| EDITORIALS |
| 614 | CRISPR-Cas9 technology: A new direction for personalized medicine in respiratory disease?
Annalicia Vaughan BSc Hons, PhD Ian A Yang MBBS Hons, FRACP, PhD, Grad Dip Clin Epid, FAPSR, FThorSoc
10.1111/resp.13570 |
| 616 | Airways wide shut: A physiological phenotype of asthma?
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| 618 | Hospitalizations for patients with acute respiratory exacerbations: In pursuit of rest or recovery?
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| 620 | Clinical trial design for acute exacerbations in idiopathic pulmonary fibrosis: A thorny path
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| 622 | Tuberculous mediastinal lymphadenopathy: Reaching the target
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| 624 | Sleep apnoea and immune regulation: The story is only beginning
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| COMMENTARY |
| 626 | Ambient air pollution in China
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| INVITED REVIEW SERIES |
| Molecular Techniques for Respiratory Diseases |
| 628 | Applications of CRISPR systems in respiratory health: Entering a new 'red pen' era in genome editing
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 638 | Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma
David A Kaminsky, David G Chapman, Janet T Holbrook, Robert J Henderson, Elizabeth A Sugar, John Mastronarde, William G Teague, Michael Busk, Kaharu Sumino, Anne E Dixon, Robert A Wise, Charles G Irvin
10.1111/resp.13496
Airway closure during methacholine challenge contributes importantly to airway hyperresponsiveness in asthma and is associated with older age and obesity. |
| COPD |
| 646 | Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin
Angelico Mendy, Radha Gopal, John F Alcorn, Erick Forno
10.1111/resp.13486
This population-based prospective cohort demonstrated that metformin use in type 2 diabetes was associated with a significant decrease in the risk of mortality from chronic lower respiratory disease (CLRD) after adjusting for relevant covariates. This reduction was even more pronounced among subjects with CLRD at baseline. |
| 652 |
Changes in physical activity during hospital admission for chronic respiratory disease
Mark W Orme, Theresa C Harvey-Dunstan, Ismet Boral, Emma J L Chaplin, S Fayyaz Hussain, Mike D L Morgan, Michael C Steiner, Sally J Singh, Neil J Greening
10.1111/resp.13513
Objectively measured inpatient physical activity (PA) was examined for 259 individuals hospitalized due to an acute exacerbation of chronic respiratory disease. PA did not recover as an inpatient, with patients averaging 616 ± 649 steps/day. A single day of PA monitoring provided data representative of the entire inpatient stay. |
| Interstitial Lung Disease |
| 658 | Recombinant thrombomodulin for acute exacerbation in idiopathic interstitial pneumonias
Toru Arai, Hiroshi Kida, Yoshitaka Ogata, Satoshi Marumo, Hiroto Matsuoka, Iwao Gohma, Suguru Yamamoto, Masahide Mori, Chikatoshi Sugimoto, Kazunobu Tachibana, Masanori Akira, Ryuya Edahiro, Toshimitsu Hamasaki, Yoshikazu Inoue, on behalf of the Osaka Acute Exacerbation of Interstitial Pneumonia Research Group
10.1111/resp.13514
Our prospective single-arm open-labelled multicentre study aimed to evaluate the efficacy and safety of recombinant human soluble thrombomodulin (rhTM) treatment for acute exacerbation in idiopathic interstitial pneumonias (AE-IIP). rhTM therapy was significantly associated with reduced mortality due to AE-IIP after a propensity score adjustment. Similar frequencies of adverse events with/without rhTM were noted. |
| Interventional Pulmonology |
| 667 |
Clinical usefulness of routine AFB culture and MTB PCR of EBUS-TBNA needle rinse fluid
Ryoung-Eun Ko, Byeong-Ho Jeong, Hae Ri Chon, Hee Jae Huh, Joungho Han, Hyun Lee, Kyungjong Lee, Hojoong Kim, O Jung Kwon, Sang-Won Um
10.1111/resp.13488
The routine acid-fast bacilli (AFB) culture of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) needle rinse fluid is useful to increase the diagnostic yield of tuberculous lymphadenitis in an intermediate tuberculosis (TB)-burden country. |
| Pulmonary Vascular Disease |
| 675 | Microparticles in systemic sclerosis: Potential pro-inflammatory mediators and pulmonary hypertension biomarkers
Matthew R Lammi, Lesley Ann Saketkoo, Samuel C Okpechi, Mohamed A Ghonim, Dorota Wyczechowska, Natalie Bauer, Kusma Pyakurel, Saito Saito, Bennett P deBoisblanc, A Hamid Boulares
10.1111/resp.13500
CD144+ endothelial microparticles (MP) were significantly higher in systemic sclerosis (SSc) patients with pulmonary hypertension (PH) compared to SSc patients without PH, suggesting that they may be a biomarker of SSc-PH. MP from SSc patients also increased endothelial inflammation in vitro, indicating a possible pathogenic role in this condition. |
| Sleep and Ventilation |
| 684 | Age-dependent hypoxia-induced PD-L1 upregulation in patients with obstructive sleep apnoea
Carolina Cubillos-Zapata, Cristina Balbás-Garcìa, Jose Avendaño-Ortiz, Victor Toledano, Marta Torres, Isaac Almendros, Raquel Casitas, Ester Zamarrón. Aldara Garcìa-Sánchez, Jaime Feliu, Luis A Aguirre, Ramón Farre, Eduardo López-Collazo, Francisco Garcìa-Rio
10.1111/resp.13470
Hypoxia-induced upregulation of the programmed cell death-1 receptor and its ligand (PD-L1) may explain associations between sleep apnoea and cancer. This link may be age-dependent but, contrary to expectations, this study shows that PD-L1 upregulation in sleep apnoea occurs mainly in younger patients. |
| CONTEMPORARY CONCISE REVIEW |
| 693 | Contemporary Concise Review 2018: Asthma and chronic obstructive pulmonary disease
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| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 700 | Letter from Greece
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| CORRESPONDENCE |
| 702 | Bronchiolitis obliterans syndrome as manifestation of lung GVHD: Not the only one
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| 702 | Bronchiolitis obliterans syndrome as manifestation of lung GVHD: Not the only one – Reply
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