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Asian 
Pacific 
Society of 
Respirology

APSR Respiratory Updates

(Latest issues)

Dr David CL Lam

APSR Respiratory Updates is a unique publication bringing you the most important clinical research in respiratory medicine. Each month an expert within the APSR will identify and review ten key publications in their field. In addition to a link to the publication, a brief commentary on why the study is important will be provided. This series represents an important initiative of the Education Committee of the APSR. We hope you find it informative and useful in your clinical practice.

Dr David CL Lam


Respiratory UpdatesContents
Volume 9, Issue 6
(June 2017)

APSR Pleural Update 2017

  • Effect of Opioids vs NSAIDS and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With MPE: The TIME1 RCT.
  • Randomized Trial of Pleural Fluid Drainage Frequency in Patients with Malignant Pleural Effusions – The ASAP Trial.
  • Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomized, controlled, open-label, phase 3 trial.
  • The effect of chemotherapy on health-related quality of life in mesothelioma: results from the SWAMP trial.
  • Malignant pleural fluid from mesothelioma has potent biological activities.
  • Tissue Plasminogen Activator Potently Stimulates Pleural Effusion via a Monocyte Chemotactic Protein-1-Dependent Mechanism.
  • Pleural Effusions at First ED Encounter Predict Worse Clinical Outcomes in Patients with Pneumonia.
  • Non-Malignant Pleural Effusions (NMPE): a prospective study of 356 consecutive unselected patients.
  • Management of Benign Pleural Effusions Using Indwelling Pleural Catheters. A Systematic Review and Meta-analysis.
  • ERS task force statement: diagnosis and treatment of primary spontaneous pneumothorax.
  • Novel imaging detailing the origins of a pneumothorax.
  • A Novel Device for Accurate Chest Tube Insertion: A Randomized Controlled Trial.
Volume 9, Issue 5
(May 2017)

Asthma

  • Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
  • Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation
  • An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells
  • Increased mitochondrial arginine metabolism supports bioenergetics in asthma
  • Targeting integrin alpha5beta1 ameliorates severe airway hyperresponsiveness in experimental asthma
  • Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma
  • Regulation of T cell receptor signaling by DENND1B in TH2 cells and allergic disease
  • Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells
  • DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma
  • Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma
  • Role for NLRP3 inflammasome-mediated, IL-1beta-dependent responses in severe, steroid-resistant asthma
Volume 9, Issue 4
(April 2017)

APSR Respiratory VTE Update

  • Deep vein thrombosis and pulmonary embolism.
  • Antithrombotic therapy for VTE disease: CHEST Guideline and Expert Panel report.
  • Prevalence of pulmonary embolism among patients hospitalized for syncope.
  • A new prognostic strategy for adult patients with acute pulmonary embolism eligible for outpatient therapy.
  • Pathways for outpatient management of venous thromboembolism in a UK centre.
  • Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment.
  • Clinical impact and course of major bleeding with rivaroxaban and vitamin K antagonists.
  • Cohort study on the management of cancer-associated venous thromboembolism aimed at the safety of stopping anticoagulation therapy in patients cured from cancer.
  • Testosterone treatment and risk of venous thromboembolism: population based case-control study.
  • Factors that predict thrombosis in relatives of patients with venous thromboembolism.
Volume 9, Issue 3
(March 2017)

Endobronchial Ultrasonography (EBUS)

  • Plasma Metabolomics Implicate Modified Transfer RNAs and Altered Bioenergetics in the Outcome of Pulmonary Arterial Hypertension.
  • Ultrathin Bronchoscopy with Multimodal Devices for Peripheral Pulmonary Lesions: A Randomized Trial
  • Pulmonologist-performed transoesophageal sampling for lung cancer staging using an endobronchial ultrasound video-bronchoscope: an Australian experience
  • The predictive value of endobronchial ultrasonography with a guide sheath in the diagnosis of the histologic subtypes of lung cancer
  • Endobronchial ultrasonography with guide sheath versus computed tomography guided transthoracic needle biopsy for peripheral pulmonary lesions: a propensity score matched analysis
  • Utility of endobronchial ultrasound-guided transbronchial needle aspiration in diagnosing nonspecific inflammatory intrathoracic lymphadenitis
  • Cell block samples from endobronchial ultrasound transbronchial needle aspiration provide sufficient material for ancillary testing in lung cancer – a quaternary referral centre experience
  • Accuracy and consequences of same-day, invasive lung cancer workup – a retrospective study in patients treated with surgical resection
  • Bispectral Index Monitoring Reduces the Dosage of Propofol and Adverse Events in Sedation for Endobronchial Ultrasound
  • Conventional Transbronchial Needle Aspiration Versus Endobronchial Ultrasound-guided Transbronchial Needle Aspiration, With or Without Rapid On-Site Evaluation, for the Diagnosis of Sarcoidosis: A Randomized Controlled Trial
  • Pulmonologist-performed Per-Esophageal Needle Aspiration of Parenchymal Lung Lesions Using an EBUS Bronchoscope: Diagnostic Utility and Safety
Volume 9, Issue 2
(February 2017)

Dyspnoea

I. Dyspnoea mechanisms, assessment, prevalence and clinical importance
  • An Official Thoracic Society Statement: Update on the mechanism, assessment and management of dyspnea
  • Prevalence of dyspnoea differs between countries
  • Dyspnoea is an independent predictor of mortality
  • Proactive identification and management of chronic refractory breathlessness has ethical and potentially, legal implications
  • Assessing multidimensional aspects of dyspnoea
II. Comprehensive management of dyspnoea
  • People with advanced disease report a range of self-management strategies to cope with episodic breathlessness; many of which were no/ low cost and required minimal resources
  • Five minutes exposure to a hand-held fan provided over 30 minutes relief of breathlessness for over 50% of people with refractory breathlessness at rest
  • Activity-related breathlessness in COPD; support for efficacy of bronchodilators and, in selected patients, low dose oral opioids
  • A predominantly home based, multidisciplinary Breathlessness Intervention Service (BIS) combining non-pharmacological and pharmacological strategies provided relief from breathlessness distress in people with advanced cancer
Volume 9, Issue 1
(January 2017)

Pulmonary Hypertension

  • Plasma Metabolomics Implicate Modified Transfer RNAs and Altered Bioenergetics in the Outcome of Pulmonary Arterial Hypertension.
  • Dynamic Risk Stratification of Patient Long-Term Outcome After Pulmonary Endarterectomy: Results From the United Kingdom National Cohort.
  • Initial combination therapy with ambrisentan and tadalafil and mortality in patients with pulmonary arterial hypertension: a secondary analysis of the results from the randomised, controlled AMBITION study.
  • The prognostic impact of thyroid function in pulmonary hypertension.
  • Endovascular treatment for chronic pulmonary hypertension: a focus on angioplasty for chronic thromboembolic pulmonary hypertension.
  • MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.
  • BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data me-ta-analysis.
  • Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Ge-netic Defects.
  • Diagnosis, Treatment, and Clinical Management of Pulmonary Arterial Hypertension in the Contempo-rary Era: A Review.
  • Treprostinil Administered to Treat Pulmonary Arterial Hypertension Using a Fully Implantable Pro-grammable Intravascular Delivery System: Results of the DelIVery for PAH Trial.
Respiratory Updates (archives)
2016 Archive
  • Pulmonary rehabilitation in COPD
  • Lung Development and Regeneration
  • Lymphangioleiomyomatosis
  • Obesity Hypoventilation Syndrome
  • Update in Acute Respiratory Distress Syndrome
  • Lung Transplantation
  • Lung cancer immunotherapy
  • Pneumonia
  • Updates in Pulmonary Function Testing 2012-2015
  • Pulmonary Aspergillosis
  • Updates on Bronchoscopy and Interventional Pulmonology
2015 Archive
  • Cystic Fibrosis (CF)
  • Tobacco/Smoking Cessation
  • Pulmonary Circulation
  • Idiopathic Pulmonary Fibrosis trials and Sarcoidosis
  • Mesothelioma
  • Bronchiectasis
  • APSR air pollution update
  • Induced Sputum 2015
  • Pneumothorax: Evolving Indications for Surgery
  • Non-invasive ventilation
  • Cellular and molecular biology of the lung
  • Quantitative Imaging of the Respiratory System
2014 Archive
  • COPD
  • Tuberculosis
  • Environmental and Occupational Health
  • APSR Paediatric Updates 2014
  • Pneumoconiosis and other related conditions
  • Sleep Medicine
  • Critical Care Medicine
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Venous Thromboembolism
2013 Archive
  • Fukuchi Award and Young Investigator Award Abstracts
  • Mesothelioma
  • Cystic Fibrosis and Bronchiectasis
  • Lung transplantation
  • Air Pollution
  • Induced sputum
  • Respirology Virtual Issues
  • Non-invasive ventilation
  • Monitoring free serum IgE in severe asthma patients treated with omalizumab
  • Lung Cancer Screening
  • Tuberculosis
  • Current Trends in Lung Cancer Surgery
2012 Archive
  • Progress of Pulmonary Function Testing in 2011/12
  • IPF trials and Sarcoidosis
  • Respiratory infections other than tuberculosis
  • Cell and Molecular Biology in Respirology
  • Pulmonary Circulation
  • Quantitative imaging of airways
  • Paediatric lung disease
  • Tuberculosis
  • Community and Public Health
  • Chronic obstructive pulmonary disease (COPD)
  • Epithelial-mesenchymal transition (EMT) in lung disease
  • Tobacco/Smoking cessation
2011 Archive
  • Pneumoconiosis
  • Environmental & Occupational Health
  • Bronchoscopy & Interventional Techniques
  • Sleep
  • Critical Care Medicine
  • Influenza
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Pulmonary and Systemic Venous Thromboembolism
2010 Archive
  • Community and Public Health
  • Tuberculosis
  • Tobacco/smoking cessation
  • Paediatric lung disease
  • Sleep
  • Pneumonia
  • Bronchoscopy & Interventional Techniques
  • Pleural diseases
  • Asthma
  • Critical Care Medicine
  • Interstitial Lung Disease
  • COPD & asthma: Differences & similarities
2009 Archive
  • Influenza
  • Lung Cancer
  • Venous Thromboembolism
Respiratory Research Review (archives)
2008 Archive
2007 Archive
2006 Archive

Disclaimer: The above publications are not intended as a replacement for regular medical education. The comments are an interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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