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| EDITORIALS |
| 566 | Simultaneous inhibition of thymic stromal lymphopoietin, IL-33 and IL-25: A therapeutic option in asthma?
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| 568 | Is asthma only an airways disorder?
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| 570 | Electronic cigarettes: Tumultuous times
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| 572 | Acute exacerbations in IPF: A clarion call for collaborative research
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| COMMENTARIES |
| 574 | Summarizing societal guidelines regarding bronchoscopy during the COVID-19 pandemic
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| 578 | Medical information and social media in the time of COVID-19
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| INVITED REVIEW SERIES |
| New frontiers in sleep-disordered breathing |
| 580 | Advances in pathophysiology and neuroimaging: Implications for sleep and dementia
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| INVITED REVIEW |
| 593 | Clinical side effects of continuous positive airway pressure in patients with obstructive sleep apnoea
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 603 | Combined blockade of IL-25, IL-33 and TSLP mediates amplified inhibition of airway inflammation and remodelling in a murine model of asthma
Gao An, Wenjun Wang, Xin Zhang, Qiong Huang, Qin Li, Shihao Chen, Xiaonan Du, Chris J Corrigan, Kewu Huang, Wei Wang, Yan Chen, Sun Ying
10.1111/resp.13711
Combined blockade of IL-25, IL-33 and TSLP may augment disease control and further reduce airways inflammation and remodelling in chronic asthma. |
| 613 | Reduced lung elastic recoil and fixed airflow obstruction in asthma
Katrina O Tonga, David G Chapman, Claude S Farah, Brian G Oliver, Sabine C Zimmermann, Stephen Milne, Farid Sanai, Kanika Jetmalani, Norbert Berend, Cindy Thamrin, Gregory G King
10.1111/resp.13688
We measured lung elastic recoil, spirometry and the forced oscillation technique in older non-smoking asthmatic subjects with fixed airflow obstruction (FAO). In addition to airway remodelling, FAO can be attributed to reduced lung elastic recoil. Identification of the mechanisms leading to loss of lung elasticity may offer new targets for intervention. |
| Environmental and Occupational Lung Disease |
| 620 |
Effects of E-cigarette E-liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis
Miranda P Ween, Rhys Hamon, Matthew G Macowan, Leigh Thredgold, Paul R Reynolds, Sandra J Hodge
10.1111/resp.13696
E-cigarettes are increasing in popularity, especially amongst non-smokers. We assess not only the toxicity of E-cigarettes on healthy airway epithelial cells and effect on secreted cytokines, but also, for the first time, the effect on efferocytosis of apoptotic airway cells by macrophages. |
| Interstitial Lung Disease |
| 629 |
Corticosteroid use is not associated with improved outcomes in acute exacerbation of IPF
Erica Farrand, Eric Vittinghoff, Brett Ley, Atul J Butte, Harold R Collard
10.1111/resp.13753
AE-IPF are unpredictable and highly morbid events, for which corticosteroids have long been a recommended treatment. This study found no evidence that corticosteroids improve outcomes in patients with IPF hospitalized with an acute exacerbation and may contribute to reduced overall survival. |
| 636 | Long-term clinical course and outcome of interstitial pneumonia with autoimmune features
Ho Cheol Kim, Joo Hee Lee, Eun Jin Chae, Joon Seon Song, Jin Woo Song
10.1111/resp.13665
The interstitial pneumonia with autoimmune feature (IPAF) group showed better survival than the non-IPAF-idiopathic interstitial pneumonia (IIP) group but similar survival to the connective tissue disease (CTD)-related interstitial lung disease (ILD) group and its prognosis is largely influenced by the presence of the usual interstitial pneumonia (UIP) pattern. The IPAF group had slower lung function declines and more frequent CTD development than the non-IPAF-IIP group. |
| Thoracic Surgery/Transplantation |
| 644 | Clinical outcomes and survival following lung transplantation in patients with pulmonary Langerhans cell histiocytosis
Nikolai Wajda, Zheng Zhu, Roman Jandarov, Daniel F Dilling, Nishant Gupta
10.1111/resp.13671
We studied post-lung transplantation survival and clinical outcomes in patients with pulmonary Langerhans cell histiocytosis (PLCH) from a national transplantation database in the United States. Median post-transplant survival in patients with PLCH is approximately 5 years, similar to other chronic lung diseases undergoing transplantation, and significantly affected by patient gender. |
| CONTEMPORARY CONCISE REVIEW |
| 651 | Contemporary Concise Review 2019: Asthma
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| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 657 | Letter from China
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| FORUM AND DEBATE |
| 659 | Is corticosteroid use truly not associated with improved outcomes in AE-IPF?
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| 659 | Is corticosteroid use truly not associated with improved outcomes in AE-IPF? – Reply
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