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APSR Respiratory Updates


Dr David CL Lam

APSR Respiratory Updates is a unique publication bringing you the most important clinical research in respiratory medicine. Each month an expert within the APSR will identify and review ten key publications in their field. In addition to a link to the publication, a brief commentary on why the study is important will be provided. This series represents an important initiative of the Education Committee of the APSR. We hope you find it informative and useful in your clinical practice.

Dr David CL Lam

Respiratory Updates (archives)
2017 (current)
2016 Archive
  • Pulmonary rehabilitation in COPD
  • Lung Development and Regeneration
  • Lymphangioleiomyomatosis
  • Obesity Hypoventilation Syndrome
  • Update in Acute Respiratory Distress Syndrome
  • Lung Transplantation
  • Lung cancer immunotherapy
  • Pneumonia
  • Updates in Pulmonary Function Testing 2012-2015
  • Pulmonary Aspergillosis
  • Updates on Bronchoscopy and Interventional Pulmonology
2015 Archive
  • Cystic Fibrosis (CF)
  • Tobacco/Smoking Cessation
  • Pulmonary Circulation
  • Idiopathic Pulmonary Fibrosis trials and Sarcoidosis
  • Mesothelioma
  • Bronchiectasis
  • APSR air pollution update
  • Induced Sputum 2015
  • Pneumothorax: Evolving Indications for Surgery
  • Non-invasive ventilation
  • Cellular and molecular biology of the lung
  • Quantitative Imaging of the Respiratory System
2014 Archive
  • COPD
  • Tuberculosis
  • Environmental and Occupational Health
  • APSR Paediatric Updates 2014
  • Pneumoconiosis and other related conditions
  • Sleep Medicine
  • Critical Care Medicine
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Venous Thromboembolism
Respiratory UpdatesContents
Volume 5, Issue 12
(December 2013)

Fukuchi Award and Young Investigator Award Abstracts

  • Effects of nutritional supplementation combined with conventional pulmonary rehabilitation in muscle-wasted chronic obstructive pulmonary disease: A prospective, randomized and controlled study
  • Knockdown of zinc finger E-box binding homeobox 1 (Zeb1) reduced stem cells characteristics of gefitinib-resistant-persisters of PC9 cells
  • Clinical and laboratory profiles and outcomes of critically ill chest disease patients in a tertiary care chest hospital
  • Healthcare utilization associated with misdiagnosis of COPD in primary care
  • PET imaging with [11C]PBR28 and [18F]FDG distinguishes macrophage from neutrophil lung inflammation
  • Study of incidence, outcome and antibiotic sensitivity pattern of ventilator associated pneumonia in ICU of tertiary care hospital in Nepal
  • Human Rhinovirus infection of asthmatic airway epithelial cells causes tight junction disassembly resulting in increased permeability.
  • One year changes of pulmonary artery pressure in interstitial lung disease
  • Mechanisms of autophagic regulation of myofibroblast differentiation in IPF pathogenesis
  • Novel noninvasive techniques for assessing dynamic pulmonary vascular function
Volume 5, Issue 11
(November 2013)


  • CD90 is a diagnostic marker to differentiate between malignant pleural mesothelioma and lung carcinoma with immunohistochemistry.
  • Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: an open-label, single-arm, phase 2 trial.
  • Phase II study of pemetrexed and carboplatin plus bevacizumab as first-line therapy in malignant pleural mesothelioma.
  • microRNA-1 induces growth arrest and apoptosis in malignant mesothelioma
  • Hyaluronic acid in the pleural fluid of patients with malignant pleural mesothelioma
  • Phase II study of first-line bortezomib and cisplatin in malignant pleural mesothelioma and prospective vali-dation of progression free survival rate as a primary end-point for mesothelioma clinical trials (European Organisation for Research and Treatment of Cancer 08052).
  • Combination of mesothelin and CEA significantly improves the differentiation between malignant pleural mesothelioma, benign asbestos disease, and lung cancer.
  • Radical pleurectomy and chemoradiation for malignant pleural mesothelioma: the outcome of incomplete resections.
  • Prognostic significance of metabolic response by positron emission tomography after neoadjuvant chemo-therapy for resectable malignant pleural mesothelioma.
  • Clinical characteristics of patients with malignant pleural mesothelioma harboring somatic BAP1 muta-tions.
Volume 5, Issue 10
(October 2013)

Cystic Fibrosis and Bronchiectasis

  • Prognostic Value of Bronchiectasis in Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease.
  • Chronic Respiratory Disease, Inhaled Corticosteroids and Risk for Non-Tuberculous Mycobacteriosis.
  • Azithromycin for Prevention of Exacerbations in Non-Cystic Fibrosis Bronchiectasis (EMBRACE): a ran-domised, double-blind, placebo-controlled trial.
  • Effect on Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients with Non-CF Bronchiectasis. The BAT Randomised Controlled Trial.
  • Effect of Long-Term, Low-Dose, Azithromycin on Pulmonary Exacerbations Among Patients with Non-Cystic Fibrosis Bronchiectasis. The BLESS randomised controlled trial.
  • Short and Long-term Antibiotic Treatment Reduces Airway and Systemic Inflammation in non-Cystic Fibro-sis Bronchiectasis.
  • Risk Factors for Bronchiectasis in Children with Cystic Fibrosis.
  • Whole-genome Sequencing to Identify Transmission of Mycobacterium abscessus between patients with Cystic Fibrosis: a retrospective cohort study.
  • Progressive Flow-to-Volume Dysanapsis in Cystic Fibrosis: A Predictor for Lung Transplantation?
  • Re-establishment of Recipient-associated Microbiota in the Lung Allograft is Linked to Reduced Risk of Bronchiolitis Obliterans Syndrome.
  • Cystic Fibrosis Pulmonary Guidelines. Chronic Medications for Maintenance of Lung Health.
Volume 5, Issue 9
(September 2013)

Lung transplantation

  • Experience with the first 50 ex vivo lung perfusions in clinical transplantation
  • Lung transplantation in patients 70 years old or older: Have outcomes changed after implementation of the lung allocation score?
  • Effect of donor smoking on survival after lung transplantation: a cohort study of a prospective registry
  • Cryoprobe transbronchial lung biopsy in patients after lung transplantation
  • Survival benefit of lung transplant for cystic fibrosis since lung allocation score implementation.
  • Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome
  • Disparities in access to lung transplantation for patients with cystic fibrosis by socioeconomic status
  • ISHLT SUMMARY STATMENT. Pathology of pulmonary antibody-mediated rejection: 2012 update from the Pathology Council of the ISHLT
  • Impact of lung transplantation on recipient quality of life – A serial, prospective, multicenter analysis through the first posttransplant year
  • Reestablishment of recipient-associated microbiota in the lung allograft is linked to reduced risk of bronchiolitis obliterans syndrome.
Volume 5, Issue 8
(August 2013)

Air Pollution

  • Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease.
  • How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan.
  • Associations of ambient air pollution with chronic obstructive pulmonary disease hospitalization and mortality.
  • Evaluation of interventions to reduce air pollution from biomass smoke on mortality in Launceston, Australia: retrospective analysis of daily mortality, 1994-2007.
  • Indoor air pollution and risk of lung cancer among Chinese female nonsmokers.
  • Long-term Residential Exposure to Air Pollution and Lung Cancer Risk.
  • Respiratory health effects of diesel particulate matter.
  • Toxicological properties of emission particles from heavy duty engines powered by conventional and biobased diesel fuels and compressed natural gas.
  • Responses of lung cells to realistic exposure of primary and aged carbonaceous aerosols.
  • Hazardous components and health effects of atmospheric aerosol particles: reactive oxygen species, soot, polycyclic aromatic compounds and allergenic proteins.
Volume 5, Issue 7
(July 2013)

Induced sputum

  • Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998-2008.
  • A large subgroup of mild-to-moderate asthma is persistently noneosinophilic
  • Impaired macrophage phagocytosis in non-eosinophilic asthma.
  • Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease.
  • Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease.
  • Microbiome diversity in the bronchial tracts of patients with chronic obstructive pulmonary disease.
  • Decreased CTLA4+ and Foxp3+ CD25highCD4+ cells in induced sputum from patients with mild atopic asthma.
  • Airway function, inflammation and regulatory T cell function in subjects in asthma remission.
  • Levels of leptin and IL-6 in lungs and blood are associated with the severity of chronic obstructive pulmonary disease in patients and rat models
  • Dupilumab in persistent asthma with elevated eosinophil levels
  • Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers.
Volume 5, Issue 6
(JJune 2013)

Respirology Virtual Issues

  • Translating Research into Practice
  • Obesity and Respiratory Disorders
  • Air Pollution and Lung Health
  • How to Set-up Pulmonary Subspecialty Services
  • Asia-Pacific Respiratory Health Issues
  • Cutting Edge Technologies
  • Pleural Diseases
Volume 5, Issue 5
(May 2013)

Non-invasive ventilation

  • Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998-2008.
  • Rescue therapy by switching to total face mask after failure of face mask-delivered noninvasive ventilation in Do-Not-Intubate patients in acute respiratory failure
  • Noninvasive ventilation in acute hypercapnic respiratory failure caused by obesity hypoventilation syndrome and chronic obstructive pulmonary disease.
  • Optimization of ventilator setting by flow and pressure waveforms analysis during noninvasive ventilation for acute exacerbations of COPD: a multicentric randomized controlled trial
  • Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessness
  • High pressure versus high intensity noninvasive ventilation in stable hypercapnic chronic obstructive pulmonary disease: a randomized crossover trial
  • Physiological changes during low- and high-intensity noninvasive ventilation.
  • Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trial.
  • Impact of different back-up respiratory rates on the efficacy of non-invasive positive pressure ventilation in obesity hypoventilation syndrome: a randomized trial
  • Volume targeted versus pressure support non-invasive ventilation in patients with super obesity and chronic respiratory failure: a randomised controlled trial
Volume 5, Issue 4
(April 2013)

Monitoring free serum IgE in severe asthma patients treated with omalizumab

  • Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma.
  • Effects of adding omalizumab, an anti-immunoglobulin E antibody, on airway wall thickening in asthma.
  • A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
  • Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody.
  • Soluble CD23 controls IgE synthesis and homeostasis in human B cells.
  • Microarray evaluation of specific IgE to allergen components in elite athletes.
  • Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma.
  • Population-based study of multiplexed IgE sensitization in relation to asthma, exhaled nitric oxide, and bronchial responsiveness.
  • High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: a double-blind, placebo-controlled study.
Volume 5, Issue 3
(March 2013)

Lung Cancer Screening

  • Annual number of lung cancer deaths potentially avertable by screening in the United States
  • Estimating overdiagnosis in low-dose computed tomography screening for lung cancer: a cohort study
  • Predictive accuracy of the Liverpool Lung Project risk model for stratifying patients for computed tomography screening for lung cancer
  • Two microRNA panels to discriminate three subtypes of lung carcinoma in bronchial brushing specimens
  • Non-invasive breath analysis of pulmonary nodules
  • Biomarkers to help guide management of patients with pulmonary nodules
  • Definition of a positive test result in computed tomography screening for lung cancer
  • Selection criteria for lung-cancer screening
  • Using socio-demographic and early clinical features in general practice to identify people with lung cancer earlier
  • Characteristics of lung cancers detected by computer tomography screening in the randomized NELSON trial
Volume 5, Issue 2
(February 2013)


  • Multidrug-resistant pulmonary tuberculosis treatment regimens and patient outcomes: an individual patient data meta-analysis of 9,153 patients.
  • Risk of progression to active tuberculosis following reinfection with Mycobacterium tuberculosis.
  • Identifying predictors of interferon-γ release assay results in pediatric latent tuberculosis: a protective role of Bacillus Calmette-Guérin A pTB-NET collaborative study.
  • Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.
  • Surgical face masks worn by patients with multidrug-resistant tuberculosis. Impact on infectivity of air on a hospital ward.
  • 14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial.
  • Delamanid for multidrug-resistant pulmonary tuberculosis.
  • The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trial.
  • Fluorescein diacetate vital staining allows earlier diagnosis of rifampicin-resistant tuberculosis.
  • Predictive value of interferon-g release assays for incident active tuberculosis: a systematic review and meta-analysis.
Volume 5, Issue 1
(January 2013)

Current Trends in Lung Cancer Surgery

  • Oncologic efficacy of anatomic segmentectomy in stage IA lung cancer patients with T1a tumors
  • Is limited pulmonary resection equivalent to lobectomy for surgical management of stage I non-small-cell lung cancer?
  • Point/Counterpoint: are limited resections appropriate in non-small cell lung cancer? Yes/No
  • Morphological analysis of circulating tumour cells in patients undergoing surgery for non-small cell lung carcinoma using the isolation by size of epithelial tumour cell (ISET) method
  • Recurrence dynamics for non-small-cell lung cancer: effect of surgery on the development of metastases
  • Patterns of recurrence and incidence of second primary tumors after lobectomy by means of videoassisted thoracoscopic surgery (VATS) versus thoracotomy for lung cancer
  • Lung cancer screening and video-assisted thoracic surgery
  • Surgical resection of highly suspicious pulmonary nodules without a tissue diagnosis
  • Operating on a suspicious lung mass without a preoperative tissue diagnosis: pros and cons
  • Improved outcomes associated with higher surgery rates for older patients with early stage non-small cell lung cancer
  • Is it safe to include octogenarians at the start of a video-assisted thoracic surgery lobectomy program?
  • Lobectomy in octogenarians with non-small cell lung cancer: ramifications of increasing life expectancy and the benefits of minimally invasive surgery
Respiratory Updates (archives)
2012 Archive
  • Progress of Pulmonary Function Testing in 2011/12
  • IPF trials and Sarcoidosis
  • Respiratory infections other than tuberculosis
  • Cell and Molecular Biology in Respirology
  • Pulmonary Circulation
  • Quantitative imaging of airways
  • Paediatric lung disease
  • Tuberculosis
  • Community and Public Health
  • Chronic obstructive pulmonary disease (COPD)
  • Epithelial-mesenchymal transition (EMT) in lung disease
  • Tobacco/Smoking cessation
2011 Archive
  • Pneumoconiosis
  • Environmental & Occupational Health
  • Bronchoscopy & Interventional Techniques
  • Sleep
  • Critical Care Medicine
  • Influenza
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Pulmonary and Systemic Venous Thromboembolism
2010 Archive
  • Community and Public Health
  • Tuberculosis
  • Tobacco/smoking cessation
  • Paediatric lung disease
  • Sleep
  • Pneumonia
  • Bronchoscopy & Interventional Techniques
  • Pleural diseases
  • Asthma
  • Critical Care Medicine
  • Interstitial Lung Disease
  • COPD & asthma: Differences & similarities
2009 Archive
  • Influenza
  • Lung Cancer
  • Venous Thromboembolism
Respiratory Research Review (archives)
2008 Archive
2007 Archive
2006 Archive

Disclaimer: The above publications are not intended as a replacement for regular medical education. The comments are an interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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