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APSR Respiratory Updates


Richard Beasley

APSR Respiratory Updates is a unique publication bringing you the most important clinical research in respiratory medicine. Each month an expert within the APSR will identify and review ten key publications in their field. In addition to a link to the publication, a brief commentary on why the study is important will be provided. This series represents an important initiative of the Education Committee of the APSR. We hope you find it informative and useful in your clinical practice.

Professor Richard Beasley

Respiratory Updates (archives)
2017 (current)
2016 Archive
  • Pulmonary rehabilitation in COPD
  • Lung Development and Regeneration
  • Lymphangioleiomyomatosis
  • Obesity Hypoventilation Syndrome
  • Update in Acute Respiratory Distress Syndrome
  • Lung Transplantation
  • Lung cancer immunotherapy
  • Pneumonia
  • Updates in Pulmonary Function Testing 2012-2015
  • Pulmonary Aspergillosis
  • Updates on Bronchoscopy and Interventional Pulmonology
2015 Archive
  • Cystic Fibrosis (CF)
  • Tobacco/Smoking Cessation
  • Pulmonary Circulation
  • Idiopathic Pulmonary Fibrosis trials and Sarcoidosis
  • Mesothelioma
  • Bronchiectasis
  • APSR air pollution update
  • Induced Sputum 2015
  • Pneumothorax: Evolving Indications for Surgery
  • Non-invasive ventilation
  • Cellular and molecular biology of the lung
  • Quantitative Imaging of the Respiratory System
2014 Archive
  • COPD
  • Tuberculosis
  • Environmental and Occupational Health
  • APSR Paediatric Updates 2014
  • Pneumoconiosis and other related conditions
  • Sleep Medicine
  • Critical Care Medicine
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Venous Thromboembolism
2013 Archive
  • Fukuchi Award and Young Investigator Award Abstracts
  • Mesothelioma
  • Cystic Fibrosis and Bronchiectasis
  • Lung transplantation
  • Air Pollution
  • Induced sputum
  • Respirology Virtual Issues
  • Non-invasive ventilation
  • Monitoring free serum IgE in severe asthma patients treated with omalizumab
  • Lung Cancer Screening
  • Tuberculosis
  • Current Trends in Lung Cancer Surgery
2012 Archive
  • Progress of Pulmonary Function Testing in 2011/12
  • IPF trials and Sarcoidosis
  • Respiratory infections other than tuberculosis
  • Cell and Molecular Biology in Respirology
  • Pulmonary Circulation
  • Quantitative imaging of airways
  • Paediatric lung disease
  • Tuberculosis
  • Community and Public Health
  • Chronic obstructive pulmonary disease (COPD)
  • Epithelial-mesenchymal transition (EMT) in lung disease
  • Tobacco/Smoking cessation
2011 Archive
  • Pneumoconiosis
  • Environmental & Occupational Health
  • Bronchoscopy & Interventional Techniques
  • Sleep
  • Critical Care Medicine
  • Influenza
  • Interstitial Lung Diseases
  • Pleural Diseases
  • Asthma
  • Lung Cancer
  • Pulmonary and Systemic Venous Thromboembolism
Respiratory UpdatesContents
Volume 2, Issue 12
(December 2010)

Community and Public Health

  • Indigenous healthcare worker involvement for Indigenous adults and children with asthma
  • An education intervention for childhood asthma by Aboriginal and Torres Strait Islander health workers
  • Lay health workers in primary and community health care for maternal and child health
  • Smoke-free legislation and hospitalizations for childhood asthma
  • Didgeridoo playing and singing to support asthma management in Aboriginal Australians
  • Management of bronchiectasis and chronic suppurative lung disease in Indigenous children and adults
  • Impact of public health interventions in controlling the spread of SARS
  • Children hospitalized with 2009 novel influenza A (H1N1) in California
  • Respiratory health effects of exposure to low-NOx unflued gas heaters in the classroom
Volume 2, Issue 11
(November 2010)


  • Development of extensively drug-resistant TB during multidrug-resistant TB treatment
  • HIV co-infection in multidrug- and extensively drug-resistant tuberculosis results in high early mortality
  • Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection
  • Evaluation of quantitative IFN-ϒ response for risk stratification of active tuberculosis suspects
  • Diagnostic yield of ultrasound-assisted Abrams and Tru-Cut needle biopsies for pleural tuberculosis
  • Efficacy of a 6-month versus 9-month intermittent treatment regimen in HIV-infected patients with TB
  • Timing of initiation of antiretroviral drugs during tuberculosis therapy
  • Treatment outcomes among patients with extensively drug-resistant tuberculosis
  • Early bactericidal activity and pharmacokinetics of PA-824 in smear-positive tuberculosis patients
Volume 2, Issue 10
(October 2010)

Tobacco/smoking cessation

  • Smoking cessation
  • Secondhand smoke exposures in indoor public places in seven Asian countries
  • Smoking, smoking cessation, and risk for type 2 diabetes mellitus: a cohort study
  • The association of pipe and cigar use with cotinine levels, lung function, and airflow obstruction
  • Depression and smoking in the U.S. household population aged 20 and over, 2005-2008
  • Assessment of DNA damage in children exposed to indoor tobacco smoke
  • Adverse events associated with nicotine replacement therapy (NRT) for smoking cessation
  • Relationships between household smoking restrictions and intention to quit smoking
  • Media campaign effectiveness in promoting a smoking-cessation program
Volume 2, Issue 9
(September 2010)

Paediatric lung disease

  • Effect of azithromycin in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa
  • Longitudinal growth and lung function in paediatric non-cystic fibrosis bronchiectasis
  • Can montelukast shorten prednisolone therapy in children with mild to moderate acute asthma?
  • The transient value of classifying preschool wheeze into episodic viral and multiple trigger wheeze
  • The influence of neonatal lung function on rhinovirus associated wheeze
  • Trial of cycled antibiotic prophylaxis to prevent initial Pseudomonas infection in children with CF
  • Trial of proton pump inhibitor lansoprazole in infants with symptoms of gastroesophageal reflux disease
  • An objective study of acid reflux and cough in children using an ambulatory pHmetry-cough logger
  • Parent initiated prednisolone for acute asthma in children of school age
Volume 2, Issue 8
(August 2010)


  • The prevalence of short sleep duration by industry and occupation
  • Sleep disordered breathing and mortality: a prospective cohort study
  • Lifestyle intervention with weight reduction: first line treatment in mild obstructive sleep apnoea
  • Effects of oropharyngeal exercises on patients with moderate obstructive sleep apnoea syndrome
  • Randomised controlled trial of variable-pressure versus fixed-pressure continuous positive airway pressure treatment for patients with obstructive sleep apnoea/hypopnoea syndrome
  • Relationship between overnight rostral fluid shift and obstructive sleep apnoea in nonobese men
  • Long-term time-course of nocturnal breathing disorders in heart failure patients
  • Effects of exercise training in patients with congestive heart failure and sleep apnoea
  • Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnoea
Volume 2, Issue 7
(July 2010)


  • Lower incidence of ARDS in community-acquired pneumonia patients aged 85 years or older
  • Newer fluoroquinolones for treating respiratory infection: do they mask tuberculosis?
  • Efficacy of corticosteroids in community-acquired pneumonia
  • Pneumococcal pneumonia presenting with septic shock
  • N-Acetylcysteine inhibits RhoA and promotes apoptotic cell clearance in lung inflammation
  • Nursing home-acquired pneumonia: a 10 year single-centre experience
  • Prospective, randomised study to compare empirical treatment versus treatment based on urine antigen results in hospitalised patients with community-acquired pneumonia
  • Pro-atrial natriuretic peptide and pro-vasopressin for predicting short-term and long-term survival in community-acquired pneumonia
  • CRP and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia
  • Coagulation and inflammation biomarkers may predict the severity of community-acquired pneumonia
Volume 2, Issue 6
(June 2010)

Bronchoscopy & Interventional Techniques

  • Early diagnosis of lung cancer
  • Color fluorescence ratio for detection of bronchial dysplasia and carcinoma in situ
  • Sonographic features during EBUS-TBNA for lymph node staging in patients with lung cancer
  • Combined endoesophageal-endobronchial ultrasound-guided, fine-needle aspiration of mediastinal lymph nodes in patients with lung cancer
  • EBUS-TBNA for restaging the mediastinum in lung cancer
  • Interventional bronchoscopy from bench to bedside: new techniques for central and peripheral airway obstruction
  • Airway stents
  • Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma
  • Management of complications from diagnostic and interventional bronchoscopy
  • Advances in thoracoscopy: 100 years since Jacobaeus
Volume 2, Issue 5
(May 2010)

Pleural diseases

  • Biomarkers of infection for the differential diagnosis of pleural effusions
  • Biomarkers of heart failure in pleural fluid
  • Thoracic ultrasound in the diagnosis of malignant pleural effusion
  • The volume of pleural fluid required for accurate diagnosis of malignant pleural effusion
  • Clinical impact and reliability of pleural fluid mesothelin in undiagnosed pleural effusions
  • Kinetics of soluble mesothelin in patients with malignant pleural mesothelioma during treatment
  • Guidelines for pathologic diagnosis of malignant mesothelioma
  • Full postpleurodesis lung expansion and successful outcome after talc pleurodesis
  • Pleural procedures and pleuroscopy
  • Serum and pleural fluid biomarkers for mesothelioma
  • Malignant pleural mesothelioma: an update on biomarkers and treatment
  • CT appearances of pleural tumours
Volume 2, Issue 4
(April 2010)


  • ATS/ERS statement: asthma control and exacerbations
  • Consistently very poorly controlled asthma increases risk for future severe asthma exacerbations
  • The FDA and safe use of long-acting beta-agonists in the treatment of asthma
  • Thirteen-year follow-up of early intervention with an inhaled corticosteroid in patients with asthma
  • Oral prednisolone for preschool children with acute virus-induced wheezing
  • Preemptive use of high-dose fluticasone for virus-induced wheezing in young children
  • Efficacy of esomeprazole for treatment of poorly controlled asthma
  • Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma
  • Mepolizumab and exacerbations of refractory eosinophilic asthma
  • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
Volume 2, Issue 3
(March 2010)

Critical Care Medicine

  • Intensive versus conventional glucose control in critically ill patients
  • Prone positioning in patients with moderate and severe acute respiratory distress syndrome
  • Outcomes associated with delirium in older patients in surgical ICUs
  • Early physical and occupational therapy in mechanically ventilated, critically ill patients
  • Effectiveness of treatments for severe sepsis
  • Non-invasive ventilation in acute respiratory failure
  • Comparison of routine and on-demand prescription of chest radiographs in mechanically ventilated adults
  • International study of the prevalence and outcomes of infection in intensive care units
  • Implementation and impact of a translational research training program in pulmonary and critical care medicine
Volume 2, Issue 2
(February 2010)

Interstitial Lung Disease

  • Pirfenidone in idiopathic pulmonary fibrosis: A phase III clinical trial in Japan
  • Survival after bilateral versus single-lung transplantation for idiopathic pulmonary fibrosis
  • Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis
  • Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis
  • Clinical course and lung function change of idiopathic nonspecific interstitial pneumonia
  • Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease
  • Pathologic patterns and survival in chronic hypersensitivity pneumonitis
  • Pneumothorax after air travel in lymphangioleiomyomatosis, idiopathic pulmonary fibrosis, and sarcoidosis
  • Comparative study of high-resolution CT findings between autoimmune and secondary pulmonary alveolar proteinosis
Volume 2, Issue 1
(January 2010)

COPD & asthma: Differences & similarities

  • The overlap syndrome of asthma and COPD: what are its features and how important is it?
  • Distinct clinical phenotypes of airways disease defined by cluster analysis
  • Exhaled breath profiling enables discrimination of COPD and asthma
  • Exhaled breath condensate biomarkers in COPD
  • Molecular biomarkers for quantitative and discrete COPD phenotypes
  • Genome-wide association studies in asthma and COPD
  • Bronchial nitric oxide is related to symptom relief during fluticasone treatment in COPD
  • Predicting corticosteroid response in COPD using exhaled nitric oxide
Respiratory Updates (archives)
2009 Archive
  • Influenza
  • Lung Cancer
  • Venous Thromboembolism
Respiratory Research Review (archives)
2008 Archive
2007 Archive
2006 Archive

Disclaimer: The above publications are not intended as a replacement for regular medical education. The comments are an interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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