No. 135 (October 2020)
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APSR News

Chairs becoming vacant soon

The APSR is committed to making sure all members are aware of opportunities — especially rewarding opportunities such as coordinating a committee by being its chairperson.

Some vacancies are coming soon and as an APSR member you are strongly encouraged to apply. However, you have only until 10 October to nominate yourself (or any other member) for the role.

Some current chairpersons will complete their two-year term at the end of November, and you have a chance to fill one of these prestigious roles from 1 December. The committees you can apply to coordinate are:

  • APSR Education Committee
  • APSR Membership Committee
  • APSR Research Committee

Chairing any of these committees gives brilliant opportunities for you to initiate projects and progress existing activities that contribute improvements to respiratory health.

The role also gives you a seat on the APSR Executive Committee, which enables you to influence the direction of the Society as a whole, and widens your exposure and connections with some of the most eminent respiratory physicians in the region and beyond.

Your first step is to apply!

And hurry! Only a very short time before the application deadline, 10 October.

APSR President-Elect
Selection confirmed

The APSR Executive Committee is delighted to announce that Dr David CL Lam PhD, MD, FAPSR and recipient of numerous achievement awards and medals, has been selected for the position of APSR President-Elect with effect from 1 December 2020.

A reminder...

As advertised in earlier issues of the Bulletin, any APSR member can nominate themselves, or another member to become the APSR President-Elect, or indeed any other position, with subsequent election by voting when needed according to APSR Policy and Procedures. Leadership roles in the APSR are generally for a fixed term, and several positions will become vacant in the near future when the current holders complete their terms of office.

These opportunities for members will be advertised in this Bulletin and on the APSR website, and as an APSR member you are strongly encouraged to apply.

The APSR is committed to the highest levels of corporate governance in order to provide open, transparent and fair service to all valued APSR members, even those whose career or experience to date might not yet be as illustrious as Dr Lam's. Only then can the APSR achieve its mission to develop and sustain the highest quality of respiratory care in our region, now and in the future.


Dr Lam

Dr Lam's involvement with the APSR stretches back to 2005, most of that time on the Education Committee which he chaired from 2011 to 2018, and the Lung Cancer Assembly where he is currently Deputy Head. He also serves on the Respirology Editorial Board as Deputy Editor while continuing his main role in the APSR as Secretary General.

In addition to his current leadership of the Hong Kong Thoracic Society (2019-2021) and earlier executive officerships on other medical associations, invited speaking engagements, and teaching appointments at the University of Hong Kong, Dr Lam continues to work as an honorary consultant at major hospitals.

His term of office as APSR President-Elect runs from 1 December 2020 until 21 November 2021, (the last day of the Kyoto Congress.)

On that day the current APSR President, Dr Yoichi Nakanishi, will hand over the presidency to Dr Lam who will then be APSR President for the next two years.

The office of the APSR President is a formidable responsibility, overseeing activities of one of the largest respiratory societies in the world, covering a geographic area which is home to half the world's population.

Therefore, please join us in congratulating Dr Lam and give him whatever is needed to support his role.

Assembly Virtual Meetings


  • Prof. Papi
    Respiratory Structure and Function Assembly Symposium
    21 November 2020, 16:00-17:30 (Japan time, UTC+9)

    Symposium Title: Exploring The Small Airway Disease

    Main speaker: Prof. Alberto Papi
    St. Anna University Hospital, Ferrara, Italy

    Sponsor: Orient EuroPharma


  • Prof. Wang
    Asthma Assembly Symposium
    28 November 2020, 16:00-17:30 (Japan time, UTC+9)

    Symposium Title: Asthma Paradoxes

    Main speaker: Prof. Hao-Chien Wang
    National Taiwan University Hospital, Taiwan
    Deputy Head of the APSR COPD Assembly

    Sponsor: AstraZeneca


  • Dr Assad
    Respiratory Infections (Non-Tuberculous) Assembly Symposium
    (Date to be confirmed)

    Symposium Title: (To be confirmed)

    Main speaker: (To be confirmed)

    Addendum 29 November 2020:

    This AVM was held on 21 November 2020 with the title Achieving Better Diagnoses and Outcomes for Patients with Respiratory Infections, With or Without a Pandemic. The main speaker was Dr Tufik Assad

    Sponsor: BioMérieux and BioFire

For each Symposium, authors of the best three abstracts will be invited to present at the Assembly Virtual Meeting. Their abstracts will also be published in a special Assembly Virtual Meeting Respirology Supplement.

For the latest news, see apsr.info


Dr Asano


Dr Nguyen


Dr Tu

News from the Bronchoscopy and Interventional Techniques Assembly

COVID-19 and Respirology

The Bronchoscopy and Interventional Techniques Assembly understands that our members have been heavily involved with COVID-19 management and guidelines in 2020. We do hope that everyone has remained safe and we look forward to the day when we can meet face to face again at a future congress – hopefully in Kyoto 2021!

Many of our members will already be aware that Respirology has recently published a special edition: Interventional Pulmonology Pearls, which contains a series of reviews from experts around the world and the Asia-Pacific region. We encourage our members to take advantage of this excellent review series which provides an update on many bronchoscopic and interventional techniques relevant to many centres' practice.

For now may we stay in touch "virtually" and continue to improve the field of interventional pulmonology research and innovation.​

Dr Phan Nguyen
Head-Elect of the APSR Bronchoscopy and Interventional Techniques Assembly


Dr Tanabe


Dr Hanaoka


Dr Sooronbaev

News from the Pulmonary Circulation Assembly

Need for imaging and functional analysis of pulmonary hypertension due to respiratory disease

Peacock et al. recently published a paper involving idiopathic pulmonary arterial hypertension (IPAH) and co-existing lung disease, as defined by the FEV1, FVC, TLC, %pred ≥60%, and lung findings on CT (Pulmonary Circulation 2020; 10(1) 1–8).

The patients were older, predominantly male, more likely to be current or ex-smokers, and had a lower DLCO. They showed improved 6-minute walk distance after PAH-targeted therapy, but poor survival compared to patients with IPAH and no lung disease; however, the severity of lung disease on CT was not mentioned. When we focus on PH due to respiratory disease (Group 3 PH), even patients with severe lung disease on CT may have mild ventilatory impairment.

Combined pulmonary fibrosis and emphysema is well-known to be associated with mild ventilatory impairment and low DLCO, concomitant PH, and poor survival. Such patients are more likely to be included in Group 1 (IPAH and co-existing lung disease), but they should be included in Group 3 PH.

We should focus on imaging analysis for Group 3 PH and quantifying the severity of lung disease on CT is needed. Combined imaging and respiratory functional analysis by respirologists or radiologists could facilitate the accurate differentiation of Group 3 PH from patients with PAH and co-existing lung disease.

Please join our assembly for further research.

As you might know, the APSR is developing a library of respiratory cases to be used for education and training of APSR members; please see the example below. The APSR Assembly kindly invites its members to submit cases for this library online. Please see apsresp.org/education/teaching-library/index.php.

Thank you for your kind consideration and we are looking forward to seeing you at the next meeting in Kyoto.

Dr Nobuhiro Tanabe, Assembly Head
Dr Masayuki Hanaoka, Assembly Head-Elect
Dr Talant Sooronbaev, Assembly Deputy Head


Dr Oku


Dr Chen


Dr Ogawa

Respiratory Neurobiology and Sleep Assembly

Special invitation

The Respiratory Neurobiology and Sleep Assembly is planning to issue a position statement regarding either the standard diagnostic process or the treatment strategy for the sleep apnoea syndrome.

We strongly feel that we should take into account regional and local circumstances in establishing these issues, and call for ideas, suggestions and questions from the assembly members.

We are also looking for corresponding author(s). The roles of the corresponding author(s) are to write, edit and revise the position statement as a member of a post hoc committee with the Respiratory Neurobiology and Sleep Assembly leaders, taking primary responsibility for communication with the APSR official journal Respirology.

Dr Yoshitaka Oku, Assembly Head
Dr Ning-Hung Chen, Assembly Head-Elect
Dr Hiromasa Ogawa, Assembly Deputy Head

To accept the invitation to be involved or for further information, please contact APSRinfo@theapsr.org

Keystone Symposia

Apply now for financial aid to attend upcoming eSymposia meetings

Keystone Symposia is offering a limited number of free registrations to researchers from low- and middle- income countries (LMICs) to participate in our new eSymposia series. This new digital format enables the inclusion of more diverse voices and global perspectives in conversations at the forefront of science and medicine, which are essential to shape research that serves the broad needs of all of humanity.

Award recipients will be provided with unique career-advancement opportunities, including:

  • Global platform to share their work with audiences around the world
  • Access to cutting-edge biomedical advances to inspire new research directions
  • Critical networking opportunities with field leaders and rising stars to advance their research and careers
  • And much more!

Applications are currently being accepted for all eSymposia through January 2021, and are open to LMIC scientists and clinicians of all career stages including students, post-docs, fellows, professors, doctors, etc.) working in relevant fields of interest. Please help spread the word to your colleagues!

Keystone Symposia events list keystonesymposia.org/KS/Online/Events/All_Events.aspx

Keystone Symposia financial aid details keystonesymposia.org/KS/Online/Financial_Aid/Financial-Aid-Landing.aspx

New Respirology articles on the coronavirus

  • Letter from Iran: Experiences with COVID-19
    Ebrahim Abbasi-Oshaghi PhD Fatemeh Mirzaei PhD Iraj Khodadadi PhD; DOI: 10.1111/resp.13948
    First published 15 September 2020
  • Respiratory management of adult patients with acute respiratory distress syndrome due to COVID-19
    Priyanka Makkar MD Stephen M Pastores MD, MACP, FCCP, FCCM; DOI: 10.1111/resp.13941
    First published 14 September 2020
  • Ethical challenges posed by COVID-19
    Paul A Komesaroff MB, BS, BSc(Hons), PhD, FRACP; DOI: 10.1111/resp.13930
    First published 29 August 2020
  • Bronchoscopy in COVID-19 intensive care unit patients
    Marie Bruyneel, Maria Gabrovska, Peter Rummens, Alain Roman, Marc Claus, Etienne Stevens, Philippe Dechamps, Lucas Demey, Laurent Truffaut, Vincent Ninane
    DOI: 10.1111/resp.13932
    First published 25 August 2020
  • Letter from New Zealand
    Robert J Hancox MD
    DOI: 10.1111/resp.13931
    First published 22 August 2020

Recent Respirology Case Reports on the coronavirus

  • Co-diagnoses of acute myeloid leukaemia and COVID-19: presentation and management implications
    Amy O'Brien, James Campling, Hugh Goodman, Catherina L Chang; DOI: 10.1002/rcr2.650
    First published 25 August 2020

More...

See a collection of COVID-19 material on the dedicated COVID-19 page on the APSR website.

Inside Respirology

Respirology Vol. 25 Issue 10

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EDITORIALS
1016Is the e-cigarette harmless among asthmatic patients?
Martin Chaumont MD, PhD; Sofia Morra MD, PhD
10.1111/resp.13868
1019Patients with idiopathic pulmonary fibrosis: Overcoming 'geographic isolation'
Nicola Cassidy MMedSc; Pippa Powell PhD; Athol U Wells MD
10.1111/resp.13883
1021Natriuretic peptides in pleural effusions: Beyond a diagnosis of heart failure
José M. Porcel MD, FACP, FCCP, FERS, FAPSR
10.1111/resp.13847
1023Three challenges of partial anomalous pulmonary venous drainage associated with pulmonary hypertension
Robert V MacKenzie Ross MB BChir
10.1111/resp.13878
1025Automated ventilator technology: Some answers and more questions
Simon A Joosten MBBS, BMedSc, PhD; Shane A Landry PhD; Garun S Hamilton MBBS, PhD
10.1111/resp.13802
COMMENTARIES
1027Outnumbered yet needed: The Lung Cancer Nurse Specialist
Sara McLaughlin-Barrett BNursing, PostGrad Cert Caring for Lung Cancer Patients
10.1111/resp.13844
1029Artificial intelligence as an emerging diagnostic approach in paediatric pulmonology
Giuliana Ferrante MD, PhD; Amelia Licari MD; Gian Luigi Marseglia MD; Stefania La Grutta MD, PhD
10.1111/resp.13842
1031The generalizability of randomized controlled trials investigating non-invasive ventilation in patients with COPD
Kathryn Le Grice MBBS, BSc; Neeraj M Shah MBBS, BSc; Catey Bunce BSc (Hons), MSc, DSc; Eui-Sik Suh MBBS, MSc, PhD
10.1111/resp.13849
1033Medical ethics in the era of COVID-19: Now and the future
Christopher Chew MBBS (Hons), BMedSc (Hons), MBioethics; Danielle Ko LLB (Hons), BA, MBBS (Hons), FRACGP, FAChPM
10.1111/resp.13927
1035Ethical challenges posed by COVID-19
Paul A. Komesaroff MB, BS, BSc(Hons), PhD, FRACP
10.1111/resp.13930
ORIGINAL ARTICLES
Asthma and Allergy
1037
Acute effects of e-cigarette vaping on pulmonary function and airway inflammation in healthy individuals and in patients with asthma
Serafeim-Chrysovalantis Kotoulas, Athanasia Pataka, Kalliopi Domvri, Dionisios Spyratos, Paraskevi Katsaounou, Konstantinos Porpodis, Evangelia Fouka, Aikaterini Markopoulou, Katalin Passa-Fekete, Ioanna Grigoriou, Theodoros Kontakiotis, Paraskevi Argyropoulou, Despoina Papakosta
10.1111/resp.13806

The e-cigarette is rapidly gaining ground on tobacco cigarettes and is a hot topic worldwide, but its safety has not been scientifically proved. This is the first study that investigates the acute effects of e-cigarettes on both lung function and airway inflammation in asthmatic patients.

Interstitial Lung Disease
1046Pleuroparenchymal fibroelastosis in patients with idiopathic pulmonary fibrosis
Song-I Lee, Eun Jin Chae, Joon Seon Song, Jae Ha Lee, Jin Woo Song
10.1111/resp.13796

Radiological PPFE was identified in 6.3% of patients with IPF. Radiological PPFE was associated with low BMI and lung function at baseline, more frequent pneumothorax and pneumomediastinum, higher decline rates in lung function and poorer prognosis during follow-up in patients with IPF.

1053
Peer Connect Service for people with pulmonary fibrosis in Australia: Participants' experiences and process evaluation
Gabriella Tikellis, Joanna Y T Lee, Tamera J Corte, Jamie Maloney, Michael Bartlett, Tonia Crawford, Ian N Glaspole, Nicole Goh, Kelcie Herrmann, Alison J Hey-Cunningham, Greg Keir, Yet H Khor, John Price, Debra G Sandford, Lissa Spencer, Alan Teoh, Jennifer Walsh, Susanne Webster, Anne E Holland
10.1111/resp.13807

The Peer Connect Service initiated by Lung Foundation Australia provides a model of support for people with a rare disease such as pulmonary fibrosis (PF) who are widely dispersed geographically. The service provides a unique opportunity for people with PF to connect and share experiences and offer mutual support.

Lung Cancer
1060Malignant mesothelioma cells secrete natriuretic peptides: Data and diagnostic clinical implications
Vasiliki Tsolaki, Sotirios Zarogiannis, Paris Zygoulis, Ioannis Kalomenidis, Rajesh Jagirdar, Demosthenes Makris, Zoe Daniil, Sofia Magkouta, Ioannis Triantafyllou, John Papanikolaou, Konstantinos I Gourgoulianis, Epaminondas Zakynthinos
10.1111/resp.13788

BNP measured in the supernatant of malignant mesothelioma cell lines was significantly higher compared to the benign cells, denoting that BNP is secreted from these cells. Furthermore, the pleural fluid to blood BNP ratio was higher in patients with malignant mesothelioma compared to patients without malignant mesothelioma.

Pulmonary Vascular Disease
1066Partial anomalous pulmonary venous drainage in patients presenting with suspected pulmonary hypertension: A series of 90 patients from the ASPIRE registry
Robert A Lewis, Catherine G Billings, Aidan Bolger, Sarah Bowater, Athanasios Charalampopoulos, Paul Clift, Charlie A Elliot, Kate English, Neil Hamilton, Catherine Hill, Judith Hurdman, Petra J Jenkins, Christopher Johns, Simon MacDonald, James Oliver, Vasilios Papaioannou, Smitha Rajaram, Ian Sabroe, Andy J Swift, A A Roger Thompson, David G Kiely, Robin Condliffe
10.1111/resp.13815

PAPVD was frequently missed in patients presenting with suspected PH. L-R shunt was higher in patients with associated ASD. Although patients may have other potential causes of PH, some patients with PAH have isolated PAPVD without other causative conditions.

Sleep and Ventilation
1073AVAPS-AE versus ST mode: A randomized controlled trial in patients with obesity hypoventilation syndrome
Maxime Patout, Frédéric Gagnadoux, Claudio Rabec, Wojciech Trzepizur, Marjolaine Georges, Christophe Perrin, Renaud Tamisier, Jean-Louis Pépin, Claudia Llontop, Valerie Attali, Frederic Goutorbe, Sandrine Pontier-Marchandise, Pierre Cervantes, Vanessa Bironneau, Adriana Portmann, Jacqueline Delrieu, Antoine Cuvelier, Jean-François Muir
10.1111/resp.13784

Automated expiratory positive airway pressure (EPAP) and volume-targeted non-invasive ventilation achieve similar control of sleep-disordered breathing as pressure support ventilation in patients with obesity hypoventilation syndrome. Objective sleep quality at 2 months of ventilation therapy is not altered by the use of automated EPAP and volume-targeted ventilation compared to pressure support ventilation.

POSITION STATEMENT
1082Electronic cigarettes: A position statement from the Thoracic Society of Australia and New Zealand*
Christine F McDonald, Stuart Jones, Lutz Beckert, Billie Bonevski, Tanya Buchanan, Jack Bozier, Kristin V Carson-Chahhoud, David G Chapman, Claudia C Dobler, Juliet M Foster, Paul Hamor, Sandra Hodge, Peter W Holmes, Alexander N Larcombe, Henry M Marshall, Gabrielle B McCallum, Alistair Miller, Philip Pattemore, Robert Roseby, Hayley V See, Emily Stone, Bruce R Thompson, Miranda P Ween, Matthew J Peters
10.1111/resp.13904
FORUM AND DEBATE
Scientific Letter
1090Tocilizumab therapy in individuals with COVID-19 infection and hyperinflammatory state
Cormac McCarthy, Stefano Savinelli, Eoin R Feeney, Marcus W Butler, Cathal O'Broin, Silke Ryan, Lorraine O'Neill, David J Murphy, Charles G Gallagher, Edward F McKone, Sarmad Waqas, Aoife Cotter, Peter Doran, Michael P Keane, Patrick W Mallon
10.1111/resp.13912
1095Non-intubated electromagnetic-guided localization and resection of small indeterminate peripheral pulmonary nodules
Po-Kuei Hsu MD, PhD; Lin-Chi Chuang BS; Chien-Kun Ting PhD; Mei-Yung Tsou MD
10.1111/resp.13819
1096Non-intubated electromagnetic-guided localization and resection of small indeterminate peripheral pulmonary nodules – Reply
Masahide Oki MD, PhD; David Fielding MBBS, FRACP, MD
10.1111/resp.13818
1097Flexible bronchoscopy-guided placement of self-expandable metallic stent for central airway obstruction-should preferably be the path less travelled!
Irfan Ismail Ayub MD, DM; Abdul Majeed Arshad MD; Sindhura Koganti MD; Dhanasekar Thangaswamy DNB
10.1111/resp.13853
1098Reply
Nicolas Guibert MD, PhD; Hideo Saka MD, PhD; Hervé Dutau MD, MSc
10.1111/resp.13850
LETTER FROM ASIA-PACIFIC AND BEYOND
1099Letter from Italy
Giovanni Sotgiu MD, PhD
10.1111/resp.13919
1101Letter from Singapore: The clinical and research response to COVID-19
Sanjay H Chotirmall MD, PhD; Lin-Fa Wang PhD; John A Abisheganaden MD
10.1111/resp.13929

Inside Respirology Case Reports

Respirology Case Reports, Volume 08 Issue 7

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Case Series
Tracheobronchial amyloidosis: an uncommon disease with a common presentation
Loveleen Mangla, Rohit Vadala, Shirish Kumar Kadli, Deepak Prajapat, Deepak Talwar
DOI: 10.1002/rcr2.630

We describe three cases who presented with haemoptysis, which on further evaluation were diagnosed as isolated tracheobronchial amyloidosis, and a review of literature.

Melioidosis—role of endobronchial ultrasound
Santhakumar Subramanian, Venugopal Jaganathan, Deepak T. Hari, Deepak Thangaraju
DOI: 10.1002/rcr2.634

Melioidosis is an emerging disease in India. Mediastinal abscess is rare in melioidosis. We have reported three such cases. Endobronchial ultrasound helped in diagnosis.

Short-course intrapleural alteplase and DNase in complex effusion with bleeding risk
Xiong Khee Cheong, Andrea Yu-Lin Ban, Mohamed Faisal Abdul Hamid
DOI: 10.1002/rcr2.648

We described three patients with complex pleural effusions who received intrapleural fibrinolysis therapy with different bleeding risks.

Thunderstorm-related asthma can occur in New Zealand
Ayan Sabih, Claire Russell, Catherina L Chang
DOI: 10.1002/rcr2.655

Thunderstorm asthma had previously been considered unlikely to occur in New Zealand (NZ), given its local weather patterns. Storm events on 2 December 2017 led to increased asthma presentations at Waikato Hospital in Hamilton. Analyses of patient presentations led us to conclude that these presentations were similar to international descriptions of thunderstorm asthma. This is the first time such presentations have been reported in NZ.

A rare case of lung squamous cell carcinoma coexisting with pulmonary MALT lymphoma presenting as a progressive pGGN
Li Yang, Ting Wang, Mingjian Ge, Min Zhang, Youde Cao, Shuliang Guo
DOI: 10.1002/rcr2.615

Here, we present an extremely rare case of coexistence of lung squamous cell carcinoma with mucosa-associated lymphoid tissue (MALT) lymphoma presenting as progressive lung ground-glass nodules.

Case Reports
Bronchial varices in a child with tricuspid atresia six years post Fontan correction
Shreya Bhushan, Vikas Goyal, Cameron Ward, Muddassir Rashid, Nitin Kapur
DOI: 10.1002/rcr2.620

Tracheal and bronchial varices are rare, especially in children. We report the first presentation of bronchial varices and haemoptysis in a child, six years after a Fontan procedure for tricuspid atresia. She had tortuous mediastinal and transpleural arterial collaterals on imaging and subsequently underwent embolization of these collaterals with haemoptysis settling after this.

Indwelling pleural catheter and successful autopleurodesis of refractory inflammatory lupus effusion
Boon Hau Ng, Nik Nuratiqah Nik, Abeed Mohamed Faisal Abdul Hamid, Chun Ian Soo, Hsueh Jing Low, Andrea Yu-Lin Ban
DOI: 10.1002/rcr2.621

Indwelling pleural catheter (IPC) is a useful tool for refractory malignant pleural effusions (MPEs). Its use in benign pleural effusions comes mainly from retrospective studies, case series, and case reports. Lupus effusion is common, causes minimal symptoms, and usually responds to either steroid therapy or immunosuppressants. We describe a 52-year-old woman whose first presentation of systemic lupus erythematosus (SLE) was a pleural effusion refractory to steroids and immunosuppressants. She successfully achieved spontaneous pleurodesis with intermittent IPC drainage at three months.

A case of non-severe COVID-19 complicated by pulmonary embolism
Yuto Akiyama, Kohei Horiuchi, Yasushi Kondo, Hiroki Kabata, Makoto Ishii, Koichi Fukunaga
DOI: 10.1002/rcr2.622

Here, we report a case of non-severe coronavirus disease 2019 (COVID-19) complicated by pulmonary embolism (PE), which indicates that the possibility of PE should consistently be considered, even in non-severe cases of COVID-19 without any risk of thrombosis.

Resolution of refractory chylothorax with a combination of talc pleurodesis and CPAP
Boon Hau Ng, Nik Nuratiqah Nik Abeed, Mohamed Faisal Abdul Hamid, Chun Ian Soo, Hsueh Jing Low, Andrea Yu-Lin Ban
DOI: 10.1002/rcr2.624

We describe a 69-year-old woman with underlying diffuse large B-cell lymphoma of the colon 16 years ago in remission, who presented with a new problem of refractory chylothorax. It was successfully treated with continuous positive airway pressure (CPAP) ventilation in tandem with talc pleurodesis.

Advanced G-CSF-producing non-small cell lung cancer-not otherwise specified, with favourable response to pembrolizumab monotherapy
Yohei Matsui, Tadaaki Yamada, Naoko Masuzawa, Shinshichi Hamada, Koichi Takayama, Osamu Hiranuma
DOI: 10.1002/rcr2.625

Here, we report a patient with non-small cell lung cancer-not otherwise specified (NSCLC-NOS) with high PD-L1 expression and aberrant granulocyte colony-stimulating factor (G-CSF) production, in whom monotherapy with the anti-PD-1 antibody pembrolizumab was effective as an initial treatment.

Bronchial mucoepidermoid carcinoma, recurrent asthmatic symptoms, and pneumonia presenting in pregnancy
Ritsuya Shiiba, Daisuke Himeji, Kiichiro Beppu, Kousuke Marutsuka, Masahiro Mitsuoka, Kazuki Nabeshimaa
DOI: 10.1002/rcr2.626

Here, we report the case of a 37-year-old pregnant Japanese woman with bronchial mucoepidermoid carcinoma, recurrent asthmatic symptoms, and pneumonia that we treated successfully via interventional bronchoscopy and surgery. At one-year follow-up, the patient was disease-free and her baby was growing well.

Incomplete metalloptysis linger pneumonia after a wedge resection of the lung for organizing pneumonia
Sen-Ei Shai, Yi-Ling Lai, Hsiao-Wen Tang, Shih-Chieh Hung
DOI: 10.1002/rcr2.627

We report the first case of incomplete metalloptysis linger pneumonia after the wedge resection of organizing pneumonia, with complete recovery by removal of residual clips, where clips from the staple cartridges had been applied on the periphery of the lung migrated and been incompletely expectorated.

Thrombocytopaenia during nintedanib treatment in a patient with idiopathic pulmonary fibrosis
Yusuke Ochi, Motoyasu Kato, Masahiro Fujioka, Mika Hayashi, Haruhi Takagi, Kazuhisa Takahashi
DOI: 10.1002/rcr2.628

We present a rare case of symptomatic thrombocytopaenia associated with nintedanib treatment in a patient with idiopathic pulmonary fibrosis (IPF).

De novo thymic carcinoma or malignant transformation: a myasthenic patient presented with multiple mediastinal tumours
Chu-Pin Pai, Chih-Ming Lin, Yi-Chen Yeh, Chien-Sheng Huang, Biing-Shiun Huanga
DOI: 10.1002/rcr2.629

Synchronous triple thymic carcinomas and thymoma have not been reported. The finding of this case report supports the hypothesis of malignant transformation of thymoma to thymic carcinoma.

Haemorrhagic bronchial casts causing complete ventilatory failure in a COVID-19 patient on ECMO
Samantha Herath, Natalie Kruit, Adam Eslick, Nicole Giroya
DOI: 10.1002/rcr2.631

We describe the surprise finding of haemorrhagic endobronchial casts causing complete ventilation failure in the first patient placed on extracorporeal membrane oxygenation (ECMO) for coronavirus disease 2019 (COVID-19) in Australia. Removal of casts with international bronchoscopy procedures leads to the restoration of ventilation.

Large cell carcinoma of the lung presenting as diffuse pulmonary infiltrates with haemoptysis
Gil Myeong Seong, Chang Lim Hyun, Jonggeun Lee, Changhwan Kima
DOI: 10.1002/rcr2.632

We report a case of large cell carcinoma identified during differential diagnosis of diffuse alveolar haemorrhage in a patient with haemoptysis.

ABCA3 deficiency from birth to adulthood presenting as paediatric interstitial lung disease
Jin-Gun Cho, Devesh Thakkar, Peter Buchanan, Nicole Graf, John Wheatleya
DOI: 10.1002/rcr2.633

We describe the clinical progress of siblings who initially presented with an undifferentiated paediatric interstitial lung disease at birth which was eventually diagnosed in adulthood as pulmonary surfactant dysfunction due to ATP-binding cassette subfamily A member 3 (ABCA3 ) mutations. Clinical deterioration was due to progressive pulmonary hypertension and a moderate decline in forced expiratory volume in 1 sec (FEV1), rather than progression of the interstitial lung disease.

Solitary fibrous tumour of the pleura arising in a pulmonary cavity
Hiroyuki Miura, Jun Miura, Keisei Tachibana, Shinichi Gotoa
DOI: 10.1002/rcr2.635

Solitary fibrous tumour of the pleura (SFTP) is a rare neoplasm. Moreover, cavity formation associated with SFTP is extremely rare. To our knowledge, only one such case has been previously reported.

Severe gastritis due to pembrolizumab treatment in a lung cancer patient
Noriko Hayama, Hiroaki Ihara, Yuichirou Honma, Yukinari Itoigawa, Kyoichi Kaira, Mitsuhiro Fujii
DOI: 10.1002/rcr2.636

The incidence of immune checkpoint inhibitor (ICI)-induced gastritis is relatively rare, compared with colitis, but a massive immunoreaction caused by ICIs can induce severe gastritis. Thus, gastritis should be considered when patients taking ICIs complain of any gastrointestinal symptoms.

Eosinophilic airway inflammation and eosinophilic chronic rhinosinusitis during nivolumab and ipilimumab
Hirofumi Watanabe, Kazuhiro Asada, Toshihiro Shirai, Hiroko Torii, Koji Yoshimura, Kimihide Kusafukaa
DOI: 10.1002/rcr2.638

There are many immune-related adverse events (irAEs) induced by immune checkpoint inhibitors; however, irAEs associated with type 2 inflammation are less known. We report a case of eosinophilic airway inflammation and eosinophilic chronic rhinosinusitis simultaneously during combination therapy with nivolumab and ipilimumab for renal cell carcinoma.

Recurrent non-traumatic idiopathic chylothorax: a diagnostic dilemma with therapeutic challenge
Rohit Vadala, Dhruv Talwar, Deepak Talwar
DOI: 10.1002/rcr2.637

This study highlights the recurrent non-traumatic idiopathic chylothorax with proposed algorithmic approach to undiagnosed milky or turbid blood-tinged pleural effusion.

Re-establishing indwelling pleural catheter patency with alteplase after failure of streptokinase
Mohamed Faisal, Siti Nurhanis, Nik Nuratiqah, Nik Abeed, Boon Hau Ng, Andrea Yu-Lin Bana
DOI: 10.1002/rcr2.639

We describe the successful use of a single low-dose intrapleural (IP) alteplase in both indwelling pleural catheter blockage and symptomatic loculation drainage, following a failed therapy with six doses of IP streptokinase.

IgG4-related lung disease progressing to respiratory failure
Yusuke Kunimatsu, Nozomi Tani, Izumi Sato, Yuri Ogura, Kazuki Hirose, Takayuki Takedaa
DOI: 10.1002/rcr2.641

Chest computed tomography (CT) showed non-segmental reticular shadow and ground-glass opacity predominantly spreading over the lymphatic tract, including the centrilobular and perilymphatic areas. 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT showed significant FDG accumulation in the lung fields, indicating the proliferative and reversible status of immunoglobulin G4-related lung disease (IgG4-RLD).

Radiographic change over 11 years in a patient with asbestos-related pleural disease
Reina Hara, Yukihiro Yano, Fukuko Okabe, Tomoki Kuge, Masahide Mori, Koji Urasaki
DOI: 10.1002/rcr2.642

We report the case of a 72-year-old man with asbestos-related disease, firstly benign asbestos pleural effusion and subsequently diffuse pleural thickening, which progressed over 11 years and finally presented chronic respiratory failure. After his death, moderate asbestos body concentration was proven in his autopsy-derived lung tissue.

Endobronchial metastases from a primary embryonal carcinoma
Chi-Kang Teng, Wen-Chien Cheng, Chieh-Lung Chen, Ting-Han Chen, Yun-Shan Lin, Chih-Yen Tu
DOI: 10.1002/rcr2.644

In this report, we present a case of endobronchial metastases from a primary embryonal carcinoma.

Endobronchial metastases from a primary embryonal carcinoma
Chi-Kang Teng, Wen-Chien Cheng, Chieh-Lung Chen, Ting-Han Chen, Yun-Shan Lin, Chih-Yen Tu
DOI: 10.1002/rcr2.644

In this report, we present a case of endobronchial metastases from a primary embryonal carcinoma.

Bronchopleural communication following intrapleural doses of tPA/DNase for empyema
Bapti Roy, Mark C Teh, Yi Jin Kuok, Y C Gary Lee
DOI: 10.1002/rcr2.646

Pulmonary migration of intrapleural drugs via a bronchopleural communication is a rare and poorly described complication of intrapleural tissue plasminogen activator/deoxyribonuclease (tPA/DNase) therapy. We report the first detailed case of a bronchopleural communication after intrapleural tPA/DNase instillation. Despite this, the patient made an uneventful recovery from the pleural infection without requiring surgical drainage.

Massive haemoptysis caused by a long-standing foreign body in the airway
Hiroaki Nagano, Akiko Maeda, Takashi Kato, Ryoichi Kitamura, Wataru Higashiura
DOI: 10.1002/rcr2.647

This case was a very unique in that a strange foreign body in the bronchi remained for a long time and massive haemoptysis was caused by dilation of the bronchial artery.

Co-diagnoses of acute myeloid leukaemia and COVID-19: presentation and management implications
Amy O'Brien, James Campling, Hugh Goodman, Catherina L Chang
DOI: 10.1002/rcr2.650

We report a case of concurrent new diagnoses of confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute myeloid leukaemia (AML). The implications of severe immunocompromise are unclear in the context of infection with SARS-CoV-2. We describe the clinical course of coronavirus disease 2019 (COVID-19) in this case, review the existing literature on SARS-CoV-2 in the immunocompromised patient, and finally the implications for managing her haematological neoplasm.

Relapsing polychondritis with isolated tracheal involvement and airway-only symptoms
Sheng-Yuan Wang, Chia-Tse Weng, Lili Cheng, Tang-Hsiu Huang
DOI: 10.1002/rcr2.651

We describe an atypical case of relapsing polychondritis that involved solely the tracheal cartilages and presented clinically as non-specific airway symptoms. Timely diagnosis and treatment through a multidisciplinary approach is crucial to prevent subsequent serious complications.

Bronchosubcutaneous fistula manifesting as massive subcutaneous emphysema treated successfully by endobronchial Watanabe spigots
Masahiro Yanagiya, Noriko Hiyama, Hideyuki Takeshima, Kazuhiro Usui, Jun Matsumoto
DOI: 10.1002/rcr2.652

In this report, we describe a successful endoscopic bronchial occlusion using endobronchial Watanabe spigots for bronchosubcutaneous fistula manifesting as massive subcutaneous emphysema.

Tracheobronchial rhinosporidiosis: an uncommon life-threatening benign cause of airway obstruction
Nirmal Kanti Sarkar, Md. Mofizur Rahman Mia, Md. Rejaul Hasan
DOI: 10.1002/rcr2.653

Tracheobronchial rhinosporidiosis is a rare benign cause of endobronchial obstruction and poses challenge for diagnosis and management. We report a 30-year-old man who developed acute hypoxaemia by a rapidly growing rhinosporidial mass causing central airway obstruction. Emergency bronchoscopic intervention saved his life.

Drug-induced interstitial lung disease associated with dasatinib coinciding with active tuberculosis
Nozomi Tani, Yusuke Kunimatsu, Izumi Sato, Yuri Ogura, Kazuki Hirose, Takayuki Takeda
DOI: 10.1002/rcr2.654

Drug-induced interstitial lung disease (ILD) and immunosuppression are known to develop in a dose-dependent manner, and we herein describe the first case of dasatinib-induced ILD which coincided with active tuberculosis.

SMARCA4-deficient lung tumour that presented with haemoptysis and progressed rapidly
Mari Inoue, Tatsuji Enomoto,Masashi Kawamoto, Naoto Mikami, Hidehiko Kuribayashi, Noriyuki Saeki
DOI: 10.1002/rcr2.656

We present the case of a heavy ex-smoking man in his early 70s who presented with haemoptysis and died following rapid progression. The excised tumour was diagnosed as a SMARCA4-deficient thoracic sarcoma. This is a disease that progresses rapidly and has a poor prognosis.

Ingenuity of minimally invasive thoracoscopic lobectomy for undiagnosed pulmonary tumour
Sumitaka Yamanaka, Takashi Yoshimatsu, Takeaki Miyata, Hanae Higa
DOI: 10.1002/rcr2.657

This study describes video-assisted thoracic surgery (VATS) with minimal chest incisions to prevent chronic post-operative intercostal neuralgia and paraesthesia, using a small subxiphoid incision only to remove the specimen.

Clinical Image
Multiple patchy pulmonary consolidation in granulomatosis with polyangiitis
Masahiro Yamasaki, Masaya Taniwaki, Shota Nakano, Naoko Matsumoto, Shinji Nabeshima, Noboru Hattori
DOI: 10.1002/rcr2.623

Multiple patchy pulmonary consolidations that are unresponsive to antibiotics and/or exist at peri-bronchial sites and bloody bronchoalveolar lavage may effectively help clinicians diagnose granulomatosis with polyangiitis.

Penetrating pulmonary injury caused by a steel rod
Dario Amore, Emanuele Muto, Dino Casazza, Marcellino Cicalese, Marco Rispoli, Carlo Curcio
DOI: 10.1002/rcr2.640

Penetrating thoracic injuries by metallic rod are relatively rare. Here, we present the case of a stable patient with penetrating thoracic trauma where a careful radiological assessment helped us to perform a correct surgical management.

Endobronchial hamartoma coexisting with lung cancer
Seigo Miyoshi, Eiji Sugimoto, Mayu Kawakami, Yoshihiro Taguchi, Naohiko Hamaguchi, Osamu Yamaguchi
DOI: 10.1002/rcr2.643

We present the case of a 70-year-old man diagnosed with endobronchial hamartoma (EH) with concurrent malignant disease. Hamartomas are rarely identified as endobronchial lesions and only a few cases of EH with concurrent malignant disease are reported. Radiographic imaging and symptoms cannot reliably differentiate between EH and malignant bronchial nodules, thus careful examination is warranted.

Pseudoaneurysm after total arch replacement mimicking malignant lymphadenopathy
Yosuke Chiba, Kei Yamasaki, Hiroaki Ikegami, Kazuhiro Yatera
DOI: 10.1002/rcr2.645

Pseudoaneurysm should be considered in the differential diagnosis when the computed tomography (CT) findings show a mediastinal mass in patients with a history of cardiovascular surgery even if such surgery occurred over two decades previously.

Clinical Video
Bronchoscopic visualization of a cavity in entirety: an unusual finding
Deebya Raj Mishra, Narendra Bhatta, Achyut Bhakta Acharya, Avatar Verma, Rejina Shahi, Niharika Shah
DOI: 10.1002/rcr2.649

It is unusual to be able to visualize an entire cavity with such clarity.

 

Regional society news

The spotlight this month is on

SRI LANKA

Each month we share details of activities of a particular country, region or society.

If you would like the spotlight to be on your country, region or society next month, contact the Bulletin Coordinator or APSR Secretariat.

Two articles kindly provided this month by Dr Dushantha Madegedara, Head of the Clinical Respiratory Medicine Assembly: the COVID-19: Sri Lankan Experience, followed by Trends of Respiratory Diseases in Sri Lanka; A Tale of Two Decades

COVID-19: Sri Lankan Experience

Madegedara RMD1, Karunadhipathi UN1, Yasaratne BMGD2

1Respiratory Medicine Unit-2, National Hospital, Kandy, Sri Lanka
2Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka

COVID-19 pandemic is an unprecedented global health crisis, ravaging human population in 2020. It is primarily transmitted between people via respiratory droplets and person-to-person contact routes. Sri Lanka, an Island country lying in the Indian Ocean, was also affected with this newly discovered virus.

[ Click any image to enlarge ]


Figure 1: Timeline of COVID-19 diagnosed cases in Sri Lanka
Source: Epidemiology unit, Daily Situation report



Figure 2: Timeline of COVID-19 diagnosed cases in Sri Lanka
Source: Health promotion Bureau



Figure 3: Doubling time
Source: Epidemiology unit, Daily Situation report



Figure 4: District Distribution of confirmed COVID-19 cases
Source: Epidemiology unit, Daily Situation report

The first case of the virus was confirmed in Sri Lanka on 27 January 2020, after a 44-year-old Chinese woman from Hubei Province in China was admitted to the National Institute of Infection Diseases. By the time this report was prepared – 13 September 2020 - a total of 3,195 confirmed cases, 2,996 recoveries, and 12 deaths had been reported in the country. Sri Lanka has thus far been successful in containing the disease and opening up the country back to a near normal functional state. It would be useful to revisit the methods used to achieve such disease control by a country with limited health resources, and to discuss any factors that may have contributed.

Following the detection of first case in late January, the second patient, a native with foreign contact, was diagnosed in early March. By the time the total number of confirmed cases reached 87, the Sri Lankan government announced a lockdown style curfew in the country on 25 March 2020. This helped to maintain the outbreak under epidemiological stage II for the next four weeks.

A collaborative COVID-19 Operational Body was formed on 23rd March with officials from Government, Health Ministry and Armed Forces. National guideline committees, Provincial and District operational committees, Hospital COVID cells were formed representing all parts of the Island. COVID treatment centres were developed in infectious disease hospitals and other selected hospitals, while isolation facilities were established in all hospitals. Public health teams were reinforced with coordinating bodies and community based quarantine centres were established. Laboratory facilities were expanded in major microbiological centres.

The first confirmed COVID death in the country occurred on 29 March. The diagnosed cases in this period were mainly from foreign contacts and their close associates, making it practical for health officials to carry out an effective quarantine process. On 23 April, 38 persons confirmed COVID and of them 30 were from officers of the Welisara Navy Camp involved in moving a group of drug addicts who tested positive for the coronavirus to quarantine. Later on, this proved to be a major step in the outbreak, spreading to 950 navy officers and close contacts to date.

With a large number of cases getting detected among overseas returnees and COVID pandemic becoming uncontainable in many parts of the world, the Sri Lankan Government decided to follow suit in closing its international airports for routine passengers from 1 May. However, Sri Lankan citizens stranded in many parts of the world were given necessary support and return air travel through respective embassies.

the Sri Lankan Government announced lifting the curfew after six weeks on 11 May, except in selected high risk areas, meaning that the public could start going to workplaces by maintaining social distancing and protective measures. However schools and universities were still closed and public gatherings, festivals, celebrations were banned. By that time total number of confirmed cases was 863, total number recovered 343 and total number of deaths 9.

To date, Sri Lanka has diagnosed 3,195 confirmed COVID-19 cases. Of those, 1,235 were Sri Lankan returnees from other countries, 950 were from the Sri Lanka Navy and their close contact clusters, 650 from Kandakadu quarantine center cluster and 47 were foreign travellers. All Government and private institutions are open and functional, with people adhering to health control guidelines, and schools and universities are open. Airports are still closed for routine passengers considering the global status of the pandemic.

In conclusion, Sri Lanka, despite being a country with limited health resources, has thus far been successful in containing the COVID-19 pandemic and reopening the country back to a near normal state. This achievement is largely due to well-coordinated and efficient public health activities including prompt diagnosis, contact tracing, effective quarantine processes, public education and preventive strategies. Being an island nation with a tropical climate, having a bearable population density, and access to various western and native treatment options, may have helped the Sri Lankan community in this cause. COVID-19 has tested the ability of all sectors in the country to mount a swift response to a pandemic situation. Continuous vigilance and preparedness will be required for coming months to years for a sustainable effort.

References

  1. Epidemiology Unit of Ministry of Health, Sri Lanka, Corona Virus 2020. epid.gov.lk/web/index.php?option=com_content&view=article&id=225&lang=en
  2. Health Promotion Bureau, COVID-19: Live Situational Analysis Dashboard of Sri Lanka. hpb.health.gov.lk/covid19-dashboard

Trends of Respiratory Diseases in Sri Lanka; A Tale of Two Decades.

Madegedara RMD1, Karunadhipathi UN1, Yasaratne BMGD2

1Respiratory Medicine Unit-2, National Hospital, Kandy, Sri Lanka
2Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka

Background

Sri Lanka, an island country officially known as the Democratic Socialist Republic of Sri Lanka is situated off the southern coast of India in the Northern Indian Ocean of South Asia, separated from the Indian sub-continent by a natural bridge of shallow water, known as Palk Strait.

The nation has a total area of 65,610 square kilometres, including 2,905 square kilometres of inland water. Sri Lanka’s climate is tropical, consists of wet and dry seasons and it is affected by its proximity to the equator as well as the elevation above sea level and the monsoons. The mean temperature ranges from 26.50° C to 28.50° C (79.70° F to 83.30° F) in the coastal area and from 14° C to 24° C (58° F to 75° F) in the upland area.

Population Size and Growth

The fourteenth national Census of Population and Housing (CPH) in 2012 enumerated that the population was 20,359,439. Annual growth rate has been a steady 1.0% - 1.5% for last several decades (Figure 1).

During last many decades, the Crude Death Rate (CDR) of Sri Lanka has been steady, with 6.4 deaths per 1,000 population in 2017 (Figure 2). However the Crude Birth Rate (CBR) has been steadily declining, which has led to doubling the percentage of elderly population from 6.6% to 12.4% during the period 1981-2018.1

[ Click any image to enlarge ]


Figure 1: Population Size and Annual Growth Rate,1911-2018
Source - Department of Census and Statistics.

Figure 2: Crude Birth and Death Rates, 1955-2018
Source - Department of Census and Statistics.

Diseases of the respiratory system

Traumatic injuries were major cause of hospitalization in 2018. Diseases of the respiratory system excluding diseases of upper respiratory tract, pneumonia and influenza, are the third leading cause since 2009 up to 2018, except in the Year 2017, when it was ranked as the fourth leading cause (Figure 3).2

Diseases of the respiratory system excluding diseases of upper respiratory tract, pneumonia and influenza were the third leading cause and pneumonia was the seventh leading cause of hospital deaths in 2018 (Figure 4).


Figure 3: Leading Causes of Hospitalization, 2018
Source - Medical Statistics Unit, Ministry of Health.

Figure 4: Leading causes of Hospital Deaths, 2018
Source - Medical Statistics Unit, Ministry of Health.

Obstructive airway diseases comprise a major proportion of lung diseases in all age groups in the country, carrying a large disease burden. The Sri Lankan arm of the International Study of Asthma and Allergy in Children (ISAAC) done in 2002, has revealed the presence of persistent nocturnal cough or wheezing among preschool and school children to be over 20%.3


Figure 5: Trends of common respiratory diseases 2006-2018
Source - Medical Statistics Unit, Ministry of Health

Trends of some common respiratory diseases in Sri Lanka during the last two decades, based on hospital live discharge statistics, are shown in Figure 5. Acute sinusitis, influenza, acute bronchitis, asthma and bronchiectasis show similar trends in both males and females. However, a male preponderance has been observed in pneumonia, COPD and respiratory malignancies, likely owing to the cultural fact that cigarette smoking is almost negligible in a traditional Sri Lankan female.

Viral respiratory infections including acute sinusitis and bronchitis are very common in the country throughout the year. A slight decreasing trend of hospital cases of these two diseases has been observed both in males and females since 2006. However, it is important to remember that most with such illnesses would not get admitted to hospitals. Conversely, a steady rise of pneumonia cases was noted both in males and females.

Seasonal Influenza has been generally observed during April to June and again in November to January in Sri Lanka. Globally seasonal influenza has shown a decreasing trend according to the World Health Organization surveillance data (2015). ).4 When looking at the trend of Influenza in Sri Lanka, after an initial drop in case numbers in 2013, there has been a steady rise.

The highest numbers of cases were noted for asthma and COPD. Throughout the last decade the number of hospital cases of asthma in both males and females has been somewhat steady. The Burden of Lung Diseases (BOLD) survey revealed an overall 10.5% (95% CI: 8.8–12.2%) prevalence of COPD among Sri Lankan adults aged over 40 years.5 Among males, the prevalence was 16.4% (95% CI:  13.2–19.5%) compared to 6.0% (95% CI:  4.2%–7.7%) in females who are largely nonsmokers. The available latest statistics revealed gradual increment in number of hospital cases with significant male predominance. Among the male population the number of hospital cases has doubled during period from 2008-2018.

The trend of bronchiectasis in Sri Lanka has been fluctuating over the period from 2008 to 2018. Reported cases of lung malignancies has been increasing and there is a significant male predominance.

Tuberculosis

The island-wide preventive and curative services of the National Programme for Tuberculosis Control and Chest Diseases (NPTCCD) in Sri Lanka have been successful in maintaining the intermediate burden state of TB in the country. Universal TB treatment coverage is 64% and incidence of multidrug resistance remains below 0.03 per 1000 individuals. Nevertheless, despite wide public awareness campaigns around the year, the national case detection rate of TB remains below the WHO estimates, which is a public health concern).6

In Sri Lanka, annually over 8000 cases of tuberculosis are detected. Microbiologically confirmed pulmonary tuberculosis comprises a major fraction of it, where there is a significant male preponderance (Figure 6). The number of cases has been steady from 2013 to date.

Clinically diagnosed pulmonary tuberculosis (smear negative) cases were also noted to have a steady course throughout this period (Figure 7). This number is expected to decline with the widespread availability of nucleic acid amplification testing (XpertMTB) in all districts. Numbers of miliary tuberculosis cases are comparatively much less and remain static (Figure 8).


Figure 6: Pulmonary tuberculosis (microbiologically confirmed cases) 2008-2018
Source - Medical Statistics Unit, Ministry of Health.

Figure 7: Pulmonary tuberculosis (clinically diagnosed cases) 2008-2018
Source - Medical Statistics Unit, Ministry of Health.

Sri Lanka has been successful in keeping the incidence of multi-drug resistant tuberculosis (MDR-TB) under control, mainly by strict follow-up of patients on anti-TB treatment (ATT) in the community and regulating prescriptions of ATT (Figure 9). Community acquired primary MDR-TB is negligible.


Figure 8: Miliary tuberculosis 2008-2018
Source - Medical Statistics Unit, Ministry of Health.

Figure 9: Multi-drug resistant tuberculosis 1998-2019
Source - Medical Statistics Unit, Ministry of Health.

Conclusion

Being a tropical country with a frequently fluctuating climate, acute and chronic respiratory diseases are a heavy burden to Sri Lanka. Diseases of the respiratory system, excluding diseases of upper respiratory tract, pneumonia and influenza, have remained the third leading cause of hospital admission since 2009. Highest cases were noted for bronchial asthma, in which hospital admissions have been static over the last decade. However, COPD and lung cancer admissions are on the rise, with a noteworthy male preponderance, likely owing to late effects of male smoking and other environmental factors. The island maintains the intermediate burden disease state of tuberculosis, with a very low incidence of drug resistance, while being in the South Asian region with a high tuberculosis burden.

References

  1. Department of Census and Statistics. National survey on self-reported health in Sri Lanka 2014. ISBN: 978–955–577–994–4. 2016. [Accessed 10 Sep 2020] Available from statistics.gov.lk/social/National%20Survey%20on%20Self-reported%20Health-2014.pdf
  2. Medical Statistics Unit, Ministry of Health, Sri Lanka. Annual Medical Statistics 2017-2019. [Accessed 15 Sep 2020.] Available from health.gov.lk/moh_final/english/public/elfinder/files/publications/AHB/2017/AHS2017.pdf
  3. Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H; ISAAC Phase Three Study Group. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional survey. Lancet 2006; 368: 733-43.
  4. Epidimiology Unit of Ministry of health Sri Lanka. Influenza update. March 2017. [Accessed 10 Sep 2020] Available from epid.gov.lk/web/index.php?option=com_content&view=article&id=206%3Ainfluenzaupdate&catid=51%3Amessage-for-public&lang=en
  5. Amarasiri L, Gunasinghe W, Sadikeen A, Fernando A, Madegedara D, Wickramasinghe R, Gunasekera K. The prevalence of chronic obstructive pulmonary disease (COPD) in Sri Lanka: outcome of the BOLD study. Eur. Respir. J. 2017; 50: PA1212.
  6. Nair N, Wares F, Sahu S. Tuberculosis in the WHO South East Asia Region. Bull. World Health Organ. 2010; 88: 164.

Other regional news:

Republic of Korea

Korean Academy of Tuberculosis and Respiratory Diseases (KATRD) International Conference

The KATRD International Conference 2020 will be held virtually on 12-13 November 2020.

As the global impact of the coronavirus pandemic grows daily, the priority is always the health and safety of our community and participants.

The KATRD has developed into an international academic conference thanks to your efforts and support. Last year, the conference attracted 1,067 participants from 20 countries. The KATRD will build a dynamic, interactive, and inclusive virtual conference.

Internationally renowned speakers will be in attendance to discuss the latest trends with plenary sessions and symposiums which will cover all areas of our rapidly changing medical environment. Throughout these programmes, the Conference will offer exciting opportunities to gain insights and new ideas as you are connected to globally well-known speakers and enthusiastic fellow scholars. This Conference hopes to build an international network and promote collaboration.

The registration fee has been substantially reduced to encourage students and trainees from non-presenting attendees from all over the world to attend the conference on a new digital meeting platform.

Registration fee
Early
(until 16 October)
Late
(after 16 October)
Medical Doctor, ProfessorDomesticKR₩ 20,000KR₩ 50,000
OverseasUS$ 20US$ 50
Fellow, Resident, Nurse,
Military Doctor, Researcher, etc.
DomesticKR₩ 10,000KR₩ 30,000
OverseasUS$ 10US$ 30

Registration will provide each participant with an access code to participate in sessions.

The conference has an impressive line-up of invited international speakers.


Dr Nakanishi
Top of the list is the APSR's president, Dr Yoichi Nakanishi, who will deliver 'How to manage lung cancer associated with COPD/ILD in the age of coronavirus'. He will be the first speaker in Plenary Session 01 at 08:30-10:00 (Korean standard time UTC+9) on Thursday 12 November.

Dr Lee
The second speaker in that Plenary Session 01 is Dr Kang-Yun Lee, Head of the APSR Asthma Assembly. He will talk of 'Aberrant inflammation in COPD'.

Dr Kim
Other assembly leaders include Dr Woo Jin Kim, Head of the APSR Environmental & Occupational Health and Epidemiology Assembly, speaking on 'Effect of ozone on lung disease' in Symposium 03 (Environmental Lung Disease - Air Pollution and Respiratory Disease) at 15:30-17:00 (KST) on the same day.

Dr Rhee
Dr Chin Kook Rhee, Head-Elect of the APSR COPD Assembly, will present 'Can we better manage the risk of future COPD exacerbations' in the COPD Satellite Symposium 1 at 17:15-18:25 (KST), also on Thursday 12 November.
He will also speak during Symposium 10 (Pulmonary Rehabilitation - Importance of Muscle in Pulmonary Rehabilitation) at 10:30-12:00 (KST) on Friday 13 November, on 'Assessment and training of diaphragm muscle'.

Several other eminent APSR members will be presenting important topics during the Conference. See the speaker list and full programme at katrdic.org/program/sub02.php

Philippines

The PCCP celebrated World Lung Day by paying tribute to the modern heroes. Advocates of protecting the environment and making efforts to save our surroundings — Advocates of clean air for human health.

(You might need to zoom your screen to fully enjoy their video.)

Singapore

Also due to the pandemic, the date of the World Conference on Lung Cancer has changed.

This had been scheduled to be held on 9-12 August 2020 and has been postponed to 26-29 January 2021.

Please check the IASLC website wclc2020.iaslc.org for the latest details.

Health news

Philippines 30 cm distancing rule seen as 'reckless'; deaths hit record

MANILA (Reuters) 14 September 2020 - Experts described as dangerous and premature on Monday the Philippines' decision to cut the social distancing minimum to 30 centimetres (12 inches) on public transport, as the country saw another daily record in newly confirmed COVID-19 deaths.

Reducing gaps between passengers incrementally to a third of the 1 metre minimum could backfire, experts and medical professionals warned, and prolong a first wave of infections that the Philippines has been battling since March.

The new rules took effect on Monday [14 September], when the country reported 259 new confirmed deaths, a record for the second time in three days. Total fatalities increased to 4,630, while infections have doubled in the past 35 days to 265,888, Southeast Asia's highest number.

"This will be risky, reckless and counter-intuitive and will delay the flattening of the curve," Anthony Leachon, ex-president of the Philippine College of Physicians, told news channel ANC. "Even if you wear a face shield and mask, reducing the distance between, it will be dangerous," he said, adding that 1 or 2 metres was the minimum international standard.

The transport ministry's new rules cut the distance to 75 cm on Monday [14 September], 50 cm on 28 September and 30 cm on 12 October. Conversation and phone calls are now prohibited.

The health ministry on Monday urged the public to be "extra vigilant" in tight travel conditions and to choose other transport modes if possible. Manila's transport systems are notoriously crowded, with commutes typically involving long queues and several changes.

"It is likely that we will see an increase in cases and our recovery will slow if we do this now," said epidemiologist Antonio Dans. Dans is a member of a health professionals alliance that last month pleaded for a tightening of Manila's lockdown - a "timeout" to stop hospitals being overrun. It urged a rethink of the 30 cm rule.

The plan aims to help an economy that the government sees contracting 5.5% this year, the worst shrinkage in 35 years. "Reopening the economy will never happen unless the viral transmission is controlled," added Leachon, a former advisor to the government's COVID-19 task force.

Singapore distributes Covid contact-tracing tokens

Singapore has started distributing Bluetooth contact-tracing tokens to its five million residents to help contain the spread of Covid-19.

The tokens, which can be worn on a lanyard or carried, are a hardware version of its existing contact-tracing app which was rolled out in March. Like the app, they use Bluetooth to look for other users' devices and then log any contact with those devices. They could be popular with older people who do not use smart phones.

The government also hopes the tokens will help to further reopen the economy, by enabling conferences to restart and providing better tracing in higher risk settings, such as busy hotels, cinemas and gyms.

The initial rollout is happening in areas with a greater concentration of elderly people, who are both at a greater health risk from Covid-19 and less likely to own a smart phone. But the token will be available to all citizens, including foreign residents.

Singapore residents currently check-in to shops and office buildings using a separate SafeEntry system, that makes use of QR codes to log users' presence. For some higher-risk activities, SafeEntry will now also require the app or token to check in.

Better for privacy?

A consultant tapped by the government's technology agency to provide feedback on the token said it's a better option for anyone concerned about privacy. "I would prefer to use the token over the app," said Bunnie Huang, who lined up for a token on the first day it was available.

Like app, information is stored on the token, purged regularly and is only uploaded - or in the case of the token physically handed over - to the Ministry of Health if the user tests positive.

The advantage to a hardware-only version, said Mr Huang, is that it makes it impossible for a software update to surreptitiously turn on location data or other sensors without the user noticing. "With the token, if I want it off, I know how to destroy it," he said.

The token will also help to cover people without a smart phone, and those who have encountered functionality problems with the app, he said.

Singapore was the first government to introduce a contact tracing app nationally in March. Since then, about 2.4 million people have downloaded the app, with about 1.4 million using it in August.

Singapore government figures have long acknowledged that those numbers need to increase to make the app and the token effective. But the Ministry of Health said the program has helped to reduce the time it takes to identify and quarantine close contacts of Covid-19 cases from four days to two.

The city-state has been more enthusiastic about contact tracing apps than many other countries, which have been slower to introduce apps or have struggled to make good use of them.

Extracted from BBC News 15 September 2020
bbc.com/news/business-54143015

Education

Teaching Library

The Teaching Library is open for your self-study. Challenging yourself to choose the correct procedure for any of the cases in the Library at apsresp.org/education/teaching-library/index.php.

Many more cases are needed for this Library and any member is welcome to submit a case (or cases!) through the same link as above.

New educational article

The following article has recently been selected from Respirology for its specific educational value. Previous articles on further topics can be seen at apsresp.org/education/articles/index.html


Table 2 of 10.1111/resp.13806
(Click image to enlarge)

Of special interest to those working in:
* Asthma
* Respiratory structure & function
* Immunology
* Clinical Respiratory Medicine

Acute effects of e-cigarette vaping on pulmonary function and airway inflammation in healthy individuals and in patients with asthma Serafeim-Chrysovalantis Kotoulas, Athanasia Pataka, Kalliopi Domvri, Dionisios Spyratos, Paraskevi Katsaounou, Konstantinos Porpodis, Evangelia Fouka, Aikaterini Markopoulou, Katalin Passa-Fekete, Ioanna Grigoriou, Theodoros Kontakiotis, Paraskevi Argyropoulou and Despoina Papakosta
onlinelibrary.wiley.com/doi/10.1111/resp.13806/full (October 2020)

Comment by Dr Mark Lavercombe:
The rapid escalation in 'vaping' using electronic nicotine delivery devices has not yet been matched by data demonstrating their safety. In a cohort of asthmatic patients taking regular inhaled corticosteroids, acute markers of airway inflammation and pulmonary function changed within five minutes of e-cigarette vaping and this did not occur in healthy controls. The authors discuss the implications for future research in both healthy subjects and patients with pre-existing obstructive lung diseases.

APSR Membership

Donations received


Dr Muntean

Dr Petru Emil Muntean FAPSR (Pitesti Queen Mary Hospital and Arges Emergency County Hospital, Romania) has kindly sent his donation towards the Society's goals, as outlined at apsresp.org/members/donors.php.

The APSR is profoundly grateful for his generosity.

Dr Tatsuma Fukuda

Congratulations to Dr Fukuda (University of the Ryukyus, Japan) an APSR Young Investigator awardee at the virtual ERS International Congress 2020.

Here is his report:

I'm greatly honoured to receive the Young Investigator Award at the virtual ERS International Congress 2020. I'd like to express my deep gratitude for the numerous supports from ERS and APSR.

I was very pleased to have the opportunity to present our work entitled "Time to advanced airway management and neurologically favourable survival after out-of-hospital cardiac arrest" in the Oral Presentation Session. In the presentation, I showed the findings of our nationwide population-based observational study of out-of-hospital cardiac arrest from 2014 to 2017, that delay in advanced airway management was associated with decreased chance of neurologically intact survival after out-of-hospital cardiac arrest. Thanks to heated discussion and constructive comments, the session was very exciting and beneficial for me. This virtual live session was my first experience, so I was very nervous before the start of the session, but it was fun and exciting actually.

During the congress, I got the latest updates on state-of-the-art Critical Care Medicine, and valuable take-home knowledge from cutting-edge presentations of original scientific research in several sessions. Also, I could view numerous interesting e-posters in a variety of presentations, including the COVID-19 sessions. The latest findings from top clinicians and scientists around the world will be of great help to me.

Thank you again for the support from the APSR and ERS to attend the virtual ERS International Congress.

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Dr Shu-Yung Lin

Congratulations to Dr Lin (Department of Internal Medicine, National Taiwan University Hospital) an APSR Young Investigator awardee at the virtual ERS International Congress 2020.

Here is his report:

It was a great honour to attend the virtual congress of ERS 2020 representing Taiwan and the National Taiwan University Hospital. This was a special year due to the global pandemics and health care personnel worldwide were facing enormous challenges in patient care and disease control. Thanks to the internet, we were still able to communicate with each other and still able to have an international conference in a virtual form.

During the presentation session, I was able to meet other excellent doctors and scholars working on respiratory medicine and had some very good times exchanging experiences. It was a unique and pleasant experience during the whole ERS meeting.

I had the opportunity to present the research entitled "Higher adverse drug reactions but better completion rate of twelve-dose weekly rifapentine plus isoniazid comparing with nine-month daily isoniazid for latent tuberculosis infection among patients under maintenance dialysis", which has nothing to do with COVID-19. This study addressed the issue of regimen selection in patients under hemodialysis when treating latent tuberculosis infection.

The online oral presentation proceeded as planned smoothly and we had a great discussion session regarding several critical and meaningful questions for the study both with the chairs and the audience. While we ended the sessions with more than 700 people viewing, unfortunately the experience was still not as interesting as a real-life presentation and face to face interaction.

Again, with greatest and sincerest gratitude to the APSR and ERS for giving me the credit on the research. I look forward to future chances of (face to face) meeting and sharing each other's work again in the near future!

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New Fellows of the APSR

Congratulations to the following members who have recently become Fellows of the APSR:

  • Dr Jyoti Bajpai FAPSR
  • Dr Sajal De FAPSR
  • Dr Petru Emil Muntean FAPSR

New and updated assembly memberships

A warm welcome to the following members who have recently joined or re-joined APSR assemblies.

Digambar Behera Clinical Respiratory Medicine
Tuberculosis
Lung Cancer
Chee Shee Chai COPD
Asthma
Respiratory Neurobiology and Sleep
Muhammad Imran Clinical Respiratory Medicine
Clinical Allergy & Immunology
Respiratory Infections (non-tuberculous)
Arnaud Prigent Clinical Respiratory Medicine
COPD
Critical Care Medicine
Chandan Kumar Sheet Chandan Kumar Shit Bronchoscopy and Interventional Techniques
Critical Care Medicine
Interstitial Lung Disease
Ying Tianlei Respiratory Infections (non-tuberculous)
Lung Cancer
COPD

Future Pulmonology Events

Here are the main respiratory events in Asia-Pacific region for the next few months. You can see our full listing on the APSR Calendar.

  • Congress of International Lung Health and World COPD Day 2020 (VNRS)
    5-7 November 2020, Hanoi, Vietnam
    (Details)
  • 130th Conference of the Korean Academy of Tuberculosis and Respiratory Diseases (KATRD)
    12–13 November 2020, Seoul, Republic of Korea
    (Details)
  • Annual Congress of Vietnam Respiratory Society 2020 (combination of VNRS Congress and Association Franco-Vietnamienne De Pneumologie) and Pre-congress Workshop on Bronchoscopy
    13-15 November 2020, Da Nang city, Vietnam
    (Details)
  • Asthma & COPD Outpatient Care Unit (ACOCU) Network Day
    15 November 2020, Ho Chi Minh City, Vietnam
    (Details)
  • Respiratory Structure and Function symposium - an APSR Assembly Virtual Meeting
    21 November 2020, Online
    (Details)
  • Asthma symposium - an APSR Assembly Virtual Meeting
    28 November 2020, Online
    (Details)
  • Malaysian Thoracic Society (MTS) 2020 Annual Congress
    10-13 December 2020, Nusajaya, Johor, Malaysia
    (Details)
  • World Conference on Lung Cancer
    26-29 January 2021, Singapore
    (Details)

For more pulmonology events, see apsresp.org/calendar.html
(These events are for information only and APSR endorsement should not be assumed.)

Contact

If you have news of interest to APSR members, please send details to one of the Bulletin Coordinators: Prof. A Azuma (a-azuma@nms.ac.jp) or Prof. C K Rhee (chinkook77@gmail.com).


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