| EDITORIALS |
| 444 | Surgical lung biopsies in elderly patients with interstitial lung disease: Weighing up the pros and cons
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| 446 | Respiratory symptoms and small airway dysfunction in current and former smokers without spirometric COPD
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| 448 | Secondary spontaneous pneumothorax in idiopathic pulmonary fibrosis: Grim news
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| 450 | Empiric antibiotics for community-acquired pneumonia: A macrolide and a beta-lactam please!
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| COMMENTARY |
| 452 | Green respiratory health care: Time for us all to act
Christopher K Hui MBBS, MRCP Bingling Xu MD, Kian Fan Chung MD, DSc, FRCP Martyn R Partridge MD, FRCP
10.1111/resp.13281 |
| INVITED REVIEW SERIES |
| Tuberculosis Updates 2018 |
| 455 | Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease
Delia Goletti, Meng-Rui Lee, Jann-Yuan Wang, Nicholas Walter, Tom H M Ottenhoff
10.1111/resp.13272 |
| SYSTEMATIC REVIEW |
| 467 | Efficacy and safety of phosphodiesterase 4 inhibitors in patients with asthma: A systematic review and meta-analysis
Jian Luo, Ling Yang, Jing Yang, Dan Yang, Bi-Cui Liu, Dan Liu, Bin-Miao Liang, Chun-Tao Liu
10.1111/resp.13276 |
| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 478 | Comparison of respiratory system impedance in asthma and COPD: A prospective observational study
Takahiro Kamada, Masahiro Kaneko, Hiromi Tomioka
10.1111/resp.13240
Changes in a single assessment of within-breath variations of respiratory system reactance (Xrs) at 5 Hz (ΔX5) in patients with chronic obstructive pulmonary disease (COPD) are significantly greater than in patients with asthma. ΔX5 may reflect the pathophysiological changes in COPD and can be useful for its long-term assessment. |
| COPD |
| 485 | The importance of symptoms in the longitudinal variability of clusters in COPD patients: A validation study
Juan P de Torres, Jose M Marin, Cristina Martinez-Gonzalez, Pilar de Lucas-Ramos, Borja Cosio, Ciro Casanova, for the COPD History Assessment In SpaiN (CHAIN) cohort
10.1111/resp.13194
This longitudinal analysis of a large chronic obstructive pulmonary disease (COPD) study explored the identification of clusters and their behaviour over 2 years. We validated previous data on the topic but in a multicentre study and with 2 years of follow-up (previously only 1 year). We also identified factors associated with cluster changes. |
| Critical Care |
| 492 | Models of care for non-invasive ventilation in the Acute COPD Comparison of three Tertiary hospitals (ACT3) study
Kerry Parker, Vara Perikala, Ali Aminazad, Zheng Deng, Brigitte Borg, Catherine Buchan, Jo Toghill, Louis B Irving, Jeremy Goldin, David Charlesworth, Ajay Mahal, Suhith Illesinghe, Matthew T Naughton, Alan Young
10.1111/resp.13228
Although non-invasive ventilation (NIV) is an established treatment for acute hypercapnic COPD, the optimal model of care is not known. We undertook a comparison of NIV delivery in general, high dependency and intensive care wards and identified equal efficacy, with considerable financial savings using the general ward model. |
| Interstitial Lung Disease |
| 498 | Phenotypic characteristics associated with slow gait speed in idiopathic pulmonary fibrosis
Claire M Nolan, Matthew Maddocks, Toby M Maher, Jane L Canavan, Sarah E Jones, Ruth E Barker, Suhani Patel, Joseph Jacob, Paul Cullinan, William D-C Man
10.1111/resp.13213
We evaluated 4 m gait speed (4MGS), a simple functional performance test, in people with stable idiopathic pulmonary fibrosis. We found 4MGS a reliable, valid and responsive measure that can detect a patient phenotype with worse dyspnoea, exercise performance, quality of life and prognostic risk. |
| 507 |
Diagnostic utility of surgical lung biopsies in elderly patients with indeterminate interstitial lung disease
Laszlo T Vaszar, Brandon T Larsen, Karen L Swanson, Jay H Ryu, Henry D Tazelaar
10.1111/resp.13223
This study addresses the utility and safety of surgical lung biopsies in diagnosing interstitial lung disease in patients older than 75 years. More than one-third of the patients with a computed tomography pattern incompatible with usual interstitial pneumonia had diagnoses other than idiopathic pulmonary fibrosis. The mortality in our cohort was higher than that reported in the literature. |
| Lung Function |
| 512 | Peripheral airway dysfunction and relationship with symptoms in smokers with preserved spirometry
Kanika Jetmalani, Cindy Thamrin, Claude S Farah, Amy Bertolin, David G Chapman, Norbert Berend, Cheryl M Salome, Gregory G King
10.1111/resp.13215
Multiple breath nitrogen washout (MBNW) or impulse oscillometry system (IOS) abnormalities were highly prevalent in smokers without COPD but highly discordant between individuals. Cough was related to peripheral conductive airway function, while wheeze was related to IOS and spirometry. In smokers with normal spirometry, MBNW and IOS abnormalities may have different underlying structural bases and prognostic significance. |
| Pleural Disease |
| 519 | The prognostic significance of pneumothorax in patients with idiopathic pulmonary fibrosis
Koji Nishimoto, Tomoyuki Fujisawa, Katsuhiro Yoshimura, Yasunori Enomoto, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Hiromitsu Sumikawa, Takeshi Johkoh, Thomas V Colby, Takafumi Suda
10.1111/resp.13219
We evaluated prognostic significance of pneumothorax and the risk factors for its onset in patients with idiopathic pulmonary fibrosis (IPF). We demonstrate that the onset of pneumothorax predicts a poor outcome in the patients with IPF. Lower BMI and the presence of extensive reticular abnormalities are associated with developing pneumothorax. |
| Respiratory Infections |
| 526 |
Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of β-lactam plus macrolide combination therapy
Junya Okumura, Yuichiro Shindo, Kunihiko Takahashi, Masahiro Sano, Yasuteru Sugino, Tetsuya Yagi, Hiroyuki Taniguchi, Hideo Saka, Shigeyuki Matsui, Yoshinori Hasegawa, on behalf of the Central Japan Lung Study Group
10.1111/resp.13232
Limited studies have been performed to assess antibiotic effects in pneumonia according to drug-resistant pathogen (DRP) risk. Our results suggest that β-lactam plus macrolide combination therapy reduces mortality in patients with community-onset pneumonia at low DRP risk. |
| LETTER FROM ASIA-PACIFIC REGION |
| 535 | Letter from Taiwan
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| YEAR IN REVIEW |
| 538 | Year in review 2017: Chronic obstructive pulmonary disease and asthma
Melissa J Benton, Tow Keang, Lim Fanny, W S Ko, Keiko Kan-o, Judith C W Mak
10.1111/resp.13285 |
| CORRESPONDENCE |
| 546 | Corticosteroids in acute exacerbations of idiopathic interstitial pneumonias: Time to debate
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| 546 | Corticosteroids in acute exacerbations of idiopathic interstitial pneumonias: Time to debate – Reply
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