Respirology Case Reorts

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November 2022
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Case Series
Pulmonary involvement in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis: A single centre case series
Peter T Bell, Robert Sheehy, Luke Droney, Kerri Prain, Richard Wong, Gregory J Keir
DOI: 10.1002/rcr2.1058

Organizing pneumonia (OP) promptly responds to corticosteroids. However, a minority of patients demonstrate corticosteroid resistance or relapse on corticosteroid tapering. The following case reports describe post COVID-19 OP patients pre-vaccination era with clinically inadequate response to corticosteroids but who improved after the addition of mycophenolate mofetil (MMF, Mycofit®).

Case Reports
Post COVID-19 organizing pneumonia treated with mycophenolate mofetil
Hui Xin Tan, Chee Kin Wong, Weng Fai Yik, Yoke Fong Lam, Kumaresh Raj Lachmanan
DOI: 10.1002/rcr2.1042

Organizing pneumonia (OP) promptly responds to corticosteroids. However, a minority of patients demonstrate corticosteroid resistance or relapse on corticosteroid tapering. The following case reports describe post COVID-19 OP patients pre-vaccination era with clinically inadequate response to corticosteroids but who improved after the addition of mycophenolate mofetil (MMF, Mycofit®).

Pneumonia caused by toxic epidermal necrolysis
Dominic Doyle, Amy Long, Desmond M Murphy
DOI: 10.1002/rcr2.1046

We describe infective pneumonia secondary to disruption of the bronchial epithelium from a severe case of Toxic Epidermal Necrolysis Syndrome (TENS). This syndrome was due to Ciprofloxacin which is a very rare cause. Our patient recovered well with conventional treatment of TENS and pneumonia.

Rapid recovery of fat embolism syndrome with acute respiratory failure due to liposuction
Yong Jie Ding, Liu Zhang, Xian Wen Sun, Ying Ni Lin, Qing Yun Li
DOI: 10.1002/rcr2.1047

Liposuction is one potential cause of fat embolism syndrome (FES). Liposuction-induced FES is a rare, but life-threatening condition. Here we report the case of a 29-year-old woman who developed FES suddenly during a liposuction operation in a cosmetic medical clinic and achieved complete recovery within 11 days by comprehensive therapeutic strategies

Huge racemose hemangioma of the bronchial artery with arterial supply via the right coronary artery and left internal thoracic artery
Rikako Horie, Kensuke Sekiya, Junichi Funada
DOI: 10.1002/rcr2.1048

We present the first case of a huge racemose hemangioma of the bronchial artery (RHBA) with multiple arterial supply, and the clinical findings indicated the possibility of coronary steal phenomenon due to the arterial supply from the right coronary artery (RCA) to the hemangioma.

Silver nitrate therapy for persistent tracheocutaneous fistula following prolonged tracheostomy and invasive ventilation: A case report
Duncan J Sweeney, Caroline Chao, Anna Ridgers, Christine Knee Chong, Joshua Goldblatt, Siven Seevanayagam, Mark E Howard
DOI: 10.1002/rcr2.1049

Most published management strategies of tracheocutaneous fistulas typically focus on surgical approaches. However, in certain scenarios such as patients with respiratory insufficiency or chronic respiratory failure, surgical management poses an unacceptable perioperative risk. This case highlights a non-surgical approach to TCF management that is not well-described in the literature and presents an alternative management option for cohorts of patients in which the risk associated with surgical interventions may be undesirable.

A case of a thoracic mass negative on thoracentesis diagnosed by cryobiopsy from the visceral pleura
Chie Morita, Atsushi Kitamura, Katsuhito Kinoshita, Kuniyo Sueyoshi, Manabu Murakami, Shosei Ro, Ryosuke Imai, Kohei Okafuji, Fumitsugu Kojima, Yutaka Tomishima, Torahiko Jinta, Toru Bando, Naoki Nishimura
DOI: 10.1002/rcr2.1050

Here we report a case of a patient who was negative on thoracentesis and underwent cryobiopsy from the visceral pleura by thoracoscopy under local anaesthesia. The technique was performed safely and led to a diagnosis.

A case of ectopic cervical thymoma with myasthenia gravis mimicking a parathyroid tumour
Go Kamimura, Kazuhiro Ueda, Aya Takeda, Ryo Miyata, Masaya Aoki, Toshiyuki Nagata, Masami Sato
DOI: 10.1002/rcr2.1052

We report an extremely rare case of cervical thymoma with 99mTcMIBI scintigraphic accumulation associated with myasthenia gravis that was difficult to diagnose and treat.

Drowning case complicated with a cardiopulmonary arrest and severe ARDS saved with a good neurological outcome by ECMO: A case report
Songhyon Cho, Toshiki Furukawa, Osamu Ogawa
DOI: 10.1002/rcr2.1053

We report a rare case of acute respiratory distress syndrome after cardiopulmonary arrest due to drowning, with a good neurological outcome by veno-venous extracorporeal membrane oxygenation.

Survival benefit of combinatorial osimertinib rechallenge and entrectinib in an EGFR-mutant NSCLC patient with acquired LMNA-NTRK1 fusion following osimertinib resistance
Jiao-Li Wang, Liu-sheng Wang, Jun-qi Zhu, Jie Ren, Di Wang, Man Luo
DOI: 10.1002/rcr2.1054

Osimertinib re-challenge could be an optional treatment for the end-stage EGFR-mutated NSLCs. The combination therapy of the driver EGFR mutation TKI and the NTRK fusion inhibitors could provide clinical benefit and could be considered as a therapeutic option for patients with NTRK fusion being acquired as a resistance mechanism.

Antibiotic administration via indwelling peritoneal catheter to treat infected malignant ascites
Thisuri Jayawardena, Sona Vekaria, Sophie Krivinskas, Calvinjit Sidhu, Aron Chakera, Y C Gary Lee
DOI: 10.1002/rcr2.1055

Indwelling pleural and peritoneal catheters improve quality of life in patients with malignant pleural effusions and ascites. However, they are associated with catheter-related infections, traditionally managed with systemic antibiotics. We present a patient with peritoneal mesothelioma who developed Staphylococcus aureus peritonitis three weeks after indwelling catheter insertion and successfully treated with intraperitoneal vancomycin directly to the site of infection.

Spindle cell hemangioma of the lung: An unusual presentation
Mariem Hamdi, Emna Braham, Sabrine Louhaichi, Besma Hamdi, Mahdi Abdennadher, Jamel Ammar, Faouzi El Mezni, Adel Marghli, Agnès Hamzaoui
DOI: 10.1002/rcr2.1057

SCHs are benign vascular tumor that occurs in young adults and typically arises in the subcutis of the distal extremities, particularly the hand. So far only two cases of pulmonary SCH were reported in the literature. Our case is instructive by its different clinical (hemoptysis) and radiological presentation (cavitary lesion) compared to the previous two cases.

An unusual isolated anterior mediastinal lesion
Nicholas Quigley, Loic Lang-Lazdunski, Catherine Boily-Daoust, Christian Couture, Marc Fortin
DOI: 10.1002/rcr2.1059

In our report, we present the case of a career welder who consulted with vocal cord palsy and an atypical anterior mediastinal lesion. An EBUS-TBNA-guided biopsy and a thorough cytological assessment led to an unexpected diagnosis of epithelioid malignant pleural mesothelioma (MPM). A localized anterior mediastinal lesion is an extremely infrequent presentation of MPM that deserves clinical recognition.

Clinical images
Lung cancer that recurred as carcinoma en cuirasse
Shohei Nozu, Norihiko Nakanishi, Yasushi Sadamoto, Atsuro Sugita
DOI: 10.1002/rcr2.1041

We report an unusual cutaneous metastasis known as “carcinoma en cuirasse” 7 years after left upper lobectomy to treat an adenocarcinoma of the lung.

When it starts in the skin and goes to the lungs, where does it stop?
Ana Rita Catarino Ferro, Ana Margarida Ferreira Campos
DOI: 10.1002/rcr2.1043

This case reports a patient diagnosed with Birt-Hogg-Dubé syndrome (BHDS), a rare disease, with an increased risk of fibrofolliculomas in the skin, multiple lung cysts predisposing to recurrent pneumothorax and increased risk of renal cancer. Its clinical expression is variable, which makes the diagnosis and management difficult.

IgG4 related lung disease mimicking multiple pleural disseminated lung cancer
Koya Ito, Yukiko Maeda, Akane Mita, Saori Aizawa, Arei Mizushima, Natsuko Taniguchi, Katsura Nagai, Hiroki Shomura, Atsuo Hattori, Toshiyuki Harada
DOI: 10.1002/rcr2.1044

Herein we report an asymptomatic patient with IgG4-related lung disease mimicking multiple pleural disseminated lung cancer.

The Macklin effect in tension pneumomediastinum in a patient with interstitial pneumonia
Hiroko Watanabe, Hiroaki Ishikawa, Toshihide Inui, Kai Kawashima, Tomohiro Namiki, Tohru Sakamoto
DOI: 10.1002/rcr2.1045

Tension pneumomediastinum is a rare complication of interstitial pneumonia. This case shows computed tomography findings of the Macklin effect, in which air dissection along the bronchovascular interstitium caused by alveolar rupture leads to pneumomediastinum.

Coronavirus disease 2019 vaccination-induced acute exacerbation in idiopathic pulmonary fibrosis
Keishi Sugino, Hirotaka Ono, Mikako Saito, Masahiro Ando, Eiyasu Tsuboi
DOI: 10.1002/rcr2.1051

Here we report a rare case of acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) after coronavirus disease 2019 (COVID-19) vaccination. Although, it is difficult to differentiate idiopathic AE from COVID-19 vaccination-induced AE, we suppose that vaccination can trigger AE of IPF characterized by a steroid-responsive episode.

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