| EDITORIALS |
| 193 | TRPA1: A potential target for cold-induced airway disease?
Chantal Donovan B.Sc.(Hons), PhD, Philip M Hansbro B.App.Sc.(Hons), PhD
10.1111/resp.13453 |
| 195 | Pressuring stable patients with hypercapnic COPD to exercise
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| 197 | The patients have spoken; now it is time for us to listen and move the needle forward
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| 199 | In search of a good fit: CPAP therapy mask selection for obstructive sleep apnoea
Peter A Cistulli MBBS, PhD, MBA, FRACP, Colin E Sullivan MBBS, PhD, FRACP
10.1111/resp.13434 |
| COMMENTARY |
| 201 | Management of adverse reactions to high-dose moxifloxacin used in multidrug-resistant tuberculosis treatment programmes
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| INVITED REVIEW SERIES |
| Molecular Techniques for Respiratory Diseases |
| 204 | Genetic risk factors for the development of pulmonary disease identified by genome-wide association
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| 215 | Somatic mutations and immune checkpoint biomarkers
Brielle A Parris, Eloise Shaw, Brendan Pang, Richie Soong, Kwun Fong, Ross A Soo
10.1111/resp.13463 |
| Paediatric and Adult Bronchiectasis |
| 227 | Airway clearance, mucoactive therapies and pulmonary rehabilitation in bronchiectasis
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 238 | Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma
Chenqiu Du, Jun Kang, Wei Yu, Mingqing Chen, Baizhan Li, Hong Liu, Han Wang
10.1111/resp.13433
We evaluated the effect of temperature variation on an ovalbumin (OVA)-induced mouse model of asthma and investigated the role of transient receptor potential A1 (TRPA1). The results showed that repeated exposure to temperature variation impaired lung function. TRPA1 upregulation exacerbated inflammatory responses, while TRPA1 inhibition presented as a potential therapeutic target. |
| Bronchiectasis |
| 246 | High-intensity inspiratory muscle training in bronchiectasis: A randomized controlled trial
Ozge Ozalp, Deniz Inal-Ince, Aslihan Cakmak, Ebru Calik-Kutukcu, Melda Saglam, Sema Savci, Naciye Vardar-Yagli, Hülya Arikan, Jale Karakaya, Lütfi Coplu
10.1111/resp.13397
The present randomized controlled study contributes to the literature about the impact of high-intensity inspiratory muscle training (H-IMT) in bronchiectasis. We showed that H-IMT increased respiratory muscle strength and endurance, exercise capacity and social aspects of quality of life in patients with non-cystic fibrosis bronchiectasis |
| COPD |
| 254 | High-pressure non-invasive ventilation during exercise in COPD patients with chronic hypercapnic respiratory failure: A randomized, controlled, cross-over trial
Rainer Gloeckl, Vasileios Andrianopoulos, Antje Stegemann, Julian Oversohl, Tessa Schneeberger, Ursula Schoenheit-Kenn, Wolfgang Hitzl, Michael Dreher, A Rembert Koczulla, Klaus Kenn
10.1111/resp.13399
Non-invasive ventilation (NIV) with a high inspiratory pressure significantly improved cycle endurance time, reduced exercise-induced hypercapnia and relieved exertional dyspnoea in chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure. Complementary NIV with high inspiratory pressure support during cycling is feasible and a beneficial modality in the most severe COPD patients. |
| 262 | Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia: A 6-year follow-up study
Kiyoshi Uemasu, Susumu Sato, Shigeo Muro, Atsuyasu Sato, Naoya Tanabe, Koichi Hasegawa, Yoko Hamakawa, Tatsushi Mizutani, Yoshinori Fuseya, Kazuya Tanimura, Tamaki Takahashi, Toyohiro Hirai
10.1111/resp.13402
We conducted serial arterial blood gas measurements in patients with COPD. Follow-up partial arterial pressure of oxygen (PaO2) at 1 year in patients with mild hypoxaemia is clinically helpful since change in PaO2 (ΔPaO2) of -3.05 Torr/year predicts patients at risk of developing chronic respiratory failure within 6 years. |
| Interstitial Lung Disease |
| 270 |
Understanding the patient's experience of care in idiopathic pulmonary fibrosis
Kimberley Burnett, Ian Glaspole, Anne E Holland
10.1111/resp.13414
People with idiopathic pulmonary fibrosis (IPF) were dissatisfied with the information provided at diagnosis but valued specialist IPF care. Participants experienced a high burden of treatment side effects. Those with co-morbidities perceived that their care was not well coordinated. Participants felt that their active role in self-management of IPF was under-appreciated by health professionals. The Alfred Hospital in Melbourne, Australia (Source: Public Affairs, The Alfred). |
| Sleep and Ventilation |
| 278 |
Choosing the right mask for your Asian patient with sleep apnoea: A randomized, crossover trial of CPAP interfaces
Ken Junyang Goh, Rui Ya Soh, Leong Chai Leow, Song Tar Toh, Pei Rong Song, Ying Hao, Ken Cheah Hooi Lee, Gan Liang Tan, Thun How Ong
10.1111/resp.13396
In this randomized crossover trial of mask interfaces in continuous positive airway pressure (CPAP) therapy for obstructive sleep apnoea (OSA), adherence was highest with nasal masks compared to oronasal masks and nasal pillows. Residual apnoea-hypopnoea index (AHI) was higher with an oronasal mask interface. Nasal masks should be the first-line interface during CPAP initiation. Example of a CPAP therapy mask for patients with OSA. |
| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 286 | Letter from the UK (if we still exist after recent events!): Air pollution: The public health challenge of our time
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