| EDITORIALS |
| 348 | Many patients labelled as having mild asthma do not have well-controlled asthma
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| 350 | Exercise desaturation and oxygen therapy in ILD and COPD: Similarities, differences and therapeutic relevance
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| 352 | Endobronchial drug delivery: Expanding techniques and possibilities in interventional pulmonology
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| 354 | How 'healthy' do children really need to be? Going beyond the limits
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| INVITED REVIEW SERIES |
| Tuberculosis Updates 2018 |
| 356 | Innovations and developments to end TB
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| 359 | Tuberculosis vaccines: Opportunities and challenges
Bingdong Zhu, Hazel M Dockrell, Tom H M Ottenhoff, Thomas G Evans and Ying Zhang
10.1111/resp.13245 |
| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 369 | Disease burden of mild asthma in China
Bo Ding and Mark Small
10.1111/resp.13189
This observational study of Chinese patients with mild asthma reveals that physicians considered 75% to be well or completely controlled, although only 14.2% were well controlled according to the Global Initiative for Asthma criteria. Treatment adherence was low, and many patients experienced nocturnal symptoms, exacerbations and work and activity impairments. |
| COPD |
| 378 |
Nasal high flow therapy and PtCO2 in stable COPD: A randomized controlled cross-over trial
Steven McKinstry, Janine Pilcher, George Bardsley, James Berry, Susanne Van de Hei, Irene Braithwaite, James Fingleton, Mark Weatherall and Richard Beasley
10.1111/resp.13185
In patients with stable COPD, the administration of nasal high flow results in flow-dependent reductions in transcutaneous partial pressure of carbon dioxide and respiratory rate. |
| Interstitial Lung Disease |
| 385 | Radiographic fibrosis score predicts survival in systemic sclerosis-associated interstitial lung disease
Reoto Takei, Machiko Arita, Shogo Kumagai, Yuhei Ito, Fumiaki Tokioka, Takashi Koyama, Rintaro Saito, Keisuke Nishimura, Hironobu Tokumasu and Tadashi Ishida
10.1111/resp.13175
It is unknown whether radiographic fibrosis score predicts mortality in systemic sclerosis-associated interstitial lung disease. This study shows that a high radiographic fibrosis score was a poor prognostic factor. More widespread fibrosis was associated with an increased risk of death, independent of high-resolution computed tomography pattern. |
| 392 | Exertional hypoxemia is more severe in fibrotic interstitial lung disease than in COPD
Jean P Du Plessis, Senan Fernandes, Rakin Jamal, Pat Camp, Kerri Johannson, Michele Schaeffer, Pearce G Wilcox, Jordan A Guenette and Christopher J Ryerson
Few studies have evaluated the severity of exertional hypoxemia in fibrotic interstitial lung disease (ILD). We demonstrate that exertional hypoxemia is more common and severe in fibrotic ILD compared to COPD. More ILD-specific studies are needed to evaluate the potential utility of ambulatory oxygen in fibrotic ILD. |
| Interventional Pulmonology |
| 399 |
Pharmacokinetics and safety of paclitaxel delivery into porcine airway walls by a new endobronchial drug delivery catheter
Hisashi Tsukada, Plamena Entcheva-Dimitrov, Armin Ernst, Samaan Rafeq, John H Keating, Kirk P Seward and Lonny Yarmus
10.1111/resp.13214
Intratumoral chemotherapeutic injection is an efficacious modality in reducing recurrence of tumours while minimizing systemic side effects. Direct intratumoral injection of malignant airway obstruction has potential therapeutic benefits but tissue drug concentrations and side effects are poorly understood. This study confirms safety and feasibility of paclitaxel administration directly into the bronchial wall and provides dosing guidance for human trials. |
| Lung Function |
| 406 | Defining 'healthy' in preschool-aged children for forced oscillation technique reference equations
Claire Shackleton, Dorottya Czovek, Keith Grimwood, Robert S Ware, Bence Radics, Zoltan Hantos and Peter D Sly
10.1111/resp.13186
Normative data for respiratory impedance (Zrs) measured with the forced oscillation technique in preschool-aged children use strict criteria to define healthy. Zrs z-scores in preterm-births and early-life wheezers did not differ from healthy children allowing a more inclusive approach for reference equations, without losing discriminative power for detecting lung disease. |
| Pleural Disease |
| 414 | Novel clinical scoring system to identify patients with pneumothorax with suspicion for Birt–Hogg–Dubé syndrome
Hiroki Ebana, Teruaki Mizobuchi, Masatoshi Kurihara, Etsuko Kobayashi, Takahiro Haga, Shoichi Okamoto, Kazuhisa Takahashi and Kuniaki Seyama
10.1111/resp.13191
The novel scoring system described here readily distinguishes Birt–Hogg–Dubé syndrome (BHDS) from primary spontaneous pneumothorax (PTX) by applying five clinical variables that are easily evaluated, are highly sensitive and have strong specificity. This system provides pulmonologists and thoracic surgeons a tool to avoid overlooking BHDS among the patients with PTX in daily clinical practice. |
| LETTER FROM ASIA-PACIFIC REGION |
| 419 | Letter from Japan
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| YEAR IN REVIEW |
| 421 | Year in review 2017: Interstitial lung disease, pulmonary vascular disease and sleep
Amanda J Piper, Stephen J Wort, Elisabetta A Renzoni and Vasileios Kouranos
10.1111/resp.13273 |
| CORRESPONDENCE |
| 434 | Importance of oesophageal ultrasound in mediastinal staging of lung cancer
Therese Maria Henriette Naur, Paul F Clementsen, Ida S Christiansen and Lars Konge
10.1111/resp.13243 |
| 434 | The importance of oesophageal ultrasound in mediastinal staging of lung cancer – Reply
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| 435 | E-cigarettes unlikely to raise significant health concerns in airways disease
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| 436 | E-cigarettes unlikely to raise significant health concerns in airways disease – Reply
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