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A selection of publications with educational value in

Cell and Molecular Biology

Most recently added articles listed at the top

  • Figure S2
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    Nasopharyngeal viral PCR in immunosuppressed patients and its association with virus detection in bronchoalveolar lavage by PCR: Daniel J Lachant, Daniel P Croft, Heather Mcgrane Minton, Paritosh Prasad & Robert M Kottmann. (DOI: 10.1111/resp.13049)
    onlinelibrary.wiley.com/doi/10.1111/resp.13049/full (Aug 2017)

    Comment by Dr Mark Lavercombe:
    Bronchoscopy with bronchoalveolar lavage is often required for immunosuppressed patients presenting with lung infiltrates. This study compares the diagnostic yield for respiratory virus PCR on nasopharyngeal and BAL specimens, and demonstrates both high concordance and low false negative rate for nasopharyngeal specimens.


  • Crude survival based on cardiac troponin T (cTnT) level on admission. (Figure 1)
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    High-sensitivity cardiac troponin T predicts mortality after hospitalization for community-acquired pneumonia Stefan M T Vestjens, Simone M C Spoorenberg, Ger T Rijkers, Jan C Grutters, Jurrien M ten Berg, Peter G Noordzi, Ewoudt M W van de Garde, Willem Jan W Bos and the Ovidius Study Group. (DOI: 10.1111/resp.12996)
    onlinelibrary.wiley.com/doi/10.1111/resp.12996/full (Jul 2017)

    Comment by Dr Mark Lavercombe:
    This paper demonstrates a significant relationship between levels of cardiac troponin measured at admission in patients with Community-Acquired Pneumonia and both 30-day and long-term mortality. The combination of Pneumonia Severity Index with Troponin level predicted mortality better than either model alone. These findings suggest cardiac evaluation might be worthwhile in patients with CAP and elevated Troponin.

  • Unproven Stem Cell Treatments for Lung Disease – An Emerging Public Health Problem
    Laertis Ikonomou, Angela Panoskaltsis-Mortari, Darcy E Wagner, Robert J Freishtat, Daniel J Weiss, on behalf of the American Thoracic Society Respiratory Cell and Molecular Biology Assembly Stem Cell Working Group. Reviewer: Marianna Sockrider
    American Journal of Respiratory and Critical Care Medicine (AJRCCM), 195(7), pp. P13–P14 www.atsjournals.org/doi/10.1164/rccm.1957P13 (Apr 2017)

    Comment by Dr Yasuhiro Yamauchi:
    This piece describes the information about unproven stem cell treatments for lung disease. It was prepared by the ATS Stem Cell Working Group. This would be a good resource for patients considering stem cell treatments for respiratory diseases.


  • (Click image to enlarge)
    Malignant pleural fluid from mesothelioma has potent biological activities. Cheah et al. (resp.12874/ RES-16-044.R1)
    onlinelibrary.wiley.com/doi/10.1111/resp.12874/full (Jan 2017)

    Comment by Dr Mark Lavercombe:
    This original article suggests that malignant pleural effusion in mesothelioma might not be purely a consequence of the malignancy, but could contribute to its pathobiology. This suggests the possibility of future therapeutic targets in this disease.

  • The Global Emergence of Unregulated Stem Cell Treatments for Respiratory Diseases
    www.atsjournals.org/doi/full/10.1513/AnnalsATS.201604-277ED#.V7ay8vl96Uk (Aug 2016)