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APSR Respiratory Updates


Dr David CL Lam

APSR Respiratory Updates is a unique publication bringing you the most important clinical research in respiratory medicine. Each month an expert within the APSR will identify and review ten key publications in their field. In addition to a link to the publication, a brief commentary on why the study is important will be provided. This series represents an important initiative of the Education Committee of the APSR. We hope you find it informative and useful in your clinical practice.

Dr David CL Lam

Respiratory Updates (archives)
2017 (current)
2016 Archive
  • Pulmonary rehabilitation in COPD
  • Lung Development and Regeneration
  • Lymphangioleiomyomatosis
  • Obesity Hypoventilation Syndrome
  • Update in Acute Respiratory Distress Syndrome
  • Lung Transplantation
  • Lung cancer immunotherapy
  • Pneumonia
  • Updates in Pulmonary Function Testing 2012-2015
  • Pulmonary Aspergillosis
  • Updates on Bronchoscopy and Interventional Pulmonology
2015 Archive
  • Cystic Fibrosis (CF)
  • Tobacco/Smoking Cessation
  • Pulmonary Circulation
  • Idiopathic Pulmonary Fibrosis trials and Sarcoidosis
  • Mesothelioma
  • Bronchiectasis
  • APSR air pollution update
  • Induced Sputum 2015
  • Pneumothorax: Evolving Indications for Surgery
  • Non-invasive ventilation
  • Cellular and molecular biology of the lung
  • Quantitative Imaging of the Respiratory System
2014 Archive
  • COPD
  • Tuberculosis
  • Environmental and Occupational Health
  • APSR Paediatric Updates 2014
  • Pneumoconiosis and other related conditions
  • Sleep Medicine
  • Critical Care Medicine
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Venous Thromboembolism
2013 Archive
  • Fukuchi Award and Young Investigator Award Abstracts
  • Mesothelioma
  • Cystic Fibrosis and Bronchiectasis
  • Lung transplantation
  • Air Pollution
  • Induced sputum
  • Respirology Virtual Issues
  • Non-invasive ventilation
  • Monitoring free serum IgE in severe asthma patients treated with omalizumab
  • Lung Cancer Screening
  • Tuberculosis
  • Current Trends in Lung Cancer Surgery
Respiratory UpdatesContents
Volume 4, Issue 12
(December 2012)

Progress of Pulmonary Function Testing in 2011/12

  • Normal values and predicted equations
  • Cut-off values of FEV1/FVC for determination of airflow obstruction
  • FEV1/FEV6 for the diagnosis of airflow limitation
  • FEV1 decline rate in COPD
  • Bronchial provocation tests
Volume 4, Issue 11
(November 2012)

IPF trials and Sarcoidosis

I About IPF trial design
  • Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis.
  • A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis
II About endpoint of IPF trial
  • Idiopathic Pulmonary Fibrosis: Clinically Meaningful Primary Endpoints in Phase 3 Clinical Trials
  • Hot on the breath: Mortality as a primary end-point in IPF treatment trials: the best is the enemy of the good
  • Idiopathic Pulmonary Fibrosis: Lung Function is a Clinically Meaningful Endpoint for Phase 3 Trials
III About Sarcoidosis
  • A Novel Sarcoidosis Risk Locus for Europeans on Chromosome 11q13.1
  • Sarcoidosis-related Mortality in the United States from 1988 to 2007
  • Inflammatory activity assessment by F18 FDG-PET/CT in persistent symptomatic sarcoidosis
  • Development of a sarcoidosis murine lung granuloma model using Mycobacterium superoxide dismutase A peptide.
  • Transforming growth factor-b gene polymorphisms in different phenotypes of sarcoidosis
Volume 4, Issue 10
(October 2012)

Respiratory infections other than tuberculosis

  • Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection
  • Exudate Macrophages Attenuate Lung Injury by the Release of IL-1 Receptor Antagonist in Gram-negative Pneumonia
  • Nebulized Ceftazidime and Amikacin in Ventilator-associated Pneumonia Caused by Pseudomonas aeruginosa
  • Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial
  • Implementation of guidelines for management of possible multidrug-resistant pneumonia in intensive care: an observational, multicentre cohort study
  • PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice
  • Procalcitonin and C-Reactive Protein in Hospitalized Adult Patients With Community-Acquired Pneumonia or Exacerbation of Asthma or COPD
  • Recombinant Tissue Factor Pathway Inhibitor in Severe Community-acquired Pneumonia — A Randomized Trial
  • Risks of Pneumonia in Patients with Asthma Taking Inhaled Corticosteroids
Volume 4, Issue 9
(September 2012)

Cell and Molecular Biology in Respirology

  • Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection
  • Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation
  • Multipotent Capacity of Immortalized Human Bronchial Epithelial Cells
  • Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs
  • Activation of Canonical Wnt Signaling Is Required for TGF-β-mediated Fibrosis
  • Aclidinium Inhibits Human Lung Fibroblast to Myofibroblast Transition
  • Development and Preclinical Efficacy of Novel Transforming Growth Factor-β1 Short Interfering RNAs for Pulmonary Fibrosis
  • Participant of miR-200 in Pulmonary Fibrosis
  • The Tumor Necrosis Factor Family Member LIGHT Is A Target for Asthmatic airway remodeling
  • IL-17A Produced by αβ T Cells Drives Airway Hyper-responsiveness in mice and Enhances Mouse and Human
  • Airway Smooth Muscle Contraction
Volume 4, Issue 8
(August 2012)

Pulmonary Circulation

  • Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report
  • The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation
  • Cell-based therapies for lung vascular diseases: lessons for the future
  • Neuromuscular blockers in early acute respiratory distress syndrome
  • Vardenafil in pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled study
  • Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ
  • Functional disability 5 years after acute respiratory distress syndrome
  • KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome
  • Pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema syndrome
  • Treatment of pulmonary arterial hypertension with targeted therapies
Volume 4, Issue 7
(July 2012)

Quantitative imaging of airways

  • Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
  • Gender Differences of Airway Dimensions in Anatomically Matched Sites on CT in Smokers
  • Association Between Airway Caliber Changes with Lung Inflation and Emphysema Assessed by Volumetric CT in Subjects with COPD
  • Measurement of Lung Airways in Three Dimensions using Hyperpolarized Helium-3 MRI
  • Comparison of Airway Remodeling Assessed by Computed Tomography in Asthma and COPD
  • Quantitative Computed Tomography Measures of Emphysema and Airway Wall Thickness are Related to Respiratory Symptoms
  • Clinical and Radiographic Predictors of GOLD — Unclassified Smokers in the COPDGene Study
  • Chronic Obstructive Pulmonary Disease Exacerbations in the COPDGene Study: Associated Radiologic Phenotypes
  • The Chronic Bronchitic Phenotype of COPD: an Analysis of the COPDGene Study
  • Effects of Adding Omalizumab, an Anti-Immunoglobulin E Antibody, on Airway Wall Thickening in Asthma
Volume 4, Issue 6
(June 2012)

Paediatric lung disease

  • Predictors of symptoms are different from predictors of severe exacerbations from asthma in children
  • Is respiratory viral infection really an important trigger of asthma exacerbations in children?
  • Nebulized budesonide added to standard pediatric emergency department treatment of acute asthma: a randomized, double-blind trial
  • Continuous versus intermittent inhaled corticosteroids for mild persistent asthma in children: not too much, not too little
  • A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils)
  • Lower airway microbiology and cellularity in children with newly diagnosed non-CF bronchiectasis
  • Long term sequelae from childhood pneumonia; systematic review and meta-analysis
  • British Thoracic Society guidelines for the management of community acquired pneumonia in children: update 2011
  • A multi-centre study on chronic cough in children: burden and etiologies based on a standardized management pathway
  • Viral and atypical bacterial detection in acute respiratory infection in children under five years
Volume 4, Issue 5
(May 2012)


  • Rapid and effective diagnosis of tuberculosis and rifampicin resistance with Xpert MTB/RIF assay: a meta-analysis
  • Commercial serological tests for the diagnosis of active pulmonary and extrapulmonary tuberculosis: an updated systematic review and meta-analysis
  • Three months of rifapentine and isoniazid for latent tuberculosis infection
  • New regimens to prevent tuberculosis in adults with HIV infection
  • Efficacy and safety of a 4-drug fixed dose combination (FDC) regimen compared with separate drugs for treatment of pulmonary tuberculosis. The study C randomized controlled trial
  • Projected effects of tobacco smoking on worldwide tuberculosis control: mathematical modeling analysis
  • Natural history of tuberculosis: duration and fatality of untreated PTB in HIV negative patients: a systematic review
  • Whole-genome sequencing and social-network analysis of a tuberculosis outbreak
  • Nutrition, diabetes and tuberculosis in the epidemiological transition
  • Multidrug-Resistant Tuberculosis not due to noncompliance but between-patient pharmacokinetic variability
Volume 4, Issue 4
(April 2012)

Community and Public Health

  • Provider demonstrations and assessment of child device technique during pediatric asthma visits
  • Concurrent use of metered dose inhalers with spacer and dry powder inhalers by asthmatic children adversely affect proper inhalation technique
  • Choosing inhaler devices for people with asthma: Current knowledge and outstanding research needs
  • Inhaler device, administration technique, adherence to inhaled corticosteroid in patients with asthma
  • Technique training does not improve the ability of most patients to use pressurized metered-dose inhalers (pMDIs)
  • Using the community pharmacy to identify patients at risk of poor asthma control and factors which contribute to the poor control
  • Improving paediatric asthma outcomes in primary health care: a randomized controlled trial
  • Asthma action plans and patient satisfaction among women with asthma
  • The Colorado Asthma Toolkit Program: A practice coaching intervention from the High Plains Research
  • Peer-led education for adolescents with asthma in Jordan: A cluster-randomised controlled trial
Volume 4, Issue 3
(March 2012)

Chronic obstructive pulmonary disease (COPD)

  • Changes in forced expiratory volume in 1 second over time in COPD
  • Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease
  • Azithromycin for prevention of exacerbations of COPD
  • Lung volumes and emphysema in smokers with interstitial lung abnormalities
  • Identification of COPD in lung cancer screening computed tomographic scans
  • Inhaled long-acting β-agonist and anticholinergic effectiveness in older patients with COPD
  • Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study
  • Roflumilast in Asian patients with COPD: A randomized placebo-controlled trial
  • Efficacy of tiotropium in COPD patients from Asia: a subgroup analysis from the UPLIFT trial
Volume 4, Issue 2
(February 2012)

Epithelial-mesenchymal transition (EMT) in lung disease

  • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
  • Epithelial to mesenchymal transition in an EGFR-mutant lung cancer cell line with resistance to erlotinib
  • Slug confers resistance to the epidermal growth gactor receptor tyrosine kinase inhibitor
  • L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
  • Epithelial to mesenchymal transition is a determinant of sensitivity to chemoradiotherapy in NSCLC
  • Epithelial to mesenchymal transition by TGFβ-1 induction increases stemness characteristics in NSCLC
  • Oct4 and Nanog enhance lung adenocarcinoma by inducing cancer stem cell-like properties and EMT
  • Knockdown of ZEB1, a master EMT gene, suppresses anchorage-independent growth of lung cancer cells
  • ZEB1-responsive genes in non-small cell lung cancer
  • A comparison of Twist and E-cadherin protein expression in primary NSCLC and its metastases
Volume 4, Issue 1
(January 2012)

Tobacco/Smoking cessation

  • Effectiveness of dust control methods during manual concrete surface grinding
  • A randomized placebo-controlled trial of varenicline for smoking cessation allowing flexible quit dates
  • Effects of varenicline in adult smokers: a multinational, randomized, placebo-controlled study
  • Reduction in cadmium exposure in the US, 1988-2008: the contribution of declining smoking rates
  • Environmental tobacco smoke exposure increases Mycobacterium tuberculosis infection risk in children
  • Placebo-controlled trial of cytisine for smoking cessation
  • Association between parental smoking behaviour and children's respiratory morbidity
  • Effectiveness of a school nurse-delivered smoking-cessation intervention for adolescents
  • Intensive intervention for alcohol-dependent smokers in early recovery: a randomized trial
  • Impact of the 2010 tobacco tax increase in Australia on short-term smoking cessation
Respiratory Updates (archives)
2011 Archive
  • Pneumoconiosis
  • Environmental & Occupational Health
  • Bronchoscopy & Interventional Techniques
  • Sleep
  • Critical Care Medicine
  • Influenza
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Pulmonary and Systemic Venous Thromboembolism
2010 Archive
  • Community and Public Health
  • Tuberculosis
  • Tobacco/smoking cessation
  • Paediatric lung disease
  • Sleep
  • Pneumonia
  • Bronchoscopy & Interventional Techniques
  • Pleural diseases
  • Asthma
  • Critical Care Medicine
  • Interstitial Lung Disease
  • COPD & asthma: Differences & similarities
2009 Archive
  • Influenza
  • Lung Cancer
  • Venous Thromboembolism
Respiratory Research Review (archives)
2008 Archive
2007 Archive
2006 Archive

Disclaimer: The above publications are not intended as a replacement for regular medical education. The comments are an interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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