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| EDITORIALS |
| 776 | Anti-inflammatory reliever therapy in asthma: The evidence mounts but more is needed
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| 779 | Shedding light on the 'black hole' of small airways physiology in asthma
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| 781 | From Osler to personalized medicine in obstructive airways disease
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| 784 | Tumour mutation burden of non-small cell lung cancer with pre-existing ILD
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| 787 | High attenuation areas in pulmonary computed tomography: Their meaning and use in interstitial lung disease
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| 790 | The 'great wait' for diagnosis in pulmonary arterial hypertension
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| 793 | Periodic leg movements: A marker of cardiovascular risk?
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| COMMENTARIES |
| 795 | Inhaled corticosteroids/formoterol as a reliever in mild asthma
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| 797 | Targeting the interleukin-17 pathway to prevent acute respiratory distress syndrome associated with SARS-CoV -2 infection
Tomas Raul Wiche Salinas MD, PhD(c); Boyang Zheng MD; Jean-Pierre Routy MD; Petronela Ancuta PhD
10.1111/resp.13875 |
| 800 | The challenge of COVID-19 has accelerated the use of new data-sharing technologies
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| 802 | Is it time to redefine obstructive sleep apnoea?
Sateesh Sakhamuri DM, FCCP, ATSF; Surujpal Teelucksingh FRCP (EDIN); Ahmed S BaHammam MD, FRCP
10.1111/resp.13880 |
| INVITED REVIEWS |
| 804 | What have we learnt about asthma control from trials of budesonide/formoterol as maintenance and reliever?
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| 816 | Pulmonary alveolar proteinosis
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| ORIGINAL ARTICLES |
| Asthma and Allergy |
| 827 |
Ventilation heterogeneity and oscillometry predict asthma control improvement following step-up inhaled therapy in uncontrolled asthma
Francesca S M Tang; Sandra Rutting; Catherine E Farrow; Katrina O Tonga; Joanna Watts; Jessica R Dame-Carrol; Amy Bertolin; Gregory G King; Cindy Thamrin; David G Chapman
10.1111/resp.13772
In the present study, we found that baseline measures of small airway function by forced oscillation technique (FOT) and multiple-breath nitrogen washout (MBNW) predicted improved asthma control upon inhaled corticosteroid (ICS) up-titration, suggesting that FOT and MBNW may provide important markers for assessing ICS responsiveness. |
| COPD |
| 836 |
Identification and definition of asthma–COPD overlap: The CanCOLD study
Miriam Barrecheguren; Lancelot Pinto; Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi; Wan C Tan; Pei Z Li; Shawn D Aaron; Andrea Benedetti; Kenneth R Chapman; Brandie Walker; J Mark Fitzgerald; Paul Hernandez; François Maltais; Darcy D Marciniuk; Denis E O'Donnell; Don D Sin; Jean Bourbeau for the CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network
10.1111/resp.13780
Lack of consensus on the diagnosis of ACO limits our understanding of impact and outcomes. We identified individuals with ACO in the CanCOLD population by using seven clinical definitions. Asthma and atopy were the features that best identified ACO, and these patients had worse outcomes. |
| Interstitial Lung Disease |
| 850 | Characterization of tumour mutation burden in patients with non-small cell lung cancer and interstitial lung disease
Haruki Kobayashi; Masakuni Serizawa; Tateaki Naito; Hayato Konno; Hideaki Kojima; Tetsuya Mizuno; Mitsuhiro Isaka; Masahiro Endo; Takeshi Nagashima; Masatoshi Kusuhara; Kenichi Urakami; Keiichi Ohshima; Ken Yamaguchi; Yasuhisa Ohde; Toshiaki Takahashi;
10.1111/resp.13726
Patients with NSCLC and ILD did not have high TMB and could develop severe pneumonitis if immune checkpoint inhibitors are used. Therefore, immune checkpoint inhibitors should not be used based on expectations of high TMB in patients with NSCLC and ILD. |
| 855 | Reference values for high attenuation areas on chest CT in a healthy, never-smoker, multi-ethnic sample: The MESA study
Imaani Easthausen; Anna Podolanczuk; Eric Hoffman; Steven Kawut; Elizabeth Oelsner; John S Kim; Ganesh Raghu; Karen Hinckley Stukovsky; Susan Redline; Robyn L McClelland; R Graham Barr; David J Lederer
10.1111/resp.13783
To better understand the natural variation of HAA (a novel quantitative CT-based measure of subclinical ILD), we developed HAA reference equations and z-scores to define expected values of HAA with adjustment for key demographic and anthropometric variables, and we demonstrated that HAA z-scores correlate with several ILD features. |
| Pulmonary Vascular Disease |
| 863 | Diagnostic delay in pulmonary arterial hypertension: Insights from the Australian and New Zealand pulmonary hypertension registry
Victor Khou; James J Anderson; Geoff Strange; Carolyn Corrigan; Nicholas Collins; David S Celermajer; Nathan Dwyer; John Feenstra; Mark Horrigan; Dominic Keating; Eugene Kotlyar; Melanie Lavender; Tanya J McWilliams; Peter Steele; Robert Weintraub; Helen Whitford; Ken Whyte ;Trevor J Williams; Jeremy P Wrobel; Anne Keogh; Edmund M Lau
10.1111/resp.13768
We examined diagnostic delay in a large binational cohort of PAH patients. Mean and median diagnostic intervals were 2.5+/–4.1 and 1.2 (IQR: 0.6–2.7) years, respectively. Age, cardiovascular and respiratory comorbidities were associated with longer diagnostic interval. Mortality was increased in patients with greater diagnostic interval. |
| Sleep and Ventilation |
| 872 | Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database
Carolina Lombardi; Gianfranco Parati; Davide Soranna; Antonella Zambon; Paweł Sliwinski; Gabriel Roisman; Jean-Louis Pepin; Sophia Schiza; Renata Riha; Pavol Joppa; Ingo Fietze; Jan Hedner; Ludger Grote; the European Sleep Apnoea Database (ESADA) Collaborators
10.1111/resp.13760
The link between PLMS and cardiovascular alterations is still debated. Our current study aimed to address the effects of PLMS on BP in a large unselected OSA patient cohort, showing that the PLMS phenotype is associated with significantly elevated clinical SBP independent of confounders. |
| POSITION STATEMENT |
| 880 | Respiratory management of infants with chronic neonatal lung disease beyond the NICU: A position statement from the Thoracic Society of Australia and New Zealand
Nitin Kapur; Gillian Nixon; Philip Robinson; John Massie; Bernadette Prentice; Andrew Wilson; Sandra Schilling; Jacob Twiss; Dominic A Fitzgerald
10.1111/resp.13876 |
| SCIENTIFIC LETTER |
| 889 | Foetal growth restriction and asthma: Airway smooth muscle thickness rather than just lung size?
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| CORRESPONDENCES |
| 892 | Efficacy and tolerance of immune checkpoint inhibitors for non-small cell lung cancer patients with interstitial lung disease
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| 892 | Efficacy and tolerance of immune checkpoint inhibitors for non-small cell lung cancer patients with interstitial lung disease – Reply
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| 894 | Face masks for community use: An awareness call to the differences in materials
Bernardo Sousa-Pinto MD, PhD; Ana Paula Fonte Eng; Antónia Andrade Lopes Eng; Bruno Oliveira MSc; João Almeida Fonseca MD, PhD; Altamiro Costa-Pereira MD, PhD; Osvaldo Correia MD, PhD
10.1111/resp.13891 |
| 895 | Universal public mask wear during COVID-19 pandemic: Rationale, design and acceptability
Christopher Liu OBE, FRCOphth, FRCSEd, FRCP, CertLRS Rawya Diab MBBS, MD, MRCSEd, FICO; Hasan Naveed MBBS, BSc (Hons); Victor Leung MSc, CIH, ROH, CRSP
10.1111/resp.13892 |
| 897 | Universal face masking in community: Material, design, and considerations—reply
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| 898 | National policies for paediatric universal BCG vaccination were associated with decreased mortality due to COVID-19
Risa Ebina-Shibuya MD, PhD; Nobuyuki Horita MD, PhD; Ho Namkoong MD, PhD; Takeshi Kaneko MD, PhD
10.1111/resp.13885 |
| 899 | Reply
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| LETTERS FROM ASIA-PACIFIC AND BEYOND |
| 900 | A letter from the United States: A New York experience with COVID-19
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| 903 | Letter from Denmark
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