Hayley A Scott, Peter G Gibson, Manohar L Garg, Jeffrey J Pretto, Philip J Morgan, Robin Callister & Lisa G Wood
This study is the first to demonstrate that more severe asthma at baseline, male sex, and improvements in eating behaviours during weight loss are associated with greater weight loss success in overweight and obese adults with asthma. Our findings may inform the development of asthma-specific weight management guidelines.
Michael Pallin, Mark Hew & Matthew T Naughton
The role of non-invasive ventilation in acute asthma is not well described and there are concerns about its safety. Over a 5-year period, non-invasive ventilation was used without significant complications in patients with moderate acute severe asthma.
Qi-Ying Shen, Lei Fang, Hui-Mei Wu, Fang He, Pei-Shan Ding & Rong-Yu Liu
The effect of repeated administration of SVF on airway inflammation in a mouse model was evaluated. SVF treatment inhibited inflammatory cell infiltration and modulated the imbalance of HMGB1, TNF-α and IL-10 responses in the lung of sensitized mice.
Ching-Hsiung Lin, Jeng-Yuan Hsu, Yi-Han Hsiao, Ching-Min Tseng, Vincent Yi-Fong Su, Yu-Hsuan Chen, Sheau-Ning Yang, Yu-Chin Lee, Kang-Cheng Su & Diahn-Warng Perng
In steroid-naïve asthmatics, a single, higher dose of inhaled budesonide/formoterol (640/18 μg) as reliever exerts greater anti-inflammatory effects and FEV1 improvement within 6 h. Budesonide/formoterol maintenance and reliever therapy achieves significant improvement of asthma control 4 weeks post-treatment. However, long-term follow up remains an issue in real-life settings.
Marceli R Leite, Ercy Mara C Ramos, Carlos A Kalva-Filho, Fernanda Maria M Rodrigues, Ana Paula C F Freire, Guilherme Y Tacao, Alessandra C de Toledo, Michel J Cecilio, Luiz Carlos M Vanderlei & Dionei Ramos
This study aimed to investigate whether the HRV indexes correlate with aerobic physiological variables obtained in cardiopulmonary exercise testing of patients with COPD Such correlation would have important clinical implications as it would allow, prior to the realization of the maximal exercise testing, to infer the patient's aerobic capacity
Farida F Berkhof, Jan W K van den Berg, Steven M Uil & Huib A M Kerstjens
Telemedicine has the potential to improve continuity of care, increase efficiency of outpatient management and prevent deterioration of health status in COPD patients. However, the effectiveness of telemedicine is still under debate. This study demonstrated that telemedicine alone, without any form of education, pulmonary rehabilitation or training, had no benefits for COPD patients at all.
Shotaro Chubachi, Hidetoshi Nakamura, Mamoru Sasaki, Mizuha Haraguchi, Masaki Miyazaki, Saeko Takahashi, Kyuto Tanaka, Yohei Funatsu, Koichiro Asano, Tomoko Betsuyaku & the Keio COPD Comorbidity Research (K-CCR) Group
Risk factors for COPD-associated osteoporosis are not fully elucidated. This observational COPD cohort study demonstrates that a polymorphism in low-density lipoprotein receptor-related protein 5 gene, female gender and the presence of severe emphysema are independent risk factors for low bone mineral density in patients with or at risk for COPD.
Chih-Ying Ou, Chiung-Zuei Chen, Tzuen-Ren Hsiue, Sheng-Hsiang Lin & Jiu-Yao Wang
We demonstrated for the first time in a Chinese population cohort that genetic polymorphisms of SP-D are not only associated with risk of COPD development, but also related to disease manifestation and that they predict outcomes.
Tzahit Simon-Tuval & Nimrod Maimon
A computerized medical database was used to estimate adherence of patients with COPD to inhaled therapy and health-care utilization following initiation of Tiotropium. Adherence to Tiotropium was associated with decreased hospitalizations only among patients who improved their adherence to additional inhaled therapy as well.
Yaping Liu, Lianqing Wang, Xinlun Tian, Kai-Feng Xu, Wenbing Xu, Xue Li, Cai Yue, Peng Zhang, Yi Xiao & Xue Zhang
We conducted research on seven Chinese cystic fibrosis patients. Their CFTR mutations are uncommon compared with those commonly found in Caucasians. Therefore, physicians in both China and western countries should pay more attention to atypically affected CF-like patients, especially those who are of Chinese origin.
Jorine E Hartman, Karin Klooster, Kiki Gortzak, Nick H T ten Hacken & Dirk-Jan Slebos
This is the first study to investigate the safety and efficacy of the lung volume reduction coil treatment in the long term. At 3-year follow-up, this treatment showed no long-term unexpected adverse and device-related events, with clinical benefit gradually declining over time.
Rajesh Thomas, Shanka Karunarathne, Barton Jennings, Sue Morey, Siaw Ming Chai, Y C Gary Lee & Martin J Phillips
This study evaluated a novel method to obtain pleural biopsies using a flexible cryoprobe during flexi-rigid pleuroscopy. It showed that cryoprobe pleural biopsy technique was safe and provided good quality diagnostic specimens. Its role as a useful adjunct or alternative to conventional pleural biopsies during flex-rigid pleuroscopy requires further evaluation.
David R Stather, Alex Chee, Paul MacEachern, Elaine Dumoulin, Christopher A Hergott, Jacob Gelberg, Eric Folch, Adnan Majid, Anne V Gonzalez & Alain Tremblay
EBUS learning rates vary significantly between trainees and for individual procedure components. Improvements in performance measures are noted even after 200 clinical cases performed. This information can be utilized to guide individualized performance assessments and assist training programmes in ensuring adequate procedure volumes required for trainees to successfully complete these assessments.
Thana Khawcharoenporn, Anucha Apisarnthanarak, Benjawan Phetsuksiri, Janisara Rudeeaneksin, Sopa Srisungngam & Linda M. Mundy
Tuberculin skin test (TST) remains the diagnostic test for latent tuberculosis in interferon-gamma release assay (IGRA)-unavailable HIV care settings, but the cut-off for reactivity needs to be adjusted accordingly. Women and patients older than 52 years with non-reactive TST and long-term smokers with reactive TST should undergo additional IGRA testing.