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| EDITORIALS |
| 666 | Prediction models in respiratory medicine
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| 668 | Sputum transcriptomics: A tool for identifying gene expression underlying mechanistic pathways in severe asthma
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| 670 | Asthma exacerbations during pregnancy: A need for precision medicine
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| 672 | Asthma–COPD overlap: No formal definition and simple diagnostic tool so far?
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| 674 | Biomarkers in idiopathic pulmonary fibrosis: Are we there yet?
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| 676 | Pleurodesis and systemic inflammatory markers: Lessons and insights
John Y H Chan MBBS, MRCP, FHKAM, FHKCP; Y C Gary Lee MBChB, PhD, FCCP, FRCP, FRACP
10.1111/resp.13765 |
| COMMENTARIES |
| 678 | Rationale for universal face masks in public against COVID-19
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| 680 | The role of SARS-CoV-2 antibodies in COVID-19: Healing in most, harm at times
Martyn A French MBChB, MD, FRCPath, FRCP, FRACP; Yuben Moodley MBChB, FCP, FRACP, MD, PhD
10.1111/resp.13852 |
| 683 | Chloroquine and hydroxychloroquine for COVID-19: A word of caution
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| 685 | Molecular testing of metastatic non-small cell lung cancer in the Asia-Pacific region
Chong-Kin Liam MBBS, FRCP(UK), FCCP, FAPSR Emily Stone MBBS, MMed, FRACP Sita Andarini MD, PhD Yong-Sheng Liam MBBS David Chi-Leung Lam MD, PhD, FRCP, FAPSR; Pyng Lee MBBS, MD, FRCP(UK), FCCP, PhD
10.1111/resp.13833 |
| INVITED REVIEW SERIES |
| New frontiers in sleep disordered breathing |
| 688 | The future of sleep-disordered breathing: A public health crisis
Philip de Chazal BE, MBiomedE, PhD; Peter A Cistulli MBBS, PhD, MBA; Matthew T Naughton MBBS, MD, FRACP
10.1111/resp.13839 |
| 690 | Global burden of sleep-disordered breathing and its implications
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| INVITED REVIEW |
| 703 | Safe performance of diagnostic bronchoscopy/EBUS during the SARS-CoV-2 pandemic
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 709 |
Sputum transcriptomics implicates increased p38 signalling activity in severe asthma
Katherine J Baines, Michael Fricker, Vanessa M McDonald, Jodie L Simpson, Lisa G Wood, Peter A B Wark, Heather E Macdonald, Andrew Reid, Peter G Gibson
10.1111/resp.13749
Sputum transcriptomic analysis revealed vast changes in gene expression in severe asthma. There was enrichment of genes in the p38 signalling pathway, four gene networks altered and 30 genes were identified that were highly differentially expressed in severe asthma compared with controlled asthma and healthy controls. |
| 719 | Biomarker-guided management reduces exacerbations in non-eosinophilic asthma in pregnancy: A secondary analysis of a randomized controlled trial
Vanessa E Murphy, Celeste M Porsbjerg, Annelies L Robijn, Peter G Gibson
10.1111/resp.13713
This study shows that a FENO-guided algorithm for asthma treatment adjustment in pregnancy better targets treatment to phenotype than a symptom control algorithm, with reduced exacerbations in non-eosinophilic asthma. |
| COPD |
| 726 |
Impact of chronic obstructive pulmonary disease on mortality: A large national cohort study
Hye Yun Park, Danbee Kang, Hyun Lee, Sun Hye Shin, Minwoong Kang, Sunga Kong, Chin Kook Rhee, Juhee Cho, Kwang Ha Yoo
10.1111/resp.13678
Chronic obstructive pulmonary disease (COPD) patients were at a statistically significant higher risk for all-cause mortality than those without COPD. This patient group died more often than subjects without COPD from chronic lower airway disease, lung cancer and pneumonia. The impact of COPD on specific mortalities was stronger in younger subjects. |
| 735 | Prospective development of practical screening strategies for diagnosis of asthma–COPD overlap
Aiyuan Zhou, Lijuan Luo, Nian Liu, Cheng Zhang, Yahong Chen, Yan Yin, Jing Zhang, Zhiyi He, Lihua Xie, Jungang Xie, Jinhua Li, Zijing Zhou, Yan Chen, Ping Chen
10.1111/resp.13743
We established a screening model for ACO. It is as effective as the GINA/GOLD document to distinguish between ACO, asthma and COPD patients but much simpler to perform. |
| Interstitial Lung Disease |
| 743 | Clinical significance of serum S100 calcium-binding protein A4 in idiopathic pulmonary fibrosis
Norimichi Akiyama, Hironao Hozumi, Takuya Isayama, Jun Okada, Katsunori Sugiura, Hideki Yasui, Yuzo Suzuki, Masato Kono, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Takafumi Suda
10.1111/resp.13707
S100 calcium-binding protein A4 is a promising serum biomarker that may predict disease progression and mortality in idiopathic pulmonary fibrosis (IPF) patients. Insights from this study may facilitate establishment of treatment strategies for IPF. |
| Pleural Disease |
| 750 | Clinically important associations of pleurodesis success in malignant pleural effusion: Analysis of the TIME1 data set
Rachel M Mercer, Jessica Macready, Hannah Jeffries, Nicole Speck, Nikolaos I Kanellakis, Nick A Maskell, Justin Pepperell, Tarek Saba, Alex West, Nabeel Ali, John P Corcoran, Robert J Hallifax, Ioannis Psallidas, Rachelle Asciak, Maged Hassan, Robert F Miller, Najib M Rahman
10.1111/resp.13755
Inflammation, as evidenced by a greater rise in CRP levels, is associated with pleurodesis success but there is no association between success and degree of pain after pleurodesis. Patients with mesothelioma are more likely to experience pleurodesis failure but the mechanisms for this are unclear. |
| CONTEMPORARY CONCISE REVIEW |
| 756 | Contemporary Concise Review 2019: Interstitial lung disease
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| FORUM AND DEBATE |
| Scientific Letter |
| 764 | Serum amyloid A is a predictor for prognosis of COVID-19
Xiao-Neng Mo, Zhu-Quan Su, Chun-Liang Lei, Di-Fei Chen, Hui Peng, Ru-Chong Chen, Ling Sang, Hong-Kai Wu, Shi-Yue Li
10.1111/resp.13840 |
| LETTERS FROM ASIA-PACIFIC AND BEYOND |
| 766 | Letter from France
Jérémy Charriot MD; Laurie Pahus PharmD, PhD; Pascal Chanez MD, PhD; Nicolas Nagot MD, PhD; Arnaud Bourdin MD, PhD
10.1111/resp.13874 |
| 769 | Letter from Iraq
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