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Table of Contents for
Volume 20 Issue 2
February 2015

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175The Editor recommends this issue's articles to the reader
176Springing forward to medium-term results for endobronchial coils for emphysema
Pallav L Shah & Samuel V Kemp
179Promoting weight loss in asthma
Anne E Dixon & Lynn B Gerald
181First you have to row a little boat
Jennifer R Honda, Richard J Wallace Jr & Edward D Chan
Lung Cancer Practice, Implementing Evidence from Around the World
183Update in lung cancer: Prologue to a modern review series
Nico van Zandwijk & Kwun M Fong
Drug Development
185Pharmaceutical industry, academia and patient advocacy organizations: What is the recipe for synergic (win-win-win) collaborations?
Daniel M Rose, Richard Marshall & Mark W Surber
Lung Cancer Practice, Implementing Evidence from Around the World
192Multidisciplinary Lung Cancer Meetings: Improving the practice of radiation oncology and facing future challenges
Belinda A Campbell, David Ball & Françoise Mornex
199Implementation of modern therapy approaches and research for non-small cell lung cancer in Japan
Yoichi Nakanishi
Respiratory Disease: Using Lung Function Measurements to Greater Advantage
209Pulmonary physiology: Future directions for lung function testing in COPD
Vito Brusasco, Giovanni Barisione & Emanuele Crimi
219Vitamin D binding protein genotype variants and risk of chronic obstructive pulmonary disease: A meta-analysis
Nobuyuki Horita, Naoki Miyazawa, Koji Tomaru, Miyo Inoue, Yoshiaki Ishigatsubo & Takeshi Kaneko
226Endobronchial ultrasound-guided transbronchial needle aspiration for diagnosis of sarcoidosis in clinically unselected study populations
Rocco Trisolini, Luigi Lazzari Agli, Carmine Tinelli, Annalisa De Silvestri, Valeria Scotti & Marco Patelli
235Portopulmonary hypertension: An update
Mateo Porres-Aguilar & Debabrata Mukherjee
Asthma and Allergy
243Determinants of weight loss success utilizing a meal replacement plan and/or exercise, in overweight and obese adults with asthma
Hayley A Scott, Peter G Gibson, Manohar L Garg, Jeffrey J Pretto, Philip J Morgan, Robin Callister & Lisa G Wood
This study is the first to demonstrate that more severe asthma at baseline, male sex, and improvements in eating behaviours during weight loss are associated with greater weight loss success in overweight and obese adults with asthma.
Our findings may inform the development of asthma-specific weight management guidelines.
251Is non-invasive ventilation safe in acute severe asthma?
Michael Pallin, Mark Hew & Matthew T Naughton
The role of non-invasive ventilation in acute asthma is not well described and there are concerns about its safety. Over a 5-year period, non-invasive ventilation was used without significant complications in patients with moderate acute severe asthma.
258Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation
Qi-Ying Shen, Lei Fang, Hui-Mei Wu, Fang He, Pei-Shan Ding & Rong-Yu Liu
The effect of repeated administration of SVF on airway inflammation in a mouse model was evaluated. SVF treatment inhibited inflammatory cell infiltration and modulated the imbalance of HMGB1, TNF-α and IL-10 responses in the lung of sensitized mice.
264Budesonide/formoterol maintenance and reliever therapy in asthma control: Acute, dose-related effects and real-life effectiveness
Ching-Hsiung Lin, Jeng-Yuan Hsu, Yi-Han Hsiao, Ching-Min Tseng, Vincent Yi-Fong Su, Yu-Hsuan Chen, Sheau-Ning Yang, Yu-Chin Lee, Kang-Cheng Su & Diahn-Warng Perng
In steroid-naïve asthmatics, a single, higher dose of inhaled budesonide/formoterol (640/18 μg) as reliever exerts greater anti-inflammatory effects and FEV1 improvement within 6 h. Budesonide/formoterol maintenance and reliever therapy achieves significant improvement of asthma control 4 weeks post-treatment. However, long-term follow up remains an issue in real-life settings.
273Correlation between heart rate variability indexes and aerobic physiological variables in patients with COPD
Marceli R Leite, Ercy Mara C Ramos, Carlos A Kalva-Filho, Fernanda Maria M Rodrigues, Ana Paula C F Freire, Guilherme Y Tacao, Alessandra C de Toledo, Michel J Cecilio, Luiz Carlos M Vanderlei & Dionei Ramos
This study aimed to investigate whether the HRV indexes correlate with aerobic physiological variables obtained in cardiopulmonary exercise testing of patients with COPD Such correlation would have important clinical implications as it would allow, prior to the realization of the maximal exercise testing, to infer the patient's aerobic capacity
279Telemedicine, the effect of nurse-initiated telephone follow up, on health status and health-care utilization in COPD patients: A randomized trial
Farida F Berkhof, Jan W K van den Berg, Steven M Uil & Huib A M Kerstjens
Telemedicine has the potential to improve continuity of care, increase efficiency of outpatient management and prevent deterioration of health status in COPD patients. However, the effectiveness of telemedicine is still under debate.
This study demonstrated that telemedicine alone, without any form of education, pulmonary rehabilitation or training, had no benefits for COPD patients at all.
286Polymorphism of LRP5 gene and emphysema severity are associated with osteoporosis in Japanese patients with or at risk for COPD
Shotaro Chubachi, Hidetoshi Nakamura, Mamoru Sasaki, Mizuha Haraguchi, Masaki Miyazaki, Saeko Takahashi, Kyuto Tanaka, Yohei Funatsu, Koichiro Asano, Tomoko Betsuyaku & the Keio COPD Comorbidity Research (K-CCR) Group
Risk factors for COPD-associated osteoporosis are not fully elucidated. This observational COPD cohort study demonstrates that a polymorphism in low-density lipoprotein receptor-related protein 5 gene, female gender and the presence of severe emphysema are independent risk factors for low bone mineral density in patients with or at risk for COPD.
296Genetic variants of pulmonary SP-D predict disease outcome of COPD in a Chinese population
Chih-Ying Ou, Chiung-Zuei Chen, Tzuen-Ren Hsiue, Sheng-Hsiang Lin & Jiu-Yao Wang
We demonstrated for the first time in a Chinese population cohort that genetic polymorphisms of SP-D are not only associated with risk of COPD development, but also related to disease manifestation and that they predict outcomes.
304Tiotropium as part of inhaled polytherapy: Adherence and associated health-care utilization
Tzahit Simon-Tuval & Nimrod Maimon
A computerized medical database was used to estimate adherence of patients with COPD to inhaled therapy and health-care utilization following initiation of Tiotropium. Adherence to Tiotropium was associated with decreased hospitalizations only among patients who improved their adherence to additional inhaled therapy as well.
Cystic Fibrosis
Editor's choice
Characterization of gene mutations and phenotypes of cystic fibrosis in Chinese patients
Yaping Liu, Lianqing Wang, Xinlun Tian, Kai-Feng Xu, Wenbing Xu, Xue Li, Cai Yue, Peng Zhang, Yi Xiao & Xue Zhang
We conducted research on seven Chinese cystic fibrosis patients. Their CFTR mutations are uncommon compared with those commonly found in Caucasians. Therefore, physicians in both China and western countries should pay more attention to atypically affected CF-like patients, especially those who are of Chinese origin.
Interventional Pulmonology
Editor's choice
Long-term follow-up after bronchoscopic lung volume reduction treatment with coils in patients with severe emphysema
Jorine E Hartman, Karin Klooster, Kiki Gortzak, Nick H T ten Hacken & Dirk-Jan Slebos
This is the first study to investigate the safety and efficacy of the lung volume reduction coil treatment in the long term. At 3-year follow-up, this treatment showed no long-term unexpected adverse and device-related events, with clinical benefit gradually declining over time.
327Pleuroscopic cryoprobe biopsies of the pleura: A feasibility and safety study
Rajesh Thomas, Shanka Karunarathne, Barton Jennings, Sue Morey, Siaw Ming Chai, Y C Gary Lee & Martin J Phillips
This study evaluated a novel method to obtain pleural biopsies using a flexible cryoprobe during flexi-rigid pleuroscopy. It showed that cryoprobe pleural biopsy technique was safe and provided good quality diagnostic specimens. Its role as a useful adjunct or alternative to conventional pleural biopsies during flex-rigid pleuroscopy requires further evaluation.
333Endobronchial ultrasound learning curve in interventional pulmonary fellows
David R Stather, Alex Chee, Paul MacEachern, Elaine Dumoulin, Christopher A Hergott, Jacob Gelberg, Eric Folch, Adnan Majid, Anne V Gonzalez & Alain Tremblay
EBUS learning rates vary significantly between trainees and for individual procedure components. Improvements in performance measures are noted even after 200 clinical cases performed. This information can be utilized to guide individualized performance assessments and assist training programmes in ensuring adequate procedure volumes required for trainees to successfully complete these assessments.
340Tuberculin skin test and QuantiFERON-TB Gold In-tube Test for latent tuberculosis in Thai HIV-infected adults
Thana Khawcharoenporn, Anucha Apisarnthanarak, Benjawan Phetsuksiri, Janisara Rudeeaneksin, Sopa Srisungngam & Linda M. Mundy
Tuberculin skin test (TST) remains the diagnostic test for latent tuberculosis in interferon-gamma release assay (IGRA)-unavailable HIV care settings, but the cut-off for reactivity needs to be adjusted accordingly. Women and patients older than 52 years with non-reactive TST and long-term smokers with reactive TST should undergo additional IGRA testing.
348Variable agreement among experts regarding Mycobacterium avium complex lung disease
Theodore K Marras, D Rebecca Prevots, Frances B Jamieson, Kevin L Winthrop & on behalf of the Pulmonary MAC Outcomes Group
352Selecting the increment size for a maximal incremental cycle test in patients with COPD
Jorine E Hartman, Dirk-Jan Slebos, H Marike Boezen, Mathieu H G de Greef, Huib A M Kerstjens & Nick H T ten Hacken