| EDITORIALS |
| 230 | COPD exacerbation phenotypes: The next frontier
|
| 232 | Reducing the burden of respiratory symptoms and illness in the elderly and general population requires multi-pronged strategies
|
| 234 | In search for a predictive marker of acute exacerbations of idiopathic pulmonary fibrosis
|
| 236 | Further evidence of the generalizability of the Global Lung Function Initiative reference equations for spirometry
|
| 238 | Expanding knowledge on non-expandable lungs
|
| 240 | Periodic breathing: Fine tuning the phenotype
|
| 242 | Obstructive sleep apnoea and susceptibility to cardiovascular disease: A blessing or curse of old age?
|
| COMMENTARIES |
| 244 | Challenges in understanding lung microbiome: It is NOT like the gut microbiome
|
| 246 | The history and future of short-acting beta2-agonist therapy in asthma
|
| INVITED REVIEW SERIES |
| New frontiers in sleep-disordered breathing |
| 249 | The future of sleep-disordered breathing: Looking beyond the horizon
Matthew T Naughton MBBS, MD, FRACP; Peter A Cistulli MBBS, PhD, MBA; Philip de Chazal BE, MBiomedE, PhD
10.1111/resp.13715 |
| 251 | Advanced polysomnographic analysis for OSA: A pathway to personalized management?
|
| ORIGINAL ARTICLES |
| COPD |
| 259 | Blood eosinophil count as a predictor of hospital length of stay in COPD exacerbations
Fanny W S Ko, Ka Pang Chan, Jenny Ngai, So-Shan Ng, Wing Ho Yip, April Ip, Tat-On Chan, David S C Hui
10.1111/resp.13660
For patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (AECOPD), an eosinophil count at a cut-off value of <2% of the total leucocyte count or an absolute count of <0.144 × 109/L was associated with a longer length of stay (LOS) independent of other factors including age, gender, past history of exacerbations and lung function. |
| 267 | Predicting life expectancy of older people using respiratory symptoms and smoking status: Data from the Australian Longitudinal Study of Ageing
Kate Petrie, Michael J Abramson, Amanda J Cross, Johnson George
10.1111/resp.13603
Respiratory symptoms (cough, shortness of breath and wheeze) predict mortality in older people and their effects are modified by smoking status. This study is the first to present mortality risk related to respiratory symptoms as an impact on life expectancy, an easier way to communicate mortality risk. |
| Interstitial Lung Disease |
| 275 | Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis
Kakuhiro Yamaguchi, Hiroshi Iwamoto, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
10.1111/resp.13634
This study showed that elevated levels of serum high-mobility group box 1, a mediator of acute lung injury through the acceleration of pro-inflammatory signalling, predicts earlier onset of acute exacerbation (AE) in patients with stable idiopathic pulmonary fibrosis and shorter survival in patients with AE. |
| Lung Function |
| 281 |
Global Lung Function Initiative-2012 'other/mixed' spirometry reference equation provides the best overall fit for Australian Aboriginal and/or Torres Strait Islander children and young adults
Tamara L Blake, Anne B Chang, Mark D Chatfield, Julie M Marchant, Margaret S McElrea
10.1111/resp.13649
We examined the appropriateness of the Global Lung Function Initiative (GLI)-2012 spirometry reference equations for Indigenous Australian children and young adults (3–25 years). Of the available GLI-2012 reference equations, other/mixed provided the best fit for Indigenous Australians (3–25 years). |
| 289 | Early menarche is associated with lower adult lung function: A longitudinal cohort study from the first to sixth decade of life
Brittany Campbell, Julie A Simpson, Dinh S Bui, Caroline J Lodge, Adrian J Lowe, Melanie C Matheson, Gayan Bowatte, John A Burgess, Garun S Hamilton, Benedicte Leynaert, Francisco Gómez Real, Paul S Thomas, Graham G Giles, Peter A Frith, David P Johns, Gita Mishra, Judith Garcia-Aymerich, Debbie Jarvis, Michael J Abramson, E Haydn Walters, Jennifer L Perret, Shyamali C Dharmage
10.1111/resp.13643
This is the first longitudinal study with data on key early life confounders to link early age at menarche to lung function deficits in middle age and provide novel evidence on potential biological pathways contributing to this link. |
| Pleural Disease |
| 298 | Inter-observer variation in image interpretation and the prognostic importance of non-expansile lung in malignant pleural effusion
Geoffrey A Martin, Andrew C Kidd, Selina Tsim, Paul Halford, Anna Bibby, Nick A Maskell, Kevin G Blyth
10.1111/resp.13681
Non-expansile Lung (NEL) often complicates malignant pleural effusion management. This multicentre study identifies significant limitations in radiographic NEL detection and an association between NEL and adverse survival. These findings are relevant to clinical practice and should be considered in future trial design. |
| Sleep and Ventilation |
| 305 |
Association of serious adverse events with Cheyne–Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE-Heart Failure substudy analysis
Faizan Javed, Renaud Tamisier, Jean-Louis Pepin, Martin R Cowie, Karl Wegscheider, Christiane Angermann, Marie-Pia d'Ortho, Erland Erdmann, Anita K Simonds, Virend K Somers, Helmut Teschler, Patrick Levy, Jeff Armitstead, Holger Woehrle
10.1111/resp.13613
Analysis of the Treatment of Sleep-Disordered Breathing with Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients with Heart Failure (SERVE-HF) substudy found that patients with systolic heart failure who experienced serious adverse events during the trial had longer Cheyne–Stokes respiration (CSR)-related characteristics at baseline. These findings suggest that CSR-related events could be used to define central sleep apnoea phenotypes for future risk stratification. |
| 312 | Effect of age on the cardiovascular remodelling induced by chronic intermittent hypoxia as a murine model of sleep apnoea
Anabel L Castro-Grattoni, Monique Suarez-Giron, Ivan Benitez, Marta Torres, Isaac Almendros, Ramon Farre, Josep M Montserrat, Mireia Dalmases, David Gozal, Manuel Sánchez-de-la-Torre, on behalf of the Spanish Sleep Network
10.1111/resp.13610
Chronic intermittent hypoxia (CIH) is a major determinant of cardiovascular morbidity associated with obstructive sleep apnoea (OSA), but its adverse impact may be influenced by ageing. We show that deleterious cardiovascular effects associated with CIH are not evident in aged mice, and early cardiovascular ageing may be potentiated by CIH in young mice. |
| POSITION STATEMENT |
| 321 | Diagnosis and treatment of lung disease associated with alpha one-antitrypsin deficiency: A position statement from the Thoracic Society of Australia and New Zealand*
Jack Dummer, Claudia C Dobler, Mark Holmes, Daniel Chambers, Ian A Yang, Lianne Parkin, Sheree Smith, Peter Wark, Anouk Dev, Sandra Hodge, Eli Dabscheck, Julian Gooi, Sameh Samuel, Steven Knowles, Anne E Holland
10.1111/resp.13774 |
| FORUM AND DEBATE |
| Scientific Letter |
| 336 | Valproic acid and sleep apnoea: A disproportionality signal from the WHO pharmacovigilance database
Bruno Revol, Ingrid Jullian-Desayes, Kelly Guichard, Jean-Arthur Micoulaud-Franchi, Renaud Tamisier, Pierre Philip, Marie Joyeux-Faure, Jean-Louis Pépin
10.1111/resp.13771 |
| LETTER FROM ASIA-PACIFIC AND BEYOND |
| 339 | Letter from Sri Lanka
Duminda Yasaratne MBBS, MD, MRCP; Shyamali C Dharmage MBBS, MSc, MD, PhD
10.1111/resp.13758 |
