EDITORIALS |
725 | 'Good enough' is 'not enough' when managing indigenous adults with bronchiectasis in Australia and New Zealand
Gabrielle B McCallum PhD, MPH, BNursing; Anne B Chang MBBS, PhD, FRACP, FAPSR, FThorSoc, FAHMS
10.1111/resp.13291 |
727 | Sighs matter
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729 | Potential clinical utility for the multiple breath nitrogen washout
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731 | Early life origins of the Asthma-COPD Overlap Syndrome?
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COMMENTARY |
733 | Guideline relevance, diagnostic uncertainty, fear and hierarchy: Intersecting barriers to antibiotic optimization in respiratory infections
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INVITED REVIEW SERIES |
Tuberculosis Updates 2018 |
735 | Implementing the End TB Strategy in the Western Pacific Region: Translating vision into reality
Kalpeshsinh Rahevar; Paula I Fujiwara; Shalala Ahmadova; Fukushi Morishita; Lee B Reichman
10.1111/resp.13308 |
ORIGINAL ARTICLES |
Bronchiectasis |
743 |
Bronchiectasis in indigenous and non-indigenous residents of Australia and New Zealand
Sean R Blackall; Jae B Hong; Paul King; Conroy Wong; Lloyd Einsiedel; Marc G W Rémond; Cindy Woods; Graeme P Maguire
10.1111/resp.13280
This study compares the nature and outcomes associated with bronchiectasis in adult indigenous and non-indigenous populations in Australia and New Zealand. It highlights the disproportionate impact of bronchiectasis in terms of premature mortality and healthcare utilization for indigenous populations, particularly Aboriginal Australians.
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COPD |
750 | Hyperinflation of bronchi in vitro impairs bronchodilation to simulated breathing and increases sensitivity to contractile activation
Alvenia Cairncross; Peter B Noble; Peter K. McFawn
10.1111/resp.13271
We investigated the effect of lung hyperinflation on mechanical properties of airways isolated from pig lungs. Findings suggest that hyperinflation impairs the bronchodilatory capacity of breathing and increases the sensitivity of the airway smooth muscle to contractile mediators, both of which may contribute to airflow limitation in obstructive disease. |
Interstitial Lung Disease |
756 | Fibroblast-matrix interplay: Nintedanib and pirfenidone modulate the effect of IPF fibroblast-conditioned matrix on normal fibroblast phenotype
Gali Epstein Shochet; Lutz Wollin; David Shitrit
10.1111/resp.13287
We developed an assay using Idiopathic pulmonary fibrosis (IPF) and normal primary fibroblasts. The IPF-fibroblast-conditioned matrix (CM) induced fibroblast to myofibroblast transition (FMT) with transforming growth factor beta (TGFβ) and signal transducer and activator of transcription 3 (STAT3) pathway activation in normal cells. This assay demonstrated differences in drug activities for newly approved IPF drugs (nintedanib and pirfenidone) at clinically relevant concentrations. |
764 | Multiple breath washout: A new and promising lung function test for patients with idiopathic pulmonary fibrosis
Sylvia Nyilas; Theresa Schreder; Florian Singer; Alexander Poellinger; Thomas Kurt Geiser; Philipp Latzin; Manuela Funke
10.1111/resp.13294
In this pilot study, we demonstrate that nitrogen-multiple breath washout (N2-MBW) is a feasible, sensitive and reproducible lung function test in patients with idiopathic pulmonary fibrosis. The N2-MBW-derived lung clearance index correlates with clinical disease severity, structural airway pathology and mortality. |
Pulmonary Vascular Disease |
771 | S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension
Argyrios Tzouvelekis; Jose D Herazo-Maya; Changwan Ryu; Jen-Hwa Chu; Yingze Zhang; Kevin F Gibson; Percy K Adonteng-Boateng; Qin Li; Hongyi Pan; Benjamin Cherry; Ferhaan Ahmad; Hubert J Ford; Erica L Herzog; Naftali Kaminski; Wassim H Fares
10.1111/resp.13302
S100A12 serum levels are elevated in patients with pulmonary hypertension and they are associated with increased mortality rates. These findings show that the S100A12 biomarker has a major role to play in determining the prognosis of pulmonary hypertension patients, and they would enrich deep phenotyping efforts in this patient population. |
Respiratory Infections |
780 |
Childhood measles contributes to post-bronchodilator airflow obstruction in middle-aged adults: A cohort study
Jennifer L Perret; Melanie C Matheson; Lyle C Gurrin; David P Johns; John A Burgess; Bruce R Thompson; Adrian J Lowe; James Markos; Stephen S Morrison; Christine F McDonald; Richard Wood-Baker; Cecilie Svanes; Paul S Thomas; John L Hopper; Graham G Giles; Michael J Abramson; E Haydn Walters; Shyamali C Dharmage
10.1111/resp.13297
Childhood measles infection as a potential early-life respiratory insult is not linked to chronic obstructive pulmonary disease (COPD) in adult life by itself. However, this prospective study found childhood measles increased the risk of post-bronchodilator airflow obstruction for middle-aged adults through its interaction with the combined effects of current adult asthma and smoking.
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LETTER FROM ASIA-PACIFIC REGION |
788 | Letter from Australia
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