| Case Series |
Safety of nintedanib before lung transplant: an Italian case series
Elisabetta Balestro Paolo Solidoro Piercarlo Parigi Massimo Boffini Alessandro Lucianetti Federico Rea
DOI: 10.1002/rcr2.312
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease that can only be cured by lung transplantation. Pharmacological agents play a role in preserving lung function and prolonging survival until a suitable donor organ becomes available. However, data on the effects of newer antifibrotic therapies on lung transplantation outcomes in IPF patients are lacking. The nine patients included in this case series were treated with nintedanib 150 mg twice daily for 3–30 (mean 13 ± 9) months before lung transplant surgery. In this series, nintedanib preserved lung function up to transplantation, was well tolerated, and had no detrimental effects on the short-term outcome of lung transplant. |
| Case Reports |
Mechanical insufflation-exsufflation for airway clearance in adults with cystic fibrosis
Madeline Gaynor Jamie Wood
DOI: 10.1002/rcr2.307
In cystic fibrosis (CF), acute exacerbations can decrease the effectiveness of patients' usual airway clearance techniques (ACT) due to fatigue, dyspnoea or a high sputum load. Mechanical insufflation-exsufflation (MI-E) is widely used in neuromuscular disorders, but has rarely been used in CF despite potential indications. We present two cases where a modified version of MI-E was used as an adjunct to traditional ACT in adults during an acute exacerbation of CF. |
Extrapleural pneumonectomy of recurrent thymoma with pleural dissemination
Haruhiko Shiiya, Yasuhiro Hida, Kichizo Kaga, Rei Inoue, Reiko Nakada-Kubota, Yoshiro Matsui
DOI: 10.1002/rcr2.308
The safety and efficacy of extrapleural pneumonectomy for recurrent, disseminated thymoma has been controversial. We report a good outcome of young fit patient after extrapleural pneumonectomy. |
Respiratory failure patient with lung cancer diagnosed by transesophageal bronchoscopic ultrasound-guided aspirates
Takayasu Ito, Masahide Oki, Hideo Saka, Yasuhiro Kondoh, Tomoki Kimura, Kensuke Kataoka
DOI: 10.1002/rcr2.309
We herein report patient with respiratory failure, whose mediastinal lymph node could not be diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) under non-invasive positive pressure ventilation (NPPV) but was successfully diagnosed by endoscopic ultrasound with bronchoscope-guided fine-needle aspiration (EUS-B-FNA). |
Desmoid fibromatosis of the chest wall
QiHao Ong, Janice Wong, Sanjay Sinha, Nand Kejriwal
DOI: 10.1002/rcr2.310
We report a rare case of desmoid fibromatosis of the chest wall. |
Report on the breakage of the tip of a radial endobronchial ultrasonic probe sheath during bronchoscopy
Daizo Yaguchi, Motoshi Ichikawa, Noriko Inoue, Daisuke Kobayashi, Masato Shizu, Naoyuki Imai
DOI: 10.1002/rcr2.311
Bronchoscopic biopsy using an ultrasonic probe with a guide sheath to confirm that the target lesion is reached is an established and routine procedure, but familiarity with the possible breakage of related devices is important. We experienced breakage of the tip of the ultrasonic probe sheath of a bronchoscope. Careful investigation concluded that the tip did not break off during the examination, but rather broke and was lost during cleaning after the examination. |
Rapid diffuse pleural thickening due to metastatic meningioma
Fumi Kobayashi, Takeshi Saraya, Kosuke Ohkuma, Masachika Fujiwara, Hajime Takizawa
DOI: 10.1002/rcr2.313
Extracranial metastases from brain meningioma have a low incidence of 0.76% and occur mostly in the lungs, bone, intraspinal, abdominal viscera, mediastinal, and cervical lymph nodes. However, pleural metastasis can occur as an extremely rare complication of brain meningioma regardless of the tumour grading. Here, we report a case with metastatic meningioma to the pleura, which radiologically and pathologically mimicked malignant mesothelioma. |
