| 25th ANNIVERSARY REFLECTIONS |
| 6 | Twenty-five years of Respirology: From the Editors
Philip G Bardin FRACP, PhD; Paul N Reynolds FRACP, PhD, MD, FThorSoc, FAPSR
10.1111/resp.13751 |
| 7 | The rise and rise of Respirology: A 25-year journey
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| Commentaries |
| 11 | Twenty-five years of Respirology: Advances in asthma
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| 14 | Twenty-five years of Respirology: Advances in bronchiectasis
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| 17 | Twenty-five years of Respirology: Advances in COPD
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| 20 | Twenty-five years of Respirology: Advances in idiopathic pulmonary fibrosis
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| 23 | Twenty-five years of Respirology: Advances in interventional pulmonology
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| 26 | Twenty-five years of Respirology: Advances in lung cancer
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| 32 | Twenty-five years of Respirology: Advances in respiratory infections and tuberculosis
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| 35 | Twenty-five years of Respirology: Advances in paediatric lung disease
Andrew Bush MBBS (Hons), MA, MD, FHEA, FRCP, FRCPCH, FERS, FAPSR, ATSF; Dominic Fitzgerald MBBS, PhD, FRACP
10.1111/resp.13739 |
| 38 | Twenty-five years of Respirology: Advances in pleural disease
Macy M S Lui MBBS, MRCP, FHKCP, FCCP; Y C Gary Lee MBChB, PhD, FCCP, FRCP, FRACP
10.1111/resp.13742 |
| 41 | Twenty-five years of Respirology: Advances in sleep
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| EDITORIALS |
| 43 | The microbiome in bronchiectasis: Cutting a lung story short
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| 45 | Suboptimal asthma care: Lessons from Australia and a way forward
André Schultz MBChB, PhD, FRACP; Peter le Souef MBBS, MD, FRACS; Melanie Barwick PhD, CPsych
10.1111/resp.13661 |
| 47 | Airway inflammation in COPD: Is it worth measuring and is it clinically meaningful?
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| 49 | Lung function and endothelial dysfunction: Is there a relationship without the presence of lung disease?
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| 51 | Incomplete control of obstructive sleep apnoea with continuous positive airway pressure therapy: Time for a personalized therapy approach?
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| INVITED REVIEW |
| 53 | Hypoxia-inducible factor and bacterial infections in chronic obstructive pulmonary disease
Shakti D Shukla, E Haydn Walters, Jodie L Simpson, Simon Keely, Peter A B Wark, Ronan F O'Toole, Philip M Hansbro
10.1111/resp.13722 |
| ORIGINAL ARTICLES |
| Bronchiectasis |
| 64 | Composition of airway bacterial community correlates with chest HRCT in adults with bronchiectasis
Katherine O'Neill, Gisli G Einarsson, Stephen Rowan, Leanne McIlreavey, Andrew J Lee, John Lawson, Tom Lynch, Alex Horsley, Judy M Bradley, J Stuart Elborn, Michael M Tunney
10.1111/resp.13653
This study reports on the relationship between airway bacterial community composition as measured by high-throughput sequencing of the 16S rRNA marker gene, chest high-resolution computed tomography (HRCT) and clinical measures in bronchiectasis (BE). The association between loss of diversity and chest HRCT severity suggests that bacterial dominance with pathogenic bacteria may contribute to disease pathology. |
| Asthma and Allergy |
| 71 | Assessing appropriateness of paediatric asthma management: A population-based sample survey
Nusrat Homaira, Louise K Wiles, Claire Gardner, Charlotte J Molloy, Gaston Arnolda, Hsuen P Ting, Peter Hibbert, Claire Boyling, Jeffrey Braithwaite, Adam Jaffe, on behalf of the CareTrack Kids Investigative Team
10.1111/resp.13611
This study provides comprehensive findings on the quality of health care received by children with asthma care across different healthcare settings in Australia. There was marked variation in the quality of both pharmacological and non-pharmacological management of paediatric asthma and children received quality care for <60% of occasions. |
| COPD |
| 80 | Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof-of-concept cohort study
Marco Contoli, Simonetta Baraldo, Valentina Conti, Giulia Gnesini, Brunilda Marku, Paolo Casolari, Paola Scrigner, Paolo Morelli, Marina Saetta, Antonio Spanevello, Alberto Papi
10.1111/resp.13607
The symptom severity and variability negatively impact the short- and long-term prognosis of chronic obstructive pulmonary disease (COPD). Our study showed an association between symptoms and the sputum inflammatory profile. In particular, changes in cough and dyspnoea were correlated with changes in neutrophils and eosinophils, respectively, providing novel information on the mechanisms of disease manifestation. |
| 89 | Associations between lung and endothelial function in early middle age
Robert J Hancox, Lathan Thomas, Michael J A Williams, Malcolm R Sears
10.1111/resp.13556
Chronic lung disease is associated with endothelial dysfunction, which may lead to cardiovascular disease, but it is unknown when this association develops. In a population-based cohort of 38-year olds, we found that low lung volumes and airflow obstruction were associated with endothelial dysfunction in women but associations in men were weaker and less convincing. |
| Pulmonary Vascular Disease |
| 97 | Pulmonary hypertension with a low cardiac index requires a higher PaO2 level to avoid tissue hypoxia
Rika Suda, Nobuhiro Tanabe, Jiro Terada, Akira Naito, Hajime Kasai, Rintaro Nishimura, Takayuki Jujo Sanada, Toshihiko Sugiura, Seiichiro Sakao, Koichiro Tatsumi
10.1111/resp.13574
Patients with pulmonary hypertension and a decreased cardiac index (CI) often have tissue hypoxia, which results in a poor prognosis, even though their arterial oxygen tension (PaO2) is ≥60 mm Hg. Conventional oxygen supplementation might be insufficient, and adequate oxygenation and medical treatment that could increase CI are important for these patients. |
| Sleep and Ventilation |
| 104 | Partial failure of CPAP treatment for sleep apnoea: Analysis of the French national sleep database
Sébastien Bailly, Najeh Daabek, Ingrid Jullian-Desayes, Marie Joyeux-Faure, Marc Sapène, Yves Grillet, Jean-Christian Borel, Renaud Tamisier, Jean-Louis Pépin
10.1111/resp.13650
Residual apnoea events during continuous positive airway pressure (CPAP) treatment of obstructive sleep apnoea (OSA) contribute to treatment drop-out. Patients with over five residual breathing events per hour of sleep were sedentary older men with severe OSA and cardiac co-morbidities using orofacial masks. This knowledge may help physicians to personalize CPAP therapy |
| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 112 | Letter from Thailand
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| FORUM AND DEBATE |
| Correspondence |
| 114 | What are the best criteria for Birt–Hogg–Dubé syndrome-related pneumothorax?
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| 115 | Incremental shuttle walking test in patients with asthma: Shedding light on its measurement properties
Afroditi K Boutou MD, MSc, PhD; Ioannis Stanopoulos MD, PhD; Despoina Papakosta MD, PhD
10.1111/resp.13719 |
