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APSR Respiratory Updates

(Latest issues)

Dr David CL Lam

APSR Respiratory Updates is a unique publication bringing you the most important clinical research in respiratory medicine. Each month an expert within the APSR will identify and review ten key publications in their field. In addition to a link to the publication, a brief commentary on why the study is important will be provided. This series represents an important initiative of the Education Committee of the APSR. We hope you find it informative and useful in your clinical practice.

Dr David CL Lam

Respiratory Updates (archives)
2017 (current)
2016 Archive
  • Pulmonary rehabilitation in COPD
  • Lung Development and Regeneration
  • Lymphangioleiomyomatosis
  • Obesity Hypoventilation Syndrome
  • Update in Acute Respiratory Distress Syndrome
  • Lung Transplantation
  • Lung cancer immunotherapy
  • Pneumonia
  • Updates in Pulmonary Function Testing 2012-2015
  • Pulmonary Aspergillosis
  • Updates on Bronchoscopy and Interventional Pulmonology
Volume 7, Issue 12
(December 2015)

Cystic Fibrosis (CF)

  • Lumacaftor-ivacaftor in patients with cystic fibrosis homozygous for Phe 508 del CFTR
  • A decade of healthcare improvement in cystic fibrosis: lessons for other chronic diseases
  • Viability of Pseudomonas aeruginosa in cough aerosols generated by persons with cystic fibrosis
  • Air contamination with bacteria in cystic fibrosis clinics: Implications for prevention strategies
  • Origins of cystic fibrosis Lung Disease
  • Medical and obstetric complications among pregnant women with cystic fibrosis
  • Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis
  • Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and out-comes
  • Oxidation contributes to low glutathione in the airways of children with cystic fibrosis
  • Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis
  • Pulmonary disease in cystic fibrosis: assessments with chest CT at chest radiography dose levels
Volume 7, Issue 11
(November 2015)

Tobacco/Smoking Cessation

  • Smoking and mortality- Beyond established causes
  • Randomized Trial of Four Financial-Incentive Programs for Smoking Cessation
  • Cytisine versus Nicotine for Smoking Cessation
  • Secondhand smoking is associated with vascular inflammation
  • Estimates of the economic contributions of the bidi manufacturing industry in India.
  • Electronic cigarettes: human health effects.
  • Maternal smoking and the risk of still birth: systematic review and meta-analysis.
  • A longitudinal study of electronic cigarette use among a population-based sample of adult smokers: association with smoking cessation and motivation to quit.
  • Association of Electronic Cigarette Use with Initiation of Combustible Tobacco Product Smoking in Early Adolescence
  • Association of Smoking Status with Angina and Health-Related Quality of Life after Acute Myocardial Infarction
  • Effects of quitting cannabis on respiratory symptoms.
  • Do smokers support smoke-free laws to help themselves quit smoking? Findings from a longitudinal study
Volume 7, Issue 10
(October 2015)

Pulmonary Circulation

  • Pro-Proliferative and Inflammatory Signaling Converge on FoxO1 Transcription Factor in Pulmonary Hypertension
  • Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models
  • Sex Affects Bone Morphogenetic Protein Type II Receptor Signaling in Pulmonary Artery Smooth Muscle Cells
  • Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension
  • Evaluation of the Microcirculation in Chronic Thromboembolic Pulmonary Hypertension Patients: The Impact of Pulmonary Arterial Remodeling on Postoperative and Follow-Up Pulmonary Arterial Pressure and Vascular Resistance.
  • Vascular Repair by Tissue-resident Endothelial Progenitor Cells in Endotoxin-induced Lung Injury
  • Effect of a Retrievable Inferior Vena Cava Filter Plus Anticoagulation vs Anticoagulation Alone on Risk of Recurrent Pulmonary Embolism: A Randomized Clinical Trial
  • Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE Randomized Clinical Trial
  • Multi-institutional Retrospective Cohort Study of Patients with Severe Pulmonary Hypertension as-sociated with Respiratory Diseases
  • A New Era of Therapeutic Strategies for Chronic Thromboembolic Pulmonary Hypertension by Two Different Interventional Therapies: Pulmonary Endarterectomy and Percutaneous Transluminal Pul-monary Angioplasty
Volume 7, Issue 9
(September 2015)

Idiopathic Pulmonary Fibrosis trials and Sarcoidosis

  • Treatment of Idiopathic Pulmonary Fibrosis with Ambrisentan.
  • Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis.
  • A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis.
  • Randomized Trial of Acetylcysteine in Idiopathic Pulmonary Fibrosis.
  • Safety and Pharmacokinetics of Nintedanib and Pirfenidone in Idiopathic Pulmonary Fibrosis.
  • An Integrated Clinicoradiological Staging System for Pulmonary Sarcoidosis: A Case-Cohort Study.
  • Proteomic Profiling Reveals Autoimmune Targets in Sarcoidosis.
  • Cardiac Positron Emission Tomography Enhances Prognostic Assessments of Patients with Suspected Cardiac Sarcoidosis.
  • Bosentan for Sarcoidosis-Associated Pulmonary Hypertension: A Double-Blind Placebo Controlled Randomized Trial.
  • Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration vs Conventional Transbronchial Needle Aspiration in the Diagnosis of Sarcoidosis.
Volume 7, Issue 8
(August 2015)


  • Molecular classification of malignant pleural mesothelioma: identification of a poor prognosis sub-group linked to the epithelial-to-mesenchymal transition.
  • Extrapleural pneumonectomy for malignant mesothelioma: an Italian multicenter retrospective study.
  • A feasibility study evaluating Surgery for Mesothelioma After Radiation Therapy: the SMART approach for resectable malignant pleural mesothelioma.
  • Anetumab Ravtansine: A Novel Mesothelin-Targeting Antibody – Drug Conjugate Cures Tumors with Heterogeneous Target Expression Favored by Bystander Effect.
  • B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis.
  • Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.
  • Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
  • Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship
  • Does surgery improve survival of patients with malignant pleural mesothelioma? A multicenter retro-spective analysis of 1365 consecutive patients.
  • Efficacy and cost of video-assisted thoracoscopic partial pleurectomy versus talc pleurodesis in pa-tients with malignant pleural mesothelioma (MesoVATS): an open-label, randomised, controlled trial.
Volume 7, Issue 7
(July 2015)


  • The Bronchiectasis Severity Index (BSI). An international derivation and validation study.
  • Multi-dimensional approach to non-cystic fibrosis bronchiectasis: the FACED score.
  • Quality of Life Questionnaire – Bronchiectasis (QoL-B): final psychometric analysis and determina-tion of minimal important difference scores.
  • National BTS bronchiectasis audit 2012: is the quality standard being adhered to in adult secondary care?
  • Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised controlled trial.
  • Inhaled Colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection.
  • Lung resection improves the quality of life of patients with symptomatic bronchiectasis.
  • Long term azithromycin for Indigenous children with non-cystic fibrosis bronchiectasis or chronic suppurative lung disease (CSLD) (Bronchiectasis Intervention Study).
  • Does failed chronic wet cough response to antibiotics predict bronchiectasis?
  • Atorvistatin as a stable treatment in bronchiectasis: a randomised trial.
Volume 7, Issue 6
(June 2015)

APSR air pollution update

  • Oxidative stress and aromatic hydrocarbon response of human bronchial epithelial cells exposed to petro- or biodiesel exhaust treated with a diesel particulate filter.
  • Diesel and biodiesel exhaust particle effects on rat alveolar macrophages with in vitro exposure.
  • Biodiesel versus diesel exposure: enhanced pulmonary inflammation, oxidative stress, and differen-tial morphological changes in the mouse lung.
  • Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells.
  • Enriched inorganic compounds in diesel exhaust particles induce mitogen-activated protein kinase activation, cytoskeleton instability, and cytotoxicity in human bronchial epithelial cells.
  • Global gene expression profiling of human bronchial epithelial cells exposed to airborne fine particu-late matter collected from Wuhan, China.
  • Ultrafine particle content in exhaled breath condensate in airways of asthmatic children.
  • Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project.
  • Long-Term Effects of Traffic Particles on Lung Function Decline in the Elderly.
  • The Cost of Air Pollution: Health Impacts of Road Transport.
Volume 7, Issue 5
(May 2015)

Induced Sputum 2015

  • Inhaled corticosteroids in COPD: the clinical evidence.
  • Diagnostic accuracy of minimally invasive markers for detection of airway eosinophilia in asthma: a systematic review and meta-analysis
  • External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma.
  • High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma.
  • Characterisation of the inflammatory response to inhaled LPS in mild to moderate COPD.
  • Anti-TNF inhibits the airways neutrophilic inflammation induced by inhaled endotoxin in humans.
  • IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers.
  • Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients.
  • Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes.
  • Xpert MTB/RIF testing of pooled induced sputum.
  • Induced Sputum is Safe and Well-Tolerated for TB Diagnosis in a Resource-Poor Primary Healthcare Setting.
Volume 7, Issue 4
(April 2015)

Pneumothorax: Evolving Indications for Surgery

  • Treatment of pneumothoraces at a tertiary centre: are we following the current guidelines?
  • Size of pneumothorax can be a new indication for surgical treatment in primary spontaneous pneumothorax: a prospective study
  • Management of pneumothoraces detected on chest computed tomography: can anatomical location identify patients who can be man-aged expectantly?
  • Treatment outcomes of pneumothorax with chronic obstructive pulmonary disease
  • Surgery for secondary spontaneous pneumothorax: risk factors for recurrence and morbidity
  • A new method to detect air leakage in a patient with pneumothorax using saline solution and multidetector-row spiral CT scan
  • Management of the pediatric spontaneous pneumothorax: is primary surgery the treatment of choice?
  • Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax in children
  • Surgical results of video-assisted thoracic surgery and risk factors for prolonged hospitalization for secondary pneumothorax in elderly patients
  • Intraoperative mechanical and chemical pleurodesis with 50 % glucose solution for secondary spontaneous pneumothorax in patients with pulmonary emphysema
  • Pneumothorax in women of child-bearing age: an update classification based on clinical and pathologic findings
  • Videothoracoscopic repair of diaphragm and pleurectomy/abrasion in patients with catamenial pneumothorax: a 9-year experience
  • Should pregnant patients with a recurrent or persistent pneumothorax undergo surgery?
  • Awake video-thoracoscopic surgery for intractable pneumothorax in pregnancy by using a single portal plus puncture
  • Needlescopic video-assisted thoracic surgery pleurodesis for primary pneumothorax
  • Surgery for primary pneumothorax: new ideas, new paradigms
Volume 7, Issue 3
(March 2015)

Non-invasive ventilation

  • Determinants of noninvasive ventilation success or failure in morbidly obese patients in acute respiratory failure
  • Energy and protein intakes of hospitalised patients with acute respiratory failure receiving noninvasive ventilation
  • Noninvasive ventilation and breathing-swallowing interplay in chronic obstructive pulmonary disease
  • Use of noninvasive ventilation in patients with acute respiratory failure, 2000–2009. A population-based study
  • Nocturnal non-invasive ventilation in COPD patients with prolonged hypercapnia after ventilatory support for acute respiratory failure: a randomised, controlled, parallel-group study
  • Non-invasive ventilation effectiveness and the effect of ventilatory mode on survival in ALS patients
  • Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial
  • Ambulatory adaptation to noninvasive ventilation in restrictive pulmonary disease: A randomized trial with cost assessment
  • Randomized trial of 'intelligent' autotitrating ventilation versus standard pressure support noninvasive ventilation: impact on adherence and physiological outcomes
  • Effects of noninvasive ventilation on treadmill 6-min walk distance and regional chest wall volumes in cystic fibrosis: Randomized controlled trial
Volume 7, Issue 2
(February 2015)

Cellular and molecular biology of the lung

  • Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer
  • Bone marrow-derived stromal cells are invasive and hyperproliferative and alter transforming growth factor-α-induced pulmonary fibrosis.
  • Untargeted lipidomic analysis in chronic obstructive pulmonary disease. Uncovering sphingolipids.
  • Cigarette Smoke-Induced Disruption of Bronchial Epithelial Tight Junctions Is Prevented by Transforming Growth Factor-β
  • Agonistic induction of PPARγ reverses cigarette smoke-induced emphysema
  • IL-17 attenuates degradation of ARE-mRNAs by changing the cooperation between AU-Binding Proteins and microRNA16
  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved Caspase 3
  • A comparative encyclopedia of DNA elements in the mouse genome
  • Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
  • Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells
Volume 7, Issue 1
(January 2015)

Quantitative Imaging of the Respiratory System

  • Cluster Analysis in the COPDGene Study Identifies Subtypes of Smokers with Distinct Patterns of Airway Disease and Emphysema
  • Hyperpolarized 3He Ventilation Defects Used to Predict Pulmonary Exacerbations in Mild to Moderate Chronic Obstructive Pulmonary Disease
  • CT Measurement of Airway Remodeling and Emphysema in Advanced COPD: Correlation to Pulmonary Hypertension
  • Comparison of Spatially Matched Airways Reveals Thinner Airway Walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD
  • Computed Tomographic Measures of Airway Morphology in Smokers and Never-Smoking Normal
  • Variation in the Percent of Emphysema-like Lung in a Healthy, Nonsmoking Multiethnic Sample: the MESA Lung Study
  • Quantitative Computed Tomography-Derived Clusters: Redefining Airway Remodeling in Asthmatic Patients
  • Poor Symptom Control is Associated with Reduced CT Segmental Airway Lumen Area in Asthmatic Smokers
  • Automated Quantification of Radiological Patterns Predicts Survival in Idiopathic Pulmonary Fibrosis
  • Automated CT Scan Scores of Bronchiectasis and Air Trapping in Cystic Fibrosis
Respiratory Updates (archives)
2014 Archive
  • COPD
  • Tuberculosis
  • Environmental and Occupational Health
  • APSR Paediatric Updates 2014
  • Pneumoconiosis and other related conditions
  • Sleep Medicine
  • Critical Care Medicine
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Venous Thromboembolism
2013 Archive
  • Fukuchi Award and Young Investigator Award Abstracts
  • Mesothelioma
  • Cystic Fibrosis and Bronchiectasis
  • Lung transplantation
  • Air Pollution
  • Induced sputum
  • Respirology Virtual Issues
  • Non-invasive ventilation
  • Monitoring free serum IgE in severe asthma patients treated with omalizumab
  • Lung Cancer Screening
  • Tuberculosis
  • Current Trends in Lung Cancer Surgery
2012 Archive
  • Progress of Pulmonary Function Testing in 2011/12
  • IPF trials and Sarcoidosis
  • Respiratory infections other than tuberculosis
  • Cell and Molecular Biology in Respirology
  • Pulmonary Circulation
  • Quantitative imaging of airways
  • Paediatric lung disease
  • Tuberculosis
  • Community and Public Health
  • Chronic obstructive pulmonary disease (COPD)
  • Epithelial-mesenchymal transition (EMT) in lung disease
  • Tobacco/Smoking cessation
2011 Archive
  • Pneumoconiosis
  • Environmental & Occupational Health
  • Bronchoscopy & Interventional Techniques
  • Sleep
  • Critical Care Medicine
  • Influenza
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Pulmonary and Systemic Venous Thromboembolism
2010 Archive
  • Community and Public Health
  • Tuberculosis
  • Tobacco/smoking cessation
  • Paediatric lung disease
  • Sleep
  • Pneumonia
  • Bronchoscopy & Interventional Techniques
  • Pleural diseases
  • Asthma
  • Critical Care Medicine
  • Interstitial Lung Disease
  • COPD & asthma: Differences & similarities
2009 Archive
  • Influenza
  • Lung Cancer
  • Venous Thromboembolism
Respiratory Research Review (archives)
2008 Archive
2007 Archive
2006 Archive

Disclaimer: The above publications are not intended as a replacement for regular medical education. The comments are an interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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