No. 136 (November 2020)

APSR News

Donations received

The following members have kindly sent their donation towards the Society's goals, as outlined at apsresp.org/members/donors.php.

Priyanka Gupta FAPSR
Akhilesh Kunoor FAPSR
Jeetendra Kumar Patra
Ali Anwar Mohammad FAPSR

The APSR is profoundly grateful for their generosity.

Assembly Virtual Meetings (AVMs)

Three meticulously-crafted symposia this month as part of the APSR's Assembly Virtual Meeting series. Free registration is now open for all three AVMs.

The symposia programme times, structure and content shown below are correct as of 28 October 2020. Please see the AVM website for the latest programmes, at apsr.info

Respiratory Infections (Non-Tuberculous) Assembly Symposium
10 November 2020, 12:00-13:45 (UTC+9) (see local times)

"Achieving Better Diagnoses and Outcomes for Patients with Respiratory Infections, With or Without a Pandemic"

Programme

Welcome message
by Dr Yoichi Nakanishi, APSR President of the APSR
Dr Assad
"Achieving Better Diagnoses and Outcomes for Patients with Respiratory Infections, With or Without a Pandemic"
the AVM's main presentation, by Dr Tufik Assad, Medical Director Critical Care Unit, Williamson Medical Center, Franklin, USA
"Comparison of CRB-65 And Quick Sequential Organ Failure Assessment (QSOFA) In Predicting Intensive Care Unit (ICU) Admission and Mortality of Adult Patients with Community Acquired Pneumonia (CAP)"
by Dr Catherine Jordan, St. Luke's Medical Center, Manila, Philippines
"Prevalence of COVID-19 in asymptomatic healthy residents of border quarantine facilities in district Khyber, Khyber Pakhtunkhwa, Pakistan"
by Dr Muhammad Imran
Institute of Hepatology, COVID-19 Hospital, Nishterabad, Peshawar, Pakistan
"Correlation of Chest CT score with baseline SpO2 on room air and laboratory findings in COVID-19 patients"
by Dr Aniket Inamdar
Omerga, India, Samarpan Clinic, India
"Management of thoracic empyema in an Australian tertiary referral hospital: A 36-month retrospective study"
by Dr Matthew Ing
Department of Respiratory and Sleep Medicine, St George Hospital, Sydney, Australia
"The effect of pulmonary rehabilitation toward duration of hospitalization, il-6 levels, respiratory muscle power in hospitalized community pneumonia patients"
by Dr Santony
Department of Respiratory and Sleep Pekanbaru, Indonesia, Brawijaya University, Indonesia
Summary
by the APSR Respiratory Infections (Non-Tuberculous) Assembly leaders
Dr Yuanlin Song, Assembly Head
Dr Chieh-Liang Wu, Assembly Head-Elect
Dr Masaki Fujita, Assembly Deputy Head

Tuesday 10 November
22:00-23:45: (9 Nov)	New York
03:00-04:45:	London
04:00-05:45:	Rome
08:30-10:15:	New Delhi, Sri Jayawardenepura Kotte
09:00-10:45:	Dhaka
10:00-11:45:	Bangkok, Hanoi, Jakarta
11:00-12:45:	Beijing, Hong Kong, Kuala Lumpur, Manila, Perth, Singapore, Taipei, Ulaanbaatar
12:00-13:45:	Seoul, Tokyo
13:30-15:15:	Adelaide
14:00-15:45:	Sydney
16:00-17:45:	Wellington

Free registration to this event is now open at us02web.zoom.us/ webinar/ register/ WN_BxSHK6sm R9C2GQDBQ9pVOA

Sponsor: BioMérieux and BioFire

Respiratory Structure and Function Assembly Symposium
21 November 2020, 16:00-17:45 (UTC+9) (see local times)

"Exploring The Small Airway Disease"

Programme

Welcome message
by Dr Yoichi Nakanishi, APSR President of the APSR
Prof. Papi
"Exploring The Small Airway Disease"
the AVM's main presentation, by Prof. Alberto Papi, St. Anna University Hospital, Ferrara, Italy
"Disproportionally impaired diffusion capacity relative to airflow limitation in COPD"
by Dr Naoya Tanabe
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
"Quantitative Analysis of Chest Computed Tomography in Idiopathic Pulmonary Fibrosis: Parenchymal Analysis on a Regional Basis"
by Dr Tomohiro Handa
Department of Advanced Medicine for Respiratory Failure / Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan
"Investigation of airway oscillometry indices in post-lung transplantation: a cross-sectional assessment"
by Dr Joan P Y Sim
St. Vincent's Clinical School, University of New South Wales, Faculty of Medicine, Sydney, Australia
Summary
by the APSR Respiratory Structure and Function Assembly leaders
Dr Hajime Kurosawa, Assembly Head
Dr Greg King, Assembly Head-Elect
Dr Tsuyoshi Oguma, Assembly Deputy Head

Saturday 21 November
02:00-03:30:	New York
07:00-08:30:	London
08:00-09:30:	Rome
12:30-14:00:	New Delhi, Sri Jayawardenepura Kotte
13:00-14:30:	Dhaka
14:00-15:30:	Bangkok, Hanoi, Jakarta
15:00-16:30:	Beijing, Hong Kong, Kuala Lumpur, Manila, Perth, Singapore, Taipei, Ulaanbaatar
16:00-17:30:	Seoul, Tokyo
17:30-19:00:	Adelaide
18:00-19:30:	Sydney
20:00-21:30:	Wellington

Free registration to this event is now open at us02web.zoom.us/ webinar/ register/ WN_HJv_PmhCQdCm CIkfrMIcOg

Sponsor: Orient EuroPharma

Asthma Assembly Symposium
28 November 2020 16:00-17:45 (UTC+9) (see local times)

"Asthma Paradoxes"

Programme

Welcome message
by Dr Yoichi Nakanishi, APSR President of the APSR
Prof. Wang
"Asthma Paradoxes"
the AVM's main presentation, by Prof. Hao-Chien Wang
National Taiwan University Hospital, Taiwan
Deputy Head of the APSR COPD Assembly
"Incense smoke induces airway hyperresponsiveness, alterations of tight junction proteins and loss of airway epithelial barrier integrity via oxidative stress"
by Dr Keiko Kan-o
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Japan
"Airway TNF-LIGHT expression and associated molecular inflammatory profiles in asthma patients with persistent airflow limitation"
by Dr Tsunahiko Hirano
Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Japan
"Upregulated type 2 cytokine-induced STAT6 interferes with IFN-STAT1 mediated anti-viral responses in rhinovirus infected bronchial epithelial cells in asthma"
by Dr Lan Wei
Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia
"Elevated serum free fatty acids may be a risk factor of adult onset asthma: Nagahama Study"
by Dr Noriyuki Tashima
Department of Respiratory Medicine, Graduate School of Medicine Kyoto University, Japan
"Epidemiology of bronchial asthma during pregnancy: A cross-sectional study of pregnant women attending antenatal clinic at Teaching Hospital Peradeniya, Sri Lanka."
by Dr Duminda Yasaratne
Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka
Summary
by the APSR Asthma Assembly leaders
Dr Kang-Yun Lee, Assembly Head
Dr Phuong Phan Thu, Assembly Head-Elect
Dr Shih-Lung Cheng, Assembly Deputy Head

Saturday 28 November
02:00-03:45:	New York
07:00-08:45:	London
08:00-09:45:	Rome
12:30-14:15:	New Delhi, Sri Jayawardenepura Kotte
13:00-14:45:	Dhaka
14:00-15:45:	Bangkok, Hanoi, Jakarta
15:00-16:45:	Beijing, Hong Kong, Kuala Lumpur, Manila, Perth, Singapore, Taipei, Ulaanbaatar
16:00-17:45:	Seoul, Tokyo
17:30-19:15:	Adelaide
18:00-19:45:	Sydney
20:00-21:45:	Wellington

Free registration to this event is now open at us02web.zoom.us/ webinar/ register/ WN_fFzHqRAP RHiYlXn4QcFaWQ

Sponsor: AstraZeneca

AVM Abstracts

For each Symposium, authors of some of the best abstracts have been invited to present at the Assembly Virtual Meeting. Their abstracts will also be published in a special Assembly Virtual Meeting Respirology Supplement.

Other accepted abstracts which couldn't be included in the programme are published on the APSR website: apsresp.org/archive/avm/abstract-index.html.

For the latest AVM news, see apsr.info

Inside Respirology

Respirology Volume 25 Issue 11

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page
EDITORIALS
1110	Bringing COPD control into the consultation Christine R Jenkins MBBS, MD, FRACP 10.1111/resp.13884
1112	Diagnosing idiopathic pulmonary fibrosis: Has the time for surgical lung biopsy passed? Laura M Glenn BMed, MD; Tamera J Corte BSc (Med), MBBS (Hons), FRACP, PhD 10.1111/resp.13909
1114	The 4-min mile and supplemental oxygen in IPF Jeffrey J Swigris DO, MS 10.1111/resp.13890
1116	Endobronchial coils for emphysema: Do they work and why? Sakhee Kotecha MBBS, FRACP; Trevor J Williams MBBS, MD, FRACP 10.1111/resp.13895
1119	Loop gain in paediatric sleep-disordered breathing: A different story from adults Raouf Amin MD; Michael Khoo PhD 10.1111/resp.13897
COMMENTARIES
1121	Exposure to bushfire and biomass smoke and the risk of bacterial and viral lung infection Shakti D Shukla MSc, PhD; Ronan F O'Toole BA(Mod), PhD 10.1111/resp.13908
1123	Predictors of response to anti-IL-5 biologics Parameswaran Nair MD, PhD, FRCP, FRCPC 10.1111/resp.13926
1126	3D printed airway simulators: Adding a dimension to bronchoscopy training Tracy L Leong MBBS (Hons), FRACP, MPH, PhD; Jasun Li BBMed 10.1111/resp.13933
1129	Concise guidance for COPD Eli Dabscheck MBBS (Hons), M Clin Epi, FRACP; Christine F McDonald AM, MBBS (Hons), PhD, FRACP, FCCP, FThorSoc; Ian A Yang MBBS (Hons), PhD, FRACP, FAPSR, FThorSoc, Grad Dip Clin Epid 10.1111/resp.13934
1133	Respiratory management of adult patients with acute respiratory distress syndrome due to COVID-19 Priyanka Makkar MD; Stephen M Pastores MD, MACP, FCCP, FCCM 10.1111/resp.13941
ORIGINAL ARTICLES
COPD
1136	Predictive value of control of COPD for risk of exacerbations: An international, prospective study Marc Miravitlles, Pawel Sliwinski, Chin Kook Rhee, Richard W Costello, Victoria Carter, Jessica H Y Tan, Therese S Lapperre, Bernardino Alcazar, Caroline Gouder, Cristina Esquinas, Juan Luis García-Rivero, Anu Kemppinen, Augustine Tee, Miguel Roman-Rodríguez, Juan José Soler-Cataluña, David B Price on behalf of the Respiratory Effectiveness Group (REG) 10.1111/resp.13811 The concept of control has been well defined in asthma. We have validated the proposal of control status in COPD consisting of easy-to-obtain clinical variables. Patients controlled had a reduced risk of exacerbations compared to uncontrolled patients.
Interstitial Lung Disease
1144	Disease progression across the spectrum of idiopathic pulmonary fibrosis: A multicentre study Giacomo Sgalla, Erminia Lo Greco, Mariarosaria Calvello, Francesco Varone, Bruno Iovene, Stefania Cerri, Pierluigi Donatelli, Ada Vancheri, Mauro Pavone, Fabrizio Luppi, Carlo Vancheri, Luca Richeldi 10.1111/resp.13805 Disease behaviour is consistent across diagnostic categories of IPF in a real-life clinical setting of patients receiving antifibrotic therapies. If SLB is contraindicated, expert ILD multidisciplinary teams may consider a prompt initiation of treatment when diagnostic confidence for IPF is sufficiently high.
1152	Supplemental oxygen improves exercise capacity in IPF patients with exertional desaturation Shinichi Arizono, Taiki Furukawa, Hiroyuki Taniguchi, Koji Sakamoto, Tomoki Kimura, Kensuke Kataoka, Tomoya Ogawa, Fumiko Watanabe, Yasuhiro Kondoh 10.1111/resp.13829 In mild–moderate IPF with exercise-induced hypoxaemia even without resting hypoxaemia, supplemental oxygen during exercise improved the endurance time, desaturation and subjective symptoms.
Interventional Pulmonology
1160	Endobronchial coils for emphysema: Dual mechanism of action on lobar residual volume reduction Jorine E Hartman, Pallav L Shah, Frank Sciurba, Felix J F Herth, Dirk-Jan Slebos on behalf of the RENEW Study Group 10.1111/resp.13816 Residual lobar volume reduction in treated lobes measured by QCT was found to be the driving mechanism of action of endobronchial coils leading to positive clinical outcomes. However, the improvement in exercise capacity and quality of life seems to be affected by the presence of cardiac disease.
Pleural Disease
1167	Role of early definitive management for newly diagnosed malignant pleural effusion related to lung cancer Ka-Yan Chiang, James Chung-Man Ho, Peony Chong, Terence Chi-Chun Tam, David Chi-Leung Lam, Mary Sau-Man Ip, Yun-Chor Gary Lee, Macy Mei-Sze Lui 10.1111/resp.13812 The availability of efficacious anti-cancer treatments, including oral targeted therapy, do not obviate the need of definitive measures for MPE in newly diagnosed lung cancer. Both early MPE control measures and cancer treatments are warranted to minimize the need of pleural re-interventions in the course of malignancy.
Sleep and Ventilation
1174	Role of ventilatory control instability in children with sleep-disordered breathing Leon S Siriwardhana, Aidan Weichard, Gillian M Nixon, Margot J Davey, Lisa M Walter, Bradley A Edwards, Rosemary S C Horne 10.1111/resp.13809 The role of physiological traits such as ventilatory control instability in children with SDB is currently unclear. Our study indicates that altered ventilatory control sensitivity may contribute to SDB in a subgroup of children, depending on their degree of upper airway anatomical compromise.
POSITION STATEMENTS
1183	Work-related asthma: A position paper from the Thoracic Society of Australia and New Zealand and the National Asthma Council Australia Ryan Hoy, Jonathan Burdon, Ling Chen, Susan Miles, Jennifer L Perret, Shivonne Prasad, Naghmeh Radhakrishna, Janet Rimmer, Malcolm R Sim, Deborah Yates, Graeme Zosky 10.1111/resp.13951
1193	Respiratory surveillance for coal mine dust and artificial stone exposed workers in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand* Jennifer L Perret, Susan Miles, Fraser Brims, Katrina Newbigin, Maggie Davidson, Hubertus Jersmann, Adrienne Edwards, Graeme Zosky, Anthony Frankel, Anthony R Johnson, Ryan Hoy, David W Reid, A William Musk, Michael J Abramson, Bob Edwards, Robert Cohen, Deborah H Yates 10.1111/resp.13952
FORUM AND DEBATE
Scientific Letter
1203	Role of endobronchial ultrasound strain elastography in the identification of fibrotic lymph nodes in sarcoidosis: A pilot study Rocco Trisolini, Roel L J Verhoeven, Alessandra Cancellieri, Annalisa De Silvestri, Filippo Natali, Erik H F M Van der Heijden 10.1111/resp.13900
Correspondences
1207	Early pleural effusion control in patients with lung cancer Shinichiro Okauchi MD; Katsunori Kagohashi MD, PhD; Toshihiro Shiozawa MD, PhD Kunihiko Miyazaki MD, PhD; Hiroaki Satoh MD, PhD 10.1111/resp.13902
1208	Reply Ka-Yan Chiang MBBS, FHKCP, FHKAM; Macy Mei-Sze Lui MBBS, FHKCP, FHKAM 10.1111/resp.13899
1209	Severe COVID-19 and interleukin-6 receptor antagonist tocilizumab: Some notes of concern Karolina Akinosoglou MD, PhD; Charalambos Gogos MD, PhD 10.1111/resp.13939
1210	Reply Stefano Savinelli MD; Cormac McCarthy MD, PhD; Patrick W Mallon MD, PhD; All Ireland Infectious Diseases (AIID) Cohort Collaborators 10.1111/resp.13940
LETTER FROM ASIA-PACIFIC AND BEYOND
1212	Letter from New Zealand Robert J Hancox MD 10.1111/resp.13931
1214	Letter from Iran: Experiences with COVID-19 Ebrahim Abbasi-Oshaghi PhD; Fatemeh Mirzaei PhD; Iraj Khodadadi PhD 10.1111/resp.13948
CORRIGENDUM
1216	Corrigendum 10.1111/resp.13944 This article corrects Technologies for targeting the peripheral pulmonary nodule including robotics. Respirology 2020; 25: 914–923. 10.1111/resp.13791

Inside Respirology Case Reports

Respirology Case Reports, Volume 08 Issue 8

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Case Series

COVID-19 rehabilitation delivered via a telehealth pulmonary rehabilitation model: a case series

Sally L Wootton, Meredith King, Jennifer A Alison, Sri Mahadev, Andrew S L Chan
DOI: 10.1002/rcr2.669

In the Australian healthcare context, it is early days in our understanding of the short and longer term rehabilitation needs of those recovering from coronavirus disease 2019 (COVID-19) (novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)). We present the rehabilitation journey of our first three cases, and discuss patient management and outcomes via a telehealth pulmonary rehabilitation model of care

Case Reports

Relapsing paradoxical reaction in miliary tuberculosis: a case report and literature review

Abdullah Mobeireek, Nasser A Al Shekail
DOI: 10.1002/rcr2.658

Worsening of miliary tuberculosis after initiation of anti-tuberculous therapy is uncommon but is potentially serious and can cause diagnostic confusion. It is, therefore, prudent to recognize this phenomenon and manage it appropriately with corticosteroid therapy.

Pleural effusion revealing a ruptured mediastinal mesothelial cyst

Ahmed Ben Saad, Saousen Cheikh Mhamed, Asma Migaou, Asma Achour, Naceur Rouatbi, Samah Joobeur
DOI: 10.1002/rcr2.659

We report a rare case of a mediastinal mesothelial cyst discovered after rupture in the pleural cavity in a 28-year-old man. The diagnosis of this complicated mesothelial cyst relied on intraoperative and anatomopathological findings. To the best of our knowledge, we report the first case of a pleural effusion revealing a ruptured mediastinal coelomic cyst into the pleural cavity.

Empyema thoracis complicated by anaemia as caused by occult bonelet aspiration

Sen-Ei Shai, Yi-Ling Lai, Hsiao-Wen Tang, Shih-Chieh Hung
DOI: 10.1002/rcr2.661

We describe the successful treatment of an adult patient who presented to our hospital with the serious condition of empyema complicated by anaemia due to occult bonelet aspiration.

Worsening respiratory failure in an adult hydrocephalic patient with a ventriculo-pleural shunt

Edmond Wong, Vishnu Jeganathan, Samuel Wreghitt, Gavin Davis, Hari Wimaleswaran, Mark E Howard
DOI: 10.1002/rcr2.660

We present a case of an adult hydrocephalic patient with a ventriculo-pleural shunt in situ presenting with worsening respiratory failure in the setting of a massive cerebrospinal fluid hydrothorax.

Management of necrotizing pneumonia with bronchopleural fistula caused by multidrug-resistant Acinetobacter baumannii

Allen Widysanto, Maranatha Liem, Karina Dian Puspita, Cindy Meidy Leony Pradhana
DOI: 10.1002/rcr2.662

We present a case of necrotizing pneumonia (NP) caused by multidrug-resistant Acinetobacter baumannii that also complicated by hydropneumothorax and bronchopleural fistula (BPF). Despite optimal antibiotic therapy, BPF and necrotic tissue often fail to resolve and surgical debridement or resection is required. This report highlights our approach and management for patients with severe NP caused by multidrug-resistant microorganisms including timing to perform surgery and choice of antimicrobial treatment.

A challenging diagnosis of malignant mesothelioma with osteosarcomatous differentiation metastasizing to bone

Michael Brown, Hubertus Jersmann, Thomas Crowhurst, Chris Van Vliet, Gareth Crouch, Arash Badiei
DOI: 10.1002/rcr2.664

We present a case of bony metastasis from a rare histological subgroup of malignant pleural mesothelioma. The diagnosis was challenging; however, modern immunohistochemistry and molecular testing provided a diagnostic opportunity and potentially saved further unnecessary investigation.

Idiopathic hypereosinophilic syndrome in remission with benralizumab treatment after relapse with mepolizumab

Koki Fujii, Hidenori Takahashi, Nami Hayakawa, Yoshinobu Iwasaki
DOI: 10.1002/rcr2.665

We report a patient with idiopathic hypereosinophilic syndrome (I-HES) who achieved remission with benralizumab after relapsing on mepolizumab. We believe this report may help develop novel therapeutic strategies for I-HES.

Interrelated atrial fibrillation and leaks triggering and maintaining central sleep apnoea and periodic breathing in a CPAP-treated patient

Arnaud Prigent, Anne-Laure Serandour, Régis Luraine, Jean Sébastien Poineuf, Christian Bosseau, Jean-Louis Pépin
DOI: 10.1002/rcr2.666

Prior to acute cardiac failure triggered by atrial fibrillation, data from the patient's continuous positive airway pressure (CPAP) device demonstrated the progressive development of high residual central apnoea–hypopnoea index with Cheyne–Stokes respiration (CSR) that both decreased after cardioversion with normalization of cardiac rhythm and function, decrease in periodic breathing cycle length, and improvement in left ventricular ejection fraction (LVEF). CSR episodes were exacerbated by ventilation overshoots following micro-arousals induced by leaks.

Hyper-progressive disease after immune checkpoint inhibitor in SMARCA4-deficient small-cell lung carcinoma

Yosuke Chiba, Toshinori Kawanami, Kei Yamasaki, Keigo Uchimura, Atsuji Matsuyama, Kazuhiro Yatera
DOI: 10.1002/rcr2.667

Herein, we report a patient with SMARCA4 (switch/sucrose non-fermentable-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4)-deficient small-cell lung carcinoma (SCLC) who had hyper-progressive disease (HPD) after the first immune checkpoint inhibitors (ICI) treatment. A 35-year-old man was treated with nivolumab, subsequent to cytotoxic chemotherapy. A week after nivolumab initiation, chest computed tomography revealed marked increase in pleural effusion in the right lung and chest wall dissemination of the tumour, which concur with the definition of HPD. This is the first study to report the occurrence of HPD after treatment with ICIs in a patient with SMARCA4-deficient SCLC. Analysis of additional data is necessary to determine the optimal treatment for these patients.

Primary CD20-positive mediastinal diffuse large B-cell lymphoma

Wulyo Rajabto, Dimas Priantono
DOI: 10.1002/rcr2.668

Primary mediastinal B-cell lymphoma (PMBCL) is a rare tumour with different characteristics from other type of lymphomas. Clinical manifestations may vary and cause delay in diagnosis and management. We reported a patient with PMBCL diagnosis and good response to treatment.

Severe Nocardia pneumonia in an immunocompromised patient with alpha-1 antitrypsin deficiency

Daryl E C Y Chan, Dima Hamed, Daniel Lennon, Peter Wark
DOI: 10.1002/rcr2.670

Pulmonary nocardiosis is an uncommon pulmonary infection that is more likely found in immunocompromised patients with underlying chronic lung disease. The presentation of pulmonary nocardiosis is widely variable and shares features with other types of pulmonary infections. Nocardia is also not as easily isolated on standard culture mediums and hence more difficult to identify. We describe the case of a patient with a severe necrotizing pneumonia who was chronically immunosuppressed with steroids and has alpha-1 antitrypsin deficiency.

Mucosa-associated lymphoid tissue lymphoma with isolated endobronchial involvement

Ting-Yu Liao, Chien-Chin Lin, Chang-Tsu Yuan, Ching-Kai Lin, Chao-Chi Ho
DOI: 10.1002/rcr2.672

We describe a case of primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma presented as an endobronchial tumor without lung parenchymal involvement.

Successful prone positioning after recent caesarean section in severe ARDS with postpartum pulmonary haemorrhage

Vorakamol Phoophiboon, Thitiwat Sriprasart
DOI: 10.1002/rcr2.673

We report a patient with severe acute respiratory distress syndrome (ARDS) and bleeding diathesis post-caesarean section resulting from acute chorioamnionitis with septic shock in whom prone positioning was a rescue procedure to improve oxygenation in the context of the patient's severe condition.

Granulomatosis (Wegener's granulomatosis) with polyangiitis presented as pulmonary manifestation: a case report

Qusay Jummaa Lazim, Sinan Shakir Gheni Atrah, Khalid Jawad Mutlag, Haider Saadoon Qasim Alhilfi, Ahmed Muhi Fahad, Ahmed Salih Alshewered
DOI: 10.1002/rcr2.674

The diagnosis of vasculitis is often delayed because several other disorders may mimic the same clinical manifestations; therefore, the knowledge of the main radiographic and high-resolution computed tomography (HRCT) findings, in association with clinical, laboratory, and serum data, often enables non-invasive diagnosis of pulmonary vasculitis.

Clinical Image

The focal hepatic hot spot sign with lung cancer in computed tomography

Van Trung Hoang, Nhu Quynh Vo, Cong Thao Trinh, Hoang Quan Nguyen, Vichit Chansomphou, Trong Binh Le
DOI: 10.1002/rcr2.671

The focal hepatic hot spot sign appears as an area of intense focal wedge-shaped enhancement of the liver in the computed tomography images. We present this sign in a 60-year-old man with superior vena cava obstruction caused by lung cancer.

Regional society news

The spotlight this month is on

MALAYSIA

Each month we share details of activities of a particular country, region or society.

If you would like the spotlight to be on your country, region or society next month, contact the Bulletin Coordinator or APSR Secretariat.

The MTS (TSPCCM) will hold an online symposium on "Lung Cancer" on Friday 11 December.

This will be Malaysia's first MTS – APSR Joint Symposium and the APSR speakers will be Dr Kwun Fong (Australia), Dr David CL Lam (Hong Kong) and Dr Alan D L Sihoe (Hong Kong).

If you are a member of an en bloc society and wish to take advantage of holding a joint symposium and you annual conference, see details at En Bloc Society - APSR Joint Symposium.

The MTS organize many activities throughout the year and here are some of their events held last year.

Malaysian Thoracic Society Annual Congress
Malaysian Thoracic Society Annual Congress
18-21 July 2019, Royale Chulan Hotel, Kuala Lumpur, Malaysia
Spirometry for Primary Care Practitioners
7 March 2019, Medical Campus, Sultan Zainal Abidin University (Unisza) Kuala Terengganu, Malaysia
Paediatric Respiratory Radiology Workshop
16 March 2019, Auditorium Hospital Serdang, Selangor, Malaysia
Kidz Asthma Workshop
23 March 2019, Th Hotel & Convention Centre, Terengganu, Malaysia
Penang Respiratory Conference
5-7 April 2019, Bayview Hotel, Georgetown, Penang, Malaysia
Interstitial Lung Disease Workshop
2-3 May 2019, Auditorium, UITM Sungai Buloh Campus, Selangor, Malaysia
Terengganu Respiratory Update
16-17 June 2019, Hotel Paya Bunga, Kuala Terengganu, Terengganu, Malaysia
MTS Spirometry Certification Programme Phase 1 Course
20-21 April 2019, Skill Laboratory, Selayang Campus UITM, Selangor, Malaysia
Spirometry Certification Course Phase 3
3-4 August 2019, Uitm Selayang Campus, Selangor Malaysia
Lung Cancer Preceptorship for Chest Trainees (Cultivate)
20-21 September 2019, MTS Office, Plaza Sentral, Kuala Lumpur Malaysia

See the full Councillor's report at apsresp.org/about/councillor-reports/2019/malaysia.php, which includes over 50 images, including the following.

(Click any image to enlarge.)

Executive Officers

President	Assoc Prof Pang Yong Kek
Vice President	Assoc Prof Ahmad Izuanuddin Ismail
Hon Secretary	Dr Hooi Lai Ngoh
Hon Treasurer	Dr Jessie Anne de Bruyne
Hon Asst Secretary	Dr Lalitha Pereirasamy
Hon Asst Treasurer	Dr Asiah Kassim
Committee Members	Dr Nurhayati Mohd Marzuki
	Dr Fauzi Mohd Anshar
	Dr Jiunn Liang Tan
	Dr Su Siew Choo
Co-Opted Committee Member	Prof Roslina Abdul Manap
Hon Auditors	Dato' Dr Ismail Yaacob
	Prof Liam Chong Kin

Other regional news:

Bangladesh

Congratulations to the officers and members of the Bangladesh Lung Foundation (BLF) on their settlement into their smart new offices. Make a note of their new address:

The Bangladesh Lung Foundation
Emporium (4th Floor)
14/1, Mirpur Road, Shyamoli
Dhaka-1207
Bangladesh
bdlungfoundation.org

Clearly useful workspace for planning their next activities!

(Click any image to enlarge)

Hong Kong

The Hong Kong Thoracic Society will hold their Autumn Respiratory Seminar on Saturday 7 November 2020.

Registering and joining the event could not be easier - it's all online!

See the registration procedure at hktsmeetings.com/ARS/reginfo.html

The broad symposia of interesting and relevant topics covered in depth by eminent speakers include:

Respiratory Infection
Professor David Hui and Dr Man-po Lee
COVID-19
(speaker TBC)
New Drugs and Regimens for the Treatment of Multidrug-resistant Tuberculosis
Dr Yong-soo Kwon (Republic of Korea)
Flu Preparedness for the Upcoming Winter Surge
Dr Albert Osterhaus (The Netherlands)
COPD
Dr Johnny Chan and Dr David Lam
Full details
Benefit-risk of Inhaled Corticosteroids in COPD
Professor Brian Lipworth (UK)
Advances in COPD Therapy
Professor Peter Barnes (UK)
Airway Diseases
Dr Fanny Ko and Dr. Loletta So
SSc-ILD Diagnosis and Management
Dr Anna Maria Hoffman Vold (Norway)
Latest Development in Severe Asthma Treatment
Professor Ian Pavord (UK)

For further details scan the QR code above of see hkts.hk/index/meetings/hkts-chest-meetings/autumn-respiratory-seminar?detail=1&aid=1505

Singapore

The Singapore Thoracic Society (STS) Annual General Meeting (AGM) was held as an online Zoom event on 29 August 2020.

Their AGM was well attended, and apart from presenting reports pertaining to annual events and finances, an online poll was conducted to ascertain member's preferences on future webinar events of the society.

The STS also conducted a COVID-19 webinar to keep our members up-to-date on this condition. We were honoured to have Professor James Chalmers, School of Medicine, University of Dundee, Scotland, UK present to us on the Recovery Trial and new European Respiratory Society Guidelines on COVID. Our second speaker, Doctor Kenneth Kwan, Radiologist of Tan Tock Seng Hospital, presented on key radiologic imaging findings in COVID. Our two speakers were engaging and this encouraged an enthusiastic discussion amongst our STS members about this important topic.

Taiwan

The Taiwan Society of Pulmonary and Critical Care Medicine (TSPCCM) will hold an online symposium with the theme "Updated management of COVID-19" on Saturday 12 December.

This will be Taiwan's first TSPCCM – APSR Joint Symposium and the APSR speakers will be Dr Yoichi Nakanishi (Japan) and Dr Rex Yung (USA).

All countries in the region

World COPD Day will be 18 November 2020. Let us know your society's activities to celebrate that Day, which can be featured in the next issue of the Bulletin. Email APSRinfo@theapsr.org

And as always, space in the Bulletin can be made to report any of your activities, big or small, past, present or future, to let the world know what you are doing!

Health news

New Respirology articles on the coronavirus

Attenuating COVID-19 infection and inflammation: Lessons from asthma
Philip G Bardin FRACP, PhD Sebastian L Johnston FRCP, PhD; DOI: 10.1111/resp.13961
First published 13 October 2020
Letter from Indonesia
Faisal Yunus MD, PhD, FCCP, FISR Sita Andarini MD, PhD, FISR; DOI: 10.1111/resp.13953
First published 7 October 2020
Pulmonary rehabilitation in COVID-19 pandemic era: The need for a revised approach
Ajay Prashad Gautam PhD Ross Arena PhD, PT2 Snehil Dixit MPT, PhD Audrey Borghi-Silva PhD, PT; DOI: 10.1111/resp.13946
First published 21 September 2020
Severe COVID-19 and interleukin-6 receptor antagonist tocilizumab: Some notes of concern
Karolina Akinosoglou MD, PhD Charalambos Gogos MD, PhD; DOI: 10.1111/resp.13939
First published 20 September 2020

Recent Respirology Case Reports on the coronavirus

COVID-19 rehabilitation delivered via a telehealth pulmonary rehabilitation model: a case series
Sally L Wootton; Meredith King; Jennifer A Alison; Sri Mahadev; Andrew S L Chan; DOI: 10.1002/rcr2.669
First published 7 October 2020

World Lung Day

World Lung Day (WLD), 25 September, is now over for another year. Thank you to all APSR members who signed up as partners and got involved in this lung health advocacy day.

This year was certainly different, very few organisations could hold physical events, but this led to great creatively and some brilliant virtual events.

Now in its fourth year, WLD has continued to grow year-on-year. There are now 198 organisations signed up as partners. Across social media, posts about WLD were seen by an estimated 49 million people, which is a 277% increase on last year.

If you haven't signed up as a WLD partner yet please email lisa.roscoe@firsnet.org to be included in our partner list and receive the 2021 toolkit directly.

Lisa Roscoe
FIRS Communications Officer

firsnet.org/index.php/news-and-events/news-article/150-world-lung-day-25-september-2020

The Philippine College of Chest Physicians commemorated National Lung Month during the whole month August 2020 with the theme "Facing the Challenges of a New Normal". The advocacy activity culminated on 25 September 2020 in time for the World Lung Day celebration. They had lots of activities and produced a fantastic lung health video, as shown in last month's Bulletin.
The Lung Foundation of India held a webinar on the importance of breathing clear air and causes of air pollution.
The Bangladesh Lung Foundation held many activities such as a radio and TV talk on lung health, online quiz competition for health professionals, online CME on COVID radiology, special poster publication on World Lung Day to create awareness and online round table discussion on lung health.
Healthy Lungs Nepal held a social media art and video competition with the theme of air quality, stop smoking and respiratory health during COVID-19. They also held a spirometry and awareness event in COPD in a rural municipality of Western Nepal.
The Chronic Obstructive Pulmonary Disease Association (Singapore) created a lung health awareness video for World Lung Day.
The Indian Academy of Respiratory Care organised a three-day webinar series in collaboration with various leading institutions in India.
The World Lung Foundation of India took part in the World Lung Day Pledge campaign and also conducted a lung health survey.

Education

Teaching Library

The Teaching Library is open for your self-study. Challenging yourself to choose the correct procedure for any of the cases in the Library at apsresp.org/education/teaching-library/index.php.

Many more cases are needed for this Library and any member is welcome to submit a case (or cases!) through the same link as above.

APSR Membership

New Fellows of the APSR

Congratulations to the following members who have recently become Fellows of the APSR:

Priyanka Gupta FAPSR
Muralidhara Reddy Kona FAPSR
Akhilesh Kunoor FAPSR
Asmita Anilkumar Mehta FAPSR
Ali Anwar Mohammad FAPSR
Avinash Murugan FAPSR
Jeetendra Kumar Patra FAPSR

New and updated assembly memberships

A warm welcome to the following members who have recently joined or re-joined APSR assemblies.

Ritesh Agarwal	Clinical Allergy & Immunology Bronchoscopy and Interventional Techniques Interstitial Lung Disease
Arvindran Alaga	Bronchoscopy and Interventional Techniques Tuberculosis Interstitial Lung Disease
Ravicharan Avala	Bronchoscopy and Interventional Techniques Critical Care Medicine Respiratory Neurobiology and Sleep
Muhammed Anas Ayoob	Asthma Interstitial Lung Disease Respiratory Infections (non-tuberculous)
Mulkan Azhary	Clinical Respiratory Medicine Respiratory Structure and Function Asthma
Anirudh Kumar Bokka	Bronchoscopy and Interventional Techniques Interstitial Lung Disease Lung Cancer
Naricha Chirakalwasan	Respiratory Neurobiology and Sleep Clinical Respiratory Medicine Critical Care Medicine
Abhradip Das	Clinical Respiratory Medicine Critical Care Medicine Interstitial Lung Disease
John Ray Galamay	COPD Tuberculosis Critical Care Medicine
Priyanka Gupta	Clinical Respiratory Medicine Critical Care Medicine Bronchoscopy and Interventional Techniques
Tomohiro Handa	Interstitial Lung Disease Respiratory Structure and Function Pulmonary Circulation
Muhammad Imran	Clinical Respiratory Medicine Asthma Respiratory Infections (non-tuberculous)
Aniket Vilasrao Inamdar	Clinical Respiratory Medicine Respiratory Infections (non-tuberculous) Critical Care Medicine
Matthew Ing	Respiratory Infections (non-tuberculous) Lung Cancer
Catherine Jordan	Respiratory Infections (non-tuberculous) Critical Care Medicine Respiratory Structure and Function
Takayuki Jujo	Pulmonary Circulation Cell and Molecular Biology Respiratory
Sanath Thushara Kudagammana	Clinical Allergy & Immunology Paediatric Lung Disease Asthma
Akhilesh Kunoor	Tuberculosis COPD Clinical Respiratory Medicine
Asmita Anilkumar Mehta	Clinical Respiratory Medicine Lung Cancer Interstitial Lung Disease
Ali Anwar Mohammad	(not yet decided)
Heda MeLinda Nataprawira	Tuberculosis Asthma Clinical Respiratory Medicine
Anna Marie Nathan	Paediatric Lung Disease Respiratory Infections (non-tuberculous) Respiratory Neurobiology and Sleep
Tashima Noriyuki	Asthma Clinical Respiratory Medicine Clinical Allergy & Immunology
Jeetendra Kumar Patra	Bronchoscopy and Interventional Techniques Critical Care Medicine Lung Cancer
Muhammad Khairul Taufiq Rosli	Lung Cancer Bronchoscopy and Interventional Techniques Clinical Respiratory Medicine
Santony Santony	Respiratory Infections (non-tuberculous)
Jakeer Hussain Shaik	COPD Tuberculosis Critical Care Medicine
H'ng Shih Ying	Paediatric Lung Disease Bronchoscopy and Interventional Techniques Respiratory Infections (non-tuberculous)
Joan Pei Yun Sim	Clinical Respiratory Medicine Respiratory Structure and Function
Anand Singh	Clinical Respiratory Medicine Respiratory Neurobiology and Sleep Interstitial Lung Disease
Gurmeet Singh	Bronchoscopy and Interventional Techniques Respiratory Infections (non-tuberculous) Clinical Respiratory Medicine
Vivekanand Vishnampettai	Paediatric Lung Disease Bronchoscopy and Interventional Techniques Clinical Allergy & Immunology
Lan Wei	Respiratory Infections (non-tuberculous) Asthma Cell and Molecular Biology
Joel Gan Weng Yew	Asthma COPD Respiratory Infections (non-tuberculous)
Ymabdul Quddus Yameenuddin	Clinical Respiratory Medicine Asthma Bronchoscopy and Interventional Techniques
Subagio Sutanto Yusup	Bronchoscopy and Interventional Techniques Clinical Respiratory Medicine Critical Care Medicine

Future Pulmonology Events

Here are the main respiratory events in Asia-Pacific region for the next few months. You can see our full listing on the APSR Calendar.

Congress of International Lung Health and World COPD Day 2020 (VNRS)
5-7 November 2020, Hanoi, Vietnam
(Details)
Hong Kong Thoracic Society Autumn Respiratory Seminar
7 November 2020, Online
(Details)
130th Conference of the Korean Academy of Tuberculosis and Respiratory Diseases (KATRD)
12–13 November 2020, Seoul, Republic of Korea
(Details)
Annual Congress of Vietnam Respiratory Society 2020 (combination of VNRS Congress and Association Franco-Vietnamienne De Pneumologie) and Pre-congress Workshop on Bronchoscopy
13-15 November 2020, Da Nang city, Vietnam
(Details)
Asthma & COPD Outpatient Care Unit (ACOCU) Network Day
15 November 2020, Ho Chi Minh City, Vietnam
(Details)
World COPD Day
18 November 2020, Worldwide
(Details)
Respiratory Structure and Function symposium - an APSR Assembly Virtual Meeting
21 November 2020, Online
(Details)
Asthma symposium - an APSR Assembly Virtual Meeting
28 November 2020, Online
(Details)
Taiwan Society of Pulmonary and Critical Care Medicine (TSPCCM) 2020 Annual Congress
12-13 December 2020, NTUH International Convention Center. Taipei, Taiwan
(Details)
Malaysian Thoracic Society (MTS) 2020 Annual Congress
10-13 December 2020, Nusajaya, Johor, Malaysia
(Details)
World Conference on Lung Cancer
26-29 January 2021, Singapore
(Details)

For more pulmonology events, see apsresp.org/calendar.html
(These events are for information only and APSR endorsement should not be assumed.)

Contact

If you have news of interest to APSR members, please send details to one of the Bulletin Coordinators: Prof. A Azuma (a-azuma@nms.ac.jp) or Prof. C K Rhee (chinkook77@gmail.com).

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© Asian Pacific Society of Respirology