscopy.
See related Editorial |
| Lung Function |
| 159 | Small for gestational age is associated with reduced lung function in middle age: A prospective study from first to fifth decade of life
Melvin Tandra, E Haydn Walters, Jennifer Perret, Adrian J Lowe, Caroline J Lodge, David P Johns, Paul S Thomas, Gayan Bowatte, Peter G Davis, Michael J Abramson, Shyamali C Dharmage, Dinh S Bui
10.1111/resp.14379
Our study provides new evidence that small for gestational age is associated with reduced lung function consistent with a restrictive pattern in middle age. This suggests that the specific long-term effect of reduced fetal lung growth relates to restrictive lung function pattern that is likely due to smaller lungs.
See related Editorial |
| Respiratory Infections |
| 166 | Trends of global and regional aetiologies, risk factors and mortality of lower respiratory infections from 1990 to 2019: An analysis for the Global Burden of Disease Study 2019
Liangyu Kang, Wenzhan Jing, Jue Liu, Min Liu
10.1111/resp.14389
In this study based on data from the Global Burden of Disease Study 2019, lower respiratory infections remain an important health problem globally. More attention should be given to children under 5 years, adults over 70 years, and some vulnerable areas including South Asia, Sub-Saharan Africa and Southern Latin America.
See related Editorial |
| Sleep and Ventilation |
| 176 |
Causes of hypercapnic respiratory failure and associated in-hospital mortality
Yewon Chung, Frances L Garden, Guy B Marks, Hima Vedam
10.1111/resp.14388
This is the first study of causes of hypercapnic respiratory failure at a population level. Obstructive lung disease and congestive cardiac failure were highly prevalent. The underlying cause or causes impacted in-hospital survival. Clinicians must consider systematic evaluation of patients with hypercapnia to detect potentially treatable conditions.
See related Editorial |
| FORUM AND DEBATE |
| Scientific Letter |
| 183 | Lung function in young adults born small for gestational age at term
Kilian Vellvé, Álvaro Sepúlveda-Martínez, Mérida Rodríguez-López, Francesca Crovetto, Gabriel Bernardino, Felip Burgos, Rosa Faner, Àlvar Agustí, Bart Bijnens, Eduard Gratacós, Fàtima Crispi, Isabel Blanco
10.1111/resp.14361
See related Editorial |
| 187 | Breathlessness
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| 189 | Guidelines? Nice if you can afford it
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| 190 | Digital transformation meets evidence based medicine
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| Letter from Asia-Pacific and Beyond |
| 192 | Letter from Vietnam
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| Correspondences |
| 194 | Effects of early mobilization on patients with COVID-19 with respiratory failure
Yoshitatsu Fukuta, Shinichi Arizono, Tomoya Yoshida, Yuji Mizuno, Masahiro Tawada, Junichi Magata, Takaki Uruno, Kazuki Watanabe, Akihiko Ozaki, Yoshinori Imaizumi
10.1111/resp.14430 |
| 196 | Prognosis of IPF patients with comorbid lung cancer: Preventing immortal time bias will make the analysis more valuable
Sho Yamada MD, Satoshi Ikeda MD, PhD, Toshihiro Misumi PhD, Akimasa Sekine MD, PhD, Takashi Ogura MD, PhD 10.1111/resp.14436 |
