Respirology Case Reorts

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May 2020
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Case Reports
A familial case of Birt–Hogg–Dubé syndrome complicated with various cancers
Yuki Goto, Kazunori Tobino, Miyuki Munechika, Yuki Yoshimatsu, Hiromi Ide, Kosuke Tsuruno
DOI: 10.1002/rcr2.549

Birt–Hogg–Dubé syndrome (BHDS) is a rare autosomal dominant inherited disorder characterized by fibrofolliculomas, renal tumours, lung cysts, and pneumothorax. This report described a familial case of BHDS complicated with various types of cancer (i.e. bladder, ureter, and lung).

IgG4-related disease in the differential diagnosis of lung nodules
Hiroki Ishikawa, Hironori Uruga, Takeshi Fujii, Atsuko Kurosaki, Nasa Morokawa, Hisashi Takaya
DOI: 10.1002/rcr2.550

We report a case of IgG4-related disease mimicking lung cancer with pleural dissemination.

Eosinophilic granulomatous polyangiitis with IgG4 hypergammaglobulinaemia and salivary gland swelling
Koichiro Takahashi, Hironori Sadamatsu, Hiroki Tashiro, Go Kato, Masaru Uchida, Naoko Sueoka-Aragane
DOI: 10.1002/rcr2.552

We present a case of a 51-year-old Japanese woman diagnosed with eosinophilic granulomatous polyangiitis (EGPA), a rare vasculitis that can occur in patients with eosinophilia and history of asthma, allergic rhinitis, and sinusitis, with immunoglobulin (Ig) G4 hypergammaglobulinaemia and salivary gland swelling.

Peripheral pulmonary hamartoma with haemoptysis from the non-adjacent bronchus
Naoya Kitamura, Toshihiro Ojima
DOI: 10.1002/rcr2.553

Here, we report a case involving a middle-aged man who developed a peripheral pulmonary hamartoma with haemoptysis from the non-adjacent bronchus and exhibited resolution of the haemoptysis after tumour enucleation.

Oesophagobronchial perforations after placement of an oesophageal self-expanding metallic stent
Ken-ichi Tomiyama, Norimasa Ito, Kenichi Hayashi, Yuki Kawamoto, Hiroaki Shinoda, Nobuyuki Katakami
DOI: 10.1002/rcr2.554

An oesophageal fully covered self-expanding metallic stent was inserted in a patient with advanced lung adenocarcinoma. After administration of pembrolizumab, he was hospitalized with septic shock caused by oesophagobronchial perforations. Owing to a drainage surgery and insertion of additional stents, he was recovered and pembrolizumab administration was re-initiated with complete resolution.

Relapse of cervical tuberculous lymphadenitis immediately after completion of effective anti-tuberculosis treatments
Yuya Kimura, Masahiro Shimada, Masahiro Kawashima, Akira Yamane, Hideaki Nagai, Hirotoshi Matsui
DOI: 10.1002/rcr2.555

Most cases of lymph node enlargement after completing tuberculosis (TB) treatment are due to paradoxical reaction (PR), not relapse, and therefore, do not require re-treatment. We herein report a case of a 28-year-old man who had developed cervical TB lymphadenitis and exhibited re-enlargement of the same lymph nodes one month after completing effective TB chemotherapy, which was microbiologically proven as relapse.

Steroid resistance in organizing pneumonia caused by pulmonary cryptococcosis
Motoko Nomura, Hiromitsu Ohta, Masahiro Hiruta, Fumiaki Kudo, Fumiyoshi Ohyanagi, Yasuhiro Yamaguchi
DOI: 10.1002/rcr2.556

Immunocompromised patients with pulmonary cryptococcosis show various computed tomography (CT) findings, and consolidation is frequently observed. Superimposed pulmonary cryptococcosis infection should be considered in cases of steroid-refractory cryptogenic organizing pneumonia (COP).

Clinical Image
Tegafur/gimeracil/oteracil-induced eosinophilic pneumonia
Toshiyuki Sumi, Hisashi Nakata, Yuji Mori, Hiroki Takahashi
DOI: 10.1002/rcr2.551

We report a case of a 66-year-old man with drug-induced eosinophilic pneumonia secondary to tegafur/gimeracil/oteracil (TS-1) treatment for adenocarcinoma of the gastro-oesophageal junction.

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