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A selection of publications with educational value in

Respiratory Structure and Function

Most recently added articles listed at the top

  • Figure 2
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    History of pulmonary tuberculosis affects the severity and clinical outcomes of COPD Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Deog Kyeom Kim, Yu Il Kim, Jin Young Oh, Hyoung Kyu Yoon, Kwang-Ha Yoo and Ki Suck Jung (DOI: 10.1111/resp.13147)
    onlinelibrary.wiley.com/doi/10.1111/resp.13147/full (Jan 2018)

    Comment by Dr Mark Lavercombe:
    The authors of this paper describe a cohort of patients with COPD who were stratified based on self-report of prior history of tuberculosis infection. Patients who admitted to prior Tb had more severe symptoms of COPD, poorer lung function and more frequent exacerbations. This difference was noted despite a lower prevalence of ongoing smoking in the tuberculosis group.


  • Table 3
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    Usefulness of a routine endoscopic assessment of laryngeal lesions after lung cancer surgery Alex Fourdrain, Florence De Dominicis, Jules Iquille, Sophie Lafitte, Geoni Merlusca, Alejandro Witte Pfister, Patrick Bagan and Pascal Berna (DOI: 10.1111/resp.13139)
    onlinelibrary.wiley.com/doi/10.1111/resp.13139/full (Jan 2018)

    Comment by Dr Mark Lavercombe:
    Vocal cord dysfunction is not uncommon in patients after lung cancer resection, and this study demonstrates a significant association with poor post-operative outcomes including pneumonia, need for bronchoscopy and re-intubation. The authors recommend routine laryngeal screening within 24h of surgery, although treatment outcomes were not assessed in this study.


  • Table 2
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    Spirometry reference values for population aged 7–80 years in China: Jingzhou Zhang, Xiao Hu and Guangliang Shan (DOI: 10.1111/resp.13118)
    onlinelibrary.wiley.com/doi/10.1111/resp.13118/full (Nov 2017)

    Comment by Dr Mark Lavercombe:
    Using data from the China National Health Survey 2012–2015, the authors of this paper propose spirometry prediction equations for a general Chinese population aged 7–80 years. Their equations compare favourably to those developed in more heterogeneous cohorts.


  • Figure 2
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    CT-determined pulmonary artery to aorta ratio as a predictor of elevated pulmonary artery pressure and survival in idiopathic pulmonary fibrosis: Mitsuaki Yagi, Hiroyuki Taniguchi, Yasuhiro Kondoh, Masahiko Ando, Tomoki Kimura, Kensuke Kataoka, Taiki Furukawa, Atsushi Suzuki, Takeshi Johkoh & Oshinori Hasegawa.
    10.1111/resp.13066 (Oct 2017)

    Comment by Dr Mark Lavercombe:
    The PA:A ratio as measured on chest CT scan has been demonstrated to predict pulmonary hypertension in some studies. In this cohort PA:A > 0.9 is found to predict both elevated mPAP and survival in patients with idiopathic pulmonary fibrosis.


  • The respiratory telerehabilitation (TeleR) trial team from Sydney, Australia
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    Home-based telerehabilitation via real-time videoconferencing improves endurance exercise capacity in patients with COPD: The randomized controlled TeleR Study Ling Ling Y Tsai, Renae J McNamara, Chloe Moddel, Jennifer A Alison, David K McKenzie & Zoe J McKeough 10.1111/resp.12966 (May 2017)

    Despite the clear health benefits in COPD patients, participation in pulmonary rehabilitation is variable with potential barriers including reduced mobility, lack of transport or travel costs. This randomised controlled trial evaluates home-based telerehabilitation compared with usual care and finds improved endurance exercise capacity and self-efficacy in the treatment group. Telerehabilitation might be an alternative option for pulmonary rehabilitation in those unable to attend centralised programmes. Table 3 presents outcomes for special consideration.


  • (Click image to enlarge)
    Frailty is common and strongly associated with dyspnoea severity in fibrotic interstitial lung disease, Kathryn M Milne, Joanne M Kwan, Sabina Guler, Tiffany A Winstone, Angela Le, Nasreen Khalil, Pat G Camp, Pearce G Wilcox & Christopher J Ryerson
    10.1111/resp.12944 (May 2017)

    Prognosis in patients with fibrotic interstitial lung diseases can vary significantly. In this study, the authors demonstrate that Frailty is highly prevalent in a cohort of patients with fibrotic ILD and strongly associated with dyspnoea severity. The authors propose a potential role for frailty assessment in identifying patients at risk of complications from invasive procedures or medical therapies, and/or mortality.

  • Pulmonary Rehabilitation Guidelines for Australia and New Zealand Jennifer A Alison, Zoe J McKeough, Kylie Johnston, Renae J McNamara, Lissa M Spencer, Sue C Jenkins, Catherine J Hill, Vanessa M McDonald, Peter Frith, Paul Cafarella, Michelle Brooke, Helen L Cameron-Tucker, Sarah Candy, Nola Cecins, Andrew S L Chan, Marita T Dale, Leona M Dowman, Catherine Granger, Simon Halloran, Peter Jung, Annemarie L Lee, Regina Leung, Tamara Matulick, Christian Osadnik, Mary Roberts, James Walsh, Sally Wootton, Anne E Holland, on behalf of the Lung Foundation Australia and the Thoracic Society of Australia and New Zealand 10.1111/resp.13025 (Apr 2017)

    The aim of these Guidelines is to provide evidence-based recommendations for the practice of pulmonary rehabilitation (PR) specific to Australian and New Zealand healthcare contexts.

    These first-ever pulmonary rehabilitation Guidelines for Australia and New Zealand were launched (24-28 March 2017) at the TSANZSRS Annual Scientific Meeting in Canberra, Australia (24-28 March 2017), and were drawn up following a systematic review of over 275 clinical trials.

    The Guidelines recommend that all COPD patients should be offered pulmonary rehabilitation regardless of their disease severity.

    See the full Editorial for these important Guidelines at onlinelibrary.wiley.com/doi/10.1111/resp.13039/full

  • Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report Claus F Vogelmeier, Gerard J Criner, Fernando J Martinez, Antonio Anzueto, Peter J Barnes, Jean Bourbeau, Bartolome R Celli, Rongchang Chen, Marc Decramer, Leonardo M Fabbri, Peter Frith, David M G Halpin, M Victorina López Varela, Masaharu Nishimura, Nicolas Roche, Roberto Rodriguez-Roisin, Don D Sin, Dave Singh, Robert Stockley, Jørgen Vestbo, Jadwiga A Wedzicha and Alvar Agusti 10.1111/resp.13012 (Apr 2017)

    This Executive Summary focuses primarily on the revised and novel parts of the document, including:

    1. the assessment of COPD has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations;
    2. for each of the groups A to D, escalation strategies for pharmacological treatments are proposed;
    3. the concept of de-escalation of therapy is introduced in the treatment assessment scheme;
    4. nonpharmacologic therapies are comprehensively presented;
    5. the importance of comorbid conditions in managing COPD is reviewed.

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    Bronchoscopy assessment of acute respiratory failure in interstitial lung disease Antonella Arcadu & Teng Moua DOI: 10.1111/resp.12909
    onlinelibrary.wiley.com/doi/10.1111/resp.12909/full (Feb 2017)

    Comment by Dr Mark Lavercombe:
    This study examines the utility of bronchoscopy in patients admitted with acute exacerbations of interstitial lung disease. Although a relatively low diagnostic yield is identified, significant potential complications are noted and there is no in-hospital mortality benefit seen in those undergoing the procedure.


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    Role of BMI, airflow obstruction, St George's Respiratory Questionnaire and age index in prognostication of Asian COPD. Chan et al. (resp12877/RES-16-062.R2)
    onlinelibrary.wiley.com/doi/10.1111/resp.12877/full (Jan 2017)

    Comment by Dr Mark Lavercombe:
    This study identifies important risk factors for mortality in Asian patients with COPD, and develops a prognosis model that is easy to use. Further validation studies will be required to assess its utility.


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    Airway stenting in the management of iatrogenic tracheal injuries: 10-Year experience Tazi-Mezalek et al. DOI: 10.1111/resp.12853
    onlinelibrary.wiley.com/doi/10.1111/resp.12853/full (Jul 2016)

    Comment by Dr Mark Lavercombe:
    This paper describes the experience of managing a very rare complication of endotracheal intubation or tracheostomy, including the nature and anatomical distribution of the injuries. Finally, outcomes using different treatment approaches is discussed.

  • Insulin resistance is associated with skeletal muscle weakness in COPD. Wells et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12716/abstract (Dec 2015)

  • Differences in baseline factors and survival between normocapnia, compensated respiratory acidosis and decompensated respiratory acidosis in COPD exacerbation: A pilot study. Lun et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12652/abstract (Oct 2015)

  • Efficacy and tolerability of budesonide/formoterol added to tiotropium compared with tiotropium alone in patients with severe or very severe COPD: A randomized, multicentre study in East Asia. Lee et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12646/abstract (Sep 2015)

  • Mother's smoking and complex lung function of offspring in middle age: A cohort study from childhood. Perret et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12750/abstract (Mar 2016)

    (FREE access: Editor's Choice)
  • Effect of long-term treatment with corticosteroids on skeletal muscle strength, functional exercise capacity and health status in patients with interstitial lung disease. Hanada et al.
    onlinelibrary.wiley.com/doi/10.1111/resp.12807/abstract (May 2016)
    (FREE access: Editor's Choice; Editorial: onlinelibrary.wiley.com/doi/10.1111/resp.12843/abstract)