No. 132 (July 2020)
unsubscribe
REGISTER
to access members-only pages
on the APSR website
APSR News
Regional society news
Health news
Education
APSR Membership
Future Events
Contact

APSR News

APSR website

You might have noticed one or two style changes on pages of the APSR website. The project is ongoing and improvement ideas are always welcome by the Secretariat at APSRinfo@theapsr.org

New Respirology articles on the coronavirus

  • National policies for paediatric universal BCG vaccination were associated with decreased mortality due to COVID-19
    Risa Ebina-Shibuya MD, PhD; Nobuyuki Horita MD, PhD; Ho Namkoong MD, PhD; Takeshi Kaneko MD, PhD; DOI: 10.1111/resp.13885
    First published 18 June 2020
  • Targeting the interleukin-17 pathway to prevent acute respiratory distress syndrome associated with SARS-CoV-2 infection
    Tomas Raul Wiche Salinas MD, PhD(c); Boyang Zheng MD; Jean-Pierre Routy MD; Petronela Ancuta PhD; DOI: 10.1111/resp.13875
    First published 17 June 2020
  • Letter from France
    Jérémy Charriot MD; Laurie Pahus PharmD, PhD; Pascal Chanez MD, PhD; Nicolas Nagot MD, PhD; Arnaud Bourdin MD, PhD DOI: 10.1111/resp.13874
    First published 8 June 2020

Recent Respirology Case Reports on the coronavirus

  • What happens when we treat the "Typhoid Mary" of COVID-19
    Boon Hau Ng, Nik Nuratiqah Nik Abeed, Mohamed Faisal Abdul Hamid, Chun Ian Soo, Hsueh Jing Low, Yu-Lin Andrea Ban
    DOI: 10.1002/rcr2.604
    First published 25 June 2020
  • High-dose, short-term corticosteroids for ARDS caused by COVID-19: a case series
    Clara So, Shosei Ro, Manabu Murakami, Ryosuke Imai, Torahiko Jinta
    DOI: 10.1002/rcr2.596
    First published 4 June 2020

More...

See a collection of COVID-19 material on the dedicated COVID-19 page on the APSR website.

Fukuchi Award winners

We are delighted to announce the recipients of the 2020 Fukuchi Award. The Selection Panel, Antonio R Anzueto and Young Whan Kim, assessed the most outstanding papers published in Respirology in the preceding year, for their novelty, importance, methodology, clarity and overall quality.

  • Predictive factors and prognostic effect of telomere shortening in pulmonary fibrosis (DOI: 10.1111/resp.13423)
    Authors: Lurdes Planas-Cerezales, Elena G Arias-Salgado, Ivette Buendia-Roldán, Ana Montes-Worboys, Cristina Esquinas, López Vanesa, Vicens-Zygmunt Patricio Luburich Hernaiz, Roger Llatjós Sanuy, Virginia Leiro-Fernandez, Eva Balcells Vilarnau, Ernest Sala Llinás, Jordi Dorca Sargatal, Rosario Perona Abellón, Moisés Selman, Maria Molina-Molina
  • Novel endosomal NOX2 oxidase inhibitor ameliorates pandemic influenza A virus-induced lung inflammation in mice (DOI: 10.1111/resp.13524)
    Authors: Eunice E To, Raymond Luong, Jiayin Diao, John J. O'Leary, Doug A Brooks, Ross Vlahos, Stavros Selemidis

The awards will be presented at the APSR Congress in Kyoto, November 2021.

Inside Respirology

Respirology Vol. 25 Issue 7

Show / Hide
page
EDITORIALS
666Prediction models in respiratory medicine
Michael J Abramson PhD, FRACP; Rory Wolfe PhD
10.1111/resp.13854
668Sputum transcriptomics: A tool for identifying gene expression underlying mechanistic pathways in severe asthma
Sandra Hodge MSc, PhD, FThorSoc
10.1111/resp.13769
670Asthma exacerbations during pregnancy: A need for precision medicine
Christopher E Brightling PhD, FRCP, FMedSci
10.1111/resp.13761
672Asthma–COPD overlap: No formal definition and simple diagnostic tool so far?
Fanny W S Ko MD; David S C Hui MD
10.1111/resp.13764
674Biomarkers in idiopathic pulmonary fibrosis: Are we there yet?
Jyotika D Prasad MBChB, FRACP
10.1111/resp.13763
676Pleurodesis and systemic inflammatory markers: Lessons and insights
John Y H Chan MBBS, MRCP, FHKAM, FHKCP; Y C Gary Lee MBChB, PhD, FCCP, FRCP, FRACP
10.1111/resp.13765
COMMENTARIES
678Rationale for universal face masks in public against COVID-19
Anthony Paulo Sunjaya MD, SM; Christine Jenkins MD, AM, FRACP
10.1111/resp.13834
680The role of SARS-CoV-2 antibodies in COVID-19: Healing in most, harm at times
Martyn A French MBChB, MD, FRCPath, FRCP, FRACP; Yuben Moodley MBChB, FCP, FRACP, MD, PhD
10.1111/resp.13852
683Chloroquine and hydroxychloroquine for COVID-19: A word of caution
Srinadh Annangi MD
10.1111/resp.13845
685Molecular testing of metastatic non-small cell lung cancer in the Asia-Pacific region
Chong-Kin Liam MBBS, FRCP(UK), FCCP, FAPSR Emily Stone MBBS, MMed, FRACP Sita Andarini MD, PhD Yong-Sheng Liam MBBS David Chi-Leung Lam MD, PhD, FRCP, FAPSR; Pyng Lee MBBS, MD, FRCP(UK), FCCP, PhD
10.1111/resp.13833
INVITED REVIEW SERIES
New frontiers in sleep disordered breathing
688The future of sleep-disordered breathing: A public health crisis
Philip de Chazal BE, MBiomedE, PhD; Peter A Cistulli MBBS, PhD, MBA; Matthew T Naughton MBBS, MD, FRACP
10.1111/resp.13839
690Global burden of sleep-disordered breathing and its implications
M Melanie Lyons, Nitin Y Bhatt, Allan I Pack, Ulysses J Magalang
10.1111/resp.13838
INVITED REVIEW
703Safe performance of diagnostic bronchoscopy/EBUS during the SARS-CoV-2 pandemic
Daniel P Steinfort, Felix J F Herth, Louis B Irving, Phan T Nguyen
10.1111/resp.13843
ORIGINAL ARTICLES
Asthma and Allergy
709
Sputum transcriptomics implicates increased p38 signalling activity in severe asthma
Katherine J Baines, Michael Fricker, Vanessa M McDonald, Jodie L Simpson, Lisa G Wood, Peter A B Wark, Heather E Macdonald, Andrew Reid, Peter G Gibson
10.1111/resp.13749

Sputum transcriptomic analysis revealed vast changes in gene expression in severe asthma. There was enrichment of genes in the p38 signalling pathway, four gene networks altered and 30 genes were identified that were highly differentially expressed in severe asthma compared with controlled asthma and healthy controls.

719Biomarker-guided management reduces exacerbations in non-eosinophilic asthma in pregnancy: A secondary analysis of a randomized controlled trial
Vanessa E Murphy, Celeste M Porsbjerg, Annelies L Robijn, Peter G Gibson
10.1111/resp.13713

This study shows that a FENO-guided algorithm for asthma treatment adjustment in pregnancy better targets treatment to phenotype than a symptom control algorithm, with reduced exacerbations in non-eosinophilic asthma.

COPD
726
Impact of chronic obstructive pulmonary disease on mortality: A large national cohort study
Hye Yun Park, Danbee Kang, Hyun Lee, Sun Hye Shin, Minwoong Kang, Sunga Kong, Chin Kook Rhee, Juhee Cho, Kwang Ha Yoo
10.1111/resp.13678

Chronic obstructive pulmonary disease (COPD) patients were at a statistically significant higher risk for all-cause mortality than those without COPD. This patient group died more often than subjects without COPD from chronic lower airway disease, lung cancer and pneumonia. The impact of COPD on specific mortalities was stronger in younger subjects.

735Prospective development of practical screening strategies for diagnosis of asthma–COPD overlap
Aiyuan Zhou, Lijuan Luo, Nian Liu, Cheng Zhang, Yahong Chen, Yan Yin, Jing Zhang, Zhiyi He, Lihua Xie, Jungang Xie, Jinhua Li, Zijing Zhou, Yan Chen, Ping Chen
10.1111/resp.13743

We established a screening model for ACO. It is as effective as the GINA/GOLD document to distinguish between ACO, asthma and COPD patients but much simpler to perform.

Interstitial Lung Disease
743Clinical significance of serum S100 calcium-binding protein A4 in idiopathic pulmonary fibrosis
Norimichi Akiyama, Hironao Hozumi, Takuya Isayama, Jun Okada, Katsunori Sugiura, Hideki Yasui, Yuzo Suzuki, Masato Kono, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Takafumi Suda
10.1111/resp.13707

S100 calcium-binding protein A4 is a promising serum biomarker that may predict disease progression and mortality in idiopathic pulmonary fibrosis (IPF) patients. Insights from this study may facilitate establishment of treatment strategies for IPF.

Pleural Disease
750Clinically important associations of pleurodesis success in malignant pleural effusion: Analysis of the TIME1 data set
Rachel M Mercer, Jessica Macready, Hannah Jeffries, Nicole Speck, Nikolaos I Kanellakis, Nick A Maskell, Justin Pepperell, Tarek Saba, Alex West, Nabeel Ali, John P Corcoran, Robert J Hallifax, Ioannis Psallidas, Rachelle Asciak, Maged Hassan, Robert F Miller, Najib M Rahman
10.1111/resp.13755

Inflammation, as evidenced by a greater rise in CRP levels, is associated with pleurodesis success but there is no association between success and degree of pain after pleurodesis. Patients with mesothelioma are more likely to experience pleurodesis failure but the mechanisms for this are unclear.

CONTEMPORARY CONCISE REVIEW
756Contemporary Concise Review 2019: Interstitial lung disease
Peter M George, Athol U Wells
10.1111/resp.13803
FORUM AND DEBATE
Scientific Letter
764Serum amyloid A is a predictor for prognosis of COVID-19
Xiao-Neng Mo, Zhu-Quan Su, Chun-Liang Lei, Di-Fei Chen, Hui Peng, Ru-Chong Chen, Ling Sang, Hong-Kai Wu, Shi-Yue Li
10.1111/resp.13840
LETTERS FROM ASIA-PACIFIC AND BEYOND
766Letter from France
Jérémy Charriot MD; Laurie Pahus PharmD, PhD; Pascal Chanez MD, PhD; Nicolas Nagot MD, PhD; Arnaud Bourdin MD, PhD
10.1111/resp.13874
769Letter from Iraq
Haidar A N Abood MBChB, MSc, PhD; Nuha Al-Zaubai MBChB, MSc, PhD
10.1111/resp.13789

Inside Respirology Case Reports

Respirology Case Reports, Volume 08 Issue 6

Show / Hide
Case Series
High-dose, short-term corticosteroids for ARDS caused by COVID-19: a case series
Clara So, Shosei Ro, Manabu Murakami, Ryosuke Imai, Torahiko Jinta
DOI: 10.1002/rcr2.596

Many questions on the clinical management of coronavirus disease (COVID-19) remain unanswered, and data on corticosteroid therapy as a choice of treatment are mixed. We present the clinical course of seven patients, review the previous evidence, and discuss management.

Case Reports
Use of pleural cryobiopsy for tissue culture specimens: a case report
Satoru Ishii, Manabu Suzuki, Hirokazu Arai, Jin Takasaki, Masayuki Hojo, Haruhito Sugiyama
DOI: 10.1002/rcr2.593

We present the case of a 43-year-old man with suspected tuberculous pleurisy (TP). Thoracoscopy under local anaesthesia showed the entire pleura with scattered nodules. Nodules were biopsied by conventional biopsy forceps, but the tissue sample was small, so a cryobiopsy was performed. Histological analysis of the conventional biopsy forceps and cryobiopsy specimen showed inflammation with lymphocytes and caseating granulomas. Tissue culture of conventional biopsy forceps was positive for Mycobacterium tuberculosis , and all sensitivity tests were positive. But, the tissue culture of the cryobiopsy sample was negative. There is a possibility that cryobiopsy is not useful for tissue culture for TP.

Endobronchial tuberculosis polyps
Christiaan Yu, Chuan Tai Foo, Ar Kar Aung, Simon A Joosten
DOI: 10.1002/rcr2.595

We present a patient with endobronchial tuberculosis (TB) polyps for which initial acid-fast bacilli staining and TB complex DNA polymerase chain reaction yielded negative results. Histopathology showed non-caseating granulomatous inflammation and the diagnosis was ultimately achieved four weeks later when bronchial washing cultures yielded Mycobacterium tuberculosis , thus highlighting the challenges in achieving a timely diagnosis.

Pulmonary pleomorphic carcinoma with pembrolizumab monotherapy
Hao-Chun Chang, Chia-Lin Hsu, Yih-Leong Chang, Chong-Jen Yu
DOI: 10.1002/rcr2.597

Adenocarcinoma (ADC) is the most common form of lung cancer; however, some other types of lung cancer, such as pulmonary pleomorphic carcinoma (PC), can sometimes mimic ADC. Here, we present a patient with initial diagnosis of pulmonary ADC later diagnosed with PC.

Multisystem Langerhans cell histiocytosis in an adult non-smoker treated with steroid therapy
Haruka Ito, Masaru Ito, Yukio Kakuta, Takeshi Kaneko, Koji Okudera, Takashi Ogura
DOI: 10.1002/rcr2.603

Multisystem Langerhans cell histiocytosis in an adult non-smoker treated with steroid therapy for a subacute exacerbation: a case report and review of the literature.

Massive atelectasis by mucoid impaction in an asthma patient during treatment with anti-interleukin-5 receptor antibody
Takayuki Takimoto, Tomoko Kagawa, Kazunobu Tachibana, Toru Arai, Yoshikazu Inoue
DOI: 10.1002/rcr2.599

We herein report a case of a patient who developed massive atelectasis by mucoid impaction during treatment with anti-interleukin (IL)-5 receptor antibody.

Tuberculosis-associated chylothorax revealing an enlarged lymphatic duct due to tuberculosis lymphadenitis
Kojiro Honda, Takeshi Saraya, Chika Miyaoka, Kazuharu Suda, Masachika Fujiwara, Haruyuki Ishii
DOI: 10.1002/rcr2.600

We report a case of chylothorax due to tuberculosis lymphadenitis with distinct evidence of enlarged lymphatic duct macroscopically.

Clinical Image
Mediastinal malignant mesothelioma discovered in a patient with dysphagia
Dario Amore, Simona Massa, Umberto Caterino, Dino Casazza, Albina Palma, Carlo Curcio
DOI: 10.1002/rcr2.592

A mediastinal mass in patients with a history of asbestos exposure should raise the suspicion of malignant mesothelioma.

Complete occlusion of right pulmonary artery in Behçet disease
Yohei Korogi, Nozomi Tanaka, Hajime Yoshifuji, Junichi Tazaki, Takeshi Kubo, Kiminobu Tanizawa
DOI: 10.1002/rcr2.594

Here, we describe a case of complete occlusion of right pulmonary artery seen in a patient with Behçet disease.

Left pulmonary artery pseudoaneurysm secondary to post-operative lung abscess
Dario Amore, Giorgio Bocchini, Dino Casazza, Umberto Caterino, Albina Palma, Carlo Curcio
DOI: 10.1002/rcr2.598

We report a rare case of post-operative pulmonary artery pseudoaneurysm. In such instance a prompt diagnosis and adequate treatment are essential to avoid catastrophic complications.

Accessory V6 during thoracoscopic middle lobectomy: "an uncomfortable presence"
Dario Amore, Roberto Scaramuzzi, Dino Casazza, Pasquale Imitazione, Emanuele Muto, Roberta Lieto
DOI: 10.1002/rcr2.601

We report a patient in whom a supernumerary venous branch draining the superior segment of the right lower lobe into the left atrium (accessory V6) was accidentally discovered near the level 7 nodal packet thus avoiding complications during surgery. The anomalous vessel was retrospectively identified on chest computed tomography (CT) scan.

Regional society news

The spotlight this month is on

HONG KONG

Each month we share details of activities of a particular country, region or society.

If you would like the spotlight to be on your country, region or society next month, contact the Bulletin Coordinator or APSR Secretariat.

The president of the Hong Kong Thoracic Society, Dr David CL Lam, is pleased to report:

With the improved situation of COVID-19 in Hong Kong, we are resuming various professional and educational activities.

The lecture by Prof Barnes on 14th July [see below] is first in a series of virtual educational seminars on the web, which will be held once or twice a month till the end of 2020, with upcoming topics like asthma, pulmonary fibrosis, etc.

While we could not host public gatherings over the past few months of COVID-19 pandemic, the HKTS has completed the contest of WhatsApp sticker design and poster design with theme on anti-tobacco smoking.

We are planning for a public educational event on Respiratory Health topics in September, to try to coincide with the World Lung Day.

Dr David CL Lam
HKTS President

Click the above image to enlarge

Scan the QR code to register
or visit bit.ly/3cNytv5

Other regional news:

China

The date has changed for the World Congress of Bronchology & Interventional Pulmonology (WCBIP), biennial flagship international congress of the WABIP (World Association of Bronchology & Interventional Pulmonology).

This had been scheduled to be held in Shanghai, China, on 16-19 April 2020 and has been postponed to 24-27 September 2020 due to the coronavirus pandemic.

Please check the WABIP webpage www.wabip.com/congress for the latest details.

Japan

The date has changed for the 60th Annual Meeting of the Japanese Respiratory Society

This had been scheduled to be held in Nagoya on 24-26 April 2020 and has been postponed to 20-22 September 2020 due to the coronavirus pandemic. The venue has also been changed and the Annual Meeting will now be held at the Kobe Convention Center, Japan.

Please check the JRS webpage www.jrs.or.jp/jrs60/en/index.html for the latest details.

Singapore

The Singapore Thoracic Society's Singhealth Interstitial Lung Disease Workshop will be held on 11 July 2020.

In view of the COVID-19 pandemic, this will be delivered online as a web-based workshop.

Please check the STS website www.thoracic.sg for the latest details.

Also due to the pandemic, the date of the World Conference on Lung Cancer has changed.

This had been scheduled to be held on 9-12 August 2020 and has been postponed to 26-29 January 2021.

Please check the IASLC website wclc2020.iaslc.org for the latest details.

Sri Lanka

World Environment Day is a UN programme celebrated on 5 June every year to encourage awareness and action for the protection of the environment, one of the major issues being air pollution.

The Sri Lanka College of Pulmonologists and the Red Cross Society of Sri Lanka have collaborated with the Kandy Society of Medicine for a busy variety of activities, as shown on these posters. (Click image to enlarge)

Health news

World Environment Day

As shown above, the Sri Lanka College of Pulmonologists was busy celebrating World Environment Day, and in print we have pertinent Respirology articles:

which have been followed by these publications collated by the Forum of International Respiratory Societies (FIRS):

Click any of these banners to enlarge, download and share

Education

Teaching Library

The Teaching Library is open for your self-study. Challenging yourself to choose the correct procedure for any of the 97 cases in the Library at apsresp.org/education/teaching-library/index.php.

Many more cases are needed for this Library and any member is welcome to submit a case through the same link as above.

APSR Membership

Donations received

The following members have kindly sent their donation towards the Society's goals, as outlined at apsresp.org/members/donors.php.

  • Dr Avya Bansal FAPSR
  • Dr Abhinav Chaudhary FAPSR

The APSR is profoundly grateful for their generosity.

New Fellows of the APSR

Congratulations to the following members who have recently become Fellows of the APSR:

  • Dr Avya Bansal FAPSR
  • Dr Abhinav Chaudhary FAPSR
  • Dr Arnab Maji FAPSR

New and updated assembly memberships

A warm welcome to the following members who have recently joined or re-joined APSR assemblies.

Shahzad Hussain Arastu Clinical Respiratory Medicine
Critical Care Medicine
Interstitial Lung Disease
Elizabeth Cadena Tuberculosis
Asthma
Daryl Emery Chee Yeow Chan Clinical Respiratory Medicine
COPD
Bronchoscopy and Interventional Techniques
Kuang Yu Chen Clinical Respiratory Medicine
Asthma
Respiratory Neurobiology and Sleep
Chi-Li Chung Clinical Respiratory Medicine
Asthma
Interstitial Lung Disease
Ester Jean Dy Respiratory Infections (non-tuberculous)
Bronchoscopy and Interventional Techniques
Critical Care Medicine
Liang Wen Hang Respiratory Neurobiology and Sleep
COPD
Asthma
Young Kyoon Kim Lung Cancer
COPD
Interstitial Lung Disease
Yong Hyun Kim Interstitial Lung Disease
Lung Cancer
Yun Seong Kim Lung Cancer
Clinical Respiratory Medicine
Interstitial Lung Disease
Mihyun Kim Lung Cancer
Shu-Hung Kuo Critical Care Medicine
Bronchoscopy and Interventional Techniques
Lung Cancer
Arnab Maji COPD
Clinical Allergy & Immunology
Clinical Respiratory Medicine
Park Moo Suk Interstitial Lung Disease
Critical Care Medicine
Pulmonary Circulation
Manoj Kumar Panigrahi Critical Care Medicine
Clinical Respiratory Medicine
Bronchoscopy and Interventional Techniques
Sateesh Sakhamuri COPD
Asthma
Tuberculosis
Dongin Suh Paediatric Lung Disease
Clinical Allergy & Immunology
Critical Care Medicine
Park Sung Woo Interstitial Lung Disease
Asthma
Critical Care Medicine
Yuk Ping Tsang Paediatric Lung Disease
Clinical Respiratory Medicine
Critical Care Medicine
Keshavan Vamanan Clinical Respiratory Medicine
COPD
Asthma
Jann-Yuan Wang Tuberculosis
Respiratory Infections (non-tuberculous)
Kuang-Yao Yang Critical Care Medicine
Respiratory Infections (non-tuberculous)
Interstitial Lung Disease

Future Pulmonology Events

Here are the main respiratory events in Asia-Pacific region for the next few months. You can see our full listing on the APSR Calendar.

  • Advances in COPD therapy
    12 July 2020, Hong Kong Thoracic Society's online lecture
    (Details)
  • Malaysian Thoracic Society (MTS) 2020 Annual Congress
    16-19 Jul 2020 Postponed to 10-13 December 2020, Nusajaya, Johor, Malaysia
    (Details)
  • Respire 12 Annual Academic Sessions of Sri Lanka College of Pulmonologists (SLCP)
    20-22 July 2020 New date will be announced when confirmed, Kandy, Sri Lanka
    (Details)
  • Annual Scientific Congress of Ho Chi Minh City Society of Asthma, Allergy & Clinical Immunology
    26 July 2020, Ho Chi Minh City, Vietnam
    (Details)
  • 60th Annual Meeting of the Japanese Respiratory Society
    20-22 September 2020, Kobe Convention Center, Japan
    (Details)
  • World Congress of Bronchology & Interventional Pulmonology (WCBIP)
    24-27 September 2020, Shanghai, China
    (Details)
  • The 16th National Congress Indonesian Society of Respirology in conjunction with 1st Indonesia Chronic Lung Disease International Meeting (ICLIME)
    23-26 September 2020, Makassar, Indonesia
    (Details)
  • Scientific conference with updates from The Congress of European Respiratory Society (ERS) 2020 (VNRS)
    25-26 September 2020, Hanoi, Vietnam
    (Details)

For more pulmonology events, see apsresp.org/calendar.html
(These events are for information only and APSR endorsement should not be assumed.)

Contact

If you have news of interest to APSR members, please send details to one of the Bulletin Coordinators: Prof. A Azuma (a-azuma@nms.ac.jp) or Prof. C K Rhee (chinkook77@gmail.com).


Click here to see previous issues of the Bulletin
If you prefer not to receive further APSR Bulletins, click unsubscribe
Comments: bulletin@apsresp.org or APSRinfo@theapsr.org
© Asian Pacific Society of Respirology