A selection of publications with educational value in
Pulmonary Circulation
Most recently added articles listed first
- Phosphodiesterase 5 inhibitor treatment and survival in interstitial lung disease pulmonary hypertension: A Bayesian retrospective observational cohort study Timothy J W Dawes, Colm McCabe, Konstantinos Dimopoulos, Iain Stewart, Simon Bax, Carl Harries, Chinthaka B Samaranayake, Aleksander Kempny, Philip L Molyneaux, Samuel Seitler, Thomas Semple, Wei Li, Peter M George, Vasileios Kouranos, Felix Chua, Elisabetta A Renzoni, Maria Kokosi, Gisli Jenkins, Athol U Wells, Stephen J Wort, Laura C Price (DOI: 10.1111/resp.14378)
(Figure 3B of 10.1111/resp.14378)
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onlinelibrary.wiley.com/doi/10.1111/resp.14378/full (March 2023)Comment by Dr Mark Lavercombe:
In this retrospective cohort study, physicians at the Royal Brompton Hospital National Pulmonary Hypertension Service report on data collected over 21 years including 128 patients with interstitial lung disease with pulmonary hypertension. Included patients were required to have had right heart catheter study, pulmonary function testing and transthoracic echocardiogram. Patients with connective tissue diseases and other causes of pulmonary hypertension were excluded. In patients treated with PDE5 inhibitors, there was a significant improvement in overall survival independent of other prognostic markers, and this was most striking in those with normal right ventricular function at baseline.20230207 - Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database Carolina Lombardi; Gianfranco Parati; Davide Soranna; Antonella Zambon; Paweł Sliwinski; Gabriel Roisman; Jean-Louis Pepin; Sophia Schiza; Renata Riha; Pavol Joppa; Ingo Fietze; Jan Hedner; Ludger Grote; the European Sleep Apnoea Database (ESADA) Collaborators (DOI: 10.1111/resp.13760)
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onlinelibrary.wiley.com/doi/10.1111/resp.13760/full (Aug 2020)Comment by Dr Mark Lavercombe:
The association between obstructive sleep apnoea and cardiovascular disease is well recognised. In this paper, the authors explore the role of comorbid elevation of the periodic limb movements in sleep index in a cohort of of patients with obstructive sleep apnoea, and demonstrate a significant elevation in systolic blood pressure, even after accounting for the degree of OSA with multivariate analysis. Further studies - including those utilising 24h BP monitoring - are recommended.20200721 - Non-invasive screening using ventilatory gas analysis to distinguish between chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension Mina Akizuki, Koichiro Sugimura, Tatsuo Aoki, Takaaki Kakihana, Shunsuke Tatebe, Saori Yamamoto, Haruka Sato, Kimio Satoh, Hiroaki Shimokawa and Masahiro Kohzuki (DOI: 10.1111/resp.13618)
Figure 5 of 10.1111/resp. 13618
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onlinelibrary.wiley.com/doi/10.1111/resp.13618/full (Apr 2020)Comment by Dr Mark Lavercombe:
Differentiation of the causes of pulmonary hypertension has become more important with targeted treatments available that can change prognosis. This study demonstrates the potential utility of a simple non-invasive test to differentiate between PH and non-PH, and CTEPH and PAH. Further studies will be required to clarify test performance in other patient groups and to exclude confounders.20200330 - Underuse of beta-blockers by patients with COPD and co-morbid acute coronary syndrome: A nationwide follow-up study in New Zealand Lianne Parkin, Joshua Quon, Katrina Sharples, David Barson and Jack Dummer (DOI: 10.1111/resp.13662)
Table 4 of 10.1111/resp-13662
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onlinelibrary.wiley.com/doi/10.1111/resp.13662/full (Feb 2020)Comment by Dr Mark Lavercombe:
In this nationwide study of 83425 patients with COPD, of whom 2637 had one or more acute coronary syndrome events during follow-up, low rates of beta-blocker prescription is found. This finding is especially pronounced in those with very severe COPD despite international guidelines recommending the use of beta-blockers in patients with coronary ischaemia and COPD.20200203 - Pulmonary arterial hypertension in a multi-ethnic Asian population: Characteristics, survival and mortality predictors from a 14-year follow-up study Yinghao Lim, Ting-Ting Low, Siew-Pang Chan,Ting Wei Teo, Jin-Hao Justin Jang, Nicole Yip, Ivandito Kuntjoro, Edgar Lik-Wui Tay And James Wei-Luen Yip
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onlinelibrary.wiley.com/doi/10.1111/resp.13392 (Feb 2019)Comment by Dr Mark Lavercombe:
The authors of this paper publish the first data for a multi-ethnic Asian cohort of patients with pulmonary arterial hypertension and have follow-up to 14 years. The REVEAL risk score for prediction of one-year mortality is evaluated with a cut off of >6 found to have a hazard ratio for earlier death of 4.4.20190116 - Pulmonary infarction secondary to pulmonary embolism: An evolving paradigm Marjan Islam, Jason Filopei, Matthew Frank, Navitha Ramesh, Stacey Verzosa, Madeline Ehrlich, Eric Bondarsky, Albert Miller and David Steiger
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onlinelibrary.wiley.com/doi/10.1111/resp.13299 (Sep 2018)Comment by Dr Mark Lavercombe:
This paper describes the findings of a retrospective review of 367 patients from a single centre who presented with pulmonary embolism. Pulmonary infarction was associated with younger age, absence of cardiopulmonary disease, presence of pleuritic chest pain and presence of an ipsilateral pleural effusion. Explanations based on pulmonary blood flow physiology and the development of collateral supply are proposed.20180823 - S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension Argyrios Tzouvelekis, Jose D Herazo-Maya, Changwan Ryu, Jen-Hwa Chu, Yingze Zhang, Kevin F Gibson, Percy K Adonteng-Boateng, Qin Li,1 Hongyi Pan, Benjamin Cherry, Ferhaan Ahmad, Hubert J Ford, Erica L Herzog, Naftali Kaminski and Wassim H Fares
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onlinelibrary.wiley.com/doi/10.1111/resp.13302 (Jul 2018)Comment by Dr Mark Lavercombe:
This intriguing study suggests the use of serum SA100A12 concentration as a prognostic marker in pulmonary hypertension. Despite relatively small sample sizes, elevated S100A12 levels were significantly associated with a diagnosis of PH, and negatively correlated to cardiac output. Increased overall mortality was associated with S100A12 levels in both discovery and validation cohorts.20180717 - Pulmonary hypertension in interstitial lung disease: Limitations of echocardiography compared to cardiac catheterization Gregory J Keir, S John Wort, Maria Kokosi, Peter M George, Simon L F Walsh, Joseph Jacob, Laura Price, Simon Bax, Elisabetta A Renzoni, Toby M Maher, Peter Macdonald, David M Hansell and Athol U Wells
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onlinelibrary.wiley.com/doi/10.1111/resp.13250 (Jun 2018)Comment by Dr Mark Lavercombe:
The use of transthoracic echocardiography as a screening tool for pulmonary hypertension in patients with interstitial lung disease is explored in this study, which finds significant numbers of patients are misclassified based on TTE parameters. The possibility of a combined risk assessment using other clinical factors is suggested.20180620 - Likelihood of pulmonary hypertension in patients with idiopathic pulmonary fibrosis and emphysema Joseph Jacob, Brian J Bartholmai, Srinivasan Rajagopalan, Ronald Karwoski, Arjun Nair, Simon L F Walsh, Joseph Barnett, Gary Cross, Eoin P Judge, Maria Kokosi, Elisabetta Renzoni, Toby M Maher and Athol U Wells (DOI: 10.1111/resp.13231)
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onlinelibrary.wiley.com/... (Jun 2018)Comment by Dr Mark Lavercombe:
In this study, the authors seek to define the risks of pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema compared with those with IPF alone. Their conclusion that CPFE is "not greater than the sum of its parts" helps guide prognostication in this patient cohort.20180523 - Year in review 2017: Interstitial lung disease, pulmonary vascular disease and sleep Amanda J Piper, Stephen J Wort, Elisabetta A Renzoni, Vasileios Kouranos (DOI: 10.1111/resp.13273)
onlinelibrary.wiley.com/doi/10.1111/resp.13273/full (Feb 2018)20180313 - CT-determined pulmonary artery to aorta ratio as a predictor of elevated pulmonary artery pressure and survival in idiopathic pulmonary fibrosis: Mitsuaki Yagi, Hiroyuki Taniguchi, Yasuhiro Kondoh, Masahiko Ando, Tomoki Kimura, Kensuke Kataoka, Taiki Furukawa, Atsushi Suzuki, Takeshi Johkoh & Oshinori Hasegawa.
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10.1111/resp.13066 (Oct 2017)Comment by Dr Mark Lavercombe:
The PA:A ratio as measured on chest CT scan has been demonstrated to predict pulmonary hypertension in some studies. In this cohort PA:A > 0.9 is found to predict both elevated mPAP and survival in patients with idiopathic pulmonary fibrosis.20170920 Pulmonary Rehabilitation Guidelines for Australia and New Zealand Jennifer A Alison, Zoe J McKeough, Kylie Johnston, Renae J McNamara, Lissa M Spencer, Sue C Jenkins, Catherine J Hill, Vanessa M McDonald, Peter Frith, Paul Cafarella, Michelle Brooke, Helen L Cameron-Tucker, Sarah Candy, Nola Cecins, Andrew S L Chan, Marita T Dale, Leona M Dowman, Catherine Granger, Simon Halloran, Peter Jung, Annemarie L Lee, Regina Leung, Tamara Matulick, Christian Osadnik, Mary Roberts, James Walsh, Sally Wootton, Anne E Holland, on behalf of the Lung Foundation Australia and the Thoracic Society of Australia and New Zealand 10.1111/resp.13025 (Apr 2017)
The aim of these Guidelines is to provide evidence-based recommendations for the practice of pulmonary rehabilitation (PR) specific to Australian and New Zealand healthcare contexts.
These first-ever pulmonary rehabilitation Guidelines for Australia and New Zealand were launched (24-28 March 2017) at the TSANZSRS Annual Scientific Meeting in Canberra, Australia (24-28 March 2017), and were drawn up following a systematic review of over 275 clinical trials.
The Guidelines recommend that all COPD patients should be offered pulmonary rehabilitation regardless of their disease severity.
See the full Editorial for these important Guidelines at onlinelibrary.wiley.com/doi/10.1111/resp.13039/full
20170329- Characteristics, incidence and outcome of patients admitted to intensive care because of pulmonary embolism Dario Winterton, Michael Bailey, David Pilcher, Giovanni Landoni & Rinaldo Bellomo DOI: 10.1111/resp.12881
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onlinelibrary.wiley.com/doi/10.1111/resp.12881/full (Feb 2017)Comment by Dr Mark Lavercombe:
This important study describes a large cohort of patients admitted with acute pulmonary embolism to Intensive Care Units across Australia and New Zealand. A subpopulation at very high risk of death is identified (those requiring mechanical ventilation). No improvement in mortality rate over time is seen.20170131 Usefulness of transcutaneous PCO2 to assess nocturnal hypoventilation in restrictive lung disorders. Georges et al.
onlinelibrary.wiley.com/doi/10.1111/resp.12812/full (May 2016)
(Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12871/abstract)20160915
