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APSR Respiratory Updates


Dr David CL Lam

APSR Respiratory Updates is a unique publication bringing you the most important clinical research in respiratory medicine. Each month an expert within the APSR will identify and review ten key publications in their field. In addition to a link to the publication, a brief commentary on why the study is important will be provided. This series represents an important initiative of the Education Committee of the APSR. We hope you find it informative and useful in your clinical practice.

Dr David CL Lam

Respiratory Updates (archives)
2017 (current)
2016 Archive
  • Pulmonary rehabilitation in COPD
  • Lung Development and Regeneration
  • Lymphangioleiomyomatosis
  • Obesity Hypoventilation Syndrome
  • Update in Acute Respiratory Distress Syndrome
  • Lung Transplantation
  • Lung cancer immunotherapy
  • Pneumonia
  • Updates in Pulmonary Function Testing 2012-2015
  • Pulmonary Aspergillosis
  • Updates on Bronchoscopy and Interventional Pulmonology
2015 Archive
  • Cystic Fibrosis (CF)
  • Tobacco/Smoking Cessation
  • Pulmonary Circulation
  • Idiopathic Pulmonary Fibrosis trials and Sarcoidosis
  • Mesothelioma
  • Bronchiectasis
  • APSR air pollution update
  • Induced Sputum 2015
  • Pneumothorax: Evolving Indications for Surgery
  • Non-invasive ventilation
  • Cellular and molecular biology of the lung
  • Quantitative Imaging of the Respiratory System
2014 Archive
  • COPD
  • Tuberculosis
  • Environmental and Occupational Health
  • APSR Paediatric Updates 2014
  • Pneumoconiosis and other related conditions
  • Sleep Medicine
  • Critical Care Medicine
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Venous Thromboembolism
2013 Archive
  • Fukuchi Award and Young Investigator Award Abstracts
  • Mesothelioma
  • Cystic Fibrosis and Bronchiectasis
  • Lung transplantation
  • Air Pollution
  • Induced sputum
  • Respirology Virtual Issues
  • Non-invasive ventilation
  • Monitoring free serum IgE in severe asthma patients treated with omalizumab
  • Lung Cancer Screening
  • Tuberculosis
  • Current Trends in Lung Cancer Surgery
2012 Archive
  • Progress of Pulmonary Function Testing in 2011/12
  • IPF trials and Sarcoidosis
  • Respiratory infections other than tuberculosis
  • Cell and Molecular Biology in Respirology
  • Pulmonary Circulation
  • Quantitative imaging of airways
  • Paediatric lung disease
  • Tuberculosis
  • Community and Public Health
  • Chronic obstructive pulmonary disease (COPD)
  • Epithelial-mesenchymal transition (EMT) in lung disease
  • Tobacco/Smoking cessation
Respiratory UpdatesContents
Volume 3, Issue 11
(December 2011)


  • Effectiveness of dust control methods during manual concrete surface grinding
  • Associations of IL-4, IL-4R, and IL-13 gene polymorphisms in coal workers' pneumoconiosis in China
  • Gene polymorphisms and the release of TNFα and IL1 cytokines in coal workers' pneumoconiosis
  • Occupational exposure to asbestos and ovarian cancer: a meta-analysis
  • Prevalence of connective tissue disease in silicosis (1985-2006) - the Michigan surveillance system
  • Coal dust exposure and mortality from ischemic heart disease among a cohort of US coal miners
  • Digital direct readout radiography and conventional radiography for the recognition of pneumoconiosis
  • Computed radiography and conventional radiography in the recognition of pneumoconiotic opacities
  • Lung function loss in relation to silica dust exposure in South African gold miners
  • DLCO relates better to short-term progression on HRCT abnormalities than spirometry in mild asbestosis
  • Early detection of central airway lung cancer in smokers with silicosis
Volume 3, Issue 10
(November 2011)

Environmental & Occupational Health

  • Indium exposure and oxidative damage in workers in indium tin oxide production plants
  • SMRP, CA125, and CYFRA 21-1 as tumour markers for malignant mesothelioma and lung cancer
  • Asbestos fibre dimensions and lung cancer mortality among workers exposed to chrysotile
  • Effect of gene environment interactions on lung function and cardiovascular disease in COPD
  • Synchrotron soft X-ray imaging and fluorescence microscopy of asbestos bodies in human lung tissues
  • Erionite exposure in North Dakota and Turkish villages with mesothelioma
  • Expression of heme oxygenase-1 in the lungs of rats exposed to potassium octatitanate whiskers
  • Intratracheal instillation of single-walled carbon nanotubes induced early lung fibrosis in mice
  • Arsenic exposure increases the risk of lower respiratory tract infection and diarrhoea during infancy
Volume 3, Issue 9
(October 2011)

Bronchoscopy & Interventional Techniques

  • Virtual bronchoscopic navigation combined with EBUS to diagnose small peripheral pulmonary lesions
  • EBUS-guided lymph node biopsy (EBUS-TBNB) with a transbronchial needle forceps (TBNF) - a pilot study
  • Endobronchial-ultrasound guided miniforceps biopsy of mediastinal and hilar lesions
  • Using EBUS features to predict lymph node metastasis in patients with lung cancer
  • Utility of EBUS-guided TBNA in patients with tuberculous intrathoracic lymphadenopathy
  • The utility of EBUS-guided TBNA biopsy in the diagnosis of mediastinal lymphoproliferative disorders
  • Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma
  • A randomized study of endobronchial valves for advanced emphysema
  • Bronchoscopic spray cryotherapy: assessment of safety and depth of airway injury
Volume 3, Issue 8
(September 2011)


  • Predictors of long-term compliance with continuous positive airway pressure
  • Flexible pressure delivery modification of CPAP for OSA does not improve compliance with therapy
  • A novel nasal expiratory positive airway pressure (EPAP) device for the treatment of OSA
  • Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure
  • Sleep apnea testing and outcomes in Medicare beneficiaries with newly diagnosed heart failure
  • Occurrence of coronary collateral vessels in patients with sleep apnea and total coronary occlusion
  • Obstructive sleep apnea-hypopnea and incident stroke: The Sleep Heart Health Study
  • Early treatment of obstructive apnoea and stroke outcome: a randomized controlled trial
  • Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment
Volume 3, Issue 7
(August 2011)

Critical Care Medicine

  • Pre-hospitalization anti-platelet therapy is associated with a reduced incidence of acute lung injury
  • Mucins carrying selectin ligands as predictive biomarkers of DIC complication in ARDS
  • A randomized clinical trial of HMG-CoA reductase inhibition for acute lung injury
  • Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury
  • Neuromuscular blockers in early acute respiratory distress syndrome
  • Functional disability 5 years after acute respiratory distress syndrome
  • Circulating mitochondrial DAMPs cause inflammatory responses to injury
  • Metabolic consequences of sepsis-induced ALI revealed by plasma 'H-NMR quantitative metabolomics
  • Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors
Volume 3, Issue 6
(July 2011)


  • Possible role of aerosol transmission in a hospital outbreak of influenza
  • Outcomes of adults hospitalised with severe influenza
  • Risk factors for severe illness with 2009 pandemic influenza A (H1N1) virus infection in China
  • Complications and outcomes of pandemic 2009 influenza A (H1N1) virus infection in hospitalized adults
  • Viral clearance and inflammatory response in adults hospitalized for pandemic 2009 influenza A (H1N1)
  • Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection
  • Corticosteroid treatment in critically ill patients with pandemic influenza A/H1N1 2009 infection
  • Early corticosteroids in severe influenza A/H1N1 pneumonia and acute respiratory distress syndrome
  • Oseltamivir ring prophylaxis for containment of 2009 H1N1 influenza outbreaks
  • Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1)
  • Safety of influenza A (H1N1) vaccine in postmarketing surveillance in China
Volume 3, Issue 5
(June 2011)

Interstitial Lung Diseases

  • Official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines
  • Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomized trials
  • A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis
  • BUILD-3: A randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis
  • A common MUC5B promoter polymorphism and pulmonary fibrosis
  • ERS guidelines for the diagnosis and management of lymphangioleiomyomatosis
  • Efficacy and safety of sirolimus in lymphangioleiomyomatosis
  • Inhaled GM-CSF as therapy for pulmonary alveolar proteinosis
  • Gene set analysis of lung samples and pathogenesis of progressive, fibrotic pulmonary sarcoidosis
  • Combined pulmonary fibrosis and emphysema syndrome in connective tissue disease
Volume 3, Issue 4
(May 2011)

Pleural Diseases

  • Setting up a specialist pleural disease service
  • Evidence base of FDG-PET/CT imaging in the clinical management of malignant pleural mesothelioma
  • Guidelines of the ERS and the ESTS for the management of malignant pleural mesothelioma
  • The relationship between chest tube size and clinical outcome in pleural infection
  • Rapid pleurodesis for malignant pleural effusions: A pilot study
  • Survey of major complications of intercostal chest drain insertion in the UK
  • Diagnostic accuracy, safety and utilisation of respiratory physician-delivered thoracic ultrasound
  • Chemotherapy should not be withheld in patients with indwelling catheter for malignant pleural effusion
  • Prognostic factors for survival after surgical palliation of malignant pleural effusion
  • Serum soluble mesothelin concentrations in malignant pleural mesothelioma
Volume 3, Issue 3
(April 2011)


  • Farm living: effects on childhood asthma and allergy
  • The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema
  • Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents
  • Tiotropium bromide step-up therapy for adults with uncontrolled asthma
  • Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma
  • Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids
  • Cost-effectiveness of fluticasone vs montelukast in children with mild-to-moderate persistent asthma
  • Overall asthma control: the relationship between current control and future risk
  • A trial of clarithromycin for the treatment of suboptimally controlled asthma
  • A mobile telephone-based interactive self-care system improves asthma control
  • Telehealthcare for asthma
Volume 3, Issue 2
(February 2011)

Lung Cancer

  • Baseline characteristics of participants in the randomized national lung screening trial
  • Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial
  • Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable NSCLC
  • Cumulative incidence of false-positive test results in lung cancer screening: a randomized trial
  • Lung cancer screening in the randomized prostate, lung, colorectal, and ovarian cancer screening trial
  • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
  • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
  • FGFR1 amplification and therapeutically tractable FGFR1 dependency in squamous cell lung cancer
  • Multiple independent loci at chromosome 15q25.1 affect smoking quantity
  • Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21
  • Gene expression-based prognostic signatures in lung cancer: ready for clinical use?
  • Early palliative care for patients with metastatic non-small-cell lung cancer
  • Lung cancer screening and smoking abstinence
Volume 3, Issue 1
(January 2011)

Pulmonary and Systemic Venous Thromboembolism

  • Oral rivaroxaban for symptomatic venous theomboembolism
  • Safety of outpatient treatment in acute pulmonary embolism
  • Early anticoagulation is associated with reduced mortality for acute pulmonary embolism
  • Venous thromboemboli and exacerbations of COPD
  • Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women
  • Risk assessment model for identification of hospitalized patients at risk for venous thromboembolism
  • Effect of home testing of international normalized ratio on clinical events
  • Prolonged work- and computer-related seated immobility and risk of venous thromboembolism
  • Acute pulmonary embolism - a review
Respiratory Updates (archives)
2010 Archive
  • Community and Public Health
  • Tuberculosis
  • Tobacco/smoking cessation
  • Paediatric lung disease
  • Sleep
  • Pneumonia
  • Bronchoscopy & Interventional Techniques
  • Pleural diseases
  • Asthma
  • Critical Care Medicine
  • Interstitial Lung Disease
  • COPD & asthma: Differences & similarities
2009 Archive
  • Influenza
  • Lung Cancer
  • Venous Thromboembolism
Respiratory Research Review (archives)
2008 Archive
2007 Archive
2006 Archive

Disclaimer: The above publications are not intended as a replacement for regular medical education. The comments are an interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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