| EDITORIALS |
| 1084 | Inflammatory insights into airway remodelling in asthma
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| 1086 | Targeting dyspnoea in patients with very severe COPD: Practical precision medicine
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| 1088 | Double combination inhalers in COPD: How to get your head around this data
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| 1090 | Increasing diversity within the Global Lung Function Initiative
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| 1092 | Obstructive sleep apnoea and cholesterol: Independence in context
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| COMMENTARIES |
| 1094 | Modelling COPD co-morbidities in preclinical models
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| 1096 | TGF-β: Master regulator of inflammation and fibrosis
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| INVITED REVIEW SERIES |
| Tuberculosis Updates 2018 |
| 1098 | Drug resistance mechanisms and drug susceptibility testing for tuberculosis
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| 1114 | Applying new tools to control tuberculosis
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| Molecular Techniques for Respiratory Diseases |
| 1117 | Insights into respiratory disease through bioinformatics
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| Paediatric and Adult Bronchiectasis |
| 1127 | Emerging therapies in adult and paediatric bronchiectasis
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 1138 |
Inflammation-dependent and independent airway remodelling in asthma
John G Elliot, Peter B Noble, Thais Mauad, Tony R Bai, Michael J Abramson, Karen O McKay, Francis H Y Green, Alan L James
10.1111/resp.13360
Findings suggest that inner and outer wall thickening coexists with airway inflammation, whereas airway smooth muscle and basement membrane remodelling may be partly independent of airway inflammation and therefore not reversible by anti-inflammatory treatment. |
| COPD |
| 1146 | Individualized breathlessness interventions may improve outcomes in patients with advanced COPD
Mary Y Y Qian, John Politis, Michelle Thompson, Darren Wong, Brian Le, Louis Irving, Natasha Smallwood
10.1111/resp.13324
Refractory breathlessness in patients with advanced COPD is a complex and difficult symptom to manage. In this feasibility study, we demonstrate that implementation of an individualized breathlessness intervention, involving a written plan, information leaflets and breathlessness education, is associated with an improvement in breathlessness scores and high patient acceptability. |
| 1152 | Efficacy and safety of the direct switch to indacaterol/glycopyrronium from salmeterol/fluticasone in non-frequently exacerbating COPD patients: The FLASH randomized controlled trial
Peter A Frith, Samiha Ashmawi, Srikanth Krishnamurthy, Alev Gurgun, Sashka Hristoskova, Virginia Pilipovic, Anna Marie Hamann, Arthur Backer, Petter Olsson, Konstantinos Kostikas, Dina V Diaz, on behalf of the FLASH Investigators
10.1111/resp.13374
Direct switch to indacaterol/glycopyrronium from salmeterol/fluticasone, without washout period, improved lung function in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) with up to one exacerbation in the previous year without adverse consequences. |
| Interstitial Lung Disease |
| 1160 | Clinical behaviour of patients exposed to organic dust and diagnosed with idiopathic pulmonary fibrosis
Laurens J De Sadeleer, Stijn E Verleden, Els De Dycker, Jonas Yserbyt, Johny A Verschakelen, Eric K Verbeken, Benoit Nemery, Geert M Verleden, Frederik Hermans, Bart M Vanaudenaerde, Wim A Wuyts
10.1111/resp.13342
Usual interstitial pneumonia (UIP) patients exposed to moulds or birds without other features of chronic hypersensitivity pneumonitis (CHP) experience a better survival compared with non-exposed idiopathic pulmonary fibrosis (IPF) patients, although still worse compared with definite CHP patients. A similar beneficial effect from antifibrotics was seen irrespective of mould/bird exposure. |
| 1166 | Expression analysis of extracellular microRNA in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis
Amit Kishore, Zdenka Navratilova, Vitezslav Kolek, Eva Novosadova, Klàra Čépe, Roland M du Bois, Martin Petrek
10.1111/resp.13364
Extracellular vesicles (EV: exosomes and microvesicles) in sarcoidosis bronchoalveolar lavage samples contained more EV miR-146a, miR-150 in chest X-ray stage-II (CXR-II) than in CXR stage-I (CXR-I); levels were negatively correlated to lung function indices. This study is the first to document bronchoalveolar vesicles containing differentially expressed extracellular microRNA (miRNA) in pulmonary sarcoidosis. |
| Lung function |
| 1173 | Global Lung Initiative 2012 spirometry reference values in a large Asian cohort of Malay, Chinese and Indian ancestry
Noraidatulakma Abdullah, Boekhtiar Borhanuddin, Shamsul A Shah, Tidi Hassan, Rahman Jamal
10.1111/resp.13330
The multi-ethnic Global Lung Initiative (GLI) 2012 reference values for spirometry lack validation in an Asian population. This large cohort population study demonstrates that GLI 2012 reference values for spirometry may not be accurate in a multi-ethnic Asian population. |
| Sleep and Ventilation |
| 1180 |
Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database
Canan Gündüz, Ozen K Basoglu, Jan Hedner, Ding Zou, Maria R Bonsignore, Holger Hein, Richard Staats, Athanasia Pataka, Ferran Barbe, Pavel Sliwinski, Brian D Kent, Jean Lois Pepin, Ludger Grote on behalf of the European Sleep Apnea Database Collaborators
10.1111/resp.13372
The present study examines the association of obstructive sleep apnoea (OSA) and dyslipidaemia in the large multicentre European Sleep Apnea Database cohort. There was an independent relationship between OSA severity and lipid concentrations which was influenced by geographical region and measures of central obesity. |
| POSITION STATEMENT |
| 1190 | Work environment risks for health care workers with cystic fibrosis
Scott C Bell, David Armstrong, Glenys Harrington, Luke Jardine, Rebekah Divakaran, Bebe Loff, Peter G Middleton, Tim McDonald, Karen Rowland, Michael Wishart, Michelle E Wood, Rhonda L Stuart
10.1111/resp.13404 |
| LETTER FROM ASIA-PACIFIC REGION |
| 1198 | Letter from Malaysia
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