| Case Series |
Eosinophilia as a treatable trait in three patients with asthma and COPD
James Michael Ramsahai, Jodie Simpson and Peter Wark
DOI: 10.1002/rcr2.295
In this series, we present three cases of patients with features of both asthma and chronic obstructive pulmonary disease, in addition to peripheral blood eosinophilia. The novel implementation of the personalized management of the individual based on this treatable trait (eosinophilia) resulted in significant benefits. These benefits included improvement in symptoms, lung function, and a marked decline in critical care admissions and exacerbation rates. |
| Case Reports |
Cryptococcal pleural infection in a recurrent pleural effusion: a case report
Audrey Chuan Rui Wee, Ju Ee Seet, Jonathen Venkatalacham and Sze Khen Tan
DOI: 10.1002/rcr2.294
Recurrent lymphocytic exudative pleural effusion in a previously well young male diagnosed to have cryptococcal pleural infection on thoracoscopic pleural biopsy, treated with intravenous amphotericin and flucytosine, and oral fluconazole. He was subsequently found to have acute myeloid leukaemia and underwent chemotherapy and bone marrow transplantation. |
Eosinophilia as a treatable trait in three patients with asthma and COPD
James Michael Ramsahai, Jodie Simpson, Peter Wark DOI: 10.1002/rcr2.295
In this series, we present three cases of patients with features of both asthma and chronic obstructive pulmonary disease, in addition to peripheral blood eosinophilia. The novel implementation of the personalized management of the individual based on this treatable trait (eosinophilia) resulted in significant benefits. These benefits included improvement in symptoms, lung function, and a marked decline in critical care admissions and exacerbation rates. |
Successful treatment by tolvaptan of the syndrome of inappropriate antidiuretic hormone secretion that may be associated with chemotherapy-induced tumour lysis in a patient with small-cell lung carcinoma
Koichi Miyashita, Shun Matsuura, Hyogo Naoi, Masaru Tsukui, Naoki Koshimizu and Takafumi Suda
DOI: 10.1002/rcr2.296
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an important complication in a patient with small-cell lung carcinoma (SCLC) and is usually diagnosed before treatment. However, tumour lysis can cause SIADH after chemotherapy. Tolvaptan may improve hyponatremia in SIADH associated with chemotherapy-induced tumour lysis. |
Facial flushing on upper limb exertion: a rare presentation of superior vena cava obstruction
Michael Plunkett, James Wethasinghe, Brendon O'Donoghue, Nigel Lever and Conroy Wong
DOI: 10.1002/rcr2.297
A 27-year-old male with infection of abandoned pacemaker leads presented with facial flushing on upper limb exertion due to superior vena cava (SVC) obstruction, as well as pleuritic chest pain due to septic emboli. Upper limb exertional facial flushing may be a useful clinical sign for the diagnosis of SVC obstruction. |
Pleuroparenchymal fibroelastosis after haematopoietic stem cell transplantation without graft-versus-host disease findings
Tamio Okimoto, Yukari Tsubata, Megumi Hamaguchi, Akihisa Sutani, Shunichi Hamaguchi and Takeshi Isobe
DOI: 10.1002/rcr2.298
We report the case of a patient with pleuroparenchymal fibroelastosis (PPFE) after haematopoietic stem cell transplantation (HSCT). A surgical specimen showed PPFE findings, without evidence of graft-versus-host disease (GVHD). In this case, development of PPFE was not associated with GVHD. |
Orthodeoxia as a presentation of intravascular large B cell lymphoma
Nophol Leelayuwatanakul and Napplika Kongpolprom
DOI: 10.1002/rcr2.299
We demonstrate the first case of orthodeoxia as an initial presentation of Intravascular large B cell lymphoma (IVLBCL), clinically compatible with Asian-variant IVLBCL, which is commonly fatal and diagnostically challenging but had here a favorable outcome. |
Critical airway compression caused by a large mediastinal tumour with spontaneous haemorrhage
Shih-Peng Liu, Hung-Che Chien, Chun-Ku Chen, Chih-Cheng Hsieh, Chien-Sheng Huang DOI: 10.1002/rcr2.300
Acute, life-threatening presentation of airway compression by a spontaneous haemorrhage substernal goitre is rare, thoracic specialists should be aware of this critical scenario and thoroughly differentiate this from other surgical or non-surgical mediastinal masses. |
Thin laryngeal foreign bodies in infants: diagnostic potential of MDCT
Antonella Concerto, Marco Cavallaro, Carmela Visalli, Anna Maria Bagnato, Ugo Barbaro, Ignazio Salamone
DOI: 10.1002/rcr2.301
A laryngeal foreign body is a rare occurrence in infant population and the diagnosis is frequently a challenge. Low-dose multidetector computed tomography (MDCT) with thin-slice reconstruction is particularly useful in detecting cases of occult foreign body aspiration in the larynx. |
Lung parenchymal involvement of primary bone marrow follicular lymphoma: a rare case study
Hiroyuki Minemura, Hiroshi Hojo, Miwako Saito, Takefumi Nikaido, Tomoko Suzuki, Katsunao Niitsuma DOI: 10.1002/rcr2.302
We presented a rare case of primary bone marrow follicular lymphoma that infiltrated the lung parenchyma. In cases suspected to be malignant lymphoma, immunohistochemistry or other genetic examination is important even if 18F-fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography-computed tomography (PET-CT) seems to be a false-positive because of the possibility of a sarcoid reaction. |
Reversible platypnoea-orthodeoxia syndrome in post-tuberculosis bronchial stenosis
Geak Poh Tan, John Arputhan Abisheganaden, Soon Keng Goh and Akash Verma
DOI: 10.1002/rcr2.303
Bronchial stenosis is known to complicate endobronchial tuberculosis (TB) despite medical therapy. It is often associated with dyspnoea and can result in respiratory failure if left untreated. We present an unusual observation of platypnoea-orthodeoxia syndrome (POS) in a case of acute lung collapse secondary to post-TB bronchial stricture, which was reversible following successful bronchoscopic intervention. |
Early diagnosis of idiopathic pulmonary haemosiderosis: increased haemosiderin-laden macrophages in repeat bronchoscopy
Yuichi Mukai, Toshihiko Agatsuma and Gen Ideura
DOI: 10.1002/rcr2.304
Idiopathic pulmonary haemosiderosis (IPH) is a diagnosis of exclusion, which is characterized by persistent or recurrent episodes of alveolar haemorrhage. Early diagnosis of IPH, especially in the case of first-time manifestation, is challenging because previous episodes of alveolar haemorrhage are often difficult to prove. We report a case of IPH, which was diagnosed early by confirming the presence of an increased number of haemosiderin-laden macrophages with alveolar haemorrhage in repeat bronchoscopy. |
Narrow-band imaging thoracoscopy in pleural amyloidosis
Yuki Kanno, Naoki Furuya, Mariko Okamoto, Akira Noguchi, Takeo Inoue, Masamichi Mineshita DOI: 10.1002/rcr2.305
In patients with undiagnosed pleural effusions, pleural amyloidosis should be considered as a differential diagnosis. Also, thoracoscopy with NBI was a useful procedure to assess the findings of pleural amyloidosis in detail. |
Malignant pleural mesothelioma presenting with remitting-relapsing pleural effusions: report of two cases
Sanjeevan Muruganandan, Deirdre Brigid Fitzgerald, Y C Gary Lee DOI: 10.1002/rcr2.306
Malignant effusions are typically persistent and progressive. Spontaneously resolving effusions are commonly presumed to be benign. We present two cases in which the presenting pleural effusion spontaneously resolved but recurred, leading to further investigations that revealed an underlying malignant pleural epithelioid mesothelioma. |
