| EDITORIALS |
| 92 | Nurturing Respirology
Philip Bardin FRACP, PhD Paul N Reynolds FRACP, PhD, MD, FThorSoc, FAPSR
10.1111/resp.13466 |
| 93 | Cystic fibrosis vigilance in Arab countries: The role of genetic epidemiology
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| 95 | Acute respiratory distress syndrome and the promise of driving pressure
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| 97 | Pulmonary fibrosis: Genetic analysis of telomere-related genes, telomere length measurement – or both?
Caroline Kannengiesser PharmD, PhD; Raphael Borie MD, PhD; Elisabetta A Renzoni MD, PhD
10.1111/resp.13456 |
| 99 | Pulmonary arterial hypertension: In Asia, as elsewhere, still a lethal disease despite modern treatment
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| 101 | Empyema: A debilitating condition that warrants further research
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| COMMENTARIES |
| 103 | Pulmonary rehabilitation for chronic obstructive pulmonary disease: Has it peaked?
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| 105 | When is a confounder not a confounder?
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| INVITED REVIEW SERIES |
| Paediatric and Adult Bronchiectasis |
| 107 | Paediatric and adult bronchiectasis: Vaccination in prevention and management
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| 115 | Paediatric and adult bronchiectasis: Monitoring, cross-infection, role of multidisciplinary teams and self-management plans
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| SYSTEMATIC REVIEW |
| 127 | Spectrum of mutations of cystic fibrosis in the 22 Arab countries: A systematic review
Duaa Al-Sadeq, Taghreed Abunada, Rajaa Dallou,l Sara Fahad, Sara Taleb, Kholoud Aljassim, Fatima Alzahra Al Hamed, Hatem Zayed
10.1111/resp.13437 |
| ORIGINAL ARTICLES |
| Critical Care |
| 137 | Driving pressure and acute respiratory distress syndrome in critically ill patients
Raiko Blondonnet, Elodie Joubert, Thomas Godet, Pauline Berthelin, Thibaut Pranal, Laurence Roszyk, Russell Chabanne, Nathanael Eisenmann, Alexandre Lautrette, Corinne Belville, Sophie Cayot, Thierry Gillart, Bertrand Souweine, Damien Bouvier, Loic Blanchon, Vincent Sapin, Bruno Pereira, Jean-Michel Constantin, Matthieu Jabaudon
10.1111/resp.13394
The driving pressure at admission to the intensive care unit in intubated patients under controlled ventilation identifies patients with clinical risk factor(s), who develop acute respiratory distress syndrome within 7 days. |
| Interstitial Lung Disease |
| 146 |
Predictive factors and prognostic effect of telomere shortening in pulmonary fibrosis
Lurdes Planas-Cerezales, Elena G Arias-Salgado, Ivette Buendia-Roldán, Ana Montes-Worboys, Cristina Esquinas, López Vanesa, Vicens-Zygmunt Patricio Luburich Hernaiz, Roger Llatjós Sanuy, Virginia Leiro-Fernandez, Eva Balcells Vilarnau, Ernest Sala Llinás, Jordi Dorca Sargatal, Rosario Perona Abellón, Moisés Selman, Maria Molina-Molina
10.1111/resp.13423
The study establishes predictive factors for telomere shortening in idiopathic pulmonary fibrosis (IPF) and demonstrates clinical implications in pulmonary fibrosis. Sporadic IPF patients younger than 60 years and/or presenting non-specific immunological or haematological abnormalities were at higher risk of telomere shortening. A poor prognosis is more frequently associated with a young disease onset. Watch the video abstract. |
| Lung Function |
| 154 | Respiratory muscle weakness increases dead-space ventilation ratio aggravating ventilation-perfusion mismatch during exercise in patients with chronic heart failure
Nobuaki Hamazaki, Takashi Masuda, Kentaro Kamiya, Ryota Matsuzawa, Kohei Nozaki, Emi Maekawa, Chiharu Noda, Minako Yamaoka-Tojo, Junya Ako
10.1111/resp.13432
Respiratory muscle weakness is often detected in patients with chronic heart failure (CHF). During exercise, we demonstrate that respiratory muscle weakness is associated with increased dead-space ventilation ratio and higher ventilation-perfusion mismatch. Our findings indicate that respiratory muscle weakness complicates CHF; possibly causing abnormal ventilation during exercise. |
| Pulmonary Vascular Disease |
| 162 |
Pulmonary arterial hypertension in a multi-ethnic Asian population: Characteristics, survival and mortality predictors from a 14-year follow-up study
Yinghao Lim, Ting-Ting Low, Siew-Pang Chan, Ting Wei Teo, Jin-Hao Justin Jang, Nicole Yip, Ivandito Kuntjoro, Edgar Lik-Wui Tay, James Wei-Luen Yip
10.1111/resp.13392
This is the first detailed pulmonary arterial hypertension (PAH) registry study from a multi-ethic Asian cohort with a long 14-year follow-up. Data are sorely lacking in the East compared with the West. We were able to apply and validate risk predictors including the REVEAL (Registry to Evaluate Early And Long-term PAH Disease Management) score. |
| Respiratory Infections |
| 171 | Bacteriology and clinical outcomes of patients with culture-positive pleural infection in Western Australia: A 6-year analysis
Fraser Brims, Natalia Popowicz, Andrew Rosenstengel, Julie Hart, Arthee Yogendran, Catherine A Read, Felicity Lee, Ranjan Shrestha, Alexander Franke, Joshua R Lewis, Ian Kay, Grant Waterer, Y C Gary Lee
10.1111/resp.13395
Pleural infection is common, with notable geographical variations in bacteriology. This state-wide longitudinal study provides the largest data set of bacteriology and outcomes of Australian adults with culture-proven pleural infection. Pleural infection is a major burden with significant length of hospital stay, high inpatient and 12-month mortality and diverse bacteriology between community- and hospital-acquired cases. |
| Sleep and Ventilation |
| 179 | Modification of the prolonged mechanical ventilation prognostic model score to predict short-term and 1-year mortalities
Yu Rang Park, Ji Sung Lee, Hwa Jung Kim, Sang-Bum Hong, Chae-Mann Lim, Younsuck Koh, Jin Won Huh
10.1111/resp.13400
ProVent (Prolonged Mechanical Ventilation Prognostic Model) probability model has low prediction power for 1-year mortality in medically ill patients at high severity. We modified the ProVent score, which considers co-morbidity and laboratory data (albumin and bilirubin), and the extended ProVent model showed good prediction power for 1-year mortality among patients with prolonged mechanical ventilation. |
| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 186 | A letter from 'O Canada'
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