| Case Reports |
Convalescent plasma therapy in an immunocompromised patient with multiple COVID-19 flares: a case report
Frini Karaolidou, Natasa-Eleni Loutsidi, Zois Mellios, Edison Jahaj, Konstantinos Eleftheriou, Maria Pagoni, Ioannis Mpaltadakis, Athanasios-Meletios Dimopoulos, Ioannis Kalomenidis, Apostolos G Pappas
DOI: 10.1002/rcr.858
We describe the case of a 45-year-old immunocompromised patient, who received convalescent plasma, in order to control multiple COVID-19 flares and prolonged SARS-CoV-2 viraemia lasting for 2 months after the initial diagnosis. |
Recurrent pneumothoraces with diffuse small ground-glass and solid nodules
Li Yan Sandra Hui, Xin Min Cheng, Ing Xiang Soo, Su Ying Low
DOI: 10.1002/rcr.870
We present here a case multifocal micronodular pneumocyte hyperplasia (MMPH) co-existing with lymphangioleiomyomatosis in a patient with genetically proven tuberous sclerosis complex. MMPH is the lesser known pulmonary manifestation of tuberous sclerosis and can be easily mistaken for its radiological differentials of malignant/infective causes or pulmonary Langerhans cell histiocytosis if histological evaluation is not obtained. We describe here the radiological and histological findings of MMPH in our patient. |
Post-coronavirus disease 2019 organizing pneumonia confirmed pathologically by video-assisted thoracoscopic surgery
Keishi Sugino, Hirotaka Ono, Shuji Haraguchi, Seiji Igarashi, Akira Hebisawa, Eiyasu Tsuboi
DOI: 10.1002/rcr.871
We present two Japanese cases of lung sequelae post coronavirus disease 2019 (COVID-19). The patients were histopathologically diagnosed with organizing pneumonia (OP) or OP with fibrosis and no diffuse alveolar damage on video-assisted thoracoscopic surgery. Case 1, who was diagnosed with OP, was successfully treated with corticosteroid and other immunosuppressive agents over a 6-month period. Although case 2, who was diagnosed with OP with fibrosis, had a partial and unsatisfactory response to immunosuppressive agents, the patient responded to antifibrotic treatment including nintedanib. |
ANOTHER syndrome - Familial presentations of progressive lung disease leading to double lung transplantation: A case report and literature review
Christina S Thornton, Lakshmi Puttagunta, Douglas Helmersen, Mitesh V Thakrar, Jayan Nagendran, Dale Lien, Rhea A Varughese
DOI: 10.1002/rcr.872
We report two brothers who presented with a constellation of features including alopecia, nail dystrophy, ophthalmic complications, thyroid disease, hypohidrosis, ephelides, enteropathy and recurrent respiratory tract infections, known as ANOTHER syndrome, a rare autosomal recessive variant of ectodermal dysplasia (ED). Both received lung transplantation, and we report their clinical course to highlight the sequelae of end-stage lung disease of hypohidrotic EDs. |
Good's syndrome with diffuse panbronchiolitis as the prominent manifestation: A case and literature review
Tian Luo, Lile Wang, Daiyan Fu, Ruicheng Hu, Chunchu Kong, Yunrong Chen, Xi Li
DOI: 10.1002/rcr.873
We report here a case of Good's syndrome (GS) with diffuse panbronchiolitis (DPB) as the prominent manifestation and carry out a literature review accordingly. Japanese scholars have reported extensively about GS combined with DPB or DPB-like pulmonary manifestation. However, such reports are rare in China; hence, the present report might help improve the understanding and diagnosis of such cases. |
Robust response of pulmonary pleomorphic carcinoma to pembrolizumab and sequential radiotherapy: A case report
Tae-Hun Kim, Sun Hyo Park, Ilseon Hwang, Jin Hee Lee, Jin Hee Kim, Hae Won Kim, Hyun Jung Kim
DOI: 10.1002/rcr.875
We report the case of an 81-year-old man with multiple comorbidities who was diagnosed with pulmonary pleomorphic carcinoma (PPC), a rare type of non-small cell lung cancer (NSCLC) with a more aggressive clinical course and a worse outcome than other types of NSCLC. Our patient showed a robust response to pembrolizumab followed by radiation therapy without adverse effects. In the absence of randomized clinical trials for PPCs, our case report demonstrates the potential application of pembrolizumab and radiation therapy for the treatment of PPCs. |
A curious case of asphyxiating thoracic dystrophy in an adult
Lachlan Stranks, Simone Barry, Aeneas Yeo
DOI: 10.1002/rcr.876
Asphyxiating thoracic dystrophy (ATD), also known as Jeune syndrome, is a rare recessively inherited disorder that is most commonly detected in infancy and is often fatal. In this report, we describe an adult patient with his first presentation of respiratory failure and a presumptive diagnosis of ATD. |
First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus
Cheuk Cheung Derek Leung, Yu Hong Chan, Man Ying Ho, Ming Chiu Chan, Chun Hoi Chen, Chin Tong Kwok, Yiu Cheong Yeung
DOI: 10.1002/rcr.877
We report the first case of late recurrence of pulmonary mucormycosis (PM) and highlight the importance of secondary antifungal prophylaxis for PM if permanent reversal of immunosuppression is not possible. |
| Clinical images |
Unusual lung adenocarcinoma spread along with pulmonary emphysema
Takuto Miyamura, Yoshiaki Kinoshita, Hisako Kushima, Hiroshi Ishii
DOI: 10.1002/rcr.874
The present case showed that lung adenocarcinoma can rarely present with imaging findings that mimic fibrotic lesions of interstitial pneumonia. Asymmetric lung involvement and symptoms of haemoptysis are clinical clues to the suspicion of lung neoplasm rather than fibrotic lung disease. |
