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EDITORIALS |
6 | Eosinophils and the burden of airway disease
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8 | Muscle loss in COPD: An 'imploding' phenotype in need of therapies
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10 | Reducing hospital readmissions for COPD exacerbations: The role of exercise and ongoing support
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12 | A closer look at the multidisciplinary interstitial lung disease clinic: Who, what and how
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14 | Complications of rigid bronchoscopy
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19 | Cigarette smoke attenuates p300-mediated Nrf2 acetylation in macrophages: Is stabilizing Nrf2 enough to halt COPD progression?
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COMMENTARY |
21 | Asthma control measures reconsidered
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POSITION STATEMENT |
23 | Diagnosis and management of connective tissue disease-associated interstitial lung disease in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand
Adelle S Jee, Robert Sheehy, Peter Hopkins, Tamera J Corte, Christopher Grainge, Lauren K Troy, Karen Symons, Lissa M Spencer, Paul N Reynolds, Sally Chapman, Sally de Boer, Taryn Reddy, Anne E Holland, Daniel C Chambers, Ian N Glaspole, Helen E Jo, Jane F Bleasel, Jeremy P Wrobel, Leona Dowman, Matthew J S Parker, Margaret L Wilsher, Nicole S L Goh, Yuben Moodley, Gregory J Keir
10.1111/resp.13977 |
ORIGINAL ARTICLES |
Asthma and Allergy |
52 |
Disease burden of eosinophilic airway disease: Comparing severe asthma, COPD and asthma–COPD overlap
Sarah A Hiles, Peter G Gibson, Vanessa M McDonald
10.1111/resp.13841
This study investigated the disease burden associated with eosinophilic airway disease. We showed high disease burden in eosinophilic severe asthma, COPD and asthma-COPD overlap (ACO). In an era of precision medicine, understanding the disease burden of phenotypes is needed, particularly in ACO where treatment evidence is limited.
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COPD |
62 | Muscle loss contributes to higher morbidity and mortality in COPD: An analysis of national trends
Amy H Attaway, Nicole Welch, Umur Hatipoğlu, Joe G Zein, Srinivasan Dasarathy
10.1111/resp.13877
Using a large national data set of patients admitted for a COPD exacerbation with and without muscle loss phenotype, we showed that mortality, LOS and cost are considerably higher in patients with muscle loss phenotype. We demonstrated the need for targeted interventions to improve outcomes for patients with COPD. |
72 |
Effect of short-course exercise training on the frequency of exacerbations and physical activity in patients with COPD: A randomized controlled trial
Fanny Wai-San Ko, Wilson Tam, Eddy H S Siu, Ka-Pang Chan, Jenny Chun-Li Ngai, So-Shan Ng, Tat On Chan, David Shu-Cheong Hui
10.1111/resp.13872
Optimal duration for exercise training post-AECOPD is unknown. A less intensive programme of 4–8 weeks of physical training followed by phone contact of the subjects every 2 weeks for 1 year decreased hospital readmissions and increased the time for readmissions.
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Interstitial Lung Disease |
80 | Priorities and expectations of patients attending a multidisciplinary interstitial lung disease clinic
Anna E B McLean, Susanne E Webster, Margaret Fry, Edmund M Lau, Peter Corte, Paul J Torzillo, Lauren K Troy, Helen E Jo, Monika Geis, Jessica E Rhodes, Shannon Cleary, Lissa Spencer, Tamera J Corte
10.1111/resp.13913
The progressive morbidity associated with ILD often impacts patients' QOL and independence. Multidisciplinary care has been shown to improve patient experience in other high morbidity conditions, such as malignancy. We study the ILD patient experience of a specialist multidisciplinary ILD clinic. |
Interventional Pulmonology |
87 | Multi-institutional retrospective analysis of adverse events following rigid tracheobronchoscopy
Marc Fortin, Lonny Yarmus, Erino Angelo Rendina, Samaan Rafeq, Rafael Andrade, Gaetane Michaud, Jordan Kazakov, Sixto Arias, Anna Maria Ciccone, Ricardo Ortiz, Moishe Liberman
10.1111/resp.13873
RTB is associated with a 6.7% non-lethal complication rate, a 1.2% periprocedural mortality rate and a 5.6% 30-day mortality in a large multicentre cohort of patients with benign and malignant airway disease. |
Pulmonary Vascular Disease |
92 | Pulmonary hypertension in Saudi Arabia: First data from the SAUDIPH registry with a focus on pulmonary arterial hypertension
Abdullah M Aldalaan, Sarfraz A Saleemi, Ihab Weheba, Abeer Abdelsayed, Maha M Aleid, Fatima Alzubi, Hamdeia Zaytoun, Nadeen Alharbi
10.1111/resp.13879
This study assessed the baseline demographic and clinical characteristics of patients in the SAUDIPH registry, and their clinical and survival outcomes. To our knowledge, this is the largest registry of PH patients in Saudi Arabia, providing relevant data regarding PH management in Saudi Arabia. |
Respiratory Infections |
102 | Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300
Kyoung-Hee Lee, Jisu Woo, Jiyeon Kim, Chang-Hoon Lee, Chul-Gyu Yoo
10.1111/resp.13867
CSE suppressed LPS-induced acetylation of Nrf2 and subsequently the expression of MARCO gene in macrophages by mediating degradation of histone acetyltransferase, p300, via the 26S proteasome. To improve phagocytic ability of macrophages, blocking the suppressive effect of CSE on p300 in the nucleus is necessary. |
112 | Serum Krebs von den Lungen-6 level in the disease progression and treatment of Mycobacterium avium complex lung disease
Takanori Asakura, Yoshifumi Kimizuka, Tomoyasu Nishimura, Shoji Suzuki, Ho Namkoong, Yohei Masugi, Yasunori Sato, Makoto Ishii, Naoki Hasegawa
10.1111/resp.13886
Serum Krebs von den Lungen-6 (KL-6) level is a useful serum biomarker that predicts disease progression and treatment response inMycobacterium avium complex lung disease (MAC-LD). Single and longitudinal assessment of serum KL-6 level may aid the management of MAC-LD and help establish management strategies for MAC-LD. |
FORUM AND DEBATE |
Scientific Letter |
120 | Multiplanar 3D fluoroscopy redefines tool–lesion relationship during robotic-assisted bronchoscopy
Or Kalchiem-Dekel, Paige Fuentes, Matthew J Bott, Jason A Beattie, Robert P Lee, Mohit Chawla, Bryan C Husta
10.1111/resp.13966 |
Correspondences |
124 | Is corticosteroid use a potential therapy for AE-IPF?
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125 | Is tomosynthesis an ingenious scheme for bronchoscopic diagnosis of lung nodules?
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126 | Reply
Matthew Aboudara MD, FCCP; Lance Roller MSc; Otis Rickman DO, FCCP; Robert J Lentz MD; Jasleen Pannu MD; Heidi Chen PhD; Fabien Maldonado MD, FCCP
10.1111/resp.13974 |
LETTER FROM ASIA-PACIFIC AND BEYOND |
127 | Letter from California, USA
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