| Page | |
| OBITUARY |
| 679 | Emeritus Professor Shu Hashimoto
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| EDITORIALS |
| 680 | Novel insights into the biological pathways involved in severe asthma
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| 682 | Towards truly ‘idiopathic’ pulmonary fibrosis
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| 684 | The role of obstructive sleep apnoea in cognitive dysfunction of the elderly: A therapeutic target or Pandora's box?
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| COMMENTARY |
| 686 | Direct oral anticoagulants for treatment of thromboembolic disease: Have we reached a plateau?
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| POSITION PAPER |
| 688 | Pulmonary function testing during SARS-CoV-2: An ANZSRS/TSANZ position statement
Brigitte M Borg, Christian Osadnik, Keith Adam, David G Chapman, Catherine E Farrow, Vanda Glavas, Kerry Hancock, Celia J Lanteri, Ewan G Morris, Nicholas Romeo, Elena K Schneider-Futschik, Hiran Selvadurai
10.1111/resp.14340 |
| INVITED REVIEW |
| 720 | Bronchial thermoplasty: State of the art
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 730 | Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts
Stephany Sánchez-Ovando, Stelios Pavlidis, Nazanin Zounemat Kermani, Katherine Joanne Baines, Daniel Barker, Peter G Gibson, Lisa G Wood, Ian M Adcock, Kian Fan Chung, Jodie Louise Simpson, Peter A B Wark
10.1111/resp.14302
Transcriptome analysis from endobronchial biopsies and induced sputum from two independent cohorts of adults with severe asthma (SA) (U-BIOPRED and Australian NOVocastrian Asthma cohort) demonstrated shared differentially expressed pathways previously linked to persistent unresolved inflammation and novel mechanisms of airway remodelling, which may represent potential novel mechanistic pathways involved in the pathogenesis of SA.
See related editorial |
| Interstitial Lung Disease |
| 739 | A comprehensible machine learning tool to differentially diagnose idiopathic pulmonary fibrosis from other chronic interstitial lung diseases
Taiki Furukawa, Shintaro Oyama, Hideo Yokota, Yasuhiro Kondoh, Kensuke Kataoka, Takeshi Johkoh, Junya Fukuoka, Naozumi Hashimoto, Koji Sakamoto, Yoshimune Shiratori, Yoshinori Hasegawa
10.1111/resp.14310
Our comprehensible combined deep learning and machine algorithm can be used to easily, rapidly and non-invasively diagnose and differentiate idiopathic pulmonary fibrosis from various interstitial lung diseases using non-invasive examinations and HRCT, with high accuracy, sensitivity, specificity and kappa coefficient values. |
| 747 |
Genetic testing in interstitial lung disease: An international survey
Michelle Terwiel, Raphael Borie, Bruno Crestani, Liam Galvin, Francesco Bonella, Aurelie Fabre, Antoine Froidure, Matthias Griese, Jan C Grutters, Kerri Johannson, Caroline Kannengiesser, Leticia Kawano-Dourado, Maria Molina-Molina, Antje Prasse, Elisabetta A Renzoni, Jasper van der Smagt, Venerino Poletti, Katerina Antoniou, Coline H M van Moorsel
10.1111/resp.14303
This survey on genetic testing in interstitial lung disease (ILD) was completed by 458 ILD patients, 181 patients' relatives and 352 pulmonologists. Overall, respondents supported the usefulness of genetic testing in ILD, but pulmonologists' eligibility criteria for patients and tests varied. Reported needs were guidelines, information and access to testing.
See related editorial |
| Respiratory Infections |
| 758 | Efficacy of single-dose and double-dose ivermectin early treatment in preventing progression to hospitalization in mild COVID-19: A multi-arm, parallel-group randomized, double-blind, placebo-controlled trial
Alireza Mirahmadizadeh, Ali Semati, Alireza Heiran, Mostafa Ebrahimi, Abdolrasool Hemmati, Mohammadreza Karimi, Souzan Basir, Marjan Zare, Antonio Charlys da Costa, Mohammad Zeinali, Maryam Sargolzaee, Owrang Eilami
10.1111/resp.14318
We conducted a double-blinded randomized placebo-controlled trial including 393 patients with mild coronavirus disease 2019 (COVID-19) and found that ivermectin, an anti-parasitic medication with known antiviral properties, was non-superior to the placebo. Neither a single nor a double dose was better in preventing progression to hospitalization and worsening of the clinical course of COVID-19 infection. |
| Sleep and Ventilation |
| 767 | Sleep-disordered breathing was associated with lower health-related quality of life and cognitive function in a cross-sectional study of older adults
Stephanie A Ward, Elsdon Storey, Danijela Gasevic, Matthew T Naughton, Garun S Hamilton, Ruth E Trevaks, Rory Wolfe, Fergal J O'Donoghue, Nigel Stocks, Walter P Abhayaratna, Sharyn Fitzgerald, Suzanne G Orchard, Joanne Ryan, John J McNeil, Christopher M Reid, Robyn L Woods
10.1111/resp.14279
The clinical implications for sleep-disordered breathing (SDB) in older age remain uncertain. This study of healthy community-dwelling older Australians reports significant associations between SDB and a lower physical health-related quality of life, in contrast to other studies of SDB in older age, and between SDB and lower cognitive function.
See related editorial |
| CONTEMPORARY CONCISE REVIEW |
| 776 | Contemporary Concise Review 2021: Pulmonary nodules from detection to intervention
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| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 786 | Letter from Australia
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| FORUM AND DEBATE |
| Correspondence |
| 788 | Long-term effects of discontinuing renin–angiotensin system inhibitors in COVID-19
Fabian Theurl MD, Nikolay Sappler MD, Konstantinos D Rizas MD, Steffen Massberg MD, Axel Bauer MD, Michael Schreinlechner MD
10.1111/resp.14306 |
