Respirology Case Reorts

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June 2021
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Case Series
Catamenial haemoptysis in females with cystic fibrosis: a case series with review of management strategies
Kubra M Bozkanat, Natalie E West, Sigrid Ladores, Kristina Montemayor, Maria Gabriela Tupayachi Ortiz, Mindy Christianson, Raksha Jain
DOI: 10.1002/rcr755

Catamenial haemoptysis, the expectoration of blood during menses, has not been extensively reported in the cystic fibrosis (CF) literature. We describe four cases (age range: 25–34 years) of catamenial haemoptysis across four CF centres in the United States. We identify common and nuanced management strategies, including medical and surgical options, with different levels of success in controlling and preventing further catamenial haemoptysis.

Case series analysis of eight underground tunnellers with chronic silicosis in Queensland
Kalesh Seevnarain, Nicholas Burke, Katrina Newbigin
DOI: 10.1002/rcr756

This article outlines the emergence of chronic silicosis in a population which has been previously thought as not being at risk for pneumoconiosis. It also outlines the concerns around fragmented reporting and compensation systems.

Intrapleural fibrinolysis in acute non‐traumatic retained haemothorax
Chuan T Foo, Jurgen Herre
DOI: 10.1002/rcr760

We describe our experience of using intrapleural fibrinolytic therapy in three patients with different bleeding risk and acute non‐traumatic retained haemothorax.

Case Reports
Dasatinib‐induced chylothorax in a patient with chronic myeloid leukaemia: a case report and literature review
Chao‐Chin Hsu, Jui‐Feng Hsu, Kuan‐Li Wu
DOI: 10.1002/rcr753

Chylothorax is a rare adverse event of dasatinib treatment, and it is often diminished after the cessation of the offending drug.

“Peanut saves the day”: an innovative solution to massive, cryptogenic haemoptysis—a case study
Sanjana Chetana Shanmukhappa, Srivatsa Lokeshwaran, Sunil Kumar K, Prakash Doraiswamy
DOI: 10.1002/rcr754

Massive (or life‐threatening) haemoptysis is a time‐sensitive emergency encountered by a physician. The lack of immediate access to an endobronchial Watanabe spigot gives rise to the need to innovate with day‐to‐day materials used in routine surgical practice and available in resource‐limited settings, which may serve the purpose of a spigot. In this report, we bring to light a case of life‐threatening cryptogenic haemoptysis that is managed by a novel technique of using peanut gauze as a spigot resulting in a successful endobronchial tamponade.

Recurrent spindle cell carcinoma of the lung successfully treated by chemoimmunotherapy
Tomohiro Akaba, Yuno Shiota, Fumi Onizawa, Tamami Isaka, Yoji Nagashima, Etsuko Tagaya
DOI: 10.1002/rcr757

Here, we report a case of spindle cell carcinoma (SpCC), which recurred after surgical resection and showed a good response to combination of carboplatin, paclitaxel, bevacizumab, and atezolizumab as a first‐line treatment.

Chronic haemothorax: an important cause of pleural effusion
David K Z Ching, Edward T H Fysh
DOI: 10.1002/rcr758

Chronic haemothorax is an uncommon cause of unilateral pleural effusion, and is a potential complication of long‐term anticoagulation therapy.

Long‐term response to osimertinib in elderly patients with lung adenocarcinoma harbouring de novo EGFR T790M: a case report and literature review
Toshiyuki Sumi, Koki Kamada, Naoki Shijubou, Yuichi Yamada, Hisashi Nakata, Yuji Mori, Hirofumi Chiba
DOI: 10.1002/rcr759

There are no safety data on the first‐line osimertinib treatment in patients aged 75 years or older, defined as the elderly in Japan, and very few reports exist on the efficacy of first‐line therapy for de novo epidermal growth factor receptor (EGFR) T790M‐positive lung cancer in elderly patients. We report a safe and long‐term response to the first‐line treatment with osimertinib in de novo EGFR T790M‐positive patients older than 75 years.

Ultrasonic humidifier lung as a mimic of COVID‐19
Shosei Ro, Ryosuke Imai, Atsushi Kitamura, Torahiko Jinta, Naoki Nishimura
DOI: 10.1002/rcr761

We report two cases of patients diagnosed with ultrasonic humidifier lung with characteristic computed tomography (CT) findings of centrilobular nodules and consolidations with upper lobe‐predominant distribution, who were initially suspected of coronavirus disease 2019 (COVID‐19) infection.

A case of lipoid pneumonia associated with occupational exposure to solvents in a dry‐cleaning worker
Sunji Park, Ji Eun Park, Jaehee Lee
DOI: 10.1002/rcr762

We report a rare case of lipoid pneumonia that occurred in a dry‐cleaning worker because of repeated exposure to a hydrocarbon‐based solvent spray.

Voriconazole treatment of pulmonary mycosis caused by Chrysosporium zonatum after treatment for pulmonary tuberculosis
Takuya Matsuzaki, Hajime Kasai, Hideki Ikeda, Yuki Tajiri, Kenichi Suzuki, Akira Watanabe, Katsuhiko Kamei, Takashi Urushibara
DOI: 10.1002/rcr763

We present a case of pulmonary mycosis caused by Chrysosporium zonatum after the completion of treatment for pulmonary tuberculosis.

Artificial stone‐associated silicosis with concurrent Cryptococcus infection
Hsiang‐Shi Shen, Yu‐Ting Lai, Han‐Chen Tsai, Shi‐Chuan Chang
DOI: 10.1002/rcr765

One young male suffered from respiratory failure with mechanical ventilator and venous to venous (VV)‐extracorporeal membrane oxygenation (ECMO) support. Artificial stone‐associated silicosis with concurrent Cryptococcus infection was diagnosed by bronchoalveolar lavage. Therapeutic segmental lung lavage was performed and the patient recovered well.

Use of saline to evaluate a cavity due to Mycobacterium kansasii infection during ultrathin bronchoscopy and endobronchial ultrasonography
Megumi Hamaguchi, Noriaki Kurimoto, Yukari Tsubata, Takae Okuno, Akari Tanino, Takamasa Hotta, Takeshi Isobe
DOI: 10.1002/rcr766

Well‐vascularized malignant tumours, tuberculosis, and chronic inflammation are the most common causes of massive bleeding during bronchoscopy. To reduce the risk of bleeding, direct examination of the blood vessels in a lesion might be helpful. We report our experience of direct observation of vessels in the wall of a cavitary lesion with ultrathin bronchoscopy and endobronchial ultrasonography (EBUS).

Development of second primary small-cell lung cancer within the irradiated field after chemoradiotherapy: a report of two cases
Yuki Seike, Yukio Kawagishi, Akihito Bando, Ko Kimoto, Masato Hongo, Shinichi Takeda
DOI: 10.1002/rcr767

We present two cases of small-cell lung cancer developed within the irradiated field relatively early after chemoradiotherapy.

Significant therapeutic effectiveness of durvalumab after chemoradiotherapy for a patient with post‐operative recurrent pulmonary pleomorphic carcinoma
So Shimamura, Masafumi Saiki, Shuichiro Ide, Kazuki Masuda, Yoshinori Uchida, Yusuke Sogami, Kazunari Kasai, Tomohiro Inoue, Hiroshi Ishihara
DOI: 10.1002/rcr781

Pulmonary pleomorphic carcinoma (PPC) is a poorly differentiated non‐small cell lung cancer. No standard therapy has been established for advanced disease. We herein report on a 62‐year‐old man with recurrent post‐operative PPC, for whom durvalumab after chemoradiotherapy was effective.

Honeycomb-like structures in sarcoidosis pathologically showing granulomas in walls of clustered bronchioles
Michiru Sawahata, Tamiko Takemura, Takeshi Kawanobe, Koichi Hagiwara, Chiyoko Kono, Tetsuo Yamaguchi
DOI: 10.1002/rcr782

We report a valuable case in which the pathology of video-assisted thoracoscopic surgery specimens collected from the lungs with honeycomb-like structures that were continuous with dilated bronchioles on chest computed tomography (CT) scans revealed granulomas in membranous bronchiole walls, demonstrating that the honeycomb-like structures were lung lesions of sarcoidosis.

Exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatment
Ryo Sekiguchi, Naohisa Urabe, Susumu Sakamoto, Masakazu Sasaki, Sakae Homma, Kazuma Kishi
DOI: 10.1002/rcr783

Exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatment.

Clinical Image
Radiological progression of COVID‐19 organizing pneumonia
Bushra Johari, Roqiah Fatmawati Abdul Kadir, Farihah Abd Ghani, Alan Basil Peter
DOI: 10.1002/rcr7564

It has recently been recognized that the clinical course of coronavirus disease 2019 (COVID‐19) and secondary organizing pneumonia (OP) tend to follow a subacute progression of respiratory illness. We present images of radiological progression of COVID‐19 pneumonia and secondary OP.

Index

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