| EDITORIALS |
| 710 | Importance of lifestyle change for patients with sleep apnoea
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| 712 | Does ISWT evaluate maximal exercise capacity in subjects with severe asthma?
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| 714 | Multidisciplinary team working for vocal cord dysfunction: Now it's GO time
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| 716 | What's in the CART? A decision rule to predict short-term mortality during COPD exacerbations
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| 718 | Novel exploratory data in interstitial lung disease
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| COMMENTARIES |
| 720 | Smokeless tobacco: Why does it need special attention?
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| 722 | E-cigarettes for smoking cessation: Current state of play
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| INVITED REVIEW SERIES |
| Non-invasive ventilation |
| 724 | Non-invasive ventilation or high-flow oxygen therapy: When to choose one over the other?
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| 732 | Home mechanical ventilation for chronic obstructive pulmonary disease: What next after the HOT-HMV trial?
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| SYSTEMATIC REVIEW |
| 740 | Assessing the impact of diet, exercise and the combination of the two as a treatment for OSA: A systematic review and meta-analysis
Bradley A Edwards, Claire Bristow, Denise M O'Driscoll, Ai-Ming Wong, Ladan Ghazi, Zoe E Davidson, Alan Young, Helen Truby, Terry P Haines, Garun S Hamilton
10.1111/resp.13580 |
| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 752 | Understanding the measurement properties of the incremental shuttle walk test in patients with severe asthma
Sally Majd, Stacey M Hewitt, Lindsay D Apps, Anna C Murphy, Peter Bradding, Sally J Singh, Ruth H Green, Rachael A Evans
10.1111/resp.13519
The measurement properties of the incremental shuttle walk test (ISWT) are unknown in patients with severe asthma. The study results show ISWT can be used to assess exercise capacity in patients with severe asthma. However, the small increase in distance on repeated testing would need to be considered in non-randomized trials. |
| 758 | Multidisciplinary team clinic for vocal cord dysfunction directs therapy and significantly reduces healthcare utilization
Malcolm Baxter, Laurence Ruane, Debra Phyland, Elizabeth Leahy, Emily Heke, Kenneth K Lau, Kathy Low, Kais Hamza, Martin MacDonald, Philip G Bardin
10.1111/resp.13520
Multidisciplinary team (MDT) clinics use an integrated approach and individualized services that may benefit vocal cord dysfunction (VCD). We show that a VCD MDT clinic can be used to allocate appropriate management leading to a reduction in healthcare utilization. |
| COPD |
| 765 | Risk stratification for short-term mortality at hospital admission for acute exacerbations of COPD
Roy T M Sprooten, Gernot G U Rohde, Glenn Lawyer, Wouter T Leijte, Emiel F M Wouters, Frits M E Franssen
10.1111/resp.13538
In the present study according Classification and Regression Tree analysis, high PaCO2 and age, low body mass index and previous (2 years) admission for exacerbations of chronic obstructive pulmonary disease (ECOPD) were the strongest predictors of 90-day mortality in patients with severe ECOPD. In absence of any of these factors, no patients died, suggesting that this model indeed enables risk stratification. |
| Interstitial Lung Disease |
| 777 | Pulmonary artery enlargement predicts poor outcome during acute exacerbations of fibrotic interstitial lung disease
Mariko Kogo, Kojiro Otsuka, Takeshi Morimoto, Kazuma Nagata, Atsushi Nakagawa, Keisuke Tomii
10.1111/resp.13504
In patients with an acute exacerbation of interstitial lung disease and a pulmonary artery (PA) enlargement occurring during the exacerbation, a PA to aorta ratio ≥ 1 predicts poor survival at 90 days. |
| 783 | In vivo probe-based confocal laser endomicroscopy in chronic interstitial lung diseases: Specific descriptors and correlation with chest CT
Mathieu Salaün, Florian Guisier, Stéphane Dominique, Anne Genevois, Vincent Jounieaux, Emmanuel Bergot, Caroline Thill, Nicolas Piton, Luc Thiberville
10.1111/resp.13507
Probe-based confocal laser endomicroscopy (pCLE) enables to image the acinar and alveolar areas at the microscopic level in vivo during flexible bronchoscopy. This study provides reproducible pCLE descriptors of idiopathic pulmonary fibrosis (IPF), asbestosis, connective-tissue disease-related interstitial lung diseases (ILD), sarcoidosis and hypersensitivity pneumonitis, which can be used to conduct prospective and follow-up studies. |
| 792 |
Efficacy of corticosteroid and intravenous cyclophosphamide in acute exacerbation of idiopathic pulmonary fibrosis: A propensity score-matched analysis
Hironao Hozumi, Hirotsugu Hasegawa, Koichi Miyashita, Hideki Yasui, Yuzo Suzuki, Masato Kono, Masato Karayama, Kazuki Furuhashi, Dai Hashimoto, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Koshi Yokomura, Hidenori Nakamura, Takafumi Suda
10.1111/resp.13506
A propensity score-matched analysis demonstrated that in patients with idiopathic pulmonary fibrosis with a first episode of idiopathic acute exacerbation, compared with corticosteroids (CS) monotherapy, CS plus intravenous cyclophosphamide (IVCY) therapy did not significantly improve their survival. This suggests that routine use of IVCY with CS is not recommended. |
| Pleural Disease |
| 799 |
Epithelial cell adhesion molecule (EpCAM) from pleural fluid cell lysates is a highly accurate diagnostic biomarker of adenocarcinomatous effusions
José M Porcel, Aureli Esquerda, Silvia Bielsa, Anna Novell, Maria Alba Sorolla, Sonia Gatius, Carlos Zamora, Silvia Vidal, Antonieta Salud
10.1111/resp.13539
The epithelial cell adhesion molecule (EpCAM) is routinely integrated into different immunocytochemical panels to detect adenocarcinoma cases in effusion samples. This study shows that its quantification in pleural fluid cell lysates by using immunoassays outperforms classical immunostainings on cell blocks for identifying adenocarcinomatous effusions (respective areas under the curve of 0.94 and 0.87). |
| SCIENTIFIC LETTER |
| 805 | Loop gain in REM versus non-REM sleep using CPAP manipulation: A pilot study
Ludovico Messineo, Luigi Taranto-Montemurro, Ali Azarbarzin, Melania Marques, Nicole Calianese, David P White, Andrew Wellman, Scott A Sands
10.1111/resp.13608 |
| CONTEMPORARY CONCISE REVIEW |
| 809 | Contemporary Concise Review 2018: Interstitial lung disease
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| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 817 | Letter from Spain
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| CORRESPONDENCE |
| 819 | Can vitamin C help in managing tuberculosis associated with diabetes mellitus?
Wing-Wai Yew MB, BS, FRCP, Kwok-Chiu Chang MD, Denise P Chan PhD, Ying Zhang MD
10.1111/resp.13579 |
| CORRIGENDUM |
| 821 | CORRIGENDUM
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