| EDITORIALS |
| 1037 | Peering deeper into asthmatic lungs
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| 1039 | Nasal high-flow therapy: Established roles and emerging opportunities
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| 1042 | Special delivery: Engineered endothelial cells for pulmonary arterial hypertension
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| 1044 | Signals and signposts: Biomarkers in IPF and PAH at the crossroads of clinical relevance
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| COMMENTARIES |
| 1046 | Implementation of evidence into practice: The key to improving patient outcomes
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| 1049 | Major contributions by and the future scope of cohort studies to advance respiratory and sleep medicine
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| INVITED REVIEW SERIES |
| Paediatric and Adult Bronchiectasis |
| 1051 | Moving forward: Bronchiectasis and chronic suppurative lung disease in children and adults in the 21st century
Adam T Hill MBChB, MD, FRCPEd, Anne B Chang MBBS, PhD, FRACP, FAPSR, FThorSoc, FAHMS
10.1111/resp.13670 |
| 1053 | Pathophysiology, causes and genetics of paediatric and adult bronchiectasis
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| 1063 | Paediatric and adult bronchiectasis: Specific management with coexisting asthma, COPD, rheumatological disease and inflammatory bowel disease
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 1073 | Quantitative assessment of airway remodelling and response to allergen in asthma
David C Adams, Alyssa J Miller, Matthew B Applegate, Josalyn L Cho, Daniel L Hamilos, Alex Chee, Jasmin A Holz, Margit V Szabari, Lida P Hariri, R Scott Harris, Jason W Griffith, Andrew D Luster, Benjamin D Medoff, Melissa J Suter
10.1111/resp.13521
Endobronchial optical coherence tomography is used to investigate the microstructural features of airway in allergic individuals with and without asthma, before and after allergen challenge. Quantification of these features reveals significant differences between the asthmatic and non-asthmatic airways both at baseline and in response to allergen. |
| COPD |
| 1081 |
Nasal high-flow therapy compared with non-invasive ventilation in COPD patients with chronic respiratory failure: A randomized controlled cross-over trial
Steven McKinstry, Joseph Singer, Jan Pieter Baarsma, Mark Weatherall, Richard Beasley, James Fingleton
10.1111/resp.13575
Non-invasive ventilation (NIV) reduces transcutaneous partial pressure of carbon dioxide (PtCO2) more than nasal high-flow (NHF) therapy in hypercapnic COPD, but NHF is better tolerated. |
| 1088 | Nasal high flow does not improve exercise tolerance in COPD patients recovering from acute exacerbation: A randomized crossover study
Guillaume Prieur, Clement Medrinal, Yann Combret, Elise Dupuis Lozeron, Tristan Bonnevie, Francis-Edouard Gravier, Jean Quieffin, Bouchra Lamia, Jean-Christian Borel, Gregory Reychler
10.1111/resp.13664
The addition of nasal high flow during high-intensity exercise does not improve endurance in patients with chronic obstructive pulmonary disease participating in pulmonary rehabilitation following exacerbation. |
| Pulmonary Vascular Disease |
| 1095 |
BMPR2-expressing bone marrow-derived endothelial-like progenitor cells alleviate pulmonary arterial hypertension in vivo
Rebecca L Harper, Suzanne Maiolo, Rebekah J Ward, Jemma Seyfang, Michaelia P Cockshell, Claudine S Bonder, Paul N Reynolds
10.1111/resp.13552
Pulmonary arterial hypertension (PAH) is causally linked to reduced bone morphogenetic protein receptor type 2 (BMPR2) expression. Endothelial progenitor cells engineered to overexpress BMPR2 are therapeutic in the rat monocrotaline PAH model, despite short retention time in the lungs. This approach may have clinical potential. |
| 1104 | Osteopontin lung gene expression is a marker of disease severity in pulmonary arterial hypertension
Marco Mura, Matthew J Cecchini, Mariamma Joseph, John T Granton
10.1111/resp.13557
Osteopontin (OPN), a pleiotropic cytokine, was identified among the top five upregulated genes in the lung explants from patients with Group I pulmonary arterial hypertension, compared to normal controls. Its expression correlated strongly to haemodynamic severity. Ingenuity pathway analysis showed the involvement of OPN in functions and networks relevant to vascular remodelling. |
| 1111 | Analysis by proteomics reveals unique circulatory proteins in idiopathic pulmonary fibrosis
Yuben P Moodley, Tamera J Corte, Brian G Oliver, Ian N Glaspole, Andreja Livk, Jason Ito, Kirsten Peters, Richard Lipscombe, Tammy Casey, Dino B A Tan
10.1111/resp.13668
This study utilized a combination of non-targeted discovery proteomics with targeted quantitation by mass spectrometry of soluble plasma biomarkers to identify potentially important molecules and pathways in idiopathic pulmonary fibrosis (IPF). Five proteins were identified to be differentially expressed in IPF compared to healthy controls. |
| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 1115 | Letter from Colombia
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