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Asian 
Pacific 
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Respirology

A selection of publications with educational value in

Clinical Respiratory Medicine

Most recently added articles listed at the top


  • Figure 2
    (Click image to enlarge)
    History of pulmonary tuberculosis affects the severity and clinical outcomes of COPD Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Deog Kyeom Kim, Yu Il Kim, Jin Young Oh, Hyoung Kyu Yoon, Kwang-Ha Yoo and Ki Suck Jung (DOI: 10.1111/resp.13147)
    onlinelibrary.wiley.com/doi/10.1111/resp.13147/full (Jan 2018)

    Comment by Dr Mark Lavercombe:
    The authors of this paper describe a cohort of patients with COPD who were stratified based on self-report of prior history of tuberculosis infection. Patients who admitted to prior Tb had more severe symptoms of COPD, poorer lung function and more frequent exacerbations. This difference was noted despite a lower prevalence of ongoing smoking in the tuberculosis group.

    20171208

  • Table 3
    (Click image to enlarge)
    Usefulness of a routine endoscopic assessment of laryngeal lesions after lung cancer surgery Alex Fourdrain, Florence De Dominicis, Jules Iquille, Sophie Lafitte, Geoni Merlusca, Alejandro Witte Pfister, Patrick Bagan and Pascal Berna (DOI: 10.1111/resp.13139)
    onlinelibrary.wiley.com/doi/10.1111/resp.13139/full (Jan 2018)

    Comment by Dr Mark Lavercombe:
    Vocal cord dysfunction is not uncommon in patients after lung cancer resection, and this study demonstrates a significant association with poor post-operative outcomes including pneumonia, need for bronchoscopy and re-intubation. The authors recommend routine laryngeal screening within 24h of surgery, although treatment outcomes were not assessed in this study.

    20171208

  • Table 3
    (Click image to enlarge)
    Natural history and clinical characteristics of multiple pulmonary nodules with ground glass opacity: Yuki Sato, DaichI Fujimoto, Takeshi Morimoto, Keiichiro Uehara, Kazuma Nagata, Ichiro Sakanoue, Hiroshi Hamakawa, Yutaka Takahashi, Yukihiro Imai and Keisuke Tomii (DOI: 10.1111/resp.13089)
    onlinelibrary.wiley.com/doi/10.1111/resp.13089/full (Nov 2017)

    Comment by Dr Mark Lavercombe:
    The authors of this paper describe the natural history of single and multiple ground glass nodules (GGN) over a 36 month period. They demonstrate that partly solid and ≥ 10mm size solitary GGN are more likely to progress, while ≥ 10 mm and past history of lung cancer were associated with progression in multiple GGN.

    20171027

  • Table 2
    (Click image to enlarge)
    Spirometry reference values for population aged 7–80 years in China: Jingzhou Zhang, Xiao Hu and Guangliang Shan (DOI: 10.1111/resp.13118)
    onlinelibrary.wiley.com/doi/10.1111/resp.13118/full (Nov 2017)

    Comment by Dr Mark Lavercombe:
    Using data from the China National Health Survey 2012–2015, the authors of this paper propose spirometry prediction equations for a general Chinese population aged 7–80 years. Their equations compare favourably to those developed in more heterogeneous cohorts.

    20171027

  • Table 5
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    Endobronchial ultrasound-guided transbronchial needle aspiration: Safe as it sounds: Preyas J Vaidya, Mohammed Munavvar, Joerg D Leuppi, Atul C Mehta & Prashant N Chhajed. (DOI: 10.1111/resp.13094)
    onlinelibrary.wiley.com/doi/10.1111/resp.13094/full (Aug 2017)

    Comment by Dr Mark Lavercombe:
    EBUS-TBNA has rapidly become the standard of care for mediastinal and hilr lymph node sampling. This systematic review outlines the range and frequency of potential complications, as well as the possibility that these reports do not represent the full scale of adverse outcomes.

    20170820

  • Table 2
    (Click image to enlarge)
    Effects of diabetes mellitus on the clinical presentation and treatment response in tuberculosis: Chi C Leung, Wing W Yew, Thomas Y W Mok, Kam S Lau, Chi F Wong, Chi H Chau, Chi K Chan, Kwok C Chang, Greta Tam & Cheuk M. Tam. (DOI: 10.1111/resp.13017)
    onlinelibrary.wiley.com/doi/10.1111/resp.13017/full (Aug 2017)

    Comment by Dr Mark Lavercombe:
    This important study demonstrates that patients with concomitant diabetes mellitus have different clinical features at diagnosis of tuberculosis, higher risk of adverse effects on treatment, slower sputum conversion, and lower treatment success at twelve months. Further data on the effect of diabetic control in patients treated for tuberculosis is required.

    20170820

  • Qualitative endobronchial ultrasound (EBUS) elastography classification of lymph nodes according to the dominant elastographic colour pattern (Figure 1)
    (Click image to enlarge)
    Diagnostic value of endobronchial ultrasound elastography for the differentiation of benign and malignant intrathoracic lymph nodes Potjanee Korrungruang and Viboon Boonsarngsuk (resp. 12832/ RES-15-983.R2)
    onlinelibrary.wiley.com/doi/10.1111/resp.12979/full (Jul 2017)

    Comment by Dr Mark Lavercombe:
    The authors of this paper outline the use of EBUS elastography for both qualitative and quantitative assessment of mediastinal lymphadenopathy for the presence of malignancy. Their promising findings suggest the need for further study to better define the elastographic features in both benign and malignant conditions, in order to guide the need for TBNA sampling.

    20170608

  • Crude survival based on cardiac troponin T (cTnT) level on admission. (Figure 1)
    (Click image to enlarge)
    High-sensitivity cardiac troponin T predicts mortality after hospitalization for community-acquired pneumonia Stefan M T Vestjens, Simone M C Spoorenberg, Ger T Rijkers, Jan C Grutters, Jurrien M ten Berg, Peter G Noordzi, Ewoudt M W van de Garde, Willem Jan W Bos and the Ovidius Study Group. (DOI: 10.1111/resp.12996)
    onlinelibrary.wiley.com/doi/10.1111/resp.12996/full (Jul 2017)

    Comment by Dr Mark Lavercombe:
    This paper demonstrates a significant relationship between levels of cardiac troponin measured at admission in patients with Community-Acquired Pneumonia and both 30-day and long-term mortality. The combination of Pneumonia Severity Index with Troponin level predicted mortality better than either model alone. These findings suggest cardiac evaluation might be worthwhile in patients with CAP and elevated Troponin.

    20170608

  • Respiratory telerehabilitation (TeleR) trial team from Sydney
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    Home-based telerehabilitation via real-time videoconferencing improves endurance exercise capacity in patients with COPD: The randomized controlled TeleR Study Ling Ling Y Tsai, Renae J McNamara, Chloe Moddel, Jennifer A Alison, David K McKenzie & Zoe J McKeough 10.1111/resp.12966 (May 2017)

    Despite the clear health benefits in COPD patients, participation in pulmonary rehabilitation is variable with potential barriers including reduced mobility, lack of transport or travel costs. This randomised controlled trial evaluates home-based telerehabilitation compared with usual care and finds improved endurance exercise capacity and self-efficacy in the treatment group. Telerehabilitation might be an alternative option for pulmonary rehabilitation in those unable to attend centralised programmes. Table 3 presents outcomes for special consideration.

    20170415
  • Pulmonary Rehabilitation Guidelines for Australia and New Zealand Jennifer A Alison, Zoe J McKeough, Kylie Johnston, Renae J McNamara, Lissa M Spencer, Sue C Jenkins, Catherine J Hill, Vanessa M McDonald, Peter Frith, Paul Cafarella, Michelle Brooke, Helen L Cameron-Tucker, Sarah Candy, Nola Cecins, Andrew S L Chan, Marita T Dale, Leona M Dowman, Catherine Granger, Simon Halloran, Peter Jung, Annemarie L Lee, Regina Leung, Tamara Matulick, Christian Osadnik, Mary Roberts, James Walsh, Sally Wootton, Anne E Holland, on behalf of the Lung Foundation Australia and the Thoracic Society of Australia and New Zealand 10.1111/resp.13025 (Apr 2017)

    The aim of these Guidelines is to provide evidence-based recommendations for the practice of pulmonary rehabilitation (PR) specific to Australian and New Zealand healthcare contexts.

    These first-ever pulmonary rehabilitation Guidelines for Australia and New Zealand were launched (24-28 March 2017) at the TSANZSRS Annual Scientific Meeting in Canberra, Australia (24-28 March 2017), and were drawn up following a systematic review of over 275 clinical trials.

    The Guidelines recommend that all COPD patients should be offered pulmonary rehabilitation regardless of their disease severity.

    See the full Editorial for these important Guidelines at onlinelibrary.wiley.com/doi/10.1111/resp.13039/full

    20170329
  • Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report Claus F Vogelmeier, Gerard J Criner, Fernando J Martinez, Antonio Anzueto, Peter J Barnes, Jean Bourbeau, Bartolome R Celli, Rongchang Chen, Marc Decramer, Leonardo M Fabbri, Peter Frith, David M G Halpin, M Victorina López Varela, Masaharu Nishimura, Nicolas Roche, Roberto Rodriguez-Roisin, Don D Sin, Dave Singh, Robert Stockley, Jørgen Vestbo, Jadwiga A Wedzicha and Alvar Agusti 10.1111/resp.13012 (Apr 2017)

    This Executive Summary focuses primarily on the revised and novel parts of the document, including:

    1. the assessment of COPD has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations;
    2. for each of the groups A to D, escalation strategies for pharmacological treatments are proposed;
    3. the concept of de-escalation of therapy is introduced in the treatment assessment scheme;
    4. nonpharmacologic therapies are comprehensively presented;
    5. the importance of comorbid conditions in managing COPD is reviewed.
    20170205

  • (Click image to enlarge)
    Characteristics, incidence and outcome of patients admitted to intensive care because of pulmonary embolism Dario Winterton, Michael Bailey, David Pilcher, Giovanni Landoni & Rinaldo Bellomo DOI: 10.1111/resp.12881
    onlinelibrary.wiley.com/doi/10.1111/resp.12881/full (Feb 2017)

    Comment by Dr Mark Lavercombe:
    This important study describes a large cohort of patients admitted with acute pulmonary embolism to Intensive Care Units across Australia and New Zealand. A subpopulation at very high risk of death is identified (those requiring mechanical ventilation). No improvement in mortality rate over time is seen.

    20170131

  • (Click image to enlarge)
    Prevalence and outcomes of diaphragmatic dysfunction assessed by ultrasound technology during acute exacerbation of COPD: A pilot study Federico Antenora, Riccardo Fantini, Andrea Iattoni, Ivana Castaniere, Antonia Sdanganelli, Francesco Livrieri, Roberto Tonelli, Stefano Zona, Marco Monelli, Enrico M Clini & Alessandro Marchioni DOI: 10.1111/resp.12916
    onlinelibrary.wiley.com/doi/10.1111/resp.12916/full (Feb 2017)

    Comment by Dr Mark Lavercombe:
    The indications for thoracic ultrasonography continue to expand, and this study suggests another indication. Diaphragmatic dysfunction found on ultrasound on admission in patients with acute hypercapnic exacerbations of COPD is identified as a risk factor for failure of NIV, duration of mechanical ventilation and short-term mortality. This non-invasive test might help clinicians identify patients at risk of failing standard care.

    20170131

  • (Click image to enlarge)
    Bronchoscopy assessment of acute respiratory failure in interstitial lung disease Antonella Arcadu & Teng Moua DOI: 10.1111/resp.12909
    onlinelibrary.wiley.com/doi/10.1111/resp.12909/full (Feb 2017)

    Comment by Dr Mark Lavercombe:
    This study examines the utility of bronchoscopy in patients admitted with acute exacerbations of interstitial lung disease. Although a relatively low diagnostic yield is identified, significant potential complications are noted and there is no in-hospital mortality benefit seen in those undergoing the procedure.

    20170131

  • (Click image to enlarge)
    Role of BMI, airflow obstruction, St George's Respiratory Questionnaire and age index in prognostication of Asian COPD. Chan et al. (resp12877/RES-16-062.R2)
    onlinelibrary.wiley.com/doi/10.1111/resp.12877/full (Jan 2017)

    Comment by Dr Mark Lavercombe:
    This study identifies important risk factors for mortality in Asian patients with COPD, and develops a prognosis model that is easy to use. Further validation studies will be required to assess its utility.

    20161220

  • (Click image to enlarge)
    Malignant pleural fluid from mesothelioma has potent biological activities. Cheah et al. (resp.12874/ RES-16-044.R1)
    onlinelibrary.wiley.com/doi/10.1111/resp.12874/full (Jan 2017)

    Comment by Dr Mark Lavercombe:
    This original article suggests that malignant pleural effusion in mesothelioma might not be purely a consequence of the malignancy, but could contribute to its pathobiology. This suggests the possibility of future therapeutic targets in this disease.

    20161220

  • (Click image to enlarge)
    Clinical impact of the interstitial lung disease Multidisciplinary service, Jo et al. DOI: 10.1111/resp.12850
    onlinelibrary.wiley.com/doi/10.1111/resp.12850/full (Jul 2016)

    Comment by Dr Mark Lavercombe:
    This study demonstrates that assessment of the diagnosis and management of interstitial lung diseases by an expert multidisciplinary panel can potentially make a major contribution to patient outcomes. A significant proportion of patients is re-classified after MDT discussion, leading to changes in management. Longer term follow-up of patient outcomes might add weight to the use of MDT discussions.

    20161021

  • (Click image to enlarge)
    Etiology of bronchiectasis in adults: a systematic literature review Gao et al. (resp. 12832/ RES-15-983.R2)
    onlinelibrary.wiley.com/doi/10.1111/resp.12832/full (Jun 2016)

    Comment by Dr Mark Lavercombe:
    This systematic review identifies regional variations in the underlying aetiologies for non-CF bronchiectasis, which is important to consider when evaluating the applicability of the bronchiectasis literature. It also provides an evidence base for the clinical workup of these patients leading to a change in management.

    20161021

  • (Click image to enlarge)
    Clinical impact of the interstitial lung disease Multidisciplinary service, Jo et al. DOI: 10.1111/resp.12850
    onlinelibrary.wiley.com/doi/10.1111/resp.12850/full (Jul 2016)

    Comment by Dr Mark Lavercombe:
    This study demonstrates that assessment of the diagnosis and management of interstitial lung diseases by an expert multidisciplinary panel can potentially make a major contribution to patient outcomes. A significant proportion of patients is re-classified after MDT discussion, leading to changes in management. Longer term follow-up of patient outcomes might add weight to the use of MDT discussions.

    20161021

  • (Click image to enlarge)
    Airway stenting in the management of iatrogenic tracheal injuries: 10-Year experience Tazi-Mezalek et al. DOI: 10.1111/resp.12853
    onlinelibrary.wiley.com/doi/10.1111/resp.12853/full (Jul 2016)

    Comment by Dr Mark Lavercombe:
    This paper describes the experience of managing a very rare complication of endotracheal intubation or tracheostomy, including the nature and anatomical distribution of the injuries. Finally, outcomes using different treatment approaches is discussed.

    20161021
  • Usefulness of transcutaneous PCO2 to assess nocturnal hypoventilation in restrictive lung disorders. Georges et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12812/full (May 2016)
    (Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12871/abstract)

    20160915
  • Need for intensive care in patients admitted for asthma: Red flags from the social history. Moghaddas et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12831/full (Jun 2016)
    (Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12870/abstract)

    20160915
  • Persistence with inhaled corticosteroids reduces the risk of exacerbation among adults with asthma: A real-world investigation. Corrao et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12791/abstract (Apr 2016)

    20160819
  • Increasing awareness of sex differences in airway diseases. Raghavan and Jain.
    onlinelibrary.wiley.com/doi/10.1111/resp.12702/abstract (Dec 2015)

    20160819
  • Insulin resistance is associated with skeletal muscle weakness in COPD. Wells et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12716/abstract (Dec 2015)

    20160819
  • Differences in baseline factors and survival between normocapnia, compensated respiratory acidosis and decompensated respiratory acidosis in COPD exacerbation: A pilot study. Lun et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12652/abstract (Oct 2015)

    20160819
  • Efficacy and tolerability of budesonide/formoterol added to tiotropium compared with tiotropium alone in patients with severe or very severe COPD: A randomized, multicentre study in East Asia. Lee et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12646/abstract (Sep 2015)

    20160819
  • Pseudomonas aeruginosa antibiotic resistance in Australian cystic fibrosis centres. Smith et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12714/abstract (Dec 2015)
    (FREE access: Editor's Choice; Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12721/abstract)

    20160819
  • Effect of long-term treatment with corticosteroids on skeletal muscle strength, functional exercise capacity and health status in patients with interstitial lung disease. Hanada et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12807/abstract (May 2016)
    (FREE access: Editor's Choice; Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12843/abstract)

    20160819
  • Interstitial lung disease associated with gemcitabine: A Japanese retrospective cohort study. Hamada et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12665/abstract (Nov 2015)

    20160819
  • Systematic review and meta-analysis of respiratory viral coinfections in children. Lim et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12741/abstract (Feb 2016)

    20160819
  • Randomized controlled trial of the effect of regular paracetamol on influenza infection. Jefferies et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12685/abstract (Dec 2015)
    (FREE access: Editor's Choice; Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12726/abstract

    20160819
  • Association of sleep apnoea with chronic kidney disease in a large cohort from Taiwan. Chu et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12739/abstract (Jan 2016)
    (FREE access: Editor's Choice; Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12796/abstract)

    20160819
  • Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials. Jullian-Desayes et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12672/abstract (Nov 2015)
    (Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12720/abstract)

    20160819